WO2005058394A1 - Dispositif de distribution de fluide - Google Patents

Dispositif de distribution de fluide Download PDF

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Publication number
WO2005058394A1
WO2005058394A1 PCT/AU2004/001771 AU2004001771W WO2005058394A1 WO 2005058394 A1 WO2005058394 A1 WO 2005058394A1 AU 2004001771 W AU2004001771 W AU 2004001771W WO 2005058394 A1 WO2005058394 A1 WO 2005058394A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
anaesthetic
patient
reservoir
catheter
Prior art date
Application number
PCT/AU2004/001771
Other languages
English (en)
Inventor
Philip Stuart Esnouf
Original Assignee
Ultimate Medical Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003906972A external-priority patent/AU2003906972A0/en
Application filed by Ultimate Medical Pty. Ltd. filed Critical Ultimate Medical Pty. Ltd.
Priority to EP04802073A priority Critical patent/EP1708767A4/fr
Priority to GB0612015A priority patent/GB2424374B/en
Priority to CA2557469A priority patent/CA2557469C/fr
Priority to AU2004298287A priority patent/AU2004298287B2/en
Publication of WO2005058394A1 publication Critical patent/WO2005058394A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/048—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids

Definitions

  • the present invention relates to a fluid delivery device.
  • the invention relates to a local anaesthetic fluid delivery device for slow delivery of local anaesthetic fluid to a patient while the device is attached to the patient.
  • a convenient way of administering such local anaesthetic is to allow the patient to carry an anaesthetic fluid delivery device which is arranged to allow release of the local anaesthetic fluid to the patient surgery site over a period of time.
  • the Pain Buster device is a 270 ml capacity device with a spherical balloon designed to be placed in a cloth pouch which can be tied around the patient's waist. Disadvantages associated with this device include that it does not affix securely to the patient and can result in tangled tubing. Because of its size, it can introduce a relatively large volume of anaesthetic liquid to the treatment site, but this also results in it being cumbersome in size and weight.
  • a similar product, called “Pain Pump” made by Stryker Corporation includes a spring-driven rigid pump that is also placed in a pouch in a similar fashion to the Pain Buster product. The Pain Pump is an even bigger device, being about 5 inches in diameter and 8 inches long, resulting in even more cumbersome size and weight characteristics. It is desired to provide a device which addresses or ameliorates one or more disadvantages associated with prior art fluid delivery devices.
  • a local anaesthetic delivery device for supplying local anaesthetic to a patient, the device including: anaesthetic supply means; an outlet line which is supplied with local anaesthetic from said supply means; a housing within which the anaesthetic supply means is located; and means for adhering the housing to a patient.
  • the invention also provides a method of delivering local anaesthetic to a patient having a catheter including the steps of: introducing a charge of local anaesthetic to anaesthetic supply means located in a housing; adhering the housing to the skin of the patient near the catheter; and coupling an outlet line of the supply means to said catheter.
  • the invention provides a fluid delivery device, including: fluid delivery means for delivering fluid to a patient; and a housing at least partially enclosing the fluid delivery means, the housing cooperating with adhesion means for adhering the housing to the patient during fluid delivery.
  • the fluid delivery device is lightweight and the housing is mostly formed of lightweight plastic.
  • the fluid delivery means includes an inflatable fluid reservoir which, when inflated with fluid, such as local anaesthetic fluid, applies pressure to the fluid so as to cause it to flow along a fluid delivery line to the patient.
  • the fluid delivery line includes a flow restriction between the inflatable reservoir and the patient site for limiting the rate of flow of fluid to the patient along the fluid delivery line.
  • a filter is included in the fluid delivery line between the inflatable fluid reservoir and the flow restriction.
  • the housing is roughly dome shaped in cross-section on a side facing away from the patient when the housing is adhered to the patient.
  • the underside of the housing is relatively planar but of a flexible material to accommodate adhesion to non-planar areas of the patient's skin.
  • the housing includes a semi- cylindrical reinforcing member within an outer wall of the housing for providing increased shape stability to the dome shape of the housing.
  • a raised area is provided on an outer portion of the domed area of the housing for affixing a label thereto.
  • the fluid delivery device has an inlet port at one end thereof and the inlet port is in fluid connection with the inflatable reservoir via a one-way valve operative such that fluid is only allowed to pass from the inlet port to the inflatable fluid reservoir.
