WO2005058885A3 - Composes - Google Patents

Composes Download PDF

Info

Publication number
WO2005058885A3
WO2005058885A3 PCT/EP2004/013222 EP2004013222W WO2005058885A3 WO 2005058885 A3 WO2005058885 A3 WO 2005058885A3 EP 2004013222 W EP2004013222 W EP 2004013222W WO 2005058885 A3 WO2005058885 A3 WO 2005058885A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidine derivatives
transporter inhibitors
glycine transporter
compounds
glycine
Prior art date
Application number
PCT/EP2004/013222
Other languages
English (en)
Other versions
WO2005058885A2 (fr
Inventor
Daniel Marcus Bradley
Clive Leslie Branch
Howard Marshall
David John Nash
Roderick Alan Porter
Original Assignee
Glaxo Group Ltd
Daniel Marcus Bradley
Clive Leslie Branch
Howard Marshall
David John Nash
Roderick Alan Porter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329363A external-priority patent/GB0329363D0/en
Priority claimed from GB0413108A external-priority patent/GB0413108D0/en
Application filed by Glaxo Group Ltd, Daniel Marcus Bradley, Clive Leslie Branch, Howard Marshall, David John Nash, Roderick Alan Porter filed Critical Glaxo Group Ltd
Publication of WO2005058885A2 publication Critical patent/WO2005058885A2/fr
Publication of WO2005058885A3 publication Critical patent/WO2005058885A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

L'invention concerne un composé de formule (I) ou un sel ou un solvant de ce composé. Dans la formule (I), R1 à R8, X et Ar sont tels que définis dans la description. L'invention concerne également l'utilisation de ces composés. Lesdits composés inhibent les transporteurs de GlyT1 et sont utiles dans le traitement de certains troubles neurologiques et neuropsychiatriques, tels que la schizophrénie.
PCT/EP2004/013222 2003-12-18 2004-11-18 Composes WO2005058885A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0329363A GB0329363D0 (en) 2003-12-18 2003-12-18 Compounds
GB0329363.6 2003-12-18
GB0413108.2 2004-06-11
GB0413108A GB0413108D0 (en) 2004-06-11 2004-06-11 Compounds

Publications (2)

Publication Number Publication Date
WO2005058885A2 WO2005058885A2 (fr) 2005-06-30
WO2005058885A3 true WO2005058885A3 (fr) 2005-09-09

Family

ID=34702518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/013222 WO2005058885A2 (fr) 2003-12-18 2004-11-18 Composes

Country Status (1)

Country Link
WO (1) WO2005058885A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8957089B2 (en) 2008-04-01 2015-02-17 AbbVie Deutschland GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US9096619B2 (en) 2009-02-16 2015-08-04 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0414797D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Compounds
CA2590287A1 (fr) * 2004-12-16 2006-06-22 Janssen Pharmaceutica N.V. Combinaison d'un inhibiteur de transporteur glycine (glyt1) et d'un antipsychotique destinee au traitement de symptomes de la schizophrenie ainsi que la preparation et l'utilisation de ce compose
JP5266042B2 (ja) * 2005-04-11 2013-08-21 エール ユニヴァーシティ 統合失調症前駆症の治療方法
EP2178842A2 (fr) 2007-08-22 2010-04-28 Abbott GmbH & Co. KG 4-benzylaminoquinolines, compositions pharmaceutiques les contenant et leur utilisation
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013072520A1 (fr) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG Dérivés aminobenzocycloheptène, aminotétraline, aminoindane et phénalkylamine n-substitués, composition pharmaceutiques les contenant, et leur application thérapeutique
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
KR20190015748A (ko) * 2016-06-08 2019-02-14 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Atf4 경로 억제제로서의 화학적 화합물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457686A1 (fr) * 1990-05-18 1991-11-21 Adir Et Compagnie Nouveaux dérivés de l'amino pipéridine de l'amino pyrrolidine et de l'amino perhydroazépine, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
WO1999044596A2 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine
WO2001081308A2 (fr) * 2000-04-20 2001-11-01 Nps Allelix Corp. Aminopiperidines
WO2003053942A1 (fr) * 2001-12-20 2003-07-03 H. Lundbeck A/S Derives d'aryloxyphenyle et d'arylsulfanylphenyle

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457686A1 (fr) * 1990-05-18 1991-11-21 Adir Et Compagnie Nouveaux dérivés de l'amino pipéridine de l'amino pyrrolidine et de l'amino perhydroazépine, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
WO1999044596A2 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine
WO2001081308A2 (fr) * 2000-04-20 2001-11-01 Nps Allelix Corp. Aminopiperidines
WO2003053942A1 (fr) * 2001-12-20 2003-07-03 H. Lundbeck A/S Derives d'aryloxyphenyle et d'arylsulfanylphenyle

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957089B2 (en) 2008-04-01 2015-02-17 AbbVie Deutschland GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US9096619B2 (en) 2009-02-16 2015-08-04 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9227930B2 (en) 2010-08-13 2016-01-05 Abbvie Inc. Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9238619B2 (en) 2010-08-13 2016-01-19 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy

Also Published As

Publication number Publication date
WO2005058885A2 (fr) 2005-06-30

Similar Documents

Publication Publication Date Title
WO2005058885A3 (fr) Composes
WO2007014762A3 (fr) Inhibiteurs de transporteurs glyt1 et leurs utilisations dans le traitement de troubles neurologiques et neuropsychiatriques
CA2510853A1 (fr) Derives de pyrrolopyrimidine
IL174075A0 (en) 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
IL173768A0 (en) 1-(2-amino-benzol)-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
PT1625126E (pt) Imidazo- e tiazolopiridinas como inibidores de cinase jak3
IL176062A0 (en) Dpp-iv inhibitors
EA200501936A1 (ru) Производные пиридо[2,1-a]изохинолина в качестве ингибиторов dpp-iv
WO2007072158A8 (fr) Dérivés pyrimidiques destinés à traiter une croissance cellulaire anormale
CA2499330A1 (fr) Nouvelles quinazolinones spiro-condensees et utilisation associee en tant qu'inhibiteurs de phosphodiesterase
ZA200705472B (en) [4-(heteroaryl) piperazin-1-yl]-(2,5-substituted-phenyl) methanone derivatives as glycine transporter 1 (GlyT-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
WO2006100082A3 (fr) Derives d'oxindole substitues, medicaments contenant ces derives et leur utilisation
WO2004022528A3 (fr) Derives d'arylglycine et leur utilisation comme inhibiteurs du transport de la glycine
WO2006116733A3 (fr) Inhibiteurs des proteines kinases
WO2007053495A3 (fr) Composes utiles en tant qu’antagonistes de ccr2
WO2005021544A3 (fr) Inhibiteurs d'un ensemble d'imidazopyridine c n3 substitue
IL165887A0 (en) Novel tetrahydropyridine derivatives as renin inhibitors
HK1089746A1 (en) Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
NO20064351L (no) Caspaseinhibitorer og anvendelser derav
UA96759C2 (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
TW200733963A (en) Cough inhibitor
WO2007053499A3 (fr) Composés pouvant être employés en tant qu'antagonistes de ccr2
WO2006124865A3 (fr) Biaryles utiles en tant que modulateurs des canaux ioniques
WO2006072000A3 (fr) Compositions pharmaceutiques a base de derives d'acide xanthurenique et methodes associees
WO2004111008A3 (fr) Utilisation d'un compose de formule i pour la preparation d'une composition pharmaceutique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase