WO2005030168A1 - Onguent de traitement de brulure de la peau - Google Patents

Onguent de traitement de brulure de la peau Download PDF

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Publication number
WO2005030168A1
WO2005030168A1 PCT/ZA2004/000119 ZA2004000119W WO2005030168A1 WO 2005030168 A1 WO2005030168 A1 WO 2005030168A1 ZA 2004000119 W ZA2004000119 W ZA 2004000119W WO 2005030168 A1 WO2005030168 A1 WO 2005030168A1
Authority
WO
WIPO (PCT)
Prior art keywords
ointment
agent
properties
weight
bpc
Prior art date
Application number
PCT/ZA2004/000119
Other languages
English (en)
Inventor
Irene Elizabeth Snyman
Original Assignee
Irene Elizabeth Snyman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irene Elizabeth Snyman filed Critical Irene Elizabeth Snyman
Publication of WO2005030168A1 publication Critical patent/WO2005030168A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite

Definitions

  • This invention relates to an ointment used for treating skin burns. While particularly useful for treating skin burns, use of the ointment of the invention is not so limited but can also be used for desloughing purposes; thus for removing eschar and dead tissue that are also found in infected skin burns.
  • Skin burns are conventionally also topically treated by using a variety of conventional agents each performing a specific function. Owing to a moist environment promoting inflammation skin burns are normally treated under dry conditions. Where slough is formed the conventional agents do not promote its removal to enable proper penetration of the wound. The conventional agent furthermore do not promote skin growth. The mentioned factors amongst others impede proper circulation of the wound in turn delaying its rapid and scarless healing.
  • a topically applicable ointment for treating burnt skin inclusive of desloughing comprises an agent having anti-microbial properties that is active against skin burn wound healing obstructing microbes in the form of 70% cineole containing eucalyptus oil, a desloughing agent and damaged tissue healing and tissue growth promoting agent in the form of a 15% zinc oxide containing zinc ointment BPC, a pH controlling agent in the form of borassic ointment BPC or acetic acid and a carrier having moisturising properties for maintaining a moist wound environment in the form of liquid paraffin, all carried by a base in the form of petroleum jelly.
  • an agent having anti-microbial properties that is active against skin burn wound healing obstructing microbes in the form of 70% cineole containing eucalyptus oil, a desloughing agent and damaged tissue healing and tissue growth promoting agent in the form of a 15% zinc oxide containing zinc ointment BPC, a pH controlling agent in the
  • the zinc oxide also serves an astringency function while having anti-bacterial properties.
  • the eucalyptus oil in addition to serving as anti-microbial agent, also has anti-fungal properties while the liquid paraffin has emulsifying properties.
  • the object of the pH controlling agent is to maintain an ointment pH within a range that promotes wound healing. To limit undesired bacterial, fungal and microbial growth while still not imparting a burning effect to an area being treated this is typically between 6,5 and 7,2.
  • the pH controlling agent When the pH controlling agent is in the form of borassic ointment BPC it forms in the order of 6% by weight of the skin burn treatment ointment. Similarly the liquid paraffin in such case also forms in the order of 6% by weight of the skin burn treatment ointment.
  • the zinc ointment forms in the order of 12% and the eucalyptus oil about 4% by weight of the skin burn treatment ointment. The balance is made up by the petroleum jelly.
  • acetic acid When the pH controlling agent is in the form of acetic acid a pre-combined mixture of 99% acetic acid as combined with the liquid paraffin into a 1% acetic acid and liquid paraffin mixture (one ml of acetic acid combined 99 ml of liquid paraffin) forms in the order of 6% by weight of the skin burn treatment ointment.
  • a typical ointment composition by weight is in such case as follows:
  • Eucalyptus oil 4% The burn wound treatment ointment is made by simply adding the liquid paraffin and borassic ointment to the petroleum jelly and mixing it into a homogeneous substance. Where acetic acid is used as pH controller it is pre-combined with the liquid paraffin into a 1% acid and liquid paraffin mixture. The zinc ointment and the eucalyptus oil are then added and the treatment ointment formed into a gritty product. The ointment is used for treating burn wounds and desloughing purposes. Treatment is effected by its regular topical application. Such application has the effect of reducing the extent of pain and swelling while progressively removing any dead tissue. The possibility of infection is also arrested.
  • antimicrobial, antifungal and antibacterial components in the ointment of the invention counteracts infection even though the wound is moistened by the liquid paraffin and the petroleum jelly.
  • Tests have indicated that the ointment counteracts the growth of klebsiella oxytoca, serratia marcescens, staphyllococcus aureus, pseudomonas martponilia, coryne bacterium species, proteus mirabilis, staphylococcsus epidermis and providencia alkali faciens.
  • Slough eschar and dead tissue
  • Slough eschar and dead tissue
  • the ointment of the invention has been found to penetrate the slough thus being able to diffuse through the wound.
  • the analgesic, anti-spasmodic and antiseptic properties of the ointment consequently reaches the exposed area requiring treatment.
  • the ability to penetrate dead tissue has the advantage that such tissue becomes extracted and thus removed from the area of the wound.
  • the ointment furthermore promotes the growth of new skin. It thus aids in collagen formation and cell membrane re-structuring.
  • the ointment has anti-inflammatory and anti-microbial properties it has also been found to be effective against bacteria.
  • the advantages of the invention, as specifically described, are found in a single product serving an anti-bacterial and antiseptic function while simultaneously serving as desloughing agent and promoting the growth of new skin that retains its elasticity owing to the moisturising effect of the product.
  • the product also gives fast relief of pain.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un onguent applicable de façon topique en vue du traitement d'une peau brûlée comprenant un agent antimicrobien sous la forme de 70 % de cinéol contenant de l'huile d'eucalyptus, un agent qui empêche l'escarrification et la guérison de tissus endommagés et un agent stimulant la croissance des tissus sous la forme de 15 % d'oxyde de zinc contenant du BPC d'onguent de zinc, un agent de régulation du pH sous la forme de BPC d'onguent de bore ou d'acide acétique et un support possédant des propriétés hydratantes sous la forme de paraffine liquide, le tout, supporté par une base sous la forme de pétrolatum. L'oxyde de zinc possède également un effet astringent, tout en ayant des propriétés antibactériennes, l'huile d'eucalyptus servant d'antifongique.
PCT/ZA2004/000119 2003-10-01 2004-10-01 Onguent de traitement de brulure de la peau WO2005030168A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ZA03/7648 2003-10-01
ZA200307648 2003-10-01
ZA04/5161 2004-06-29
ZA200405161 2004-06-29