  • the inlet port may include a female luer fitting for engaging with a male luer fitting of a syringe, whereby the anaesthetic fluid can be injected in to the inflatable fluid reservoir, thereby inflating the reservoir with the anaesthetic fluid.
  • an amount of local anaesthetic fluid can be stored in the inflatable reservoir over a period of time, for example in the order of 24 hours, and the fluid delivery device will slowly deliver the local anaesthetic fluid to the patient site during that time.
  • the fluid delivery device has a relatively large adhesive area on its underside, including wings extending to either side to increase the surface area to which the adhesive is applied.
  • the invention provides a method of local anaesthetic delivery, including: providing the fluid delivery device described above; securing the housing to the patient, preferably using the adhesion means; and providing local anaesthetic fluid to the fluid delivery means.
  • the invention provides a fluid delivery device, including: fluid delivery means for delivering fluid to a patient; and a housing formed predominantly of lightweight plastics at least partially enclosing the fluid delivery means and being adapted for direct attachment to the patient.
  • the direct attachment is to the patient's skin proximate a patient fluid delivery site.
  • the invention provides a local anaesthetic fluid delivery device, including: a fluid reservoir for delivering local anaesthetic fluid to a patient via an outlet of the fluid delivery device; and securing means at least partially enclosing the fluid reservoir, the securing means having adhesion means on one side thereof for securing the device to the patient during fluid delivery.
  • the invention provides a fluid delivery device, including: an inflatable fluid reservoir; a fluid outlet in connection with the fluid reservoir for delivering fluid to a patient site; a flow limiting device disposed between, and in connection with, the fluid reservoir and the outlet for limiting fluid delivery to the patient site; means for at least partially housing the fluid reservoir; and means for affixing the means for housing to a patient in proximity to the patient site.
  • the means for affixing includes at least part of the means for housing and includes, or is adapted to cooperate with, an adhesive or adhesion means.
  • the means for affixing affixes the means for housing to a patient's skin.
  • a further aspect of the invention relates to a special bladder for use as the inflatable fluid reservoir, as described in the detailed description.
  • fluid delivery devices are light and may be easily affixed to patients by means of an adhesive underside surface.
  • the amount of local anaesthetic fluid held in the fluid reservoir is generally less than the amount held by prior art devices, thus reducing the weight carried by the fluid delivery device.
  • the components of the device are all relatively cheap to purchase or manufacture, the device has a significantly lower manufacturing cost than prior art devices.
  • the fluid reservoir in the form of an inflatable balloon or bladder, is formed of a flexible polyisoprene material, rather than latex. While latex would normally be an ideal material for an inflatable bladder of the kind contemplated, a number of patients are allergic to latex and therefore the choice of an alternative material, such as polyisoprene, is desirable.
  • the device can be better fixed in place, with less chance of the fluid delivery line becoming entangled or the fluid delivery device being dislodged or getting in the way when the patient moves.
  • the dome form of the device helps to prevent or reduce external pressure being applied to the fluid reservoir if, for example, the patient should inadvertently contact the outside of the domed outer wall of the device.
  • the device of the invention can be made with inexpensive material so that it is a single use or disposable device.
  • the device is lightweight and compact so that it can be discretely worn under the clothing of a patient.
  • the device has a housing which has a length in the range from 120 to
  • the weight of the device is in the range from 25 to 50gms and preferably about 35gms.
  • Figure 1 is a plan view of a fluid delivery device according to an embodiment of the invention
  • Figure 2 is a longitudinal cross section through the device
  • Figure 3 is a transverse cross-sectional view through the device
  • Figure 4 is an enlarged view of part of the device
  • Figure 5 is a cross-sectional view along the line 5-5
  • Figure 6 shows the device with the fluid reservoir inflated
  • Figure 7 shows an attachment for altering the delivery rate from the device
  • Figure 8 is a schematic view showing deployment of the device on a patient.
  • the device 2 illustrated in the drawings is for delivery of local anaesthetic to a patient 3 at a controlled rate.
  • the device includes an inflatable reservoir 4 which as best seen in Figures 4 and 5 includes a central cylindrical portion 8 and smaller diameter end portions 10 and 12.
