WO2005042142A3 - Thermosensitive, biokompatible polymerträger mit veränderbarer physikalischer struktur für die therapie, diagnostik und analytik - Google Patents

Thermosensitive, biokompatible polymerträger mit veränderbarer physikalischer struktur für die therapie, diagnostik und analytik Download PDF

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Publication number
WO2005042142A3
WO2005042142A3 PCT/EP2004/011937 EP2004011937W WO2005042142A3 WO 2005042142 A3 WO2005042142 A3 WO 2005042142A3 EP 2004011937 W EP2004011937 W EP 2004011937W WO 2005042142 A3 WO2005042142 A3 WO 2005042142A3
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WIPO (PCT)
Prior art keywords
polymer matrix
diagnosis
thermosensitive
analysis
treatment
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PCT/EP2004/011937
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English (en)
French (fr)
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WO2005042142A8 (de
WO2005042142A2 (de
Inventor
Detlef Mueller-Schulte
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Magnamedics Gmbh
Detlef Mueller-Schulte
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Application filed by Magnamedics Gmbh, Detlef Mueller-Schulte filed Critical Magnamedics Gmbh
Priority to EP04766003A priority Critical patent/EP1680142A2/de
Priority to US10/578,024 priority patent/US20070148437A1/en
Publication of WO2005042142A2 publication Critical patent/WO2005042142A2/de
Publication of WO2005042142A3 publication Critical patent/WO2005042142A3/de
Publication of WO2005042142A8 publication Critical patent/WO2005042142A8/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/25—Web or sheet containing structurally defined element or component and including a second component containing structurally defined particles
    • Y10T428/254—Polymeric or resinous material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/32—Composite [nonstructural laminate] of inorganic material having metal-compound-containing layer and having defined magnetic layer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Die Erfindung betrifft biokompatible, thermosensitive Polymere, die durch Einkapselung magnetischer und/oder metallischer Kolloide bzw. magnetischer Nanopartikel mit Hilfe eines hochfrequenten magnetischen Wechselfeldes aufgeheizt werden können. Infolge der induktiven Erwärmung der Polymermatrix werden physikalische Strukturveränderungen in der Polymermatrix ausgelöst, die dazu führen, dass in der Polymermatrix eingekapselte bioaktive Substanzen in kurzer Zeit freigegeben werden. Dieses 'Stimulus-Response'-Prinzip wird zur Herstellung steuerbarer Medikamantendepots, kontrastverstärkender Mittel für die NMR-Diagnostik, manipulierbarer Mikrowerkzeuge, als Mittel zur Blockierung von Blutgefäßen und als steuerbare Porogene bei der Membranherstellung verwendet.
PCT/EP2004/011937 2003-10-28 2004-10-22 Thermosensitive, biokompatible polymerträger mit veränderbarer physikalischer struktur für die therapie, diagnostik und analytik WO2005042142A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04766003A EP1680142A2 (de) 2003-10-28 2004-10-22 Thermosensitive, biokompatible polymerträger mit veränderbarer physikalischer struktur für die therapie, diagnostik und analytik
US10/578,024 US20070148437A1 (en) 2003-10-28 2004-10-22 Thermosensitive, biocompatible polymer carriers with changeable physical structure for therapy, diagnostics and analytics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10350248A DE10350248A1 (de) 2003-10-28 2003-10-28 Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
DE10350248.3 2003-10-28

Publications (3)

Publication Number Publication Date
WO2005042142A2 WO2005042142A2 (de) 2005-05-12
WO2005042142A3 true WO2005042142A3 (de) 2005-11-10
WO2005042142A8 WO2005042142A8 (de) 2005-12-08

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Country Status (4)

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US (1) US20070148437A1 (de)
EP (1) EP1680142A2 (de)
DE (1) DE10350248A1 (de)
WO (1) WO2005042142A2 (de)

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