WO2005060377A3 - Modulation of immunostimulatory properties by small oligonucleotide-based compounds - Google Patents

Modulation of immunostimulatory properties by small oligonucleotide-based compounds Download PDF

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Publication number
WO2005060377A3
WO2005060377A3 PCT/US2004/016298 US2004016298W WO2005060377A3 WO 2005060377 A3 WO2005060377 A3 WO 2005060377A3 US 2004016298 W US2004016298 W US 2004016298W WO 2005060377 A3 WO2005060377 A3 WO 2005060377A3
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WIPO (PCT)
Prior art keywords
modulation
based compounds
immunostimulatory properties
small oligonucleotide
detail
Prior art date
Application number
PCT/US2004/016298
Other languages
French (fr)
Other versions
WO2005060377A2 (en
Inventor
Sudhir Agrawal
Fu-Gang Zhu
Ekambar R Kandimalla
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Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Priority to JP2006543783A priority Critical patent/JP2007530449A/en
Priority to CN2004800414798A priority patent/CN101094594B/en
Priority to AU2004304770A priority patent/AU2004304770B2/en
Priority to KR1020067013704A priority patent/KR101138131B1/en
Priority to EP04820710A priority patent/EP1699814A4/en
Priority to CA002549173A priority patent/CA2549173A1/en
Publication of WO2005060377A2 publication Critical patent/WO2005060377A2/en
Publication of WO2005060377A3 publication Critical patent/WO2005060377A3/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/50—Physical structure
    • C12N2310/52—Physical structure branched

Abstract

While the foregoing invention has been described in some detail for purposes of clarity and understanding, it will be appreciated by one skilled in the art from a reading of this disclosure that various changes in form and detail can be made without departing from the true scope of the invention and appended claims.
PCT/US2004/016298 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds WO2005060377A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2006543783A JP2007530449A (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by compounds based on small oligonucleotides
CN2004800414798A CN101094594B (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds
AU2004304770A AU2004304770B2 (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds
KR1020067013704A KR101138131B1 (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds
EP04820710A EP1699814A4 (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds
CA002549173A CA2549173A1 (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52827703P 2003-12-08 2003-12-08
US60/528,277 2003-12-08

Publications (2)

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WO2005060377A2 WO2005060377A2 (en) 2005-07-07
WO2005060377A3 true WO2005060377A3 (en) 2007-07-05

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PCT/US2004/016298 WO2005060377A2 (en) 2003-12-08 2004-05-24 Modulation of immunostimulatory properties by small oligonucleotide-based compounds

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US (2) US7713535B2 (en)
EP (2) EP2060269A3 (en)
JP (1) JP2007530449A (en)
KR (1) KR101138131B1 (en)
CN (1) CN101094594B (en)
AU (1) AU2004304770B2 (en)
CA (1) CA2549173A1 (en)
WO (1) WO2005060377A2 (en)

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JP2007530449A (en) 2007-11-01
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