  • the end portion 12 is received within a threaded socket 14 of a female luer connector 16.
  • the luer connector may include a one-way valve (not shown) which permits fluid to pass from an inlet port 18 to the interior of the reservoir 4 but not in the reverse direction.
  • the other end portion 12 is connected to an outlet line 20.
  • the end of the reservoir 4 is a snug fit on the outer diameter of the line 20 and is retained in position by means of a retaining band 22.
  • the outlet line 20 is connected to a micro filter 30 of known type for filtering out any solid materials in the fluid delivered from the reservoir.
  • the filter 30 is then connected to a flow restricting line 32 which terminates in a male luer connector 34.
  • the male luer connector 34 can be connected to a female luer connector 36 or to a cap (not shown).
  • the reservoir 4 is located within a protective housing 38 which includes a base wall 40 which is generally cruciform in shape and having rounded ends.
  • the housing can be regarded as a lightweight flexible pouch which enables it to be directly adhered to the skin of the patient 3 whilst not causing significant discomfort.
  • the housing 38 also includes a top wall 42 which is generally complementary in shape to the base but is domed so as to accommodate the reservoir 4.
  • the top wall 42 is formed with a peripheral flange 44 enabling it to be glued or bonded to the base wall 40.
  • the top wall 42 is formed with an inlet formation 46 to permit the female luer connector to pass therethrough.
  • the top wall 42 is formed with an outlet formation 48 which permits the outlet line 20 to pass therethrough.
  • the housing 38 also includes a stiffening sleeve 50 which is generally semi-cylindrical and located adjacent to the top wall 42 as shown in Figures 2 and 3.
  • the cruciform shape of the base wall 40 defines two lateral wings 54 and 56, the ends of which are generally rounded, as shown in Figure 1.
  • the underside surface of the wings 54 and 56 and the part of the base wall 40 therebetween are provided with a layer 58 of adhesive.
  • the adhesive layer 58 is covered by a removable backing strip 60.
  • the backing strip 60 can be removed so that the adhesive layer 58 can be used to adhere the housing 38 to the skin of a patient adjacent to the site 61 where the local anaesthetic is to be delivered, as shown in Figure 8.
  • the housing 38 can be adhered to a dressing which may be present near a surgical site rather than directly to the skin of the patient.
  • the adhesive is preferably a hypoallergenic medical grade adhesive such as product code 467MP made by 3M.
  • the surface area of the adhesive layer is preferably in the range from 80 to 150sq cm and most preferably about 115sq cm in order to provide secure adhesion to the patient's skin.
  • the wings 54 and 56 preferably extend from about 30 to 100mm and more preferably about 40mm laterally from the outer periphery of the flange 44. This enables the flaps to be used to secure delivery lines beneath them and the patient's skin, as will be described below.
  • the housing 38 is formed from clear flexible polyvinylchloride which is relatively soft to touch and is comfortable for the patient.
  • the PNC materials can be glued together using a cyclohexanone adhesive. Alternatively, the PNC components can be ultrasonically welded.
  • the domed shape of the top wall 42 and the inlet and outlet formations 46 and 48 can be moulded by vacuum forming an initially flat sheet of PNC.
  • the sheet of PNC which is used to form the top wall preferably has an initial thickness of say 0.6mm.
  • the base wall 40 is preferably die cut from a flat sheet of PNC having a thickness of say 0.25mm.
  • the stiffening sleeve 50 is preferably formed from a relatively stiff plastics material.
  • the stiffening sheet 50 is initially flat and is held in the hemi-cylindrical shape as shown in Figure 3 by elastic forces. Edges of the stiffening sleeve 50 butt against the upper side of the base wall 40. The stiffening sleeve 50 helps to maintain the domed shape of the top wall 42.
  • the reservoir 4 is preferably formed from flexible polyisoprene material and may be say 60mm long and having an outside diameter in the range from say 6.3 to 10.5mm. The wall thickness is approximately 2mm.
  • a syringe 62 preferably having a male luer connector on its end, can be coupled to the female luer connector 16.
  • the syringe 62 is used to fill the reservoir 4 with local anaesthetic and the pressure of the anaesthetic inflates the reservoir to an inflated position as shown in Figure 6. Normally the reservoir will hold about 120mls of local anaesthetic when fully inflated. Once the reservoir 4 has been inflated, the syringe 62 can be disconnected and the resilient pressure applied by the inflated reservoir 4 will force the local anaesthetic through the outlet line 20, through the filter 30 and into the flow restricting line 32 so that the system is flushed with anaesthetic in readiness for use.
