AU2000277238A1 - Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy - Google Patents

Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy

Info

Publication number
AU2000277238A1
AU2000277238A1 AU2000277238A AU7723800A AU2000277238A1 AU 2000277238 A1 AU2000277238 A1 AU 2000277238A1 AU 2000277238 A AU2000277238 A AU 2000277238A AU 7723800 A AU7723800 A AU 7723800A AU 2000277238 A1 AU2000277238 A1 AU 2000277238A1
Authority
AU
Australia
Prior art keywords
gnrh
analogs
mammalian
tumor cell
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000277238A
Inventor
Gabriel S. Khodr
Theresa M. Siler-Khodr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GABRIEL S KHODR
THERESA M SILER KHODR
Original Assignee
GABRIEL S KHODR
THERESA M SILER KHODR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GABRIEL S KHODR, THERESA M SILER KHODR filed Critical GABRIEL S KHODR
Publication of AU2000277238A1 publication Critical patent/AU2000277238A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Specially designed non-mammalian GnRH analogs resistant to degradation by the tumor tissue enzymes, post-proline peptidases as well as endopeptidases, are disclosed. The GnRH analogs are further defined as analogs of chicken II GnRH, salmon GnRH, or herring GnRH, but can include any non-mammalian GnRH analog with similar amino acid structure. These non-mammalian analogs incorporate D-arginine, D-leucine, D-tBu-Serine or D-Trp or other similar amino acids at position 6 and ethylamide or aza-Gly-amide or similar amides at position 10. These analogs demonstrate preferential binding to tumor cell GnRH receptors that is greater relative to the binding of the mammalian analogs to the tumor cell GnRH receptor. These non-mammalian GnRH analogs may be used in pharmaceutical preparations, and it specifically in various treatments as an anti-tumor, anti-proliferation, anti-metastatic and/or an apoptotic agent. The non-mammalian GnRH analogs are also provided in pharmaceutical preparations that may be used clinically for tumor regression when used in very low doses and administered in pulsatile fashion.
AU2000277238A 2000-03-31 2000-09-26 Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy Abandoned AU2000277238A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09540685 2000-03-31
US09/540,685 US7834141B1 (en) 2000-03-31 2000-03-31 Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
PCT/US2000/026575 WO2001074377A1 (en) 2000-03-31 2000-09-26 Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy

Publications (1)

Publication Number Publication Date
AU2000277238A1 true AU2000277238A1 (en) 2001-10-15

Family

ID=24156514

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000277238A Abandoned AU2000277238A1 (en) 2000-03-31 2000-09-26 Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy

Country Status (7)

Country Link
US (2) US7834141B1 (en)
EP (1) EP1272206B1 (en)
JP (1) JP2004512011A (en)
AT (1) ATE494902T1 (en)
AU (1) AU2000277238A1 (en)
DE (1) DE60045524D1 (en)
WO (1) WO2001074377A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635739B2 (en) * 1999-10-15 2003-10-21 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US20040152639A1 (en) * 2001-08-28 2004-08-05 Siler-Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
WO2004010146A1 (en) 2002-07-22 2004-01-29 Ardana Bioscience Limited Screening method and anti-tumor drug candidate obtained therefrom
CN1688696A (en) * 2002-09-18 2005-10-26 蒙特利尔大学医疗中心 GHRH analogues
AU2003292696A1 (en) 2002-12-26 2004-08-10 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
EP1604682A4 (en) 2003-03-12 2009-06-24 Takeda Chemical Industries Ltd Gonadal function improving agents
US20050043245A1 (en) * 2003-08-11 2005-02-24 Siler -Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in the immune system
US20050054576A1 (en) * 2003-08-12 2005-03-10 Siler-Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
EP1605962A1 (en) * 2003-08-12 2005-12-21 Theresa M. Siler-Khodr Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy
AR049938A1 (en) 2004-06-25 2006-09-13 Takeda Pharmaceutical METASTININE DERIVATIVES AND USE OF THE SAME
WO2007012430A1 (en) * 2005-07-26 2007-02-01 Georg-August-Universität-Göttingen Method for induction and enhancement of apoptosis in tumor cells
TWI386417B (en) 2005-12-22 2013-02-21 Takeda Pharmaceutical Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
GB0616111D0 (en) 2006-06-16 2006-09-20 Ardana Bioscience Ltd Agents, methods and uses
JO3048B1 (en) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co Metastin Derivatives And Use Thereof
WO2010046530A1 (en) * 2008-10-20 2010-04-29 Helsingin Yliopiston Rahastot Methods and uses involving genetic aberrations of nav3 and aberrant expression of multiple genes
WO2010107832A1 (en) 2009-03-17 2010-09-23 Bracco Imaging Spa Lhrh-ii peptide analogs
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9849160B2 (en) * 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
KR20190117541A (en) * 2017-01-20 2019-10-16 이뮨 시스템 레귤레이션 홀딩 에이비 Novel Compounds (Imunorelin)
AU2018209239B2 (en) * 2017-01-20 2023-02-02 ISR Immune System Regulation Holding AB (publ) Novel compounds (immunorhelins- intracellular infections)
EP3570866B1 (en) 2017-01-20 2023-05-10 ISR Immune System Regulation Holding AB (publ) Novel use of known compounds- intracellular infections
JP2020508306A (en) 2017-02-22 2020-03-19 イミューン システム レギュレェイション ホールディング エービー Gonadotropin-releasing hormone for use as an adjuvant immunotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2029018A1 (en) * 1989-11-01 1991-05-02 Robert P. Millar Analogues of gonadotropin releasing hormone
US5760000A (en) * 1994-05-13 1998-06-02 University Technologies International,Inc. Inhibition of liver cancer by the use of GnRH and GnRH analogs
US6635739B2 (en) * 1999-10-15 2003-10-21 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
US6323179B1 (en) * 1999-10-15 2001-11-27 Theresa Siler-Khodr Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy

Also Published As

Publication number Publication date
EP1272206B1 (en) 2011-01-12
JP2004512011A (en) 2004-04-22
WO2001074377A1 (en) 2001-10-11
US20040097412A1 (en) 2004-05-20
US7834141B1 (en) 2010-11-16
DE60045524D1 (en) 2011-02-24
ATE494902T1 (en) 2011-01-15
EP1272206A1 (en) 2003-01-08

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