WO2005053609A3 - Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante - Google Patents
Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante Download PDFInfo
- Publication number
- WO2005053609A3 WO2005053609A3 PCT/US2004/039220 US2004039220W WO2005053609A3 WO 2005053609 A3 WO2005053609 A3 WO 2005053609A3 US 2004039220 W US2004039220 W US 2004039220W WO 2005053609 A3 WO2005053609 A3 WO 2005053609A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nad
- methods
- deacetylase inhibitors
- dependent deacetylase
- dependent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52530303P | 2003-11-26 | 2003-11-26 | |
US60/525,303 | 2003-11-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005053609A2 WO2005053609A2 (fr) | 2005-06-16 |
WO2005053609A3 true WO2005053609A3 (fr) | 2005-09-01 |
Family
ID=34652323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/039220 WO2005053609A2 (fr) | 2003-11-26 | 2004-11-23 | Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2005053609A2 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US8691534B2 (en) | 2006-12-29 | 2014-04-08 | Celgene Corporation | Preparation of romidepsin |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
US8957027B2 (en) | 2006-06-08 | 2015-02-17 | Celgene Corporation | Deacetylase inhibitor therapy |
US9101579B2 (en) | 2012-11-14 | 2015-08-11 | Celgene Corporation | Inhibition of drug resistant cancer cells |
US9134325B2 (en) | 2012-09-07 | 2015-09-15 | Celgene Corporation | Resistance biomarkers for HDAC inhibitors |
US9463215B2 (en) | 2013-12-27 | 2016-10-11 | Celgene Corporation | Romidepsin formulations and uses thereof |
US9518094B2 (en) | 2010-07-12 | 2016-12-13 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US9539303B2 (en) | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
JP2007527418A (ja) | 2003-12-29 | 2007-09-27 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 肥満及びインシュリン耐性障害を治療又は防止するための組成物 |
WO2006138418A2 (fr) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Amelioration de la performance cognitive avec des activateurs de sirtuine |
KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
US8168658B2 (en) | 2006-02-28 | 2012-05-01 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
GB0816269D0 (en) | 2008-09-05 | 2008-10-15 | Univ Ramot | Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of alzheimers disease |
WO2011137320A2 (fr) * | 2010-04-30 | 2011-11-03 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de petites molécules de l'activité de l'enzyme de déubiquination usp1 |
CN103124563B (zh) * | 2010-08-04 | 2016-08-10 | 佩尔菲丘尔制药有限公司 | 用于前列腺癌治疗的联合治疗 |
US9861596B2 (en) | 2012-11-09 | 2018-01-09 | Musc Foundation For Research Development | Compositions and methods for treating neurological diseases or injury |
US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
KR101876750B1 (ko) * | 2016-07-26 | 2018-07-11 | 한밭대학교 산학협력단 | 신규한 2-아민 치환 1,4-나프토퀴논 화합물 및 이를 포함하는 암의 예방 또는 치료용 약제학적 조성물 |
JP2021533115A (ja) * | 2018-07-29 | 2021-12-02 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメントMusc Foundation For Research Development | 神経疾患またはミトコンドリア疾患の処置のための化合物 |
CN113368087A (zh) * | 2020-03-10 | 2021-09-10 | 复旦大学附属华山医院 | 胡桃醌其衍生物及其在制备化疗脑肿瘤的药物中的用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511990B1 (en) * | 1999-09-08 | 2003-01-28 | Sloan-Kettering Institute For Cancer Research | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
WO2003007933A1 (fr) * | 2001-07-16 | 2003-01-30 | The University Court Of The University Of Aberdeen | Derives de napthoquinone en tant qu'inhibiteurs de l'agregation des tau pour le traitement de la maladie d'alzheimer et des troubles de neurodegenerescence associes |
-
2004
- 2004-11-23 WO PCT/US2004/039220 patent/WO2005053609A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511990B1 (en) * | 1999-09-08 | 2003-01-28 | Sloan-Kettering Institute For Cancer Research | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
WO2003007933A1 (fr) * | 2001-07-16 | 2003-01-30 | The University Court Of The University Of Aberdeen | Derives de napthoquinone en tant qu'inhibiteurs de l'agregation des tau pour le traitement de la maladie d'alzheimer et des troubles de neurodegenerescence associes |
Non-Patent Citations (1)
Title |
---|
HODNETT E. ET AL: "Subtituted 1,4-Naphthoquinones vs. the Ascitic Sarcoma 180 of Mice.", J.MED.CHEM., vol. 23, no. 4, 1983, pages 570 - 574, XP002988938 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US9539303B2 (en) | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
US8957027B2 (en) | 2006-06-08 | 2015-02-17 | Celgene Corporation | Deacetylase inhibitor therapy |
US9259452B2 (en) | 2006-06-08 | 2016-02-16 | Gelgene Corporation | Deacetylase inhibitor therapy |
US8691534B2 (en) | 2006-12-29 | 2014-04-08 | Celgene Corporation | Preparation of romidepsin |
US9518094B2 (en) | 2010-07-12 | 2016-12-13 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
US9134325B2 (en) | 2012-09-07 | 2015-09-15 | Celgene Corporation | Resistance biomarkers for HDAC inhibitors |
US9101579B2 (en) | 2012-11-14 | 2015-08-11 | Celgene Corporation | Inhibition of drug resistant cancer cells |
US9463215B2 (en) | 2013-12-27 | 2016-10-11 | Celgene Corporation | Romidepsin formulations and uses thereof |
US9468664B2 (en) | 2013-12-27 | 2016-10-18 | Celgene Corporation | Romidepsin formulations and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2005053609A2 (fr) | 2005-06-16 |
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