WO2005022163A3 - Method for determining adult neurogenesis - Google Patents

Method for determining adult neurogenesis Download PDF

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Publication number
WO2005022163A3
WO2005022163A3 PCT/DE2004/001887 DE2004001887W WO2005022163A3 WO 2005022163 A3 WO2005022163 A3 WO 2005022163A3 DE 2004001887 W DE2004001887 W DE 2004001887W WO 2005022163 A3 WO2005022163 A3 WO 2005022163A3
Authority
WO
WIPO (PCT)
Prior art keywords
determining
adult neurogenesis
neurogenesis
determining adult
relates
Prior art date
Application number
PCT/DE2004/001887
Other languages
German (de)
French (fr)
Other versions
WO2005022163A2 (en
Inventor
Gerd Kempermann
Moritz Brandt
Sebastian Jessberger
Original Assignee
Max Delbrueck Centrum
Gerd Kempermann
Moritz Brandt
Sebastian Jessberger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum, Gerd Kempermann, Moritz Brandt, Sebastian Jessberger filed Critical Max Delbrueck Centrum
Publication of WO2005022163A2 publication Critical patent/WO2005022163A2/en
Publication of WO2005022163A3 publication Critical patent/WO2005022163A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method for determining adult neurogenesis, and to the use of endogenous, transiently postmitotically expressed cell constituents for determining adult neurogenesis. The invention also relates to a bioassay and to a kit for determining said neurogenesis.
PCT/DE2004/001887 2003-08-22 2004-08-23 Method for determining adult neurogenesis WO2005022163A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003139727 DE10339727A1 (en) 2003-08-22 2003-08-22 Method for the determination of adult neurogenesis
DE10339727.2 2003-08-22

Publications (2)

Publication Number Publication Date
WO2005022163A2 WO2005022163A2 (en) 2005-03-10
WO2005022163A3 true WO2005022163A3 (en) 2005-05-12

Family

ID=34202166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001887 WO2005022163A2 (en) 2003-08-22 2004-08-23 Method for determining adult neurogenesis

Country Status (2)

Country Link
DE (1) DE10339727A1 (en)
WO (1) WO2005022163A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067751A1 (en) * 2003-01-28 2004-08-12 Klinikum Der Universität Regensburg Use of regulatory sequences for specific, transient expression in neuronal determined cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067751A1 (en) * 2003-01-28 2004-08-12 Klinikum Der Universität Regensburg Use of regulatory sequences for specific, transient expression in neuronal determined cells

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRANDT M ET AL: "NEW INTERNEURONS IN THE DENTATE GYRUS OF ADULT MICE.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 230.3 URL - http://sf, XP001202697 *
BRANDT MORITZ D ET AL: "Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice.", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 24, no. 3, November 2003 (2003-11-01), pages 603 - 613, XP002315157, ISSN: 1044-7431 *
KEMPERMANN G ET AL: "Genetic influence on neurogenesis in the dentate gyrus of adult mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 16 SEP 1997, vol. 94, no. 19, 16 September 1997 (1997-09-16), pages 10409 - 10414, XP002315756, ISSN: 0027-8424 *
KEMPERMANN GERD ET AL: "Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice.", DEVELOPMENT (CAMBRIDGE, ENGLAND) JAN 2003, vol. 130, no. 2, January 2003 (2003-01-01), pages 391 - 399, XP002315758, ISSN: 0950-1991 *
KLUSKA M M ET AL: "CELL PROLIFERATION AND NEUROGENESIS IN THE ADULT HIPPOCAMPUS FOLLOWING SMALL CORTICAL INFARCTS IN DIFFERENT BRAIN REGIONS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 696.9 URL - http://sf, XP001202696 *
LIU SHUHONG ET AL: "Generation of functional inhibitory neurons in the adult rat hippocampus.", JOURNAL OF NEUROSCIENCE, vol. 23, no. 3, 1 February 2003 (2003-02-01), pages 732 - 736, XP002315757, ISSN: 0270-6474 *

Also Published As

Publication number Publication date
DE10339727A1 (en) 2005-03-17
WO2005022163A2 (en) 2005-03-10

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