WO2005044192A2 - Triazole compounds and uses related thereto - Google Patents

Triazole compounds and uses related thereto Download PDF

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Publication number
WO2005044192A2
WO2005044192A2 PCT/US2004/035805 US2004035805W WO2005044192A2 WO 2005044192 A2 WO2005044192 A2 WO 2005044192A2 US 2004035805 W US2004035805 W US 2004035805W WO 2005044192 A2 WO2005044192 A2 WO 2005044192A2
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Prior art keywords
group
triazol
methyl
chloro
phenyl
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PCT/US2004/035805
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French (fr)
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WO2005044192A3 (en
Inventor
Mario G. Cardozo
Jay P. Powers
Hiroyuki Goto
Kazuhito Harada
Katsuaki Imamura
Makoto Kakutani
Isamu Matsuda
Yasuhiro Ohe
Shinji Yata
Hua Tu
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Amgen Inc.
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Priority to JP2006538245A priority Critical patent/JP2007509959A/en
Priority to CA002543602A priority patent/CA2543602A1/en
Priority to AU2004286836A priority patent/AU2004286836A1/en
Priority to EP04796647A priority patent/EP1680114A4/en
Priority to US10/587,846 priority patent/US7683059B2/en
Publication of WO2005044192A2 publication Critical patent/WO2005044192A2/en
Publication of WO2005044192A3 publication Critical patent/WO2005044192A3/en
Priority to US12/621,922 priority patent/US8153631B2/en

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
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    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Definitions

  • the present invention relates to triazole compounds useful for, for example, the treatment or prophylaxis of diabetes, obesity and metabolic syndrome.
  • HBeta-hydroxysteroid dehydrogenase 1 catalyzes the interconversio of glucocorticoids (hereinafter, "GC") between inert 11-keto forms (e.g. cortisone, 11-dehydrocorticosterone) and active llbeta- hydroxy forms (e.g. cortisol, corticosterone, respectively).
  • GC glucocorticoids
  • the enzyme in vivo, prefers the reductase direction from the 11-keto to the llbeta-hydroxy, in other words, the production of active GC.
  • HBeta-HSDl is ubiquitously expressed, most notably in liver, lung, adipose tissue, vasculature, ovary and trie central nervous system.
  • the active GC is known to stimulate gluconeogenic enzymes and have effects at least in part in inducing hyperglycemia.
  • HSDl can be a second source of GC production in addition to the adrenal glands .
  • active GC is demonstrated to enhance the differentiation of preadipocytes into adipocytes.
  • Mature adipocytes express HSDl activity, which causes an increase in local concentration of the active form and further expansion of adipose tissue.
  • HSDl should be critical in pathogenesis of obesity.
  • a local immunosuppressive effect of HSDl in placental deciduas, and a relationship between the expression of the enzyme in adrenal cortex and the induction of adrenaline synthesis are suggested.
  • drugs having inhibitory effects against HSDl would be useful for treating or preventing diabetes mellitus, obesity, metabolic syndrome in connection with any of such diseases, or any other diseases which occur by reason of the actions of HSDl.
  • Diabetes mellitus main feature of which disease is chronic hyperglycemia, introduces various metabolic abnormalities and shows symptoms of thirst, polydipsia, polyuria, and so on based on high glucose concentration. Continuing hyperglycemic state would also lead to diabetic complications such as retinopathy, nephropathy, neuropathy, and myocardial and/or cerebral infarction by reason of arteriosclerosis .
  • Obesity is defined as a state of fatness coinciding with any disease that would be improved or not be progressed in case of weight decrease (e.g. diabetes, hyperlipidemia, hypertension) or with an excessive amount of fat in viscera. It is considered that, if such a state should continue, at least two of diabetes, hyperlipidemia, hypertension and etc. would concur, and then onset of myocardial and/or cerebral infarction by reason of arteriosclerosis would occur.
  • Major therapeutic methods in treating obesity are dietetics and ergotherapy, and pharmacotherapy is undertaken only if necessary, for example, because of difficulty in the first two alternatives.
  • the existing drugs have several problems in adverse effects and usages, since most of them suppress feeding mainly via central action.
  • R 1 is unsubstituted or substituted adamantyl
  • the compounds of the present invention improve physicochemical (stability, etc.) and biological (activity to inhibit HSDl, specificity, bioavailability, metabolism, etc.) profiles, as a result of the selection of structural characteristics as disclosed herein.
  • triazole compounds represented by the following formula have superior HSDl inhibitory activity, and are useful as HSDl inhibitors or therapeutic drugs of diabetes or obesity.
  • R 1 is an alkyl group or a cycloalkyl group wherein the alkyl group and the cycloalkyl group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF 3 , -OH, -NH 2 , an alkoxy group, a cycloalkyl group, an alkenyl group, -COOH, -CO-O-alkyl, -CO-N (R 7 ) (R 8 ) , -N (R 7 ) -CO-R 8 , an aryl group and a heteroaryl group wherein R 7 and R 8 are each independently a hydrogen atom or an alkyl group, and the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH 2 ) n -OH, -N(R 9 ) (
  • Y]_ is a cycloalkyl group or a heterocycloalkyl group wherein the cycloalkyl group and the heterocycloalkyl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, ⁇ (CH 2 ) n -OH, -N(R 9 ) (R 10 ), -CN, -N0 2 , an alkoxy group, a cycloalkyl group, an alkenyl group, -CO- R 11 , an aryl group and a heteroaryl group (n, R 9 , R 10 and R 11 are as defined above) , p is 0-3, q is 0-3, R 14 and R 15 are each independently a hydrogen atom, a halogen atom, a haloalkyl group, an alkyl group, -(CH 2 ) n -OH, -N(R 9 )
  • X 2 is -0-, -(CH 2 ) t ⁇ or -N(R 25 )- wherein t is as defined above and R 25 is a hydrogen atom, -CO-R 26 , -S0 2 -R 26 or -(CH 2 ) U -Ar 4 wherein R 26 is an alkyl group, an alkoxy group, -NH-alkyl or - (-alkyl) 2 , u is 0-3, and Ar 4 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH 2 ) n _ OH,
  • Li is -(CH 2 ) V -, -0- or -C0- wherein v is 0-3, and Ar 3 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH 2 ) n ⁇ OH, -N (R 9 ) (R 10 ) , -CN, -N0 2 , an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R 11
  • R 21 and R 22 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, -CO-O-alkyl or -Li-Ar 3 (Li and Ar 3 are as defined above)
  • R 19 is a hydrogen atom, -CO-R 26 , -S0 2 -R 26 or -(CH 2 ) U -Ar 4 (R 26 , u and Ar 4 are as defined above)
  • R 5 are each independently a hydrogen atom, a halogen atom, -OH, -N0 2 , -CN, an alkyl group, an alkoxy group, -CO-R 27 , -S0 2 -R 27 , -CO-N(R 28 ) (R 29 ) or -N(R 30 ) (R 31 ) wherein the alkyl group and the alkoxy group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF 3 ,
  • R 27 is -OH, an alkoxy group, an alkyl group, -NH 2 , -NH-alkyl or -N (-alkyl) 2 ,
  • R 28 and R 29 are each independently a hydrogen atom, an alkyl group or -(CH 2 ) W -R 32 , wherein w is 0-3 and R 32 is -OH, -CF 3 , an alkoxy group, -CONH 2 or -N (R 33 ) (R 34 ) wherein R 33 and R 34 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, or in combination form
  • X 2 is as defined above or R ,28 and R ,29 in combination form wherein X 3 is -CO-, -CH 2 - or -CH 2 -CH 2 -, X 4 is
  • R 35 and R 36 are each independently a hydrogen atom, a halogen atom, an alkyl group optionally substituted by -OH, -OH, -CN, -N0 2 , an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R 37 , -N(R 38 ) (R 39 ) wherein R 37 is -OH, an alkoxy group, -NH 2 ,
  • R 9 , R 10 and R 11 are as defined above
  • the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH 2 ) n -OH, -N (R 9 ) (R 10 ) , -CN, -N0 2 , an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R 11 , an aryl group and a heteroaryl group (n, R , R and R are as defined above)
  • R 38 and R 39 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-O-alkyl
  • R 30 and R 31 are each independently a hydrogen atom, an alkyl group optionally substituted by -OH
  • R 40 -(CH 2 ) x -CO-R 41 or wherein x is 0-3, R 40 is an alkyl group or -NH 2 , R 41 is a hydrogen atom, an alkyl group optionally substituted by -OH, -OH, an alkoxy group, an alkoxyalkyl group or -(CH 2 ) S ⁇ N(R 42 ) (R 43 ) wherein s is as defined above and R and R are each independently a hydrogen atom, an alkyl group, -OH, an alkoxy group, or in combination form
  • R 44 and R 45 are each independently a hydrogen atom, an alkyl group, an alkoxy group, a haloalkyl group, -(CH 2 ) r -OH, -CO-R 47 or -N(R 48 ) (R 49 ) wherein r is as defined above, R 47 is -OH, an alkoxy group, an alkoxyalkyl group, -N(R 50 ) (R 51 ) wherein R 50 and R 51 are each independently a hydrogen atom, an alkyl group, -(CH 2 ) s -OH (s is as defined above) or an alkoxyalkyl group, and R 48 and R 49 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-0-alkyl, and R 46 is a hydrogen atom, -CO-R 52 or -S0 2 -R 52 wherein R 52 is an alkyl group, an alkoxy group,
  • X 3 is -CO-, a prodrug thereof or a pharmaceutically acceptable salt thereof.
  • a pharmaceutical composition comprising the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
  • An HSDl (llbeta-hydroxysteroid dehydrogenase 1) inhibitor comprising the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
  • a therapeutic or prophylactic drug of diabetes which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
  • a therapeutic or prophylactic drug of obesity which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
  • a therapeutic or prophylactic drug of metabolic syndrome which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
  • a method for the treatment or prophylaxis of diabetes which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
  • a method for the treatment or prophylaxis of obesity which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
  • a method for the treatment or prophylaxis of metabolic syndrome which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
  • the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbuta ide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metfor in hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
  • pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbuta ide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metfor in hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
  • the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an ⁇ -glucosidase inhibitor and an insulin sensitizer.
  • the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
  • pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
  • the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an ⁇ -glucosidase inhibitor and an insulin sensitizer.
  • the different 5 therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, ⁇ o - acarbose and pioglitazone hydrochloride.
  • pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, ⁇ o - acarbose and pioglitazone hydrochloride.
  • the triazole compound of the present invention shows a markedly enhanced HSDl inhibitory activity in vivo, which 25 results from improved metabolic resistance.
  • alkyl group means a straight chain or branched 30 chain alkyl group. Examples thereof include methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, isopentyl group, neopentyl group, tert-pentyl group, 1- ethylpropyl group, hexyl group and the like. It is preferably a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atoms.
  • R preferred are methyl, ethyl, propyl, isopropyl, butyl and isobutyl, and particularly preferred are methyl and isopropyl.
  • cycloalkyl group means a saturated cyclic alkyl group. Examples thereof include cyclopropyl group, cyclobutyl group, cyclopentyl group, ⁇ cyclohexyl group, cycloheptyl group, cyclooctyl group and the like. It is preferably a cycloalkyl group having 3 to 8, more preferably 3 to 6, carbon atoms.
  • R r preferred is cyclopropyl.
  • cycloalkyl group as a substituent on alkyl is preferably cyclopropyl.
  • Y preferred are cyclopropyl, cyclobutyl and cyclopentyl, and particularly preferred is cyclopropyl.
  • cyclopropyl preferred are cyclopropyl, cyclobutyl and cyclopentyl, and particularly preferred is cyclopropyl.
  • heterocycloalkyl group means a saturated 5- to 7- membered heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom.
  • heterocycloalkyl group examples thereof include tetrahydrofuryl group, tetrahydrothienyl group, pyrrolidinyl group, pyrazolidinyl group, imidazolidinyl group, oxazolidinyl group, thiazolidinyl group, tetrahydropyranyl group, dioxolanyl group, dioxanyl group, piperidinyl group, piperazinyl group, morpholinyl group and the like.
  • alkenyl group means a straight chain or branched chain alkenyl group. Examples thereof include vinyl group, 1- propenyl group, allyl group, l-methyl-2-propenyl group, 1- butenyl group, 2-butenyl group, 3-butenyl group, 1-pentenyl group, 2-pentenyl group, 1-hexenyl group, 2-hexenyl group and the like. It is preferably a straight chain or branched chain alkenyl group having 2 to 6, more preferably 2 to 4, carbon atoms .
  • alkenyl group as a substituent on alkyl is preferably vinyl.
  • aryl group means an aromatic hydrocarbon group. Examples thereof include phenyl group, naphthyl group, anthryl group and the like. It is preferably a phenyl group or naphthyl group.
  • Ar Ar , Ar and Ar
  • heteroaryl group means a monocyclic or fused 5- to 14-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom.
