WO2005056054A3 - Procedes pour inhiber une apoptose au moyen d'inducteurs de nf-$g(k)b - Google Patents

Procedes pour inhiber une apoptose au moyen d'inducteurs de nf-$g(k)b Download PDF

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Publication number
WO2005056054A3
WO2005056054A3 PCT/US2004/040749 US2004040749W WO2005056054A3 WO 2005056054 A3 WO2005056054 A3 WO 2005056054A3 US 2004040749 W US2004040749 W US 2004040749W WO 2005056054 A3 WO2005056054 A3 WO 2005056054A3
Authority
WO
WIPO (PCT)
Prior art keywords
inducers
methods
inhibiting apoptosis
apoptosis
inhibiting
Prior art date
Application number
PCT/US2004/040749
Other languages
English (en)
Other versions
WO2005056054A2 (fr
Inventor
Andrei V Gudkov
George Stark
Tao Lu
Lyudmila Burdelya
Original Assignee
Cleveland Clinic Foundation
Andrei V Gudkov
George Stark
Tao Lu
Lyudmila Burdelya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation, Andrei V Gudkov, George Stark, Tao Lu, Lyudmila Burdelya filed Critical Cleveland Clinic Foundation
Publication of WO2005056054A2 publication Critical patent/WO2005056054A2/fr
Publication of WO2005056054A3 publication Critical patent/WO2005056054A3/fr
Priority to US11/421,918 priority Critical patent/US7638485B2/en
Priority to US12/617,639 priority patent/US8106005B2/en
Priority to US12/617,653 priority patent/US8784840B2/en
Priority to US14/305,709 priority patent/US9296793B2/en
Priority to US15/049,953 priority patent/US9585939B2/en
Priority to US15/413,949 priority patent/US10406206B2/en
Priority to US16/527,770 priority patent/US11235028B2/en
Priority to US17/557,438 priority patent/US20220105155A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation thérapeutique d'inducteurs d'activité de NF-λB dans le traitement de maladies, de pathologies et de lésions à médiation par NF-λB.
PCT/US2004/040749 2003-12-02 2004-12-02 Procedes pour inhiber une apoptose au moyen d'inducteurs de nf-$g(k)b WO2005056054A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US11/421,918 US7638485B2 (en) 2003-12-02 2006-06-02 Modulating apoptosis
US12/617,639 US8106005B2 (en) 2003-12-02 2009-11-12 Modulating apoptosis
US12/617,653 US8784840B2 (en) 2003-12-02 2009-11-12 Method for screening modulators of apoptosis
US14/305,709 US9296793B2 (en) 2003-12-02 2014-06-16 Modulating apoptosis
US15/049,953 US9585939B2 (en) 2003-12-02 2016-02-22 Protection against apoptosis from ionizing radiation
US15/413,949 US10406206B2 (en) 2003-12-02 2017-01-24 Protection against stress-mediated damage from ionizing radiation
US16/527,770 US11235028B2 (en) 2003-12-02 2019-07-31 Protection against stress-mediated damage from ionizing radiation
US17/557,438 US20220105155A1 (en) 2003-12-02 2021-12-21 Protection against stress-mediated damage from ionizing radiation

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US52666603P 2003-12-02 2003-12-02
US52646103P 2003-12-02 2003-12-02
US52649603P 2003-12-02 2003-12-02
US60/526,496 2003-12-02
US60/526,460 2003-12-02
US60/526,461 2003-12-02
US60/526,666 2003-12-02
US52646004P 2004-12-02 2004-12-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/040750 Continuation WO2005056055A2 (fr) 2003-12-02 2004-12-02 Procedes de protection contre une irradiation au moyen d'inducteurs de nf-$g(k)b

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2004/040579 Continuation WO2005057218A2 (fr) 2003-12-02 2004-12-02 Methodes d'identification de modulateurs de l'apoptose issus de parasites et utilisations correspondantes
PCT/US2004/040753 Continuation WO2005056042A2 (fr) 2003-12-02 2004-12-02 Methodes de protection contre les radiations au moyen de flagelline
US11/421,918 Continuation US7638485B2 (en) 2003-12-02 2006-06-02 Modulating apoptosis

