WO2005016255A3 - Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds - Google Patents

Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds Download PDF

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Publication number
WO2005016255A3
WO2005016255A3 PCT/US2004/023093 US2004023093W WO2005016255A3 WO 2005016255 A3 WO2005016255 A3 WO 2005016255A3 US 2004023093 W US2004023093 W US 2004023093W WO 2005016255 A3 WO2005016255 A3 WO 2005016255A3
Authority
WO
WIPO (PCT)
Prior art keywords
acids
hnf
nuclear factor
modulator compounds
hepatocyte nuclear
Prior art date
Application number
PCT/US2004/023093
Other languages
French (fr)
Other versions
WO2005016255A2 (en
Inventor
Pierre Michellys
Jyun-Hung Chen
Hoyt Meyer
Donald Karanewsky
Original Assignee
Ligand Pharm Inc
Pierre Michellys
Jyun-Hung Chen
Hoyt Meyer
Donald Karanewsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc, Pierre Michellys, Jyun-Hung Chen, Hoyt Meyer, Donald Karanewsky filed Critical Ligand Pharm Inc
Publication of WO2005016255A2 publication Critical patent/WO2005016255A2/en
Publication of WO2005016255A3 publication Critical patent/WO2005016255A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Abstract

This invention relates to substituted tetrahydroquinoline phenylacetic acids and benzoic acids that bind to and/or modulate hepatocyte factor 4α receptors and to methods for making and using such compounds.
PCT/US2004/023093 2003-07-16 2004-07-16 Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds WO2005016255A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48807103P 2003-07-16 2003-07-16
US60/488,071 2003-07-16

Publications (2)

Publication Number Publication Date
WO2005016255A2 WO2005016255A2 (en) 2005-02-24
WO2005016255A3 true WO2005016255A3 (en) 2005-06-16

Family

ID=34193072

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023093 WO2005016255A2 (en) 2003-07-16 2004-07-16 Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds

Country Status (1)

Country Link
WO (1) WO2005016255A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250423B2 (en) * 2001-09-24 2007-07-31 Chao-Jun Li Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
DE102004031656A1 (en) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydroquinolines
DE102005027170A1 (en) * 2005-06-13 2006-12-14 Merck Patent Gmbh New substituted tetrahydroquinoline compounds are mitotic motor-protein Eg5 modulators useful to treat or prevent e.g. cancer, glioblastoma, lymphatic leukemia, arteriosclerosis, eye disease, diabetic retinopathy and arthritis
EP2647638A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Substituted tricyclic compounds with activity towards ep1 receptors
EP2647628A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Substituted tricyclic compounds with activity towards ep1 receptors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631050A (en) * 1968-11-13 1971-12-28 Parke Davis & Co Hexahydro-9b-methylfuro(3 2-c) quinoline compounds
WO1998027093A1 (en) * 1996-12-18 1998-06-25 Eli Lilly And Company Combinatorial process for preparing hydrofuroquinoline libraries

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631050A (en) * 1968-11-13 1971-12-28 Parke Davis & Co Hexahydro-9b-methylfuro(3 2-c) quinoline compounds
WO1998027093A1 (en) * 1996-12-18 1998-06-25 Eli Lilly And Company Combinatorial process for preparing hydrofuroquinoline libraries

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REDDY ET AL.: "Bismuth (III) chloride catalyzed aza-Diels-Adler reaction", SYNTHETIC COMMUNICATIONS, vol. 31, no. 7, 2001, pages 1075 - 1080, XP008045206 *

Also Published As

Publication number Publication date
WO2005016255A2 (en) 2005-02-24

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