  • Examples thereof include furyl group, thienyl group, pyrrolyl group, oxazolyl group, isooxazolyl group, thiazolyl group, isothiazolyl group, i idazolyl group, pyrazolyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, indolyl group, isoindolyl group, benzofuranyl group, benzothienyl group, benzoimidazolyl group, benzothiazolyl group, benzoxazolyl group, indolizinyl group, quinolyl group, isoquinolyl group, quinazolinyl group, cinnolinyl group
  • It is preferably a monocyclic or fused 5- to 10-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, which includes furyl group, thienyl group, pyrrolyl group, oxazolyl group, isooxazolyl group, thiazolyl group, isothiazolyl group, imidazolyl group, pyrazolyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, indolyl group, isoindolyl group, benzofuranyl group, benzothienyl group, benzoimidazolyl group, benzothiazolyl group, benzooxazolyl group and the like.
  • Ar 1 preferred are thienyl, pyrrolyl and pyridyl.
  • Ar 2 preferred are thienyl, pyrrolyl, oxazolyl, isooxazolyl, thiazolyl, imidazolyl, pyrazolyl and pyridyl, and particularly preferred are thienyl and pyridyl.
  • halogen atom means fluorine atom, chlorine atom, bromine atom or iodine atom. It is preferably fluorine atom or chlorine atom.
  • R 2 and R3 preferred is fluorine atom.
  • Ar is particularly preferably phenyl, where only the 4- position of the phenyl is substituted by fluorine atom.
  • R 4 and R 5 preferred is chlorine atom.
  • Ar is particularly preferably phenyl, where at least the 2-position of the phenyl is substituted by chlorine atom.
  • haloalkyl group means a haloalkyl group wherein the above-defined “alkyl group” is substituted by the above- defined "halogen atom".
  • halogen atom examples thereof include fluoromethyl group, difluoromethyl group, trifluoromethyl group, bromomethyl group, chloromethyl group, 1, 2-dichloroethyl group, 2,2- dichloroethyl group, 2, 2, 2-trifluoroethyl group and the like. It is preferably a straight chain or branched chain haloalkyl group having 1 to 6, more preferably 1 to 4, carbon atoms, particularly preferably a trifluoromethyl group.
  • alkoxy group means a straight chain or branched chain alkoxy group. Examples thereof include methoxy group, ethoxy group, propoxy group, isopropoxy group, butoxy group, isobutoxy group, tert-butoxy group, pentyloxy group, hexyloxy group and the like. It is preferably a straight chain or branched chain alkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms.
  • R 2 and R preferred is methoxy.
  • R 4 and R 5 preferred are methoxy, ethoxy and isopropoxy.
  • haloalkoxy group means a haloalkoxy group wherein the above-defined “alkoxy group” is substituted by the above- defined "halogen atom".
  • examples thereof include fluoromethoxy group, difluoromethoxy group, trifluoromethoxy group, bromo ethoxy group, chloro ethoxy group, 1, 2-dichloroethoxy group, 2, 2-dichloroethoxy group, 2, 2, 2-trifluoroethoxy group and the like. It is preferably a straight chain or branched chain haloalkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms .
  • alkoxyalkyl group means an alkoxyalkyl group wherein the above-defined "alkyl group” is substituted by the above-defined "alkoxy group”. Examples thereof include methoxymethyl group, ethoxymethyl group, propoxyirtethyl group, isopropoxymethyl group, butoxymethyl group, isobutoxymethyl group, tert-butoxymethyl group, 2-methoxyethyl group, pentyloxy ethyl group, hexyloxymethyl group and the like.
  • alkoxyalkyl group wherein the alkyl group is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atoms and the alkoxy group is a straight chain or branched chain alkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms.
  • R 2 , R 24 and R 41 preferred are methoxymethyl and 2- methoxyethyl.
  • the "-CO-alkyl” means an alkylcarbonyl group having the above-defined "alkyl group” as the alkyl moiety. Examples thereof include acetyl group, propionyl group, butyryl group, isobutyryl group, valeryl group, isovaleryl group, pivaloyl group, pentanoyl group, hexanoyl group and the like. It is preferably an alkylcarbonyl group wherein the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4 , carbon atoms .
  • R 9 , R 10 , R 21 , R 22 , R 33 , R 34 , R 38 , R 39 , R 48 and R 49 particularly preferred are acetyl, propionyl, butyryl and ⁇ sobutyryl .
  • the "-CO-O-alkyl” means an alkyloxycarbonyl group l aving the above-defined "alkyl group” as the alkyl moiety .
  • Examples thereof include methyloxycarbonyl group, ethyloxycarbonyl group, propyloxycarbonyl group, ⁇ sopropyloxycarbonyl group, butyloxycarbonyl group, ⁇ sobutyloxycarbonyl group, sec-butyloxycarbonyl group, tert- fc tyloxycarbonyl group, pentyloxycarbonyl group, zLsopentyloxycarbonyl group, neopentyloxycarbonyl group, tert- pentyloxycarbonyl group, 1-ethylpropyloxycarbonyl group, riexyloxycarbonyl group and the like . It is preferably an alkyloxycarbonyl group wherein the "alkyl moiety" is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4 , carbon atoms .
  • R 21 , R 22 , R 38 , R 39 , R 48 and R 49 particularly preferred are methyloxycarbonyl, ethyloxycarbonyl, propyloxycarbonyl , r sopropyloxycarbonyl and tert-butyloxycarbonyl .
  • the "-NH-alkyl” means an alkylamino group having the above-defined "alkyl group” as the alkyl moiety. Examples thereof include methylamino group, ethylamino group, propyla ino group, isopropylamino group, butylamino group, r sobutylamino group, sec-butylamino group, tert-butylamino group, pentylamino group, isopentylamino group, tert- pentylamino group, hexylamino group and the like . It is preferably an alkylamino group wherein the alkyl moiety is a s traight chain or branched chain alkyl group having 1 to 6 , more preferably 1 to 4 , carbon atoms .
  • R 26 , R 27 , R 32 and R 52 particularly preferred are methylamino, ethylamino, propylamino and isopropylamino .
  • the "-N (-alkyl) 2 " means a dialkylamino group having the above-defined "alkyl group” as the alkyl moiety. Examples thereof include dimethylamino group, diethyla ino group, dipropylamino group, diisopropylamino group, dibutylamino group, diisobutylamino group, di (sec-butyl) a ino group, di (tert-butyl) amino group, dipentylamino group, diisopentylamino group, di (tert-pentyl) amino group, dihexylamino group, N-ethyl-N-methylamino group, N-methyl-N- propylamino group, N-ethyl-N-propylamino group and the like. It is preferably a dialkylamino group wherein the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atom
  • R , R , R and R particularly preferred are dimethylamino, diethylamino and N-ethyl-N-methylamino.
  • alkyl moieties of the "alkylamino group” and “dialkylamino group” are optionally substituted by 1 to 5 substituents each independently selected from halogen atom, -CF 3 , -OH, alkoxy group, haloalkoxy group, -N (R 9 ) (R 10 ) (R 9 and R 10 are each independently hydrogen atom, alkyl group or -CO-alkyl) , -CN, -N0 2 , cycloalkyl group, alkenyl group, -CO-R 11 (R 11 is -OH, alkoxy group, alkyl group or -N(R 12 ) (R 13 ) wherein R 12 and R 13 are each independently hydrogen atom or alkyl group), aryl group and heteroaryl group.
  • alkyl group and the "alkoxy group” for R 4 and R 5 , and the “alkoxy group” for R 37 are optionally substituted by 1 to 5 substituents each independently selected from halogen atom, -CF 3 , -OH, alkoxy group, haloalkoxy group, -N(R 9 ) (R 10 ) (R 9 and R 10 are each independently hydrogen atom, alkyl group or - CO—alkyl) , -CN, -N0 2 , cycloalkyl group, alkenyl group, -CO-R 11 (R 11 is -OH, alkoxy group, alkyl group or -N(R 12 ) (R 13 ) wherein R 12 and R 13 are each independently hydrogen atom or alkyl group), aryl group and heteroaryl group.
  • R 4 and R 5 in combination may form -O-alkylene-0-.
  • the "alkylene” means a divalent hydrocarbon. Examples thereof include methylene, ethylene, propylene, butylene, pentylene, hexylene and the like. It is preferably an alkylene having 1 to 6, more preferably 1 to 4, carbon atoms, particularly preferably methylene.
  • Z is preferably
  • Y is preferably a C 3 - 8 cycloalkyl group
  • Ar 1 is preferably a phenyl group
  • Ar 2 is preferably a phenyl group
  • R 1 is preferably an alkyl group
  • R 2 is preferably a hydrogen atom
  • R 3 is preferably a halogen atom
  • R 4 is preferably a hydrogen atom, a halogen atom or an alkoxy group
  • R 5 is preferably -CO-N(R 28 ) (R 29 ) (wherein R 28 and R 29 are preferably each independently a hydrogen atom or an alkyl group) or -N(R 30 ) (R 31 )
  • R 30 is preferably a hydrogen atom and R 31 is preferably - (CH 2 ) x -CO-R 41 wherein X is preferably 0 and R 41 is preferably an alkoxy group, or X is preferably 0 and R 41 is preferably preferably
  • X 3 is preferably -CO- and X is preferably -0-) .
  • the "pharmaceutically acceptable salt” may be any salt as long as it forms a non-toxic salt with a triazole compound represented by the above-mentioned formula.
  • it can be obtained by reaction with inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, hydrobromic acid and the like; organic acids such as oxalic acid, malonic acid, citric acid, fumaric acid, lactic acid, malic acid, succinic acid, tartaric acid, acetic acid, trifluoroacetic acid, gluconic acid, ascorbic acid, methylsulfonic acid, benzylsulfonic acid and the like; inorganic bases such as sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, ammonium hydroxide and the like; organic bases such as methylamine, diethylamine, triethylamine, triethanolamine, ethylenediamine, tris (hydroxymethyl) methylamine, guanidine, choline,
  • the triazole compound represented by the above-mentioned formula includes various isomers.
  • E form and Z form are present as geometric isomers, and when an asymmetric carbon atom is present, enantiomers and diastereomers are present as stereoisomers based thereon. In some cases, a tautomer may be present. Accordingly, the present invention encompasses all these isomers and mixtures thereof.
  • the present invention also encompasses prodrugs and metabolites of the triazole compound represented by the formula.
  • a "prodrug” is a derivative of the compound of the present invention, which has a chemically or metabolically decomposable group, which, after being administered to a living organism, restores to its original compound form and exhibit its intrinsic efficacy, and which includes complexes and salts free of a covalent bond.
  • ester derivatives known as prodrugs in the field of pharmaceutical agents can be used.
  • the compound of the present invention When used as a pharmaceutical preparation, it is generally admixed with a pharmaceutically acceptable carrier, excipient, diluent, extender, disintegrant, stabilizer, preservative, buffer, emulsifier, fragrance, coloring agent, sweetening agent, thickening agent, corrigent, dissolution aids and other additives known per se, such as water, vegetable oil, alcohols such as ethanol, benzyl alcohol and the like, polyethylene glycol, glycerol triacetate, gelatin, lactose, carbohydrates such as starch and the like, magnesium stearate, talc, lanolin, vaseline and the like, and produced in the form of tablet, pill, powder, granule, suppository, injection, eye drop, liquid, capsule, troche , aerosol, elixir, suspension, emulsion, syrup and the like by a conventional method for systemic or local, oral or parenteral administration.
  • a pharmaceutically acceptable carrier such as water, vegetable oil
  • the dose of the compound of the present invention varies depending on the age, body weight, symptom, disease to be treated, administration method and the like, it is generally 50 mg to 800 mg for an adult per administration, which is given once to several times a day.
  • the compound of the present invention can be administered to a mammal (human, mouse, rat, rabbit, dog, cat, bovine, pig, monkey etc.) as an HSDl inhibitor, a prophylactic or therapeutic drug of diabetes, a prophylactic or therapeutic drug of diabetic complication (retinopathy, nephropathy, neuropathy, cardiac infarction and cerebral infarction based on arteriosclerosis etc.), a prophylactic or therapeutic drug of hyperlipemia, a prophylactic or therapeutic drug of obesity, neurodegenerative disease and the like, or a prophylactic or therapeutic drug of diseases mediated by HSDl.
  • a mammal human, mouse, rat, rabbit, dog, cat, bovine, pig, monkey etc.
  • the compound of the present invention can be administered to a mammal concurrently with other therapeutic drug of diabetes or obesity with the aim of the prophylaxis or treatment of diabetes.
  • the "therapeutic drug of diabetes” encompasses therapeutic drugs of diabetic complications.
  • the compound of the present invention can be administered in combination with other therapeutic drugs of diabetes or obesity to a mammal for the prophylaxis or treatment of obesity.
  • the compound of the present invention may be administered simultaneously with other therapeutic drugs of diabetes or other therapeutic drugs of obesity (hereinafter to be referred to as a combined pharmaceutical agent) or may be administered at time intervals.
  • a pharmaceutical composition containing the compound of the present invention and a combined pharmaceutical agent can be administered.
  • a pharmaceutical composition containing the compound of the present invention and a pharmaceutical composition containing a combined pharmaceutical agent may be administered separately.
  • the administration routes of respective pharmaceutical compositions may be the same or different.
