WO2005019448A3 - NON-MAMMALIAN GnRH ANALOGS AND USES THEREOF IN REGULATION OF FERTILITY AND PREGNANCY - Google Patents

NON-MAMMALIAN GnRH ANALOGS AND USES THEREOF IN REGULATION OF FERTILITY AND PREGNANCY Download PDF

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Publication number
WO2005019448A3
WO2005019448A3 PCT/US2004/020413 US2004020413W WO2005019448A3 WO 2005019448 A3 WO2005019448 A3 WO 2005019448A3 US 2004020413 W US2004020413 W US 2004020413W WO 2005019448 A3 WO2005019448 A3 WO 2005019448A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
mammalian
gly
amide
gnrh
Prior art date
Application number
PCT/US2004/020413
Other languages
French (fr)
Other versions
WO2005019448A2 (en
Inventor
Theresa M Siler-Khodr
Original Assignee
Theresa M Siler-Khodr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theresa M Siler-Khodr filed Critical Theresa M Siler-Khodr
Publication of WO2005019448A2 publication Critical patent/WO2005019448A2/en
Publication of WO2005019448A3 publication Critical patent/WO2005019448A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Chicken II and salmon GnRH analog decapeptides resistant to degradation by peptidase incorporating D-arginine, D-leucine, D-tBu-Serine, D-Trp or other active D amino acids at position 6 and ethylamide, aza-Gly-amide or other Gly amide at position 10. The analogs demonstrate preferential binding to male and female reproductive system GnRH receptors. Biopotency is greater within the reproductive system than at the pituitary. These non-mammalian GnRH analogs may be used in pharmaceutical preparations, and specifically in various treatment methods as a contraceptive or post-coital contraceptive agent. The non-mammalian GnRH analogs are also provided in pharmaceutical preparations that may be used clinically for maintaining pregnancy when used in very low doses and administered in pulsatile fashion, as well as in preparations for the treatment of male and female reproductive system disorders. The aza-Gly (10) amide non-mammalian analogs are yet other embodiments of the non-mammalian GnRH analogs provided as a part of the invention.
PCT/US2004/020413 2003-08-12 2004-06-24 NON-MAMMALIAN GnRH ANALOGS AND USES THEREOF IN REGULATION OF FERTILITY AND PREGNANCY WO2005019448A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63914203A 2003-08-12 2003-08-12
US10/639,142 2003-08-12

Publications (2)

Publication Number Publication Date
WO2005019448A2 WO2005019448A2 (en) 2005-03-03
WO2005019448A3 true WO2005019448A3 (en) 2005-05-06

Family

ID=34216317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020413 WO2005019448A2 (en) 2003-08-12 2004-06-24 NON-MAMMALIAN GnRH ANALOGS AND USES THEREOF IN REGULATION OF FERTILITY AND PREGNANCY

Country Status (1)

Country Link
WO (1) WO2005019448A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043245A1 (en) * 2003-08-11 2005-02-24 Siler -Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in the immune system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003020205A2 (en) * 2001-08-28 2003-03-13 Siler-Khodor Theresa M Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003020205A2 (en) * 2001-08-28 2003-03-13 Siler-Khodor Theresa M Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WHITE R B ET AL: "SECOND GENE FOR GONADOTROPIN-RELEASING HORMONE IN HUMANS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 1, January 1998 (1998-01-01), pages 305 - 309, XP000882990, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2005019448A2 (en) 2005-03-03

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