WO2005042723A3 - Nouvelles cellules souches multipotentes - Google Patents

Nouvelles cellules souches multipotentes Download PDF

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Publication number
WO2005042723A3
WO2005042723A3 PCT/US2004/036298 US2004036298W WO2005042723A3 WO 2005042723 A3 WO2005042723 A3 WO 2005042723A3 US 2004036298 W US2004036298 W US 2004036298W WO 2005042723 A3 WO2005042723 A3 WO 2005042723A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
multipotent stem
disclosed
cells
novel multipotent
Prior art date
Application number
PCT/US2004/036298
Other languages
English (en)
Other versions
WO2005042723A2 (fr
WO2005042723A9 (fr
Inventor
Young-Sup Yoon
Douglas W Losordo
Original Assignee
Caritas St Elizabeths Boston
Young-Sup Yoon
Douglas W Losordo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caritas St Elizabeths Boston, Young-Sup Yoon, Douglas W Losordo filed Critical Caritas St Elizabeths Boston
Priority to JP2006538403A priority Critical patent/JP2007519397A/ja
Priority to EP04796882A priority patent/EP1685237A4/fr
Priority to CA002543794A priority patent/CA2543794A1/fr
Priority to AU2004286322A priority patent/AU2004286322A1/en
Publication of WO2005042723A2 publication Critical patent/WO2005042723A2/fr
Publication of WO2005042723A9 publication Critical patent/WO2005042723A9/fr
Publication of WO2005042723A3 publication Critical patent/WO2005042723A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une cellule souche de moelle osseuse isolée (BMSC) possédant des niveaux indétectables ou faibles de marqueurs cellulaires sélectionnés, dont ceux typiques des cellules endothéliales, neuronales et des muscles lisses. L'invention porte également sur des greffons et sur des produits pharmaceutiques comprenant lesdites cellules. Des méthodes de fabrication des BMSC sont également décrites. Le tout trouve une plage étendue d'applications, dont l'utilisation dans la prévention et le traitement de maladies cardiovasculaires.
PCT/US2004/036298 2003-10-28 2004-10-28 Nouvelles cellules souches multipotentes WO2005042723A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006538403A JP2007519397A (ja) 2003-10-28 2004-10-28 新規多能性幹細胞およびその使用
EP04796882A EP1685237A4 (fr) 2003-10-28 2004-10-28 Nouvelles cellules souches multipotentes
CA002543794A CA2543794A1 (fr) 2003-10-28 2004-10-28 Nouvelles cellules souches multipotentes
AU2004286322A AU2004286322A1 (en) 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51532003P 2003-10-28 2003-10-28
US60/515,320 2003-10-28

Publications (3)

Publication Number Publication Date
WO2005042723A2 WO2005042723A2 (fr) 2005-05-12
WO2005042723A9 WO2005042723A9 (fr) 2005-08-18
WO2005042723A3 true WO2005042723A3 (fr) 2007-03-29

Family

ID=34549391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036298 WO2005042723A2 (fr) 2003-10-28 2004-10-28 Nouvelles cellules souches multipotentes

Country Status (7)

Country Link
EP (1) EP1685237A4 (fr)
JP (1) JP2007519397A (fr)
KR (1) KR20070007030A (fr)
CN (1) CN101072867A (fr)
AU (1) AU2004286322A1 (fr)
CA (1) CA2543794A1 (fr)
WO (1) WO2005042723A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047963A2 (fr) * 2005-10-20 2007-04-26 Caritas St. Elizabeth Medical Center Of Boston, Inc. Utilisation de cellules souches derivees de la moelle osseuse dans le traitement de l'ischemie
US20090220466A1 (en) * 2005-12-08 2009-09-03 Mariusz Ratajczak Very small embryonic-like (vsel) stem cells and methods of isolating and using the same
US9155762B2 (en) 2005-12-08 2015-10-13 University Of Louisville Research Foundation, Inc. Uses and isolation of stem cells from bone marrow
JP2009535347A (ja) * 2006-04-28 2009-10-01 テュレーン・ユニバーシティ・ヘルス・サイエンシーズ・センター 糖尿病の治療方法
US20100260725A1 (en) * 2007-09-24 2010-10-14 Mohapatra Shyam S Materials and Methods for Treating Allergic and Inflammatory Conditions
WO2011053690A1 (fr) * 2009-10-30 2011-05-05 The University Of North Carolina At Chapel Hill Cellules souches pluripotentes à partir de l'arbre biliaire extrahépatique et procédés pour leur isolement
US11312940B2 (en) 2015-08-31 2022-04-26 University Of Louisville Research Foundation, Inc. Progenitor cells and methods for preparing and using the same
US11072777B2 (en) 2016-03-04 2021-07-27 University Of Louisville Research Foundation, Inc. Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs)
CN115369077B (zh) * 2022-07-29 2023-07-18 佛山市中科律动生物科技有限公司 Meflc细胞株及其构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
US20020026235A1 (en) * 1999-04-27 2002-02-28 Sulzer Biologics, Inc. Prosthetic grafts
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
US20020026235A1 (en) * 1999-04-27 2002-02-28 Sulzer Biologics, Inc. Prosthetic grafts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PITTENGER M.F. ET AL.: "Multilineage Potential of Adult Human Mesenchymal Stem Cells", SCIENCE, vol. 284, no. 5411, 2 April 1999 (1999-04-02), pages 143 - 147, XP002942313 *
See also references of EP1685237A4 *

Also Published As

Publication number Publication date
EP1685237A2 (fr) 2006-08-02
KR20070007030A (ko) 2007-01-12
WO2005042723A2 (fr) 2005-05-12
EP1685237A4 (fr) 2007-12-26
CA2543794A1 (fr) 2005-05-12
JP2007519397A (ja) 2007-07-19
CN101072867A (zh) 2007-11-14
AU2004286322A1 (en) 2005-05-12
WO2005042723A9 (fr) 2005-08-18

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