  • the compound of the present invention may be administered at a dose of 50 mg to 800 mg per administration, which is given once to several times a day.
  • the compound may be administered at a smaller dose.
  • the combined pharmaceutical agent can be administered at a dose generally employed for the prophylaxis or treatment of diabetes or obesity or at a smaller dose than that.
  • insulin preparation As other therapeutic drug of diabetes to be used for the combined administration, insulin preparation, sulfonylurea, insulin secretagogue, sulfonamide, biguanide, ⁇ -glucosidase inhibitor, insulin sensitizer and the like can be mentioned.
  • insulin glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose, pioglitazone hydrochloride and the like can be used for combined administration with the compound of the present invention.
  • mazindol As other therapeutic drug of obesity to be used for the combined administration, for example, mazindol can be mentioned.
  • Production Method 1 In this production method, a triazole compound, wherein the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring is carbon, is produced, and the method includes any of the following steps.
  • each symbol is as defined above, provided that the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring of the triazole compound to be formed is carbon.
  • Acylhydrazide (1) synthesized by a known method and thioimidate (2) synthesized by a known method are reacted in a solvent to give triazole (3) .
  • the solvent methanol, ethanol, n-propanol, n-butanol, isopropanol, acetonitrile, diethyl ether, tetrahydrofuran (THF) , 1,4-dioxane, N,N- dimethylformamide, dimethyl sulfoxide, dichloromethane, 1,2- dichloroethane, chloroform, benzene, chlorobenzene, o- dichlorobenzene, toluene, xylene, pyridine, 2, 6-lutidine, 2, 4, 6-collidine, acetic acid, water, or a mixed solvent thereof can be mentioned.
  • the reaction temperature is preferably 20°C - 250°C.
  • acylhydrazide (1) or thioimidate (2) is a salt
  • the reaction is carried out in the presence of a base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium acetate, potassium acetate, sodium hydride, potassium hydride, triethylamine, N,N- diisopropylethylamine, pyridine and the like.
  • triazole (3) can be obtained according to a similar method from thioimidate (4) synthesized by a known method and acylhydrazide (5) synthesized by a known method.
  • Production Method 2 In this production method, a triazole compound, wherein the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring is nitrogen, is produced, and the method includes the following steps.
  • Triazole (7) can be obtained by reacting isothiourea (6) synthesized by a known method with acylhydrazide (5) synthesized by a known method in a solvent.
  • a solvent methanol, ethanol, n-propanol, n-butanol, isopropanol, acetonitrile, diethyl ether, tetrahydrofuran (THF) , 1,4- dioxane, N,N-dimethylformamide, dimethyl sulfoxide, dichloromethane, 1, 2-dichloroethane, chloroform, benzene, chlorobenzene, o-dichlorobenzene, toluene, xylene, pyridine, 2, 6-lutidine, 2, 4, 6-collidine, acetic acid, water, or a mixed solvent thereof can be mentioned.
  • the reaction temperature is preferably 20°C - 250°C.
  • acylhydrazide (5) When isothiourea (6) or acylhydrazide (5) is a salt, the reaction is carried out in the presence of a base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium acetate, potassium acetate, sodium hydride, potassium hydride, triethylamine, N,N- diisopropylethylamine, pyridine and the like.
  • a base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium acetate, potassium acetate, sodium hydride, potassium hydride, triethylamine, N,N- diisopropylethylamine, pyridine and the like.
  • Example 1-1 Production of 3' , 5' -dichloro-4- (5- (1- (4- chlorophenyl) cyclopropyl) -4-methyl-4H- [1,2,4] triazol-3-yl) - 3, 4, 5, 6-tetrahydro-2H- [1, 4' ] bipyridyl hydrochloride
  • Example 2-1 Production of 1- [4-methyl-5- (1-phenylcyclopropyl) - 4H- [1,2,4] triazol-3-yl] -4-phenylpiperidine
  • Methyl N-methyl-4-phenylpiperidine-l- imidethiocarboxylate hydroiodide (452 mg) and 1- phenylcyclopropane carbohydrazide (176 mg) were suspended in 1,4-dioxane (2 ml) and water (0.4 ml), sodium acetate (98 mg) was added and the mixture was heated under reflux overnight. The reaction solution was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed successively with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness.
  • Example 2-2 to 2-99 In the same manner as in Example 1-1, and using other conventional methods as necessary, a triazole compound was produced.
  • the structural formula and property values of each Example compound are shown in the following Table. Examples 2-2 to 2-99:
  • Example 2-1 In the same manner as in Example 2-1, and using other conventional methods as necessary, a triazole compound was produced.
  • the structural formula and property values of each Example compound are shown in the following Table.
  • the HSDl inhibitory activity was examined by quantitative determination by an SPA (scintillation proximity assay) system of the suppressive action on the conversion from cortisone to cortisol using human HSDl (hereinafter recombinant HSDl) expressed using a baculo-virus system as an enzyme source.
  • SPA sintillation proximity assay
  • a reagent was added to a 96 well plate (96 well Opti-platesTM-96 (Packard)) to the following final concentration and a volume of 100 ⁇ l was reacted at room temperature for 90 min.
  • reaction solution used was 0.1 ⁇ g/ml recombinant HSDl, 500 ⁇ M NADPH, 16 nM 3 H cortisone (Amersham Biosciences, 1.78 Tbq/mol) dissolved in 0.1% BSA (Sigma) -containing PBS and the test drug was 2 ⁇ l of a compound solution (dissolved in DMSO) .
  • reaction was stopped by adding PBS (40 ⁇ l, containing 0.1% BSA (Sigma)) containing 0.08 ⁇ g of anti-cortisol mouse monoclonal antibody (East Coast Biologies) , 365 ⁇ g SPA PVT mouse antibody-binding beads (Amersham Biosciences) and 175 ⁇ M carbenoxolone (Sigma) to the reaction solution.
  • PBS 40 ⁇ l, containing 0.1% BSA (Sigma)
  • anti-cortisol mouse monoclonal antibody East Coast Biologies
  • 365 ⁇ g SPA PVT mouse antibody-binding beads 365 ⁇ g SPA PVT mouse antibody-binding beads
  • 175 ⁇ M carbenoxolone Sigma
  • the triazole compound of the present invention has superior HSDl inhibitory activity and is useful as an HSDl inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity.

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Abstract

The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.

Description

SPECIFICATION
TRIAZOLE COMPOUNDS AND USES RELATED THERETO
TECHNICAL FIELD OF THE INVENTION
The present invention relates to triazole compounds useful for, for example, the treatment or prophylaxis of diabetes, obesity and metabolic syndrome.
BACKGROUND OF THE INVENTION
HBeta-hydroxysteroid dehydrogenase 1 (hereinafter, "llbeta-HSDl" or "HSDl") catalyzes the interconversio of glucocorticoids (hereinafter, "GC") between inert 11-keto forms (e.g. cortisone, 11-dehydrocorticosterone) and active llbeta- hydroxy forms (e.g. cortisol, corticosterone, respectively). The enzyme, in vivo, prefers the reductase direction from the 11-keto to the llbeta-hydroxy, in other words, the production of active GC.
HBeta-HSDl is ubiquitously expressed, most notably in liver, lung, adipose tissue, vasculature, ovary and trie central nervous system.
Until recently, experimental results have suggested that the active form of GC produced through HSDl as well as the enzyme itself is involved in several biological actions and diseases .
For example, the active GC is known to stimulate gluconeogenic enzymes and have effects at least in part in inducing hyperglycemia. In this situation, HSDl can be a second source of GC production in addition to the adrenal glands .
As another example, continuous excessiveness o f the active GC in peripheral tissues, as observed in Gushing'' s syndrome, leads to insulin resistance, where HSDl is considered to have an important role.
Also, in adipose tissue, active GC is demonstrated to enhance the differentiation of preadipocytes into adipocytes. Mature adipocytes express HSDl activity, which causes an increase in local concentration of the active form and further expansion of adipose tissue. Such an action of HSDl should be critical in pathogenesis of obesity. In addition, a local immunosuppressive effect of HSDl in placental deciduas, and a relationship between the expression of the enzyme in adrenal cortex and the induction of adrenaline synthesis, are suggested.
(The above are referred to in: Quinkler M, Oelkers W & Diederich S (2001) European Journal of Endocrinology Vol. 144, Pages 87-97; and Seckl JR & Walker BR (2001) Endocrinology Vol. 142, Pages 1371-1376.)
According to the above suggestions, it is expected that drugs having inhibitory effects against HSDl would be useful for treating or preventing diabetes mellitus, obesity, metabolic syndrome in connection with any of such diseases, or any other diseases which occur by reason of the actions of HSDl.
Diabetes mellitus, main feature of which disease is chronic hyperglycemia, introduces various metabolic abnormalities and shows symptoms of thirst, polydipsia, polyuria, and so on based on high glucose concentration. Continuing hyperglycemic state would also lead to diabetic complications such as retinopathy, nephropathy, neuropathy, and myocardial and/or cerebral infarction by reason of arteriosclerosis .
In treating diabetes, moderate suppression of hyperglycemia is critical in order that onset and progress of the complications would be repressed. For these purposes, dietetics, ergotherapy and pharmacotherapy are utilized in combination on a suitable basis and, amongst the pharmacotherapy, many approaches different in mechanisms of action have been attempted. In spite of those various existing ,„ methods, sufficient therapeutic effect has not ever been achieved.
Obesity is defined as a state of fatness coinciding with any disease that would be improved or not be progressed in case of weight decrease (e.g. diabetes, hyperlipidemia, hypertension) or with an excessive amount of fat in viscera. It is considered that, if such a state should continue, at least two of diabetes, hyperlipidemia, hypertension and etc. would concur, and then onset of myocardial and/or cerebral infarction by reason of arteriosclerosis would occur.
Major therapeutic methods in treating obesity are dietetics and ergotherapy, and pharmacotherapy is undertaken only if necessary, for example, because of difficulty in the first two alternatives. However, the existing drugs have several problems in adverse effects and usages, since most of them suppress feeding mainly via central action.
In consequence, development of any drug to treat diabetes and/or obesity with a novel mechanism of action has so far been required. Under these circumstances, it is expected that drugs having inhibitory effects against HSDl would be useful as another alternative with separate mechanistic approach to treat diabetes mellitus, as well as a novel "adipose tissue-acting" class among other drugs against obesity. As drugs in development to treat diabetes and/or obesity through inhibition of HSDl, for example, WO 03/065983 discloses triazole compounds of the following general formula:
Figure imgf000004_0001
[wherein: R1 is unsubstituted or substituted adamantyl;
W is -N (Ra) - or single bond; X is -CH2- or single bond; Z is -S- or single bond; Ra is -H or Cι-6 alkyl unsubstituted or substituted with one to five fluorines; R2 is -H, unsubstituted or substituted Cι-ιo alkyl, unsubstituted or substituted C2-10 alkenyl, -CH2C02H, - CH2C02Cι_6 alkyl, -CH2CONHRa, - (CH2) 0-2C3-9 cycloalkyl (optionally having double bonds, and either unsubstituted or substituted), - (CH2) 0-2C5-12 bicycloalkyl (optionally having double bonds, and either unsubstituted or substituted), - (CH2) 0-2 adamantyl (either unsubstituted or substituted) or -(CH2)o-2R; R3 is -H, unsubstituted or substituted Cι-10 alkyl, unsubstituted or substituted C2-10 alkenyl, -YC3-9 cycloalkyl (optionally having double bonds, and either unsubstituted or substituted) , -YC5-12 bicycloalkyl (optionally having double bonds, and either unsubstituted or substituted) , -Yadamantyl (either unsubstituted or substituted) or YR; R is benzodioxolane, furan, tetrahydrofuran, thiophene, tetrahydrothiophene, dihydropyran, tetrahydropyran, pyridine, piperidine, benzofuran, dihydrobenzofuran, benzothiophene, dihydrobenzothiophene, indole, dihydroindole, indene, indane, 1, 3-dioxolane, 1,3- dioxane, phenyl or naphthyl (any such R unsubstituted or substituted) ; and Y is -(CH2)o-2- or (-HC=CH-) ] . However, any description under said application does not disclose nor refer to any of the compounds having the structure of the present invention.
The compounds of the present invention improve physicochemical (stability, etc.) and biological (activity to inhibit HSDl, specificity, bioavailability, metabolism, etc.) profiles, as a result of the selection of structural characteristics as disclosed herein.
SUMMARY OF THE INVENTION According to the present invention, it has been found that triazole compounds represented by the following formula have superior HSDl inhibitory activity, and are useful as HSDl inhibitors or therapeutic drugs of diabetes or obesity.
The present invention provides the following. (1) A triazole compound represented by the following formula:
Figure imgf000006_0001
wherein R1 is an alkyl group or a cycloalkyl group wherein the alkyl group and the cycloalkyl group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF3, -OH, -NH2, an alkoxy group, a cycloalkyl group, an alkenyl group, -COOH, -CO-O-alkyl, -CO-N (R7) (R8) , -N (R7) -CO-R8, an aryl group and a heteroaryl group wherein R7 and R8 are each independently a hydrogen atom or an alkyl group, and the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R , an aryl group and a heteroaryl group wherein n is 0-3, R9 and R10 are each independently a hydrogen atom, an alkyl group or -CO-alkyl, and R11 is -OH, an alkoxy group, an alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently a hydrogen atom or an alkyl group; Y is a cycloalkyl group or a heterocycloalkyl group wherein the cycloalkyl group and the heterocycloalkyl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ; Ar1 is an aryl group or a heteroaryl group; R2 and R3 are each independently a hydrogen atom, a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-0H, -N(R9) (R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ; Z is -(CH(R14))P-, -(CH(R14))p-N(R16)-(CH(R15))q- or
Figure imgf000007_0001
wherein Y]_ is a cycloalkyl group or a heterocycloalkyl group wherein the cycloalkyl group and the heterocycloalkyl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, ~(CH2)n-OH, -N(R9) (R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO- R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , p is 0-3, q is 0-3, R14 and R15 are each independently a hydrogen atom, a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n _OH, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , and R16 is a hydrogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, - (CH2) n-CO-R11, a cycloalkyl group, an alkenyl group, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ; is an aryl group, a heteroaryl group or
Figure imgf000009_0001
wherein Xi is -(CH2)t- wherein t is 0-2, Vi is =CH- or =N-, and Wi is -C(R17) (R18)-, -0-, -S-, -S02-, -SO-, -CO- or -N(R19)- wherein R17 and R18 are each independently a hydrogen atom, an alkyl group, an alkoxy group, a haloalkyl group, -(CH2)r-OH, -CO-R20, -N(R21) (R22) or -Li-Ar3 wherein r is 0-3, R20 is -OH, an alkoxy group, an alkoxyalkyl group or -N(R23) (R24) wherein R23 and R24 are each independently a hydrogen atom, an alkyl group, -(CH2)s-OH, an alkoxyalkyl group, or in combination form
-N X,
wherein s is 0-3, X2 is -0-, -(CH2)t~ or -N(R25)- wherein t is as defined above and R25 is a hydrogen atom, -CO-R26, -S02-R26 or -(CH2)U-Ar4 wherein R26 is an alkyl group, an alkoxy group, -NH-alkyl or - (-alkyl) 2, u is 0-3, and Ar4 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n _OH,
-N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , Li is -(CH2)V-, -0- or -C0- wherein v is 0-3, and Ar3 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n~OH, -N (R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , and
R21 and R22 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, -CO-O-alkyl or -Li-Ar3 (Li and Ar3 are as defined above) , and R19 is a hydrogen atom, -CO-R26, -S02-R26 or -(CH2)U-Ar4 (R26, u and Ar4 are as defined above) ; and R5 are each independently a hydrogen atom, a halogen atom, -OH, -N02, -CN, an alkyl group, an alkoxy group, -CO-R27, -S02-R27, -CO-N(R28) (R29) or -N(R30) (R31) wherein the alkyl group and the alkoxy group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF3, -OH, an alkoxy group, a haloalkoxy group, -N(R9) (R10) , -CN, -N02, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (R9, R10 and R11 are as defined above) , wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH,
-N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) R27 is -OH, an alkoxy group, an alkyl group, -NH2, -NH-alkyl or -N (-alkyl) 2,
R28 and R29 are each independently a hydrogen atom, an alkyl group or -(CH2)W-R32, wherein w is 0-3 and R32 is -OH, -CF3, an alkoxy group, -CONH2 or -N (R33) (R34) wherein R33 and R34 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, or in combination form
— X,
(X2 is as defined above) or R ,28 and R ,29 in combination form
Figure imgf000011_0001
wherein X3 is -CO-, -CH2- or -CH2-CH2-, X4 is
-0-, -(CH2)t-, -N(R25)- or
Figure imgf000011_0002
wherein Y2 is cycloalkyl or heterocycloalkyl and t and R25 are as defined above, and R35 and R36 are each independently a hydrogen atom, a halogen atom, an alkyl group optionally substituted by -OH, -OH, -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R37, -N(R38) (R39) wherein R37 is -OH, an alkoxy group, -NH2,
— X2
-NH-alkyl, -N (-alkyl) 2 or (X2 is as defined above) wherein the alkyl group in -NH-alkyl and - (-alkyl) 2 and the alkoxy group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, ~CF3, -OH, an alkoxy group, a haloalkoxy group, -N(R9)(R10), -CN, -N02, a cycloalkyl group, an alkenyl group,
-CO-R11, an aryl group and a heteroaryl group (R9, R10 and R11 are as defined above) , wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N (R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R , R and R are as defined above) , and R38 and R39 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-O-alkyl, and R30 and R31 are each independently a hydrogen atom, an alkyl group optionally substituted by -OH, -S02-
-v. 2
R40, -(CH2)x-CO-R41 or wherein x is 0-3, R40 is an alkyl group or -NH2, R41 is a hydrogen atom, an alkyl group optionally substituted by -OH, -OH, an alkoxy group, an alkoxyalkyl group or -(CH2)S~ N(R42) (R43) wherein s is as defined above and R and R are each independently a hydrogen atom, an alkyl group, -OH, an alkoxy group, or in combination form
Figure imgf000013_0001
(X3, X,
Figure imgf000013_0002
a„n,d R ,33b6 are as defined above) ,
V2 is =CH- or =N- and W2 is -C(R44) (R45)-, -0- or
-N(R46)- wherein R44 and R45 are each independently a hydrogen atom, an alkyl group, an alkoxy group, a haloalkyl group, -(CH2)r-OH, -CO-R47 or -N(R48) (R49) wherein r is as defined above, R47 is -OH, an alkoxy group, an alkoxyalkyl group, -N(R50) (R51) wherein R50 and R51 are each independently a hydrogen atom, an alkyl group, -(CH2)s-OH (s is as defined above) or an alkoxyalkyl group, and R48 and R49 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-0-alkyl, and R46 is a hydrogen atom, -CO-R52 or -S02-R52 wherein R52 is an alkyl group, an alkoxy group, -NH-alkyl or -N (-alkyl) 2 or R30 and R31 in combination form
D36
Figure imgf000013_0003
RJb are as defined above ) or R ,4y a„„ndJ πR5α in combination may form -0-alkylene-O-, a prodrug thereof or a pharmaceutically acceptable salt thereof. (2) The triazole compound of (1) above, wherein Z is
-(CH(R14))P- and p is 0, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(3) The triazole compound of (2) above, wherein Y is a C3-e cycloalkyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(4) The triazole compound of (3) above, wherein Ar1 is a phenyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof. (5) The triazole compound of (4) above, wherein R2 and R3 are each independently a halogen atom or a hydrogen atom, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(6) The triazole compound of any of (1) to (5) above, wherein Ar2 is a phenyl group, R4 is a hydrogen atom, a halogen atom or an alkoxy group and R5 is -CO-N(R28) (R29) , a prodrug thereof or a pharmaceutically acceptable salt thereof.
(7) The triazole compound of (6) above, wherein R28 and R29 are each independently a hydrogen atom or an alkyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof. (8) The triazole compound of any of (1) to (5) above, wherein Ar2 is a phenyl group, R4 is a hydrogen atom or a halogen atom and R5 is -N(R30) (R31) wherein R30 is a hydrogen atom and R31 is - (CH2) x-CO-R41, a prodrug thereof or a pharmaceutically acceptable salt thereof. (9) The triazole compound of (8) above, wherein X is 0 and R41 is an alkoxy group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(10) The triazole compound of (8) above, wherein X is 0 and R41 is - (CH2) S-N (R42) (R43) , a prodrug thereof or a pharmaceutically acceptable salt thereof.
(11) The triazole compound of (10) above, wherein s is 0, R42 is a hydrogen atom and R43 is an alkoxy group, a prodrug thereof or a pharmaceutically acceptable salt thereof. (12) The triazole compound of any of (1) to (5) above, wherein Ar2 is a phenyl group, R4 is a hydrogen atom and R5 is - N(R30) (R31) wherein R30 and R31 are joined to form
Figure imgf000015_0001
and X3 is -CO-, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(13) The triazole compound of (12) above, wherein X is -0-, a prodrug thereof or a pharmaceutically acceptable salt thereof. (14) The triazole compound of (1) above, which is
3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H-
[1, 2,4] triazol-3-yl] -benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzoyl}morpholine, 3-chloro-N-methyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzamide,
3-chloro-N,N-dimethyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
,[1, 2, 4] triazol-3-yl] benzamide,
3-chloro-N- (2-hydroxy-ethyl) -4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1, 2, 4] triazol-3-yl] benzamide,
3-chloro-N-isopropyl-4- [4-methyl-5- (1-phenylcyclopropyl) 4H-
[1, 2, 4] triazol-3-yl] benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -
4H[1, 2,4] triazol-3-yl]benzoyl}piperidine, { 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H [1, 2,4] triazol-
3-yl] enzoyl} - ( 4-hydroxy) piperidine,
N-carbamoylmethyl-3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -
4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol- 3-yl] -N- (2,2, 2-trifluoro-ethyl) -benzamide,
N- (2-acetylamino) ethyl-3-chloro-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide, 3-chloro-N- (2-methoxy) ethyl-4- [ 4-methyl-5- ( 1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
1-acetyl- (4-{ 3-Chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2, 4] triazol-3-yl]benzoyl}piperazine, 3-chloro-N- (2-dimethylamino) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-
3-yl] -N- (2-morpholin-4-yl) ethylbenzamide,
4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3-yl] -3- methoxybenza ide,
3-chloro-4-{ 4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H-
[1,2,4] triazol-3-yl}benzamide,
3-chloro-N~metyl-4-{ 4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1, 2, 4] triazol-3-yl}benzamide, 4- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3- yl] benzamide,
4-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2, 4] triazol-3-yl}benzamide,
4-chloro-3-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1, 2, 4] triazol-3-yl}benzamide,
4-chloro-3-{5- [1-phenylcyclopropyl] -4-methyl-4H- [1,2,4] triazol-
3-yl}benzamide,
3-chloro-4- [4-ethyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-
3-yl] benzamide, 3-chloro-4-{ 4-ethyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H-
[1, 2, 4] triazol-3-yl}benzamide,
3- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3- yl] benzamide,
3- {5- [1- (4-fluoro-phenyl) cyclopropyl] -4-isopropyl-4H- [1, 2, 4] triazol-3-yl}benzamide,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1, 2, 4] triazol-3-yl] phenyl } -1-morpholinecarboxamide,
3-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] -phenyl}-l, 1-dimethylurea,
{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2, 4] triazol-3-yl] -phenyl}urea, ethyl N-{3-Chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H- [1,2, 4] triazol-3-yl] -phenyl }-carbamate,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2,4] triazol-3-yl] phenyl } -1- (4-methoxyρiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2,4] triazol-3-yl] phenyl } -1- (3-hydroxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2,4] triazol-3-yl] phenyl } -1- (4-hydroxypiperidine) carboxamide, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] -phenyl} -3-methoxyurea, l-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }-3-hydroxy-3-methylurea,
1- (3-chloro-4-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H-
[1,2,4] triazol-3-yl}phenyl) -3-methoxyurea,
1- (4-{5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl }phenyl) -3-methoxyurea, 1- (3- { 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}phenyl) -3-methoxyurea,
3-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] -phenyl }oxazolidin-2-one, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }imidazolidin-2-one,
3- (3-chloro-4-{ 5- [1- (4-fluoro-phenyl) cyclopropyl] -4-methyl-4H-
[1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (4-{5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}phenyl) oxazolidin-2-one, 3- (4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H-
[1, 2, 4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (3- {5- [1- (4-fluorophenyl) cyclopropyl] -4-isoρropyl-4H-
[1,2,4] triazol-3-yl}phenyl) oxazolidin-2-one, methyl N- (4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4- methyl-4H- [1,2, 4] triazol-3-yl}phenyl) carbamate, a prodrug thereof or a pharmaceutically acceptable salt thereof.
