WO2005042712A3 - Heterocyclic compounds and methods of making and using thereof - Google Patents

Heterocyclic compounds and methods of making and using thereof Download PDF

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Publication number
WO2005042712A3
WO2005042712A3 PCT/US2004/035939 US2004035939W WO2005042712A3 WO 2005042712 A3 WO2005042712 A3 WO 2005042712A3 US 2004035939 W US2004035939 W US 2004035939W WO 2005042712 A3 WO2005042712 A3 WO 2005042712A3
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Prior art keywords
methods
compounds
making
heterocyclic compounds
compositions
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PCT/US2004/035939
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French (fr)
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WO2005042712A2 (en
Inventor
Yeleswarapu Koteswar Rao
Manojit Pal
Vedula Manohar Sharma
Akella Venkateswarlu
Ram Pillarisetti
Original Assignee
Reddy Us Therapeutics Inc
Yeleswarapu Koteswar Rao
Manojit Pal
Vedula Manohar Sharma
Akella Venkateswarlu
Ram Pillarisetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Reddy Us Therapeutics Inc, Yeleswarapu Koteswar Rao, Manojit Pal, Vedula Manohar Sharma, Akella Venkateswarlu, Ram Pillarisetti filed Critical Reddy Us Therapeutics Inc
Priority to AU2004286277A priority Critical patent/AU2004286277A1/en
Priority to CA002540460A priority patent/CA2540460A1/en
Priority to JP2006538290A priority patent/JP2007509966A/en
Priority to BRPI0414737-5A priority patent/BRPI0414737A/en
Priority to EP04817481A priority patent/EP1678157A4/en
Publication of WO2005042712A2 publication Critical patent/WO2005042712A2/en
Publication of WO2005042712A3 publication Critical patent/WO2005042712A3/en
Priority to IL174249A priority patent/IL174249A0/en
Priority to NO20061292A priority patent/NO20061292L/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.
PCT/US2004/035939 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using thereof WO2005042712A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2004286277A AU2004286277A1 (en) 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using thereof
CA002540460A CA2540460A1 (en) 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using thereof
JP2006538290A JP2007509966A (en) 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using them
BRPI0414737-5A BRPI0414737A (en) 2003-10-28 2004-10-28 heterocyclic compounds and methods of preparing and using these
EP04817481A EP1678157A4 (en) 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using thereof
IL174249A IL174249A0 (en) 2003-10-28 2006-03-12 Heterocyclic compounds and pharmaceutical compositions containing the same
NO20061292A NO20061292L (en) 2003-10-28 2006-03-21 Heterosyllic compounds and processes for their preparation and use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN861/CHE/2003 2003-10-28
IN861CH2003 2003-10-28
US61016304P 2004-09-15 2004-09-15
US60/610,163 2004-09-15

Publications (2)

Publication Number Publication Date
WO2005042712A2 WO2005042712A2 (en) 2005-05-12
WO2005042712A3 true WO2005042712A3 (en) 2005-07-21

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PCT/US2004/035939 WO2005042712A2 (en) 2003-10-28 2004-10-28 Heterocyclic compounds and methods of making and using thereof

Country Status (9)

Country Link
EP (1) EP1678157A4 (en)
JP (2) JP2007509966A (en)
KR (1) KR20070026306A (en)
AU (1) AU2004286277A1 (en)
CA (1) CA2540460A1 (en)
IL (1) IL174249A0 (en)
NO (1) NO20061292L (en)
RU (1) RU2006112343A (en)
WO (1) WO2005042712A2 (en)

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NZ566180A (en) * 2005-07-29 2011-04-29 Resverlogix Corp Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
PT2118074E (en) 2007-02-01 2014-03-20 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
WO2010079431A2 (en) 2009-01-08 2010-07-15 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
EP2408454A2 (en) 2009-03-18 2012-01-25 Resverlogix Corp. Novel anti-inflammatory agents
KR101892987B1 (en) 2009-04-22 2018-08-30 리스버로직스 코퍼레이션 Novel anti-inflammatory agents
CZ2009358A3 (en) * 2009-06-03 2010-12-15 C3 Bio Gmbh 5,7-Disubstituted 3-isopropylpyrazolo[4,3-d]pyrimidines for use as medicament and pharmaceutical compositions comprising thereof
EP2484349B1 (en) 2009-09-30 2014-04-02 Shiseido Co., Ltd. 4-isobutylresorcinol, as heparanase-activity inhibitor, for preventing or suppressing the formation of wrinkles
JP5992049B2 (en) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション Oral immediate release formulations for substituted quinazolinones
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (en) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． Novel heterocyclic compounds as bromodomain inhibitors
CN107530356A (en) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 For treating the composition and treatment method of complement-associated disease
CN109475565B (en) 2016-04-05 2021-11-02 免疫传感器公司 cGAS antagonist compounds
RU2635112C1 (en) * 2016-12-12 2017-11-09 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Halides of 1-(4-tert-butylphenyl)-2-{3-[2-(4-fluoro-phenoxy)ethyl]-2-methyl-3h-benzimidazole-1-yl}ethanone with property of rupture cross-linkers of glycated proteins
CN113507929A (en) * 2018-12-21 2021-10-15 阿科利斯制药有限责任公司 DNA polymerase IIIC inhibitor and application thereof
CN112300141B (en) * 2020-10-12 2023-04-18 贵州大学 Quinazoline-containing myricetin derivative, and preparation method and application thereof
WO2022255765A1 (en) * 2021-06-01 2022-12-08 주식회사 에즈큐리스 Novel fluorine-substituted flavonoid derivative, and pharmaceutical composition for preventing or treating allergic diseases, comprising same
WO2023078252A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

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AU2004286277A1 (en) 2005-05-12
NO20061292L (en) 2006-07-28
IL174249A0 (en) 2006-08-01
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KR20070026306A (en) 2007-03-08
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