  • the reservoir is preferably injection moulded from polyisoprene. It contains no latex and is therefore suitable for use with patients who may be allergic to latex.
  • the reservoir 4 preferably complies with US FDA and International Pharmacoepia requirements including requirements for ISO 10993-5.
  • the fluid reservoir is highly elastic and behaves like a resilient bladder. Its initial volume is expanded from a relaxed state of about 7 to 10ml to an expanded state of 120ml.
  • the elastic properties of the reservoir 4 exert the pressure on the local anaesthetic and this property in conjunction with the flow restricting line 32 is a particularly simple and effective way of delivering a relatively constant supply of anaesthetic to the patient.
  • the internal pressure of the anaesthetic will be about 8.5 to 9 psi and this pressure will remain substantially constant as the anaesthetic is dispensed and the elastic extension of the reservoir becomes less. It has been found that there is little variation in pressure until about the last 5% of the anaesthetic remains in the reservoir after which there will be a rise in pressure and a brief increase in delivery rate.
  • the technique is low cost and does not involve the use of any pump or motor or other form of power input to the device other than the initial energy which is expended when the syringe 62 is used to inflate the reservoir 4.
  • the rate of flow of local anaesthetic from the inflated reservoir 4 would be non-linear and generally proportional to the extent of expansion of the reservoir.
  • the provision of the flow restricting line 32 ensures a generally uniform rate of delivery of anaesthetic to the patient, notwithstanding the variation in pressure applied by the reservoir 4.
  • the flow restricting line 32 has a very fine bore and the pressure drop therein is substantial compared with pressure drops in other parts of the device and hence the flow rate is more or less constant. It is preferred that the flow restricting line 32 is formed of PNC microbore tubing having a nominal internal diameter of about 0.1 mm and nominal outside diameter of 2 mm. It is preferred for flow restricting line 32 to be about 95 mm in length, which allows an anaesthetic fluid flow of about 5 ml per hour. Generally speaking, the flow rate is inversely proportional to the length of the flow restricting line 32. If a lower flow rate is required an additional flow restricting line 64 can be provided, as seen in Figure 7.
  • the additional flow restricting line 64 has the same length as the line 32 so that when connected in series the flow delivery rate will be reduced from about 5ml per hour to about 2.5ml per hour.
  • the additional flow restricting line 64 can be provided with a female luer coupling 65 at one end and a male luer coupling 66 at the other.
  • Figure 8 shows the device 2 deployed on the patient 3.
  • the reservoir 4 has been filled with local anaesthetic.
  • the backing strip 60 has been removed so that the adhesive layer 58 can be applied directly to the skin of the patient.
  • part of the line 20 and/or flow restricting line 32 can be located under one or other of the wings 54 or 56 in order to prevent fouling of these components.
  • the male luer connector 34 can then be connected to a female luer mounted on the end of a catheter 68 which enters the skin of the patient beneath an adhesive bandage 70, as shown.
  • the device of the invention is simple and inexpensive to make which makes it suitable as a single use product. It is also convenient and comfortable for the patient 3 when compared to the bulky rigid structures of the prior art.
  • the device has a housing which has a length in the range from 120 to 180mm and preferably about 160mm, a width in the range from 60 to lOOmm and preferably 80mm and a height in the range from 20 to 50mm and preferably 35mm.
  • the weight of the device (without local anaesthetic) is in the range from 25 to 50gms and preferably about 35gms. Accordingly, the device is compact and lightweight and so it can be discretely worn by a patient beneath the patient's clothes.
  • the wings 54 and 56 have sufficient lateral extent so that the outlet line 20 arid/or the flow restricting lines 32 and 64 can be fastened between one or both wings 54, 56 and the patient's skin adjacent to the site where the catheter 68 is located and this minimises the possibility of the lines being caught and torn away from the patient if these lines were external to the patient's clothing as they are in the prior art devices.
  • the compact, lightweiglit device of the invention having a pouch like housing with a flat base provided with adhesive material constitutes a significant advantage over prior art devices.
  • the primary use of the device of the invention is for delivery of local anaesthetic, it is possible that the same or a similar device could be used for delivering local anaesthetic together with other medical agents or alternatively other medical agents not necessarily including local anaesthetic.
  • Many modifications will be apparent to those skilled in the art without departing from the spirit and scope of the invention.