(15) The triazole compound of (1) above, which is 3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H-
[1,2,4] triazol-3-yl] -benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1, 2, 4] triazol-3-yl]benzoyl}morpholine,
3-chloro-N-methyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1, 2,4] triazol-3-yl] benzamide,
3-chloro-N, N-dimethyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1, 2, 4] triazol-3-yl] enzamide,
3-chloro-N- (2-hydroxy-ethyl) -4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, ] triazol-3-yl] benzamide, 3-chloro-N-isopropyl-4- [4-methyl-5- (1-phenylcyclopropyl) 4H-
[1, 2, 4] triazol-3-yl] benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -
4H [1, 2, 4] triazol-3-yl] benzoyl}piperidine,
{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H[1,2, 4] triazol- 3-yl]benzoyl}- (4-hydroxy) piperidine,
N-carbamoylmethyl-3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -
4H- [1,2,4] triazol-3-yl] enzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] -N- (2,2, 2-trifluoro-ethyl) -benzamide, N- (2-acetylamino) ethyl-3-chloro-4- [4-methyl-5- ( 1- phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] benzamide,
3-chloro-N- (2-methoxy) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
1-acetyl- (4-{ 3-Chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1, 2,4] triazol-3-yl]benzoyl}piperazine,
3-chloro-N- (2-dimethylamino) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol- 3-yl] -N- (2-morpholin-4-yl) ethylbenzamide,
4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] -3- methoxybenzamide,
3-chloro-4-{4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1, 2, 4] triazol-3-yl}benzamide,
3-chloro-N-metyl-4-{4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1,2,4] triazol-3-yl }benzamide,
4- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3- yl] enzamide, 4-{5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}benzamide,
4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H-
[1, 2,4] triazol-3-yl}benzamide,
4-chloro-3-{5- [1-phenylcyclopropyl] -4-methyl-4H- [1,2,4] triazol- 3-yl}benzamide,
3-chloro-4- [4-ethyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] benzamide,
3-chloro-4-{ 4-ethyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H-
[1,2, ] triazol-3-yl}benzamide, 3- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3- yl] benzamide,
3-{5- [1- (4-fluoro-phenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}benzamide, a prodrug thereof or a pharmaceutically acceptable salt thereof. (16) The triazole compound of (1) above, which is
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1, 2, 4] triazol-3-yl] phenyl } -1-morpholinecarboxamide,
3-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1, 2, 4] triazol-3-yl] -phenyl}-!, 1-dimethylurea, {3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1, 2, 4] triazol-3-yl] -phenyl}urea,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1, 2, 4] triazol-3-yl] phenyl } -1- (4-methoxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2, 4] triazol-3-yl] phenyl } -1- (3-hydroxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1- (4-hydroxypiperidine) carboxamide, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] -phenyl}-3-methoxyurea, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3-yl]phenyl}-3-hydroxy-3-methylurea, 1- (3-chloro-4-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, l-(4-{5-[l- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, 1- (3- {5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, a prodrug thereof or a pharmaceutically acceptable salt thereof. (17) The triazole compound of (1) above, which is 3-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] -phenyl }oxazolidin-2-one, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }imidazolidin-2-one,
3- (3-chloro-4-{5- [1- (4-fluoro-phenyl) cyclopropyl] -4-methyl-4H- [1, 2,4] triazol-3-yl}phenyl) oxazolidin-2-one, 3-(4-{5-[l- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) oxazolidin-2-one, 3- (4-chloro-3-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2,4] triazol-3-yl}phenyl) oxazolidin-2-one, 3-(3-{5-[l- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1, 2, 4] triazol-3-yl}phenyl) oxazolidin-2-one, a prodrug thereof or a pharmaceutically acceptable salt thereof. (18) A pharmaceutical composition comprising the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. (19) An HSDl (llbeta-hydroxysteroid dehydrogenase 1) inhibitor comprising the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component. (20) A therapeutic or prophylactic drug of diabetes, which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
(21) A therapeutic or prophylactic drug of obesity, which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
(22) A therapeutic or prophylactic drug of metabolic syndrome, which comprises the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
(23) A method for the treatment or prophylaxis of diabetes, which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
(24) A method for the treatment or prophylaxis of obesity, which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
(25) A method for the treatment or prophylaxis of metabolic syndrome, which comprises administering an effective amount of the triazole compound of any of (1) to (17) above, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
(26) The method of (23) above, wherein a different therapeutic drug of diabetes is used in combination. (27) The method of (26) above, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
(28) The method of (27) above, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbuta ide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metfor in hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
(29) The method of (24) above, wherein a different therapeutic drug of diabetes is used in combination.
(30) The method of (29) above, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
(31) The method of (30) above, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
(32) The method of (25) above, wherein a different therapeutic drug of diabetes is used in combination.
(33) The method of (32) above, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
(34) The method of (33) above, wherein the different 5 therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, ι o - acarbose and pioglitazone hydrochloride.
( (35) The method of (23) above, wherein a different therapeutic drug of obesity is used in combination. (36) The method of (35) above, wherein the different therapeutic drug of obesity is Mazindol.
15 (37) The method of (24) above, wherein a different therapeutic drug of obesity is used in combination.
(38) The method of (37) above, wherein the different therapeutic drug of obesity is Mazindol.
(39) The method of (25) above, wherein a different therapeutic 20 drug of obesity is used in combination.
(40) The method of (39) above, wherein the different therapeutic drug of obesity is Mazindol.
The triazole compound of the present invention shows a markedly enhanced HSDl inhibitory activity in vivo, which 25 results from improved metabolic resistance.
DETAILED DESCRIPTION OF THE INVENTION Respective substituents and moieties used in the present specification are defined in the following.
The "alkyl group" means a straight chain or branched 30 chain alkyl group. Examples thereof include methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, isopentyl group, neopentyl group, tert-pentyl group, 1- ethylpropyl group, hexyl group and the like. It is preferably a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atoms.
For R , preferred are methyl, ethyl, propyl, isopropyl, butyl and isobutyl, and particularly preferred are methyl and isopropyl.
The "cycloalkyl group" means a saturated cyclic alkyl group. Examples thereof include cyclopropyl group, cyclobutyl group, cyclopentyl group, { cyclohexyl group, cycloheptyl group, cyclooctyl group and the like. It is preferably a cycloalkyl group having 3 to 8, more preferably 3 to 6, carbon atoms.
For R r preferred is cyclopropyl.
When R is alkyl, cycloalkyl group as a substituent on alkyl is preferably cyclopropyl. For Y, preferred are cyclopropyl, cyclobutyl and cyclopentyl, and particularly preferred is cyclopropyl.
For Y]_, preferred are cyclopropyl, cyclobutyl and cyclopentyl, and particularly preferred is cyclopropyl.
The "heterocycloalkyl group" means a saturated 5- to 7- membered heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom. Examples thereof include tetrahydrofuryl group, tetrahydrothienyl group, pyrrolidinyl group, pyrazolidinyl group, imidazolidinyl group, oxazolidinyl group, thiazolidinyl group, tetrahydropyranyl group, dioxolanyl group, dioxanyl group, piperidinyl group, piperazinyl group, morpholinyl group and the like.
For Y, preferred is piperidinyl.
For Y2, preferred is dioxolanyl. The "alkenyl group" means a straight chain or branched chain alkenyl group. Examples thereof include vinyl group, 1- propenyl group, allyl group, l-methyl-2-propenyl group, 1- butenyl group, 2-butenyl group, 3-butenyl group, 1-pentenyl group, 2-pentenyl group, 1-hexenyl group, 2-hexenyl group and the like. It is preferably a straight chain or branched chain alkenyl group having 2 to 6, more preferably 2 to 4, carbon atoms . When R1 is alkyl, alkenyl group as a substituent on alkyl is preferably vinyl.
The "aryl group" means an aromatic hydrocarbon group. Examples thereof include phenyl group, naphthyl group, anthryl group and the like. It is preferably a phenyl group or naphthyl group.
For Ar , Ar , Ar and Ar , preferred are phenyl and naphthyl, and particularly preferred is phenyl.
The "heteroaryl group" means a monocyclic or fused 5- to 14-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom. Examples thereof include furyl group, thienyl group, pyrrolyl group, oxazolyl group, isooxazolyl group, thiazolyl group, isothiazolyl group, i idazolyl group, pyrazolyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, indolyl group, isoindolyl group, benzofuranyl group, benzothienyl group, benzoimidazolyl group, benzothiazolyl group, benzoxazolyl group, indolizinyl group, quinolyl group, isoquinolyl group, quinazolinyl group, cinnolinyl group, quinoxalinyl group, phthalazinyl group, acridinyl group, phenazinyl group, naphthyridinyl group and the like. It is preferably a monocyclic or fused 5- to 10-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, which includes furyl group, thienyl group, pyrrolyl group, oxazolyl group, isooxazolyl group, thiazolyl group, isothiazolyl group, imidazolyl group, pyrazolyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, indolyl group, isoindolyl group, benzofuranyl group, benzothienyl group, benzoimidazolyl group, benzothiazolyl group, benzooxazolyl group and the like.
For Ar1, preferred are thienyl, pyrrolyl and pyridyl. For Ar2, preferred are thienyl, pyrrolyl, oxazolyl, isooxazolyl, thiazolyl, imidazolyl, pyrazolyl and pyridyl, and particularly preferred are thienyl and pyridyl.
For Ar3 and Ar4, preferred is pyridyl.
The "halogen atom" means fluorine atom, chlorine atom, bromine atom or iodine atom. It is preferably fluorine atom or chlorine atom.
For R 2 and R3, preferred is fluorine atom. In thi's case, Ar is particularly preferably phenyl, where only the 4- position of the phenyl is substituted by fluorine atom. For R4 and R5, preferred is chlorine atom. In this case, Ar is particularly preferably phenyl, where at least the 2-position of the phenyl is substituted by chlorine atom.
The "haloalkyl group" means a haloalkyl group wherein the above-defined "alkyl group" is substituted by the above- defined "halogen atom". Examples thereof include fluoromethyl group, difluoromethyl group, trifluoromethyl group, bromomethyl group, chloromethyl group, 1, 2-dichloroethyl group, 2,2- dichloroethyl group, 2, 2, 2-trifluoroethyl group and the like. It is preferably a straight chain or branched chain haloalkyl group having 1 to 6, more preferably 1 to 4, carbon atoms, particularly preferably a trifluoromethyl group.
The "alkoxy group" means a straight chain or branched chain alkoxy group. Examples thereof include methoxy group, ethoxy group, propoxy group, isopropoxy group, butoxy group, isobutoxy group, tert-butoxy group, pentyloxy group, hexyloxy group and the like. It is preferably a straight chain or branched chain alkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms. For R2 and R , preferred is methoxy. For R4 and R5, preferred are methoxy, ethoxy and isopropoxy.
The "haloalkoxy group" means a haloalkoxy group wherein the above-defined "alkoxy group" is substituted by the above- defined "halogen atom". Examples thereof include fluoromethoxy group, difluoromethoxy group, trifluoromethoxy group, bromo ethoxy group, chloro ethoxy group, 1, 2-dichloroethoxy group, 2, 2-dichloroethoxy group, 2, 2, 2-trifluoroethoxy group and the like. It is preferably a straight chain or branched chain haloalkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms .
The "alkoxyalkyl group" means an alkoxyalkyl group wherein the above-defined "alkyl group" is substituted by the above-defined "alkoxy group". Examples thereof include methoxymethyl group, ethoxymethyl group, propoxyirtethyl group, isopropoxymethyl group, butoxymethyl group, isobutoxymethyl group, tert-butoxymethyl group, 2-methoxyethyl group, pentyloxy ethyl group, hexyloxymethyl group and the like. It is preferably an alkoxyalkyl group wherein the alkyl group is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atoms and the alkoxy group is a straight chain or branched chain alkoxy group having 1 to 6, more preferably 1 to 4, carbon atoms. For R2 , R24 and R41, preferred are methoxymethyl and 2- methoxyethyl.
The "-CO-alkyl" means an alkylcarbonyl group having the above-defined "alkyl group" as the alkyl moiety. Examples thereof include acetyl group, propionyl group, butyryl group, isobutyryl group, valeryl group, isovaleryl group, pivaloyl group, pentanoyl group, hexanoyl group and the like. It is preferably an alkylcarbonyl group wherein the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4 , carbon atoms .
For R9, R10, R21, R22, R33, R34 , R38 , R39, R48 and R49, particularly preferred are acetyl, propionyl, butyryl and ±sobutyryl . The "-CO-O-alkyl" means an alkyloxycarbonyl group l aving the above-defined "alkyl group" as the alkyl moiety . Examples thereof include methyloxycarbonyl group, ethyloxycarbonyl group, propyloxycarbonyl group, ±sopropyloxycarbonyl group, butyloxycarbonyl group, ±sobutyloxycarbonyl group, sec-butyloxycarbonyl group, tert- fc tyloxycarbonyl group, pentyloxycarbonyl group, zLsopentyloxycarbonyl group, neopentyloxycarbonyl group, tert- pentyloxycarbonyl group, 1-ethylpropyloxycarbonyl group, riexyloxycarbonyl group and the like . It is preferably an alkyloxycarbonyl group wherein the "alkyl moiety" is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4 , carbon atoms .
For R21, R22, R38, R39, R48 and R49, particularly preferred are methyloxycarbonyl, ethyloxycarbonyl, propyloxycarbonyl , r sopropyloxycarbonyl and tert-butyloxycarbonyl .
The "-NH-alkyl" means an alkylamino group having the above-defined "alkyl group" as the alkyl moiety. Examples thereof include methylamino group, ethylamino group, propyla ino group, isopropylamino group, butylamino group, r sobutylamino group, sec-butylamino group, tert-butylamino group, pentylamino group, isopentylamino group, tert- pentylamino group, hexylamino group and the like . It is preferably an alkylamino group wherein the alkyl moiety is a s traight chain or branched chain alkyl group having 1 to 6 , more preferably 1 to 4 , carbon atoms .
For R26, R27, R32 and R52, particularly preferred are methylamino, ethylamino, propylamino and isopropylamino .
