WO2005023304A3 - Antimalarial compositions and manufacturing process thereof - Google Patents

Antimalarial compositions and manufacturing process thereof Download PDF

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Publication number
WO2005023304A3
WO2005023304A3 PCT/GB2004/003748 GB2004003748W WO2005023304A3 WO 2005023304 A3 WO2005023304 A3 WO 2005023304A3 GB 2004003748 W GB2004003748 W GB 2004003748W WO 2005023304 A3 WO2005023304 A3 WO 2005023304A3
Authority
WO
WIPO (PCT)
Prior art keywords
manufacturing process
artesunate
derivative
salt
antimalarial compositions
Prior art date
Application number
PCT/GB2004/003748
Other languages
French (fr)
Other versions
WO2005023304A2 (en
Inventor
Geena Malhotra
Amar Lulla
Original Assignee
Cipla Ltd
Geena Malhotra
Amar Lulla
Wain Christopher Paul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd, Geena Malhotra, Amar Lulla, Wain Christopher Paul filed Critical Cipla Ltd
Priority to BRPI0413767-1A priority Critical patent/BRPI0413767A/en
Priority to AP2006003557A priority patent/AP2006003557A0/en
Publication of WO2005023304A2 publication Critical patent/WO2005023304A2/en
Publication of WO2005023304A3 publication Critical patent/WO2005023304A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pharmaceutical composition for treating malaria includes at least one artenisinin or a salt or derivative thereof, and at least one quinoline or a salt or derivative thereof, as a combined preparation, for simultaneous or separate use in the treatment of malaria. In preferred embodiments, bilayer tablets are formulated comprising artesunate + amodiaquine, artesunate + chloroquine or artesunate + mefloquine.
PCT/GB2004/003748 2003-09-04 2004-09-03 Antimalarial compositions and manufacturing process thereof WO2005023304A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0413767-1A BRPI0413767A (en) 2003-09-04 2004-09-03 pharmaceutical product or pharmaceutical formulation, process for preparing a pharmaceutical product or pharmaceutical formulation, method for treating a disease and use of at least one artemisinin or a salt, solvate or derivative thereof
AP2006003557A AP2006003557A0 (en) 2003-09-04 2004-09-03 Antimalarial compositions and process thereof.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN902MU2003 2003-09-04
IN902/MUM/2003 2003-09-04

Publications (2)

Publication Number Publication Date
WO2005023304A2 WO2005023304A2 (en) 2005-03-17
WO2005023304A3 true WO2005023304A3 (en) 2005-07-07

Family

ID=34259970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003748 WO2005023304A2 (en) 2003-09-04 2004-09-03 Antimalarial compositions and manufacturing process thereof

Country Status (4)

Country Link
AP (1) AP2006003557A0 (en)
BR (1) BRPI0413767A (en)
WO (1) WO2005023304A2 (en)
ZA (1) ZA200602031B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0401107A (en) * 2004-04-13 2005-11-22 Fundacao Oswaldo Cruz Compounds derived from artesunate, process of preparing these compounds, pharmaceutical composition containing said compounds, use of the respective medicine in the treatment or prevention of malaria or other parasitic diseases and therapeutic method
FR2884715B1 (en) * 2005-04-20 2007-06-15 Sanofi Aventis Sa ASSOCIATION BETWEEN FERROQUIN AND AN ARTEMISININE DERIVATIVE FOR THE TREATMENT OF MALARIA
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
WO2007043061A1 (en) * 2005-10-11 2007-04-19 Ipca Laboratories Ltd. Anti-malarial combination and methods of formulation
CH696229A5 (en) * 2006-05-13 2007-02-28 Professeur Dr Achille Benakis Antimalarial composition in geometrical solid tablet form obtained by the compression of a medicine powder and excipients, useful to treat malaria, comprises three separate layers
FR2914860B1 (en) * 2007-04-12 2009-05-22 Ile D Inventeurs Apis Spheromo MULTILAYER SPHEROIDS WITH ANTIPALUDITIC ACTION IN WHICH ONE OF THE LAYERS CONTAINS ARTESUNATE
CN101756982B (en) * 2008-12-17 2012-07-04 重庆医药工业研究院有限责任公司 Artesunate compound medicine composition with improved mouth feeling and high stability
FR2951945B1 (en) * 2009-11-05 2013-08-09 Sanofi Aventis PHARMACEUTICAL COMPOSITION
WO2015041723A1 (en) * 2013-09-17 2015-03-26 Kryptonite Group, Ltd Artemisinin-based combination therapy for treating viral mediated disease
TWI733649B (en) * 2014-03-07 2021-07-21 巴哈馬商克利普頓集團公司 Enhanced artemisinin-based combination therapy for treating parasitic mediated disease
WO2016083827A1 (en) * 2014-11-27 2016-06-02 Cipla Limited Pharmaceutical composition comprising an artemisinin derivative for nasal or pulmonary delivery
CN107982227A (en) * 2017-12-05 2018-05-04 昆药集团股份有限公司 A kind of tablet of dihydroartemisinine and preparation method thereof
CN107982228B (en) * 2017-12-05 2022-08-16 昆药集团股份有限公司 Dihydroartemisinin tablet and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019169A (en) * 1958-06-23 1962-01-30 Sterling Drug Inc Salicylate dry shell coating of dry 4-aminoquinoline core, and dry-compressing tablet-making process
EP0362810A1 (en) * 1988-10-07 1990-04-11 Hoechst Aktiengesellschaft Antimalarial compositions using quinidine, artemisinine and its derivatives
WO1992002217A1 (en) * 1990-08-08 1992-02-20 Ciba-Geigy Ag Antimalarial compositions
US5219865A (en) * 1987-05-08 1993-06-15 Hoechst Aktiengesellschaft Pharmaceutical combination for the prophylaxis and therapy of malaria
WO2003075927A1 (en) * 2002-02-13 2003-09-18 Mepha Ltd. Pharmaceutical combination of artesunate and mefloquine for therapy of malaria

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019169A (en) * 1958-06-23 1962-01-30 Sterling Drug Inc Salicylate dry shell coating of dry 4-aminoquinoline core, and dry-compressing tablet-making process
US5219865A (en) * 1987-05-08 1993-06-15 Hoechst Aktiengesellschaft Pharmaceutical combination for the prophylaxis and therapy of malaria
EP0362810A1 (en) * 1988-10-07 1990-04-11 Hoechst Aktiengesellschaft Antimalarial compositions using quinidine, artemisinine and its derivatives
WO1992002217A1 (en) * 1990-08-08 1992-02-20 Ciba-Geigy Ag Antimalarial compositions
WO2003075927A1 (en) * 2002-02-13 2003-09-18 Mepha Ltd. Pharmaceutical combination of artesunate and mefloquine for therapy of malaria

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILAIRATANA P ET AL: "A CLINICAL TRIAL OF COMBINATION OF ARTESUNATE AND MEFLOQUINE IN THE TREATMENT OF ACUTE UNCOMPLICATED FALCIPARUM MALARIA: A SHORT AND PRACTICAL REGIMEN", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, REGIONAL TROPICAL MEDICINE AND PUBLIC HEALTH, TH, vol. 29, no. 4, December 1998 (1998-12-01), pages 696 - 701, XP008009363, ISSN: 0125-1562 *

Also Published As

Publication number Publication date
AP2006003557A0 (en) 2006-04-30
ZA200602031B (en) 2007-05-30
WO2005023304A2 (en) 2005-03-17
BRPI0413767A (en) 2006-10-31

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