WO2005040757A3 - Test de detection precoce d'infections virales - Google Patents

Test de detection precoce d'infections virales Download PDF

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Publication number
WO2005040757A3
WO2005040757A3 PCT/US2004/035339 US2004035339W WO2005040757A3 WO 2005040757 A3 WO2005040757 A3 WO 2005040757A3 US 2004035339 W US2004035339 W US 2004035339W WO 2005040757 A3 WO2005040757 A3 WO 2005040757A3
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WO
WIPO (PCT)
Prior art keywords
virus
donor
test
viral infection
early detection
Prior art date
Application number
PCT/US2004/035339
Other languages
English (en)
Other versions
WO2005040757A2 (fr
Inventor
William Andrews
Charles Harrington
Ken Kuramoto
Bruce Phelps
Original Assignee
Chiron Corp
William Andrews
Charles Harrington
Ken Kuramoto
Bruce Phelps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, William Andrews, Charles Harrington, Ken Kuramoto, Bruce Phelps filed Critical Chiron Corp
Publication of WO2005040757A2 publication Critical patent/WO2005040757A2/fr
Publication of WO2005040757A3 publication Critical patent/WO2005040757A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Les méthodes de détection des virus dans le sang de donneurs utilisés jusqu'à présent ont accru la sécurité des dons de sang et fourni au corps médical des moyens améliorés de suivi de la réplication des virus chez les patients infectés. Cependant ces méthodes sont incapables de détecter les virus chez des donneurs immédiatement après leur infection, ou si les virus présents dans un échantillon ont un niveau très faible. La détection des virus dans le sang entier ou dans les globules rouges permet d'améliorer la sensibilité des tests de détection des virus et prolonge la période faisant suite à une infection pendant laquelle la détection de virus est possible.
PCT/US2004/035339 2003-10-24 2004-10-22 Test de detection precoce d'infections virales WO2005040757A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51358503P 2003-10-24 2003-10-24
US60/513,585 2003-10-24

Publications (2)

Publication Number Publication Date
WO2005040757A2 WO2005040757A2 (fr) 2005-05-06
WO2005040757A3 true WO2005040757A3 (fr) 2006-07-06

Family

ID=34520116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/035339 WO2005040757A2 (fr) 2003-10-24 2004-10-22 Test de detection precoce d'infections virales

Country Status (1)

Country Link
WO (1) WO2005040757A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111542744B (zh) * 2020-03-10 2024-03-15 深圳迈瑞生物医疗电子股份有限公司 血液分析仪、血液分析方法和计算机可读存储介质
CN111206123B (zh) * 2020-04-21 2020-07-24 珠海丽珠试剂股份有限公司 用于血液筛查的核酸组合物和试剂盒

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOLK D.P. ET AL.: "Significant Closure for the Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Preseroconversion Detection Windows with a Transcription-Mediated-Amplification-Driven Assay", J. CLIN. MICROBIOL., vol. 40, May 2002 (2002-05-01), pages 1761 - 1766 *
MINE H. ET AL.: "High throughput screening of 16 million serologically negative blood donors for hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1 by nucleic acid amplification testing with specific and sensitive multiplex reagent in Japan", J. VIROL. METH., vol. 112, September 2003 (2003-09-01), pages 145 - 151 *
SCHMIDT W.N. ET AL.: "Distribution of Hepatitis C Virus (HCV) RNA in Whole Blood and Blood Cell Fractions: Plasma HCV RNA Analysis Underestimates Circulating Virus Load", J. INFECT. DISEASES, vol. 176, July 1997 (1997-07-01), pages 20 - 26 *

Also Published As

Publication number Publication date
WO2005040757A2 (fr) 2005-05-06

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