The "-N (-alkyl) 2" means a dialkylamino group having the above-defined "alkyl group" as the alkyl moiety. Examples thereof include dimethylamino group, diethyla ino group, dipropylamino group, diisopropylamino group, dibutylamino group, diisobutylamino group, di (sec-butyl) a ino group, di (tert-butyl) amino group, dipentylamino group, diisopentylamino group, di (tert-pentyl) amino group, dihexylamino group, N-ethyl-N-methylamino group, N-methyl-N- propylamino group, N-ethyl-N-propylamino group and the like. It is preferably a dialkylamino group wherein the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6, more preferably 1 to 4, carbon atoms.
For R , R , R and R , particularly preferred are dimethylamino, diethylamino and N-ethyl-N-methylamino.
The "alkyl" moieties of the "alkylamino group" and "dialkylamino group" are optionally substituted by 1 to 5 substituents each independently selected from halogen atom, -CF3, -OH, alkoxy group, haloalkoxy group, -N (R9) (R10) (R9 and R10 are each independently hydrogen atom, alkyl group or -CO-alkyl) , -CN, -N02, cycloalkyl group, alkenyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group), aryl group and heteroaryl group. Here, the substituent "aryl group" and "heteroaryl group" are optionally substituted by 1 to 3 substituents each independently selected from halogen atom, haloalkyl group, alkyl group, -(CH2)n _0H (n=0 - 3) , - N(R9) (R10) (R9 and R10 are independently hydrogen atom, alkyl group or -CO-alkyl) , -CN, -N02, alkoxy group, cycloalkyl group, alkenyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group) , aryl group and heteroaryl group.
The "aryl group" and the "heteroaryl group" for R2, R3, R6, R14, R15, R16, Ar3 and Ar4 are optionally substituted by 1 to 3 substituents each independently selected from halogen atom, haloalkyl group, alkyl group, -(CH2)n-OH (n=0 - 3), -N(R9)(R10) (R9 and R10 are each independently hydrogen atom, alkyl group or -CO-alkyl) , -CN, -N02, alkoxy group, cycloalkyl group, alkenyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group) , aryl group and heteroaryl group. The "cycloalkyl group" and the "heterocycloalkyl group" fox Y and Yi are optionally substituted by 1 to 3 substituents each independently selected from halogen atom, haloalkyl group, alkyl group, -(CH2)n-OH (n=0 - 3), -N(R9) (R10) (R9 and R10 are each independently hydrogen atom, alkyl group or -CO-alkyl) , - C , -N02, alkoxy group, cycloalkyl group, alkenyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group) , aryl group and heteroaryl group.
The "alkyl group" and the "alkoxy group" for R4 and R5, and the "alkoxy group" for R37 are optionally substituted by 1 to 5 substituents each independently selected from halogen atom, -CF3, -OH, alkoxy group, haloalkoxy group, -N(R9) (R10) (R9 and R10 are each independently hydrogen atom, alkyl group or - CO—alkyl) , -CN, -N02, cycloalkyl group, alkenyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group), aryl group and heteroaryl group. Here, the substituent group" and "heteroaryl group" are optionally substituted by 1 to 3 substituents each independently selected from halogen atom, haloalkyl group, alkyl group, -(CH2)n~OH (n=0 - 3) , - N(R9) (R10) (R9 and R10 are independently hydrogen atom, alkyl group or -CO-alkyl) , -CN, -N02, alkoxy group, cycloalkyl group, alk:enyl group, -CO-R11 (R11 is -OH, alkoxy group, alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently hydrogen atom or alkyl group) , aryl group and heteroaryl group. The above-mentioned substituents "halogen atom", "haloalkyl group", "alkyl group", "alkoxy group", "haloalkoxy group", "cycloalkyl group", "alkenyl group", "aryl group" and "heteroaryl group" are as defined above.
R4 and R5 in combination may form -O-alkylene-0-. Here, the "alkylene" means a divalent hydrocarbon. Examples thereof include methylene, ethylene, propylene, butylene, pentylene, hexylene and the like. It is preferably an alkylene having 1 to 6, more preferably 1 to 4, carbon atoms, particularly preferably methylene. In the above-mentioned formulas, Z is preferably
-(CH(R1 ))P- and p is 0; Y is preferably a C3-8 cycloalkyl group; Ar1 is preferably a phenyl group; Ar2 is preferably a phenyl group; R1 is preferably an alkyl group; R2 is preferably a hydrogen atom; R3 is preferably a halogen atom; R4 is preferably a hydrogen atom, a halogen atom or an alkoxy group; R5 is preferably -CO-N(R28) (R29) (wherein R28 and R29 are preferably each independently a hydrogen atom or an alkyl group) or -N(R30) (R31) (wherein R30 is preferably a hydrogen atom and R31 is preferably - (CH2) x-CO-R41 wherein X is preferably 0 and R41 is preferably an alkoxy group, or X is preferably 0 and R41 is preferably - (CH2) S-N (R42) (R43) wherein s is preferably 0., R42 is preferably a hydrogen atom and R43 is preferably an alkoxy group, or R30 and R31 are preferably joined to form
Figure imgf000031_0001
wherein X3 is preferably -CO- and X is preferably -0-) .
The "pharmaceutically acceptable salt" may be any salt as long as it forms a non-toxic salt with a triazole compound represented by the above-mentioned formula. For example, it can be obtained by reaction with inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, hydrobromic acid and the like; organic acids such as oxalic acid, malonic acid, citric acid, fumaric acid, lactic acid, malic acid, succinic acid, tartaric acid, acetic acid, trifluoroacetic acid, gluconic acid, ascorbic acid, methylsulfonic acid, benzylsulfonic acid and the like; inorganic bases such as sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, ammonium hydroxide and the like; organic bases such as methylamine, diethylamine, triethylamine, triethanolamine, ethylenediamine, tris (hydroxymethyl) methylamine, guanidine, choline, cinchonine, N-methyl-D-glucamine and the like; or amino acids such as lysin, histidine, arginine, alanine and the like. In the present invention, a water-containing form, a hydrate and a solvate of each compound are also encompassed therein.
In addition, the triazole compound represented by the above-mentioned formula includes various isomers. For example, E form and Z form are present as geometric isomers, and when an asymmetric carbon atom is present, enantiomers and diastereomers are present as stereoisomers based thereon. In some cases, a tautomer may be present. Accordingly, the present invention encompasses all these isomers and mixtures thereof.
The present invention also encompasses prodrugs and metabolites of the triazole compound represented by the formula. A "prodrug" is a derivative of the compound of the present invention, which has a chemically or metabolically decomposable group, which, after being administered to a living organism, restores to its original compound form and exhibit its intrinsic efficacy, and which includes complexes and salts free of a covalent bond. For example, ester derivatives known as prodrugs in the field of pharmaceutical agents can be used. When the compound of the present invention is used as a pharmaceutical preparation, it is generally admixed with a pharmaceutically acceptable carrier, excipient, diluent, extender, disintegrant, stabilizer, preservative, buffer, emulsifier, fragrance, coloring agent, sweetening agent, thickening agent, corrigent, dissolution aids and other additives known per se, such as water, vegetable oil, alcohols such as ethanol, benzyl alcohol and the like, polyethylene glycol, glycerol triacetate, gelatin, lactose, carbohydrates such as starch and the like, magnesium stearate, talc, lanolin, vaseline and the like, and produced in the form of tablet, pill, powder, granule, suppository, injection, eye drop, liquid, capsule, troche , aerosol, elixir, suspension, emulsion, syrup and the like by a conventional method for systemic or local, oral or parenteral administration.
While the dose of the compound of the present invention varies depending on the age, body weight, symptom, disease to be treated, administration method and the like, it is generally 50 mg to 800 mg for an adult per administration, which is given once to several times a day.
The compound of the present invention can be administered to a mammal (human, mouse, rat, rabbit, dog, cat, bovine, pig, monkey etc.) as an HSDl inhibitor, a prophylactic or therapeutic drug of diabetes, a prophylactic or therapeutic drug of diabetic complication (retinopathy, nephropathy, neuropathy, cardiac infarction and cerebral infarction based on arteriosclerosis etc.), a prophylactic or therapeutic drug of hyperlipemia, a prophylactic or therapeutic drug of obesity, neurodegenerative disease and the like, or a prophylactic or therapeutic drug of diseases mediated by HSDl.
The compound of the present invention can be administered to a mammal concurrently with other therapeutic drug of diabetes or obesity with the aim of the prophylaxis or treatment of diabetes. In the present invention, the "therapeutic drug of diabetes" encompasses therapeutic drugs of diabetic complications. Furthermore, the compound of the present invention can be administered in combination with other therapeutic drugs of diabetes or obesity to a mammal for the prophylaxis or treatment of obesity.
In the case of a combined administration, the compound of the present invention may be administered simultaneously with other therapeutic drugs of diabetes or other therapeutic drugs of obesity (hereinafter to be referred to as a combined pharmaceutical agent) or may be administered at time intervals. In the case of a combined administration, a pharmaceutical composition containing the compound of the present invention and a combined pharmaceutical agent can be administered. Alternatively, a pharmaceutical composition containing the compound of the present invention and a pharmaceutical composition containing a combined pharmaceutical agent may be administered separately. The administration routes of respective pharmaceutical compositions may be the same or different.
In the case of a combined administration, the compound of the present invention may be administered at a dose of 50 mg to 800 mg per administration, which is given once to several times a day. In addition, the compound may be administered at a smaller dose. The combined pharmaceutical agent can be administered at a dose generally employed for the prophylaxis or treatment of diabetes or obesity or at a smaller dose than that.
As other therapeutic drug of diabetes to be used for the combined administration, insulin preparation, sulfonylurea, insulin secretagogue, sulfonamide, biguanide, α-glucosidase inhibitor, insulin sensitizer and the like can be mentioned. por example, insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose, pioglitazone hydrochloride and the like can be used for combined administration with the compound of the present invention.
As other therapeutic drug of obesity to be used for the combined administration, for example, mazindol can be mentioned.
Now one example of the production method of the triazole compound of the present invention is described in the following, which does not limit the production method of the compound of the present invention. Even in the absence of description in the production method, efficient production can be afforded by introducing, where necessary, a protecting group into a functional group followed by deprotection in a subsequent step, exchanging the order of respective production methods and steps, and the like. The post-reaction treatment can be applied by a typical method by selecting or combining conventional methods as necessary, such as isolation and purification, crystallization, recrystallization, silica gel chromatography, preparative HPLC and the like.
Production Method 1: In this production method, a triazole compound, wherein the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring is carbon, is produced, and the method includes any of the following steps.
Figure imgf000036_0001
Figure imgf000036_0002
Figure imgf000036_0003
Figure imgf000036_0004
wherein each symbol is as defined above, provided that the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring of the triazole compound to be formed is carbon.
Acylhydrazide (1) synthesized by a known method and thioimidate (2) synthesized by a known method are reacted in a solvent to give triazole (3) . As the solvent, methanol, ethanol, n-propanol, n-butanol, isopropanol, acetonitrile, diethyl ether, tetrahydrofuran (THF) , 1,4-dioxane, N,N- dimethylformamide, dimethyl sulfoxide, dichloromethane, 1,2- dichloroethane, chloroform, benzene, chlorobenzene, o- dichlorobenzene, toluene, xylene, pyridine, 2, 6-lutidine, 2, 4, 6-collidine, acetic acid, water, or a mixed solvent thereof can be mentioned. The reaction temperature is preferably 20°C - 250°C.
When acylhydrazide (1) or thioimidate (2) is a salt, the reaction is carried out in the presence of a base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium acetate, potassium acetate, sodium hydride, potassium hydride, triethylamine, N,N- diisopropylethylamine, pyridine and the like. Alternatively, triazole (3) can be obtained according to a similar method from thioimidate (4) synthesized by a known method and acylhydrazide (5) synthesized by a known method. Production Method 2: In this production method, a triazole compound, wherein the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring is nitrogen, is produced, and the method includes the following steps.
Figure imgf000038_0001
Figure imgf000038_0002
wherein each symbol is as defined above, provided that the atom linked to the 2- or 5-position (where the substituent Z is linked) of the triazole ring of the triazole compound to be formed is nitrogen.
Triazole (7) can be obtained by reacting isothiourea (6) synthesized by a known method with acylhydrazide (5) synthesized by a known method in a solvent. As the solvent, methanol, ethanol, n-propanol, n-butanol, isopropanol, acetonitrile, diethyl ether, tetrahydrofuran (THF) , 1,4- dioxane, N,N-dimethylformamide, dimethyl sulfoxide, dichloromethane, 1, 2-dichloroethane, chloroform, benzene, chlorobenzene, o-dichlorobenzene, toluene, xylene, pyridine, 2, 6-lutidine, 2, 4, 6-collidine, acetic acid, water, or a mixed solvent thereof can be mentioned. The reaction temperature is preferably 20°C - 250°C.
When isothiourea (6) or acylhydrazide (5) is a salt, the reaction is carried out in the presence of a base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium acetate, potassium acetate, sodium hydride, potassium hydride, triethylamine, N,N- diisopropylethylamine, pyridine and the like.
The production methods described in this specification are examples of the production methods of the compounds of the present invention, and compounds other than the compounds explained above can be produced by combining conventional methods known in the field of organic synthetic chemistry.