Publications (2)

Publication Number Publication Date
WO2005056054A2 WO2005056054A2 (fr) 2005-06-23
WO2005056054A3 true WO2005056054A3 (fr) 2006-02-09

Family

ID=34682349

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/040749 WO2005056054A2 (fr) 2003-12-02 2004-12-02 Procedes pour inhiber une apoptose au moyen d'inducteurs de nf-$g(k)b

Country Status (1)

Country Link
WO (1) WO2005056054A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069198A1 (fr) 2004-12-22 2006-06-29 Cleveland Clinic Foundation Polypeptides associes a la flagelline et utilisations de ceux-ci
CA2732763A1 (fr) 2008-08-01 2010-02-04 Cleveland Biolabs, Inc. Procedes pour traiter des blessures de reperfusion
KR20140030132A (ko) 2011-01-10 2014-03-11 클리브랜드 바이오랩스, 아이엔씨. 암을 치료하기 위한 톨-유사 수용체 효능제의 용도
JP6940916B2 (ja) 2014-07-30 2021-09-29 ゲノム プロテクション，インコーポレイテッド フラジェリン組成物および使用
US10183056B2 (en) 2014-10-16 2019-01-22 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
EAVES-PYLES T D ET AL: "Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 DEC 2001, vol. 167, no. 12, 15 December 2001 (2001-12-15), pages 7009 - 7016, XP002341395, ISSN: 0022-1767 *
EAVES-PYLES T ET AL: "Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction", JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO, US, vol. 166, no. 2, 15 January 2001 (2001-01-15), pages 1248 - 1260, XP002210841, ISSN: 0022-1767 *
EGAN LAURENCE J ET AL: "IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 8, 24 February 2004 (2004-02-24), pages 2452 - 2457, XP002341240, ISSN: 0027-8424 *
GRDINA DAVID J ET AL: "Relationships between cytoprotection and mutation prevention by WR-1065.", MILITARY MEDICINE. FEB 2002, vol. 167, no. 2 Suppl, February 2002 (2002-02-01), pages 51 - 53, XP008051184, ISSN: 0026-4075 *
HERBERT J M ET AL: "Involvement of u-PA in the anti-apoptotic activity of TGF-beta for vascular smooth muscle cells", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 413, no. 3, 1997, pages 401 - 404, XP002347628, ISSN: 0014-5793 *
JUNG CHUL W ET AL: "Antiproliferative effect of a vitamin D3 analog, EB1089, on HL-60 cells by the induction of TGF-beta receptor", LEUKEMIA RESEARCH, vol. 23, no. 12, December 1999 (1999-12-01), pages 1105 - 1112, XP002357507, ISSN: 0145-2126 *
KOENIG H-G ET AL: "TRANSFORMING GROWTH FACTOR BETA 1 ACTIVATES NFKB IN RAT PHEOCHROMOCYTOMA PC 12 CELLS", ABSTRACTS OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, vol. 27, no. 1, 2001, pages 1244, XP008053612, ISSN: 0190-5295 *
MURLEY JEFFREY S ET AL: "Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine", RADIATION RESEARCH, vol. 158, no. 1, July 2002 (2002-07-01), pages 101 - 109, XP008051326, ISSN: 0033-7587 *
MURLEY JEFFREY S ET AL: "Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs", RADIATION RESEARCH, vol. 162, no. 5, November 2004 (2004-11-01), pages 536 - 546, XP008051185, ISSN: 0033-7587 *
TALLANT THOMAS ET AL: "Flagellin acting via TLR5 is the major-activator of key signaling pathways leading to NF-kappaB and proinflammatory gene program activation in intestinal epithelial cells", BMC MICROBIOLOGY, vol. 4, no. 33, 23 August 2004 (2004-08-23), pages 1-24, XP002341239, ISSN: 1471-2180 *

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Publication number Publication date
WO2005056054A2 (fr) 2005-06-23

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