WO2005025575A1 - Solution de protection destinee a etre utilisee dans des traitements oculaires - Google Patents

Solution de protection destinee a etre utilisee dans des traitements oculaires Download PDF

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Publication number
WO2005025575A1
WO2005025575A1 PCT/DE2003/002959 DE0302959W WO2005025575A1 WO 2005025575 A1 WO2005025575 A1 WO 2005025575A1 DE 0302959 W DE0302959 W DE 0302959W WO 2005025575 A1 WO2005025575 A1 WO 2005025575A1
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WO
WIPO (PCT)
Prior art keywords
eye
protective solution
substances
protective
used during
Prior art date
Application number
PCT/DE2003/002959
Other languages
German (de)
English (en)
Inventor
Peter Halfwassen
Original Assignee
Peter Halfwassen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter Halfwassen filed Critical Peter Halfwassen
Priority to PCT/DE2003/002959 priority Critical patent/WO2005025575A1/fr
Publication of WO2005025575A1 publication Critical patent/WO2005025575A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Definitions

  • the invention relates to a protective solution, in particular a viscoelastic or a rinsing liquid, for use in eye treatments and eye operations.
  • protective solutions in particular viscoelastics or rinsing liquids, are used which, for. B. are applied to the cornea of the eye or - as is usually the case - during the implantation of an intraocular lens as a rinsing liquid, pumped into the anterior chamber of the eye and sucked out of it again.
  • the invention has for its object to provide a way in which any damage to the retina can be prevented even during long operations on the eye.
  • the protective solution has substances which at least partially filter out specific frequency ranges from light radiation which penetrates the protective solution and enters the eye.
  • the light radiation can e.g. B. the radiation of a bright microscope or a treatment laser.
  • the invention provides the possibility of filtering out radiation of different specific wavelengths from the visible as well as from the invisible components of the light, which are the cause of retinal damage. This results in the possibility of improving the viscoelastic agents or rinsing liquids that are usually used in eye treatments or eye operations, so that damage to the eye is avoided. Such a possibility was previously not available in ophthalmic surgery of the fundus, therapeutically oriented cataract surgery, glaucoma surgery or refractive surgery.
  • the protective solutions are mixed with absorber substances which, depending on the use or application filter out unwanted light radiation during the corresponding operation.
  • protective solutions according to the invention can be used to filter out light radiation which is in the UV or also in the IR range.
  • the absorber substances must of course be physiologically biocompatible; in particular, they should be designed so that they are attached to the carrier of the protective solution, for.
  • a viscoelastic such as methyl cellulose or a sterilized physiological saline are bound so that they can be completely removed with this carrier after the end of eye treatment or eye surgery.
  • the invention can e.g. B. used in glaucoma surgery.
  • the eye lens must be protected from the relatively long-wave UV rays of an excimer laser that radiates in the range of 308 nm, since these can induce a so-called secondary cataract.
  • the trabecular mechanism which is a filter fabric between the Schlemmsch 'canal and the anterior chamber, is removed by means of a laser probe.
  • a protective solution e.g. B. washed into the anterior chamber of the eye, damage to the retina can be avoided in glaucoma surgery.
  • This protective solution can also be used for laser trepanation of the cornea, the protective solution then being applied to the cornea. After a trepanation The natural protection by the cornea is eliminated, so that the eye lens is intensively exposed to the light radiation of the laser, in this case UV light radiation.
  • a protective solution according to the invention can also be used in various operations on the posterior pole of the eye. It is important to specifically suppress heat-transporting light radiation, i.e. radiation that is also effective in the IR range.
  • UV absorber substances can be used that are physiologically compatible, i.e. H. are biocompatible; they should also enter into bonds with the carrier substances of the protective solutions, which ensure coupling of the absorber with the carrier substance, so that the absorber substances do not settle in the protective solution and the absorber substance together with the protective solution after the end of the eye treatment or eye operation can be removed.
  • Dervates of benzophenone are suitable as absorber substances, in particular for the UV range.
  • Other absorbers for specific frequency ranges are known to the person skilled in the art, so z.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Solution de protection, en particulier substance viscoélastique ou liquide de rinçage, destinée à être utilisée dans des traitements oculaires ou lors d'opérations des yeux, qui contient, selon la présente invention, des substances éliminant tout au moins partiellement par filtrage les plages de fréquence spécifiques d'un rayonnement lumineux traversant ladite solution de protection et incident sur l'oeil. A cet effet, les substances absorbantes sont sélectionnées de manière à agir dans la plage des UV.
PCT/DE2003/002959 2003-09-04 2003-09-04 Solution de protection destinee a etre utilisee dans des traitements oculaires WO2005025575A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/DE2003/002959 WO2005025575A1 (fr) 2003-09-04 2003-09-04 Solution de protection destinee a etre utilisee dans des traitements oculaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DE2003/002959 WO2005025575A1 (fr) 2003-09-04 2003-09-04 Solution de protection destinee a etre utilisee dans des traitements oculaires