Examples
The triazole compound represented by the formula of the present invention and the production method thereof are explained in detail in the following by referring to Examples, which are not to be construed as limitative.
Example 1-1: Production of 3' , 5' -dichloro-4- (5- (1- (4- chlorophenyl) cyclopropyl) -4-methyl-4H- [1,2,4] triazol-3-yl) - 3, 4, 5, 6-tetrahydro-2H- [1, 4' ] bipyridyl hydrochloride
Figure imgf000039_0001
Methyl 3' , 5' -dichloro-N-methyl-3, 4,5, 6-tetrahydro-2H- [1, 4' ]bipyridinyl-4-imidethiocarboxylate hydroiodide (452 mg) and 1- (4-chlorophenyl) -cyclopropane carbohydrazide (178 mg) were suspended in 1,4-dioxane (1.8 ml) and water (0.4 ml), sodium acetate (83 mg) was added and the mixture was heated under reflux overnight. The reaction solution was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed successively with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness. The obtained residue was purified by silica gel chromatography (chloroform: acetone=l : 1) . Thereto was added 4N solution of hydrogen chloride in ethyl acetate (0.16 ml) and the mixture was concentrated to dryness to give the title compound (203 mg) .
1H-NMR (400MHz, DMS0-d6) δ 1.53-1.69 (4H, ' m) , 1.91-2.08 (4H, m) , 3.34-3.62 (5H, m) , 3.62 (3H, s) , 7.22 (2H, d, J=6.0Hz), 7.38-7.41 (2H, m) , 8.47 (2H, s) .
Example 2-1: Production of 1- [4-methyl-5- (1-phenylcyclopropyl) - 4H- [1,2,4] triazol-3-yl] -4-phenylpiperidine
Figure imgf000040_0001
Methyl N-methyl-4-phenylpiperidine-l- imidethiocarboxylate hydroiodide (452 mg) and 1- phenylcyclopropane carbohydrazide (176 mg) were suspended in 1,4-dioxane (2 ml) and water (0.4 ml), sodium acetate (98 mg) was added and the mixture was heated under reflux overnight. The reaction solution was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed successively with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness. The obtained residue was purified by silica gel chromatography (chloroform: acetone=l : 1) . Thereto was added 4N solution of hydrogen chloride in ethyl acetate (0.25 ml) and the mixture was concentrated to dryness. Acetone was added and insoluble solids were collected by filtration and dried to give the title compound (117 mg) .
XH-NMR (300MHz, DMSO-d6) δ 1.50-1.66 (4H, m) , 1.76-1.91 (4H, m) , 2.70-2.80 (1H, m) , 3.19-3.28 (2H, m) , 3.43 (3H, s) , 3.77 (2H, d, J=12.8 Hz), 7.20-7.39 (10H, m) . Examples 1-2 to 1-161:
In the same manner as in Example 1-1, and using other conventional methods as necessary, a triazole compound was produced. The structural formula and property values of each Example compound are shown in the following Table. Examples 2-2 to 2-99:
In the same manner as in Example 2-1, and using other conventional methods as necessary, a triazole compound was produced. The structural formula and property values of each Example compound are shown in the following Table.
Figure imgf000041_0001
Figure imgf000042_0001
Figure imgf000043_0001
Figure imgf000044_0001
Figure imgf000045_0001
Figure imgf000046_0001
Figure imgf000047_0001
Figure imgf000048_0001
Figure imgf000049_0001
Figure imgf000050_0001
Figure imgf000051_0001
Figure imgf000052_0001
Figure imgf000053_0001
Figure imgf000054_0001
Figure imgf000055_0001
Figure imgf000056_0001
Figure imgf000057_0001
Figure imgf000058_0001
Figure imgf000059_0001
Figure imgf000060_0001
Figure imgf000061_0001
Figure imgf000062_0001
Figure imgf000063_0001
Figure imgf000064_0001
Figure imgf000065_0001
Figure imgf000066_0001
Figure imgf000067_0001
Figure imgf000068_0001
Figure imgf000069_0001
Figure imgf000070_0001
Figure imgf000071_0001
Figure imgf000072_0001
Figure imgf000073_0001
Experimental Example: in vitro HSDl (hydroxysteroid dehydrogenase 1) activity inhibitory action
The HSDl inhibitory activity was examined by quantitative determination by an SPA (scintillation proximity assay) system of the suppressive action on the conversion from cortisone to cortisol using human HSDl (hereinafter recombinant HSDl) expressed using a baculo-virus system as an enzyme source. For the reaction, a reagent was added to a 96 well plate (96 well Opti-plates™-96 (Packard)) to the following final concentration and a volume of 100 μl was reacted at room temperature for 90 min. The reaction solution used was 0.1 μg/ml recombinant HSDl, 500 μM NADPH, 16 nM 3H cortisone (Amersham Biosciences, 1.78 Tbq/mol) dissolved in 0.1% BSA (Sigma) -containing PBS and the test drug was 2 μl of a compound solution (dissolved in DMSO) . After 90 min, the reaction was stopped by adding PBS (40 μl, containing 0.1% BSA (Sigma)) containing 0.08 μg of anti-cortisol mouse monoclonal antibody (East Coast Biologies) , 365 μg SPA PVT mouse antibody-binding beads (Amersham Biosciences) and 175 μM carbenoxolone (Sigma) to the reaction solution. After the completion of the reaction, trie plate was incubated overnight at room temperature and the radioactivity was measured by Topcount (Packard) . For control, the value (0% inhibition) of the well containing 2 μl of DMSO instead of the test drug was used, and for positive control, the value (100% inhibition) of the well containing carbenoxolone instead of the test drug at the final concentration of 50 μM was used. The inhibition (%) of the test drug was calculated by ( (value of control - value of test drug) / (value of control - value of positive control) ) x 100 (%) . The IC50 value was analyzed using a computer-based curve fitting soft . The obtained results are shown in the following Table.
Figure imgf000074_0001
Figure imgf000075_0001
Figure imgf000076_0001
Figure imgf000077_0001
Figure imgf000078_0001
Figure imgf000079_0001
Figure imgf000080_0001
Figure imgf000081_0001
In the above Table, "+" in the column of IC50 means 10nM<lC5o<l, OOOnM and "++" in the column of IC50 means IC50 < lOnM. In the same manner as in Example 1-1 or 2-1, and using other conventional methods as necessary, the triazole compounds shown in the following Table can be also produced.
Figure imgf000081_0002
Figure imgf000082_0001
Figure imgf000083_0001
Figure imgf000084_0001
Figure imgf000085_0001
Figure imgf000086_0001
Figure imgf000087_0001
As mentioned above, the triazole compound of the present invention has superior HSDl inhibitory activity and is useful as an HSDl inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity.

Claims

WHAT IS CLAIMED I S
1. A triazole compound represented by the following formula:
Figure imgf000089_0001
R1 is an alkyl group or a cycloalkyl group wherein the alkyl group and the cycloalkyl group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF3, -OH,
-NH2, an alkioxy group, a cycloalkyl group, an alkenyl group, -C00H, -CO-O-alkyl, -CO-N (R7) (R8) , -N (R7) -CO-R8, an aryl group and a heteroaryl group wherein R7 and R8 are each independently a hydrogen atom or an alkyl group, and the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-0H, -N(R9) (R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group wherein n is 0-3, R9 and R10 are each independently a hydrrogen atom, an alkyl group or -CO-alkyl, and R11 is -OH, an alkoxy group, an alkyl group or -N(R12) (R13) wherein R12 and R13 are each independently a hydrogen atom or an alkyl group; Y is a cycloalkyl group or a heterocycloalkyl group wherein the cycloalkyl group and the heterocycloalkyl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, ~(CH2)n-OH, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ;
Ar1 is an aryl group or a heteroaryl group; R2 and R3 are each independently a hydrogen atom, a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-0H, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ;
Z is -(CH(R14))P-, -(CH(R1 ))P-N(R16)-(CH(R15) )q- or
Figure imgf000090_0001
wherein Yx is a cycloalkyl group or a heterocycloalkyl group wherein the cycloalkyl group and the heterocycloalkyl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, ~(CH2)n-OH, -N(R9) (R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -C0-
R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , p is 0—3, q is 0-3, R14 and R15 are each independently a hydrogen atom, a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9)(R10), -CN, -N02, an alkoxy -group, a cycloalkyl group, an alkenyl group,
-CO-R11, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a " haloalkyl group, an alkyl group, -(CH2)n _OH,
-N(R9) (R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , and R16 is a hydrogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, - (CH2) n-CO-R11, a cycloalkyl group, an alkenyl group, an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) ;
Ar2 is an aryl group, a heteroaryl group or
Figure imgf000091_0001
wherein Xi is -(CH2)t- wherein t is 0-2, Vi is =CH- or =N-, and Wi is -C(R17) (R18) -, -0-, -S-, -S02~, -SO-, -CO- or
-N(R19)- wherein R17 and R18 are each independently a hydrogen atom, an alkyl group, an alkoxy group, a haloalkyl group, -(CH2)r-0H, -CO-R20, -N(R21)(R22) or -Lx-Ar3 wherein r is 0-3, R is -OH, an alkoxy group, an alkoxyalkyl group or -N(R23) (R24) wherein R23 and R24 are each independently a hydrogen atom, an alkyl group, -(CH2)s-0H, an alkoxyalkyl group, or in combination form
—N X.
wherein s is 0-3, X2 is -0-, -(CH2)t~ or -N(R25)- wherein t is as defined above and R25 is a hydrogen atom, -CO-R26, -S02-R26 or -(CH2)U-Ar4 wherein R2β is an alkyl group, an alkoxy group, -NH-alkyl or -N (-alkyl) 2, u is 0-3, and Ar4 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted fc>y 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-0H,
-N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , Li is -(CH2)V-, -O- or -CO- wherein v is 0-3, and Ar3 is an aryl group or a heteroaryl group wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , and
R21 and R22 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, -CO-O-alkyl or -Li-Ar3 (Li and Ar3 are as defined above) , and
R19 is a hydrogen atom, -CO-R26, -S02-R26 or -(CH2)U-Ar4 (R26, u and Ar4 are as defined above) ; and R5 are each independently a hydrogen atom, a halogen atom, -OH, —N02, -CN, an alkyl group, an alkoxy group, -CO-R27,
-S02-R27, -CO-N(R28) (R29) or -N(R30) (R31) wherein the alkyl group and the alkoxy group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF3, -OH, an alkoxy group, a haloalkoxy group, -N(R9) (R10) , -CN,
-N02, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (R9, R10 and R11 are as defined above) , wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9) (R10) , -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and
R11 are as defined above) R27 is -OH, an alkoxy group, an alkyl group, -NH2, -NH-alkyl or -N (-alkyl) 2,
R28 and R29 are each independently a hydrogen atom, an alkyl group or -(CH2)W-R32, wherein w is 0-3 and R32 is -OH, -CF3, an alkoxy group, -CONH2 or -N(R33) (R34) wherein R33 and R34 are each independently a hydrogen atom, an alkyl group, -CO-alkyl, or in combination form
—N X,
(X2 is as defined above) 28 and R29 in combination form
Figure imgf000094_0001
wherein X3 is -CO-, -CH2- or -CH2-CH2-, X4 is
-0-, -(CH2)t-, -N(R25)- or
Figure imgf000094_0002
wherein Y2 is cycloalkyl or heterocycloalkyl and t and R25 are as defined above, and R35 and R36 are each independently a hydrogen atom, a halogen atom, an alkyl group optionally substituted by -OH, -OH, -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R37, -N(R38) (R39) wherein R37 is -OH, an alkoxy group, -NH2,
-N X,
-NH-alkyl, -N (-alkyl) 2 or x— ' (X2 is as defined above) wherein the alkyl group in -NH-alkyl and -N (-alkyl) 2 and the alkoxy group are optionally substituted by 1 to 5 substituents each independently selected from a halogen atom, -CF3, -OH, an alkoxy group, a haloalkoxy group, -N(R9)(R10), -CN, -N02, a cycloalkyl group, an alkenyl group,
-CO-R11, an aryl group and a heteroaryl group (R9, R10 and R11 are as defined above) , wherein the aryl group and the heteroaryl group are optionally substituted by 1 to 3 substituents each independently selected from a halogen atom, a haloalkyl group, an alkyl group, -(CH2)n-OH, -N(R9)(R10), -CN, -N02, an alkoxy group, a cycloalkyl group, an alkenyl group, -CO-R11, an aryl group and a heteroaryl group (n, R9, R10 and R11 are as defined above) , and R38 and R39 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-O-alkyl, and R30 and R31 are each independently a hydrogen atom, an alkyl group optionally substituted by -OH, -S02-
Figure imgf000095_0001
wherein x is 0-3, R40 is an alkyl group or -NH2, R41 is a hydrogen atom, an alkyl group optionally substituted by -OH, -OH, an alkoxy group, an alkoxyalkyl group or -(CH2)S- N(R42) (R43) wherein s is as defined above and R42 and R43 are each independently a hydrogen atom, an alkyl group, -OH, an alkoxy group, or in combination form
/ — R35 "N * 3fi
Xs R36 (X3 , X4 A R35 and R36 are as defined above ) , V2 is =CH- or =N- and 2 is -C (R44 ) ( R45) - , -0- or -N ( R45) - wherein R44 and R45 are each independently a hydrogen atom, an alkyl group, an alkoxy group, a haloalkyl group, -(CH2)r-0H, -CO-R47 or -N(R48) (R49) wherein r is as defined above, R47 is -OH, an alkoxy group, an alkoxyalkyl group, -N(R50) (R51) wherein R50 and R51 are each independently a hydrogen atom, an alkyl group, -(CH2)S-0H (s is as defined above) or an alkoxyalkyl group, and R48 and R49 are each independently a hydrogen atom, an alkyl group, -CO-alkyl or -CO-O-alkyl, and
R46 is a hydrogen atom, -CO-R52 or -S02-R52 wherein R52 is an alkyl group, an alkoxy group, -NH-alkyl or - (-alkyl) 2 or R30 and R31 in combination form
Figure imgf000096_0001
(X3 , X , RJS and RJ& are as defined above ) , or R4 and R5 in combination may form -0-alkylene-O-, a prodrug thereof or a pharmaceutically acceptable salt thereof,
2. The triazole compound of claim 1, wherein Z is -(CH(R1 ))P- and p is 0, a prodrug thereof or a pharmaceutically acceptable salt thereof.
