WO2005019435A3 - Anti-cancer vaccines - Google Patents

Anti-cancer vaccines Download PDF

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Publication number
WO2005019435A3
WO2005019435A3 PCT/US2004/027790 US2004027790W WO2005019435A3 WO 2005019435 A3 WO2005019435 A3 WO 2005019435A3 US 2004027790 W US2004027790 W US 2004027790W WO 2005019435 A3 WO2005019435 A3 WO 2005019435A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
cancer vaccines
restricted antigens
hla
vaccines
Prior art date
Application number
PCT/US2004/027790
Other languages
French (fr)
Other versions
WO2005019435A8 (en
WO2005019435A2 (en
Inventor
A John Barrett
Jeffrey Molldrem
Original Assignee
Univ Texas
Us Gov Health & Human Serv
Jeffrey Molldrem
A John Barrett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Us Gov Health & Human Serv, Jeffrey Molldrem, A John Barrett filed Critical Univ Texas
Priority to AU2004267506A priority Critical patent/AU2004267506A1/en
Priority to CA002536654A priority patent/CA2536654A1/en
Priority to EP04782297A priority patent/EP1660636A4/en
Priority to JP2006524856A priority patent/JP2007504149A/en
Publication of WO2005019435A2 publication Critical patent/WO2005019435A2/en
Publication of WO2005019435A8 publication Critical patent/WO2005019435A8/en
Publication of WO2005019435A3 publication Critical patent/WO2005019435A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001158—Proteinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464458—Proteinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present provides tumor-associated HLA-restricted antigens, and in particular HLA-­A2 restricted antigens, as vaccines for treating or preventing cancers in a patient. In specific aspects, there is proteinase 3 peptides are provided. Such peptides can be used to elicit specific CTLs that preferentially attack myeloid leukemia based on overexpression of the target protein cells.
PCT/US2004/027790 2003-08-26 2004-08-26 Anti-cancer vaccines WO2005019435A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2004267506A AU2004267506A1 (en) 2003-08-26 2004-08-26 Anti-cancer vaccines
CA002536654A CA2536654A1 (en) 2003-08-26 2004-08-26 Anti-cancer vaccines
EP04782297A EP1660636A4 (en) 2003-08-26 2004-08-26 Anti-cancer vaccines
JP2006524856A JP2007504149A (en) 2003-08-26 2004-08-26 Anti-cancer vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49823803P 2003-08-26 2003-08-26
US60/498,238 2003-08-26

Publications (3)

Publication Number Publication Date
WO2005019435A2 WO2005019435A2 (en) 2005-03-03
WO2005019435A8 WO2005019435A8 (en) 2006-04-27
WO2005019435A3 true WO2005019435A3 (en) 2006-06-29

Family

ID=34216164

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/027792 WO2005035714A2 (en) 2003-08-26 2004-08-26 Vaccines for cancer, autoimmune disease and infections
PCT/US2004/027790 WO2005019435A2 (en) 2003-08-26 2004-08-26 Anti-cancer vaccines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027792 WO2005035714A2 (en) 2003-08-26 2004-08-26 Vaccines for cancer, autoimmune disease and infections

Country Status (5)

Country Link
EP (2) EP1670899A2 (en)
JP (1) JP2007504149A (en)
AU (1) AU2004267506A1 (en)
CA (1) CA2536654A1 (en)
WO (2) WO2005035714A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101355928B (en) * 2005-04-26 2013-05-22 卫材R&D管理株式会社 Compositions and methods for cancer immunotherapy
CA2523032A1 (en) 2005-10-07 2007-04-07 Immunovaccine Technologies Inc. Vaccines for cancer therapy
JP5731198B2 (en) 2007-09-27 2015-06-10 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Use of liposomes in carriers containing a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20110097312A1 (en) * 2008-02-15 2011-04-28 Board Of Regents, The University Of Texas System Anti-cancer vaccines
JP5715051B2 (en) 2008-06-05 2015-05-07 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Composition comprising carrier comprising liposome, antigen, polynucleotide and continuous phase of hydrophobic substance
GB201009222D0 (en) 2010-06-02 2010-07-21 Immatics Biotechnologies Gmbh Improved cancer therapy based on tumour associated antigens derived from cyclin D1
WO2012079075A1 (en) 2010-12-10 2012-06-14 Concert Pharmaceuticals, Inc. Deuterated phthalimide derivatives
US10105435B2 (en) 2011-10-06 2018-10-23 Immunovaccine Technologies Inc. Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof
WO2013130849A1 (en) 2012-02-29 2013-09-06 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
WO2013159026A1 (en) 2012-04-20 2013-10-24 Concert Pharmaceuticals, Inc. Deuterated rigosertib
JP2015534989A (en) 2012-10-22 2015-12-07 コンサート ファーマシューティカルズ インコーポレイテッド {S-3- (4-Amino-1-oxo-isoindolin-2-yl) (piperidine-3,4,4,5,5-D5) -2,6-dione} solid form
WO2014110322A2 (en) 2013-01-11 2014-07-17 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
CA2840974A1 (en) * 2013-02-05 2014-08-05 Nitto Denko Corporation Vaccine composition for mucosal administration
US20140220056A1 (en) * 2013-02-05 2014-08-07 Nitto Denko Corporation Vaccine composition for transdermal administration
GB201519303D0 (en) 2015-11-02 2015-12-16 Imp Innovations Ltd Phagemid vector
GB201706451D0 (en) 2017-04-24 2017-06-07 Imp Innovations Ltd Cancer treatment

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1286693A4 (en) * 2000-06-02 2005-07-13 Univ Connecticut Health Ct Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOLLDREM ET AL: "Cytotoxic T Lymphocytes Specific for a Nonpolymorphic Proteinase 3 Peptide Preferentially Inhibit Chronic Myeloid Leukemia Colony-Forming Units.", BLOOD., vol. 90, no. 7, October 1997 (1997-10-01), pages 2529 - 2534, XP002300135 *
VAN DER GELD ET AL: "In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG).", CLIN EXP IMMUNOL., vol. 122, December 2000 (2000-12-01), pages 504 - 513, XP008072447 *

Also Published As

Publication number Publication date
EP1670899A2 (en) 2006-06-21
WO2005019435A8 (en) 2006-04-27
JP2007504149A (en) 2007-03-01
EP1660636A4 (en) 2009-07-01
WO2005019435A2 (en) 2005-03-03
CA2536654A1 (en) 2005-03-03
WO2005035714A3 (en) 2009-04-16
WO2005035714A2 (en) 2005-04-21
EP1660636A2 (en) 2006-05-31
AU2004267506A1 (en) 2005-03-03

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