Publications (1)

Publication Number Publication Date
WO2005025575A1 true WO2005025575A1 (fr) 2005-03-24

Family

ID=34305466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/002959 WO2005025575A1 (fr) 2003-09-04 2003-09-04 Solution de protection destinee a etre utilisee dans des traitements oculaires

Country Status (1)

Country Link
WO (1) WO2005025575A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046933A1 (fr) 2006-10-16 2008-04-24 Universidad Complutense De Madrid Dispositif d'éclairage équipé d'un filtre thérapeutique et préventif pour des yeux sains, pseudo-aphaques et/ou subissant un processus de neurodégénérescence
WO2008096020A1 (fr) 2007-02-07 2008-08-14 Universidad Complutense De Madrid Rectorado Source d'éclairage qui permet de réduire l'émission de longueurs d'onde courte pour protéger les yeux
US7832903B2 (en) 2006-11-07 2010-11-16 Universidad Complutense De Madrid Illumination system fitted with a therapeutic/prophylactic filter for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration
US7914177B2 (en) 2006-11-07 2011-03-29 Universidad Complutense De Madrid Prophylaxic/therapeutic vehicle filter component for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686099A (en) * 1985-12-10 1987-08-11 Victor Palinczar Aerosol waterproof sunscreen compositions
US4788007A (en) * 1986-11-28 1988-11-29 Baron Neville A Ophthalmic U.V. absorptive emollient
US4853374A (en) * 1987-06-09 1989-08-01 M.D.R. Group, Inc. Viscoelastic vitreous substitute with UV blocker
EP0356355A1 (fr) * 1988-08-22 1990-02-28 Neville A. Baron Liquide ophtalmique pour lunettes de soleil

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686099A (en) * 1985-12-10 1987-08-11 Victor Palinczar Aerosol waterproof sunscreen compositions
US4788007A (en) * 1986-11-28 1988-11-29 Baron Neville A Ophthalmic U.V. absorptive emollient
US5041244A (en) * 1986-11-28 1991-08-20 Liquid Sunglasses Corporation Ophthalmic liquid sunglasses
US4853374A (en) * 1987-06-09 1989-08-01 M.D.R. Group, Inc. Viscoelastic vitreous substitute with UV blocker
EP0356355A1 (fr) * 1988-08-22 1990-02-28 Neville A. Baron Liquide ophtalmique pour lunettes de soleil

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046933A1 (fr) 2006-10-16 2008-04-24 Universidad Complutense De Madrid Dispositif d'éclairage équipé d'un filtre thérapeutique et préventif pour des yeux sains, pseudo-aphaques et/ou subissant un processus de neurodégénérescence
US7832903B2 (en) 2006-11-07 2010-11-16 Universidad Complutense De Madrid Illumination system fitted with a therapeutic/prophylactic filter for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration
US7914177B2 (en) 2006-11-07 2011-03-29 Universidad Complutense De Madrid Prophylaxic/therapeutic vehicle filter component for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration
WO2008096020A1 (fr) 2007-02-07 2008-08-14 Universidad Complutense De Madrid Rectorado Source d'éclairage qui permet de réduire l'émission de longueurs d'onde courte pour protéger les yeux

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