WO2005058953A3 - Ogh fusion polypeptides and therapeutic uses thereof - Google Patents

Ogh fusion polypeptides and therapeutic uses thereof Download PDF

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Publication number
WO2005058953A3
WO2005058953A3 PCT/US2004/041227 US2004041227W WO2005058953A3 WO 2005058953 A3 WO2005058953 A3 WO 2005058953A3 US 2004041227 W US2004041227 W US 2004041227W WO 2005058953 A3 WO2005058953 A3 WO 2005058953A3
Authority
WO
WIPO (PCT)
Prior art keywords
ogh
fusion polypeptides
therapeutic uses
fusion
hfc
Prior art date
Application number
PCT/US2004/041227
Other languages
French (fr)
Other versions
WO2005058953A2 (en
Inventor
Andrew J Murphy
Lynn Macdonald
Mark W Sleeman
Original Assignee
Regeneron Pharma
Andrew J Murphy
Lynn Macdonald
Mark W Sleeman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Andrew J Murphy, Lynn Macdonald, Mark W Sleeman filed Critical Regeneron Pharma
Publication of WO2005058953A2 publication Critical patent/WO2005058953A2/en
Publication of WO2005058953A3 publication Critical patent/WO2005058953A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit α1 or α2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). in one embodiment, the fusion protein comprises hOGH-hFc-hα2 or hTSH-hFc-hα1.
PCT/US2004/041227 2003-12-12 2004-12-09 Ogh fusion polypeptides and therapeutic uses thereof WO2005058953A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52903603P 2003-12-12 2003-12-12
US60/529,036 2003-12-12
US54841504P 2004-02-27 2004-02-27
US60/548,415 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005058953A2 WO2005058953A2 (en) 2005-06-30
WO2005058953A3 true WO2005058953A3 (en) 2005-09-01

Family

ID=34704263

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/041227 WO2005058953A2 (en) 2003-12-12 2004-12-09 Ogh fusion polypeptides and therapeutic uses thereof

Country Status (1)

Country Link
WO (1) WO2005058953A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0510627D0 (en) 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
CN103539860B (en) 2013-11-01 2014-12-03 广州优联康医药科技有限公司 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (hFSH-Fc)
CN103539862B (en) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 Long-acting recombinant follicle-stimulating hormone and application thereof
CN103554268B (en) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 Long-acting recombinant follicle-stimulating hormone and application thereof
CN106279437B (en) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 Hyperglycosylated human coagulation factor VIII fusion proteins and preparation method thereof and purposes
CN107759694B (en) * 2016-08-19 2023-01-13 安源医药科技（上海）有限公司 Bispecific antibody, preparation method and application thereof
CN106117370B (en) * 2016-08-19 2017-05-17 安源医药科技（上海）有限公司 Hyperglycosylated Extendin-4, fusion protein of analogue thereof, and preparation method and application of fusion protein
WO2018032638A1 (en) 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 Linker peptide for constructing fusion protein
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
WO2001073034A2 (en) * 2000-03-28 2001-10-04 Amgen Inc. Beta-like glycoprotein hormone polypeptide and heterodimer
WO2002014348A2 (en) * 2000-08-11 2002-02-21 Applied Research Systems Ars Holding N.V. Glycoproteins and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
WO2001073034A2 (en) * 2000-03-28 2001-10-04 Amgen Inc. Beta-like glycoprotein hormone polypeptide and heterodimer
WO2002014348A2 (en) * 2000-08-11 2002-02-21 Applied Research Systems Ars Holding N.V. Glycoproteins and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAKABAYASHI KOJI ET AL: "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor", JOURNAL OF CLINICAL INVESTIGATION, vol. 109, no. 11, June 2002 (2002-06-01), pages 1445 - 1452, XP002322637, ISSN: 0021-9738 *

Also Published As

Publication number Publication date
WO2005058953A2 (en) 2005-06-30

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