Publications (1)

Publication Number Publication Date
WO2005030168A1 true WO2005030168A1 (fr) 2005-04-07

Family

ID=34396653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ZA2004/000119 WO2005030168A1 (fr) 2003-10-01 2004-10-01 Onguent de traitement de brulure de la peau

Country Status (1)

Country Link
WO (1) WO2005030168A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330980A (en) * 1992-08-25 1994-07-19 Shin Jae S Medicament for the topical treatment of skin
CN1125139A (zh) * 1995-12-06 1996-06-26 张金安 一种消炎止痛烧伤药膏
WO1998044914A1 (fr) * 1997-04-04 1998-10-15 Lukacs Karoly Compositions de traitement de brulures et de plaies externes et procede de preparation associe
CN1228986A (zh) * 1999-02-02 1999-09-22 艾广林 一种烧伤膏
ES2138939A1 (es) * 1998-07-14 2000-01-16 Herrero Gonzalez Jose Luis Pomada para quemaduras.
US20030158165A1 (en) * 2001-03-06 2003-08-21 Wilk J. Ronald Wound treatment solution and method for using same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330980A (en) * 1992-08-25 1994-07-19 Shin Jae S Medicament for the topical treatment of skin
CN1125139A (zh) * 1995-12-06 1996-06-26 张金安 一种消炎止痛烧伤药膏
WO1998044914A1 (fr) * 1997-04-04 1998-10-15 Lukacs Karoly Compositions de traitement de brulures et de plaies externes et procede de preparation associe
ES2138939A1 (es) * 1998-07-14 2000-01-16 Herrero Gonzalez Jose Luis Pomada para quemaduras.
CN1228986A (zh) * 1999-02-02 1999-09-22 艾广林 一种烧伤膏
US20030158165A1 (en) * 2001-03-06 2003-08-21 Wilk J. Ronald Wound treatment solution and method for using same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199344, Derwent World Patents Index; Class D21, AN 1993-347307, XP002311775 *
DATABASE WPI Section Ch Week 199748, Derwent World Patents Index; Class B04, AN 1997-513699, XP002311776 *
DATABASE WPI Section Ch Week 199823, Derwent World Patents Index; Class B05, AN 1998-253665, XP002311773 *
DATABASE WPI Section Ch Week 200002, Derwent World Patents Index; Class B04, AN 2000-013948, XP002311774 *

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