3. The triazole compound of claim 2, wherein Y is a C3_8 cycloalkyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
4. The triazole compound of claim 3, wherein Ar1 is a phenyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
5. The triazole compound of claim 4, wherein R2 and R3 are each independently a halogen atom or a hydrogen atom, a prodrug thereof or a pharmaceutically acceptable salt thereof.
6. The triazole compound of any of claims 1 to 5, wherein Ar2 is a phenyl group, R4 is a hydrogen atom, a halogen atom or an alkoxy group and R5 is -CO-N(R28) (R29) , a prodrug thereof or a pharmaceutically acceptable salt thereof.
7. The triazole compound of claim 6, wherein R28 and R29 are each independently a hydrogen atom or an alkyl group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
8. The triazole compound of any of claims 1 to 5, wherein Ar2 is a phenyl group, R4 is a hydrogen atom or a halogen atom and R5 is -N(R30) (R31) wherein R30 is a hydrogen atom and R31 is - (CH2 ) x-C0-R41, a prodrug thereof or a pharmaceutically acceptable salt thereof.
9. The triazole compound of claim 8, wherein X is 0 and R41 is an alkoxy group, a prodrug thereof or a pharmaceutically acceptable salt thereof.
10. The triazole compound of claim 8, wherein X is 0 and R41 is --((CCHH22))SS--NN((RR4422)) ((RR4433)),, aa pprreodrug thereof or a pharmaceutically acceptable salt thereof.
11. The triazole compound of claim 10, wherein s is 0, R42 is a hhyyddrrooggeenn aattoomm aanndd RR4433 iiss aann aallkkooxxyy ggrroouupp,, aa prodrug thereof or a pharmaceutically acceptable salt thereof.
12. The triazole compound of any of claims 1 to 5, wherein Ar2 is a phenyl group, R4 is a hydrogen atom and R5 is -N(R30) (R31) wherein R30 and R31 are joined to form
Figure imgf000098_0001
and X3 is -CO-, a prodrug thereof or a pharmaceutically acceptable salt thereof.
13. The triazole compound of claim 12, wherein X4 is -0-, a prodrug thereof or a pharmaceutically acceptable salt thereof.
14. The triazole compound of claim 1, which is
3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H-
[1,2,4] triazol-3-yl] -benzamide,
{3-chloro-4- [ -methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzoyl}morpholine, 3-chloro-N-methyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2, 4] triazol-3-yl] benzamide,
3-chloro-N, N-dimethyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzamide,
3-chloro-N- (2-hydroxy-ethyl) -4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-N-isopropyl-4- [4-methyl-5- (1-phenylcyclopropyl) 4H-
[1,2,4] triazol-3-yl] benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -
4H [1, 2, 4] triazol-3-yl] benzoyl}piperidine, {3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H[1,2, 4] triazol-
3-yl] benzoyl } - ( 4-hydroxy) piperidine,
N~carbamoylmethyl-3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) ■ 4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] -N- (2,2, 2-trifluoro-ethyl) -benzamide,
N- (2-acetylamino) ethyl-3-chloro-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-N- (2-methoxy) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] benzamide,
1-acetyl- (4-{ 3-Chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl]benzoyl}piperazine, 3-chloro-N- (2-dimethylamino) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] -N- (2-morpholin-4-yl) ethylbenzamide,
4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] -3- methoxybenzamide,
3-chloro-4-{ 4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H-
[1,2,4] triazol-3-yl}benzamide,
3-chloro-N-metyl-4-{ 4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1,2,4] triazol-3-yl}benzamide, 4- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3- yl] benzamide,
4- { 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}benzamide,
4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2,4] triazol-3-yl}benzamide,
4-chloro-3-{ 5- [1-phenylcyclopropyl] -4-methyl-4H- [1,2,4] triazol-
3-yl}benzamide,
3-chloro-4- [4-ethyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] benzamide, 3-chloro-4-{ 4-ethyl-5- [1- (4-fluorophenyl) cycloprppyl] -4H-
[1,2, 4'] triazol-3-yl}benzamide,
3- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3- yl] benzamide, 3-{5- [1- (4-fluoro-phenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}benzamide,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1-morpholinecarboxamide, 3-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] -phenyl}-l, 1-dimethylurea, {3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] tri'azol-3-yl] -phenyl}urea, ethyl N-{ 3-Chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H- [1, 2, 4] triazol-3-yl] -phenyl }-carbamate,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1- (4-methoxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1- (3-hydroxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2,4] triazol-3-yl] phenyl } -1- (4-hydroxypiperidine) carboxamide, l-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] -phenyl} -3-methoxyurea, l-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }-3-hydroxy-3-methylurea,
1- (3-chloro-4-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, 1- (4- {5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, 1- (3-{ 5- [1- (4-fluoroρhenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, 3-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3-yl] -phenyl }oxazolidin-2-one, l-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }imidazolidin-2-one,
3- (3-chloro-4-{ 5- [1- (4-fluoro-phenyl) cyclopropyl] -4-methyl-4H-
[1,2,4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (4-{ 5- [1- (4-fluoroρhenyl) cyclopropyl] -4-isopropyl-4H- [1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one, 3- (3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1, 2, 4] triazol-3-yl}phenyl) oxazolidin-2-one, methyl N- (4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4- methyl-4H- [1, 2, 4] triazol-3-yl}phenyl) carbamate, a prodrug thereof or a pharmaceutically acceptable salt thereof.
15. The triazole compound of claim 1, which is
3-chloro-4- [4-methyl-5- (1-phenyl-cyclopropyl) -4H-
[1,2,4] triazol-3-yl] -benzamide,
{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzoyl}morpholine, 3-chloro-N-methyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzamide,
3-chloro-N, N-dimethyl-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] benzamide,
3-chloro-N- (2-hydroxy-ethyl) -4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] benzamide,
3-chloro-N-isopropyl-4- [4-methyl-5- (1-phenylcyclopropyl) H-
[1,2, 4] triazol-3-yl] benzamide,
{ 3-chloro-4- [ 4-methyl-5- (1-phenyl-cyclopropyl ) -
4H[1, 2, 4] triazol-3-yl]benzoyl}piperidine, {3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H [1,2, 4] triazol-
3-yl] benzoyl} - (4-hydroxy) piperidine,
N-carbamoylmethyl-3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -
4H- [1, 2,4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol- 3-yl] -N- (2,2, 2-trifluoro-ethyl) -benzamide,
N- (2-acetylamino) ethyl-3-chloro-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] benzamide,
3-chloro-N- (2-methoxy) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
1-acetyl- (4-{3-Chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1, 2, 4] triazol-3-yl]benzoyl}piperazine,
3-chloro-N- (2-dimethylamino) ethyl-4- [4-methyl-5- (1- phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] benzamide,
3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-
3-yl] -N- (2-morpholin-4-yl) ethylbenzamide,
4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] -3- methoxybenzamide, 3-chloro-4-{4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H-
[1,2, 4] triazol-3-yl}benzamide,
3-chloro-N-metyl-4-{ 4-methyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1,2,4] triazol-3-yl}benzamide,
4- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3- yl] benzamide,
4-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}benzamide,
4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H-
[1,2, 4] triazol-3-yl}benzamide, 4-chloro-3-{ 5- [1-phenylcyclopropyl] -4-methyl-4H- [1,2,4] triazol-
3-yl}benzamide,
3-chloro-4- [4-ethyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-
3-yl] benzamide,
3-chloro-4-{ 4-ethyl-5- [1- (4-fluorophenyl) cyclopropyl] -4H- [1,2,4] triazol-3-yl}benzamide,
3- [4-isopropyl-5- (1-phenylcyclopropyl) -4H- [1, 2, 4] triazol-3- yl] benzamide,
3-{5- [1- (4-fluoro-phenyl) cyclopropyl] -4-isopropyl-4H-
[1,2,4] triazol-3-yl}benzamide, a prodrug thereof or a pharmaceutically acceptable salt thereof.
16. The triazole compound of claim 1, which is N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2, 4] triazol-3-yl] phenyl } -1-morpholinecarboxamide, 3-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2, 4] triazol-3-yl] -phenyl}-!, 1-dimethylurea, {3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] -phenyl}urea,
N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1- (4-methoxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H- [1,2,4] triazol-3-yl] phenyl } -1- (3-hydroxypiperidine) carboxamide, N- { 3-chloro-4- [4-methyl-5- (1-phenylcycloproppyl) -4H-
[1,2,4] triazol-3-yl] phenyl } -1- (4-hydroxypiperidine) carboxamide, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] -phenyl} -3-methoxyurea, l-{3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H- [1,2,4] triazol-3-yl] phenyl }-3-hydroxy-3-methylurea,
1- (3-chloro-4-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, l-(4-{5-[l- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, 1- (3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H- [1,2,4] triazol-3-yl}phenyl) -3-methoxyurea, a prodrug thereof or a pharmaceutically acceptable salt thereof.
17. The triazole compound of claim 1, which is 3-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] -phenyl }oxazolidin-2-one, l-{ 3-chloro-4- [4-methyl-5- (1-phenylcyclopropyl) -4H-
[1,2,4] triazol-3-yl] phenyl }imidazolidin-2-one,
3- (3-chloro-4-{5- [1- (4-fluoro-phenyl) cyclopropyl] -4-methyl-4H- [1, 2,4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (4-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (4-chloro-3-{5- [1- (4-fluorophenyl) cyclopropyl] -4-methyl-4H- [1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one,
3- (3-{ 5- [1- (4-fluorophenyl) cyclopropyl] -4-isopropyl-4H-
[1,2, 4] triazol-3-yl}phenyl) oxazolidin-2-one, a prodrug thereof or a pharmaceutically acceptable salt thereof.
18. A pharmaceutical composition comprising the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
19. An HSDl (llbeta-hydroxysteroid dehydrogenase 1) inhibitor comprising the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
20. A therapeutic or prophylactic drug of diabetes, which comprises the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
21. A therapeutic or prophylactic drug of obesity, which comprises the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
22. A therapeutic or prophylactic drug of metabolic syndrome, which comprises the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof as an effective component.
23. A method for the treatment or prophylaxis of diabetes, which comprises administering an effective amount of the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal.
24. A method for the treatment or prophylaxis of obesity, which comprises administering an effective amount of the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal.
25. A method for the treatment or prophylaxis of metabolic syndrome, which comprises administering an effective amount of the triazole compound of any of claims 1 to 17, a prodrug thereof or a pharmaceutically acceptable salt thereof to a mammal .
26. The method of claim 23, wherein a different therapeutic drug of diabetes is used in combination.
27. The method of claim 26, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of anι insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
28. The method of claim 27, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
29. The method of claim 24, wherein a different therapeutic drug of diabetes is used in combination.
30. The method of claim 29, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
31. The method of claim 30, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
32. The method of claim 25, wherein a different therapeutic drug of diabetes is used in combination.
33. The method of claim 32, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of an insulin preparation, a sulfonylurea, an insulin secretagogue, a sulfonamide, a biguanide, an α-glucosidase inhibitor and an insulin sensitizer.
34. The method of claim 33, wherein the different therapeutic drug of diabetes is one or more pharmaceutical agents selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformine hydrochloride, voglibose, acarbose and pioglitazone hydrochloride.
35. The method of claim 23, wherein a different therapeutic drug of obesity is used in combination.
36. The method of claim 35, wherein the different therapeutic drug of obesity is Mazindol.
37. The method of claim 24, wherein a different therapeutic drug of obesity is used in combination.
38. The method of claim 37, wherein the different therapeutic drug of obesity is Mazindol.
39. The method of claim 25, wherein a different therapeutic drug of obesity is used in combination.
40. The method of claim 39, wherein the different therapeutic drug of obesity is Mazindol.
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AU2004286836A1 (en) 2005-05-19
US8153631B2 (en) 2012-04-10
CA2543602A1 (en) 2005-05-19
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