WO2005061462A3 - Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators - Google Patents

Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators Download PDF

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Publication number
WO2005061462A3
WO2005061462A3 PCT/US2004/043103 US2004043103W WO2005061462A3 WO 2005061462 A3 WO2005061462 A3 WO 2005061462A3 US 2004043103 W US2004043103 W US 2004043103W WO 2005061462 A3 WO2005061462 A3 WO 2005061462A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurokinin
receptor modulators
pyrazole derivatives
diaryl pyrazole
compounds
Prior art date
Application number
PCT/US2004/043103
Other languages
French (fr)
Other versions
WO2005061462A2 (en
Inventor
George D Maynard
Jun Yuan
John M Peterson
Original Assignee
Neurogen Corp
George D Maynard
Jun Yuan
John M Peterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, George D Maynard, Jun Yuan, John M Peterson filed Critical Neurogen Corp
Publication of WO2005061462A2 publication Critical patent/WO2005061462A2/en
Publication of WO2005061462A3 publication Critical patent/WO2005061462A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of general Formula (I) wherein the variables are as defined herein. Pharmaceutical compositions comprising compounds of general Formula (I), and methods for treating patients suffering from a disorder responsive to neurokinin-3 receptor modulation are also provided. Compounds provided herein are also useful as probes for the localization of NK-3 receptors.
PCT/US2004/043103 2003-12-19 2004-12-17 Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators WO2005061462A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53156403P 2003-12-19 2003-12-19
US60/531,564 2003-12-19

Publications (2)

Publication Number Publication Date
WO2005061462A2 WO2005061462A2 (en) 2005-07-07
WO2005061462A3 true WO2005061462A3 (en) 2005-11-17

Family

ID=34710235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043103 WO2005061462A2 (en) 2003-12-19 2004-12-17 Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators

Country Status (1)

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WO (1) WO2005061462A2 (en)

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DK1781618T3 (en) 2004-08-27 2012-10-29 Esteve Labor Dr Sigma receptor inhibitors
PL1781618T3 (en) * 2004-08-27 2013-03-29 Esteve Labor Dr Sigma receptor inhibitors
EP1953145B1 (en) * 2005-11-21 2015-11-04 Shionogi & Co., Ltd. Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i
KR101376432B1 (en) 2007-05-18 2014-05-16 시오노기세이야쿠가부시키가이샤 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 β-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
NZ582057A (en) 2007-07-19 2012-03-30 Lundbeck & Co As H 5-membered heterocyclic amides and related compounds
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
WO2009137338A1 (en) * 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
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EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
AU2014364647A1 (en) 2013-12-17 2016-06-23 Laboratorios Del Dr. Esteve, S.A. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations
EP3331872B1 (en) 2015-08-05 2019-09-25 Bristol-Myers Squibb Company Novel substituted glycine derived fxia inhibitors
WO2022169004A1 (en) * 2021-02-05 2022-08-11 연세대학교 산학협력단 Composition for promoting ciliogenesis comprising novel fabp4 inhibitor as active ingredient

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Publication number Priority date Publication date Assignee Title
DE2612155A1 (en) * 1975-03-25 1976-10-14 Byk Gulden Lomberg Chem Fab NITROFURYL PYRAZOLE DERIVATIVES, METHOD FOR MANUFACTURING THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM
SU1427781A1 (en) * 1987-02-13 1992-04-23 Научно-исследовательский институт фармакологии АМН СССР 4-aminocarbpnyl- or 4-aminoethyl-5-methylpyrazols displaying capability of controlling ethanol removal rate
US20020198232A1 (en) * 1999-03-29 2002-12-26 Neurogen Corporation 4-substituted quinoline derivatives
WO2004043951A1 (en) * 2002-10-24 2004-05-27 Carex S.A. Pyrazole derivatives as modulators of peroxisome proliferator activated receptors
WO2004076418A1 (en) * 2003-02-28 2004-09-10 Galderma Research & Development, S.N.C. Ligands that modulate lxr-type receptors

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
DE2612155A1 (en) * 1975-03-25 1976-10-14 Byk Gulden Lomberg Chem Fab NITROFURYL PYRAZOLE DERIVATIVES, METHOD FOR MANUFACTURING THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM
SU1427781A1 (en) * 1987-02-13 1992-04-23 Научно-исследовательский институт фармакологии АМН СССР 4-aminocarbpnyl- or 4-aminoethyl-5-methylpyrazols displaying capability of controlling ethanol removal rate
US20020198232A1 (en) * 1999-03-29 2002-12-26 Neurogen Corporation 4-substituted quinoline derivatives
WO2004043951A1 (en) * 2002-10-24 2004-05-27 Carex S.A. Pyrazole derivatives as modulators of peroxisome proliferator activated receptors
WO2004076418A1 (en) * 2003-02-28 2004-09-10 Galderma Research & Development, S.N.C. Ligands that modulate lxr-type receptors

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M. K. BRATENKO ET AL.: "4-Functionally Substituted 3-Heterylpyrazoles: III. 3-Aryl(heteryl)pyrazole-4-carboxylic Acids and Their Derivatives", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY., vol. 37, no. 4, 2001, US CONSULTANTS BUREAU., pages 552 - 555, XP002332303 *
P. A. S. SMITH ET AL.: "Thermally Induced Fragmentation of Some Azidopyrazole Derivatives", JOURNAL OF ORGANIC CHEMISTRY., vol. 38, no. 17, 1973, USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 2958 - 2963, XP002332302 *
V. A. ZAGOREVSKII ET AL.: "Pyrazole-4-carboxamides and -acetamides as antialcoholic agents", KHIMIKO-FARMATSEVTICHESKII ZHURNAL., vol. 23, no. 8, 1989, RU, MOSCOW., pages 966 - 971 *

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