WO2005020883A3 - Procedes de production d'ansamitocines - Google Patents

Procedes de production d'ansamitocines Download PDF

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Publication number
WO2005020883A3
WO2005020883A3 PCT/US2004/013002 US2004013002W WO2005020883A3 WO 2005020883 A3 WO2005020883 A3 WO 2005020883A3 US 2004013002 W US2004013002 W US 2004013002W WO 2005020883 A3 WO2005020883 A3 WO 2005020883A3
Authority
WO
WIPO (PCT)
Prior art keywords
ansamitocins
production
methods
ansamitocin
purifying
Prior art date
Application number
PCT/US2004/013002
Other languages
English (en)
Other versions
WO2005020883A2 (fr
Inventor
Cynthia Kuo
Graham S Byng
Wayne C Widdison
Original Assignee
Immunogen Inc
Cynthia Kuo
Graham S Byng
Wayne C Widdison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc, Cynthia Kuo, Graham S Byng, Wayne C Widdison filed Critical Immunogen Inc
Publication of WO2005020883A2 publication Critical patent/WO2005020883A2/fr
Publication of WO2005020883A3 publication Critical patent/WO2005020883A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un procédé de fermentation à grande échelle de souches de production d'ansamitocines à forte production. L'invention concerne également un procédé d'isolement d'ansamitocines brutes et un procédé de purification des ansamitocines.
PCT/US2004/013002 2003-05-08 2004-05-10 Procedes de production d'ansamitocines WO2005020883A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46863803P 2003-05-08 2003-05-08
US60/468,638 2003-05-08

Publications (2)

Publication Number Publication Date
WO2005020883A2 WO2005020883A2 (fr) 2005-03-10
WO2005020883A3 true WO2005020883A3 (fr) 2005-12-29

Family

ID=34272422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013002 WO2005020883A2 (fr) 2003-05-08 2004-05-10 Procedes de production d'ansamitocines

Country Status (1)

Country Link
WO (1) WO2005020883A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN100420754C (zh) * 2006-10-26 2008-09-24 浙江海正药业股份有限公司 一种制备蒽莎姆菌素的方法
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
CN107881137A (zh) * 2017-09-25 2018-04-06 辽宁斯韦尔生物科技有限公司 增强转录水平的高产安丝菌素菌株及其制备方法
WO2019105835A1 (fr) 2017-11-29 2019-06-06 Bayer Consumer Care Ag Combinaisons de copanlisib et d'anetumab ravtansine
WO2020234114A1 (fr) 2019-05-21 2020-11-26 Bayer Aktiengesellschaft Nouvelle formulation stable à haute concentration pour anetumab ravtansine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307016A (en) * 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4322348A (en) * 1979-06-05 1982-03-30 Takeda Chemical Industries, Ltd. Maytansinoids
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307016A (en) * 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4322348A (en) * 1979-06-05 1982-03-30 Takeda Chemical Industries, Ltd. Maytansinoids
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production

Also Published As

Publication number Publication date
WO2005020883A2 (fr) 2005-03-10

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