Abstract

L'invention concerne un dispositif de distribution d'un anesthésique local permettant d'administrer un anesthésique local à un patient, ledit dispositif comprenant un moyen (4) de distribution d'anesthésique, un tuyau (20) de sortie contenant l'anesthésique local injecté par le moyen (4) de distribution, un logement (38) contenant le moyen de distribution d'anesthésique, et un moyen permettant de fixer le logement sur la peau d'un patient (54, 56).
PCT/AU2004/001771 2003-12-16 2004-12-16 Dispositif de distribution de fluide WO2005058394A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04802073A EP1708767A4 (fr) 2003-12-16 2004-12-16 Dispositif de distribution de fluide
GB0612015A GB2424374B (en) 2003-12-16 2004-12-16 Fluid delivery device
CA2557469A CA2557469C (fr) 2003-12-16 2004-12-16 Dispositif de distribution de fluide
AU2004298287A AU2004298287B2 (en) 2003-12-16 2004-12-16 Fluid delivery device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003906972 2003-12-16
AU2003906972A AU2003906972A0 (en) 2003-12-16 Fluid delivery device

Publications (1)

Publication Number Publication Date
WO2005058394A1 true WO2005058394A1 (fr) 2005-06-30

Family

ID=34682613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2004/001771 WO2005058394A1 (fr) 2003-12-16 2004-12-16 Dispositif de distribution de fluide

Country Status (4)

Country Link
EP (1) EP1708767A4 (fr)
CA (1) CA2557469C (fr)
GB (1) GB2424374B (fr)
WO (1) WO2005058394A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015183612A1 (fr) * 2014-05-29 2015-12-03 Avent, Inc. Dispositif portable de régulation du débit permettant d'administrer un fluide à un patient
US9265904B2 (en) 2009-07-06 2016-02-23 Teleflex Life Sciences Artificial airway
US9528897B2 (en) 2009-08-13 2016-12-27 Chimden Medical Pty Ltd Pressure indicator
US10549054B2 (en) 2011-02-02 2020-02-04 Teleflex Life Sciences Unlimited Company Artificial airway
US10576229B2 (en) 2009-03-03 2020-03-03 The Laryngeal Mask Company Limited Artificial airway device

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US5019047A (en) * 1989-06-16 1991-05-28 Science Incorporated Fluid delivery apparatus
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10576229B2 (en) 2009-03-03 2020-03-03 The Laryngeal Mask Company Limited Artificial airway device
US9265904B2 (en) 2009-07-06 2016-02-23 Teleflex Life Sciences Artificial airway
US10576230B2 (en) 2009-07-06 2020-03-03 Teleflex Life Sciences Unlimited Company Artificial airway
US9528897B2 (en) 2009-08-13 2016-12-27 Chimden Medical Pty Ltd Pressure indicator
US10126197B2 (en) 2009-08-13 2018-11-13 Teleflex Life Sciences Pressure indicator
US10549054B2 (en) 2011-02-02 2020-02-04 Teleflex Life Sciences Unlimited Company Artificial airway
WO2015183612A1 (fr) * 2014-05-29 2015-12-03 Avent, Inc. Dispositif portable de régulation du débit permettant d'administrer un fluide à un patient
US9931465B2 (en) 2014-05-29 2018-04-03 Avent, Inc. Compact flow regulating device

Also Published As

Publication number Publication date
GB2424374A (en) 2006-09-27
CA2557469C (fr) 2011-05-10
EP1708767A1 (fr) 2006-10-11
GB0612015D0 (en) 2006-07-26
GB2424374B (en) 2008-05-21
EP1708767A4 (fr) 2008-10-22
CA2557469A1 (fr) 2005-06-30

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