WO2005014841A1 - Procede de preparation de l-threonine - Google Patents
Procede de preparation de l-threonine Download PDFInfo
- Publication number
- WO2005014841A1 WO2005014841A1 PCT/EP2004/008389 EP2004008389W WO2005014841A1 WO 2005014841 A1 WO2005014841 A1 WO 2005014841A1 EP 2004008389 W EP2004008389 W EP 2004008389W WO 2005014841 A1 WO2005014841 A1 WO 2005014841A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- process according
- threonine
- gene
- culture
- source
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Definitions
- a strain which contains the mutation described in the rpoS gene and the suppressor supE is obtainable under the Accession Number DSM 15189 from the Deutsche Sammlung fur Mikroorganismen und Zellkulturen [German Collection of Microorganisms and Cell Cultures] (Braunschweig, Germany) .
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04763524A EP1649032A1 (fr) | 2003-08-01 | 2004-07-27 | Procede de preparation de l-threonine |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10335254 | 2003-08-01 | ||
DE10335254.6 | 2003-08-01 | ||
US49198203P | 2003-08-04 | 2003-08-04 | |
US60/491,982 | 2003-08-04 | ||
DE102004029340A DE102004029340A1 (de) | 2003-08-01 | 2004-06-17 | Verfahren zur Herstellung von L-Threonin |
DE102004029340.6 | 2004-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005014841A1 true WO2005014841A1 (fr) | 2005-02-17 |
Family
ID=34139203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/008389 WO2005014841A1 (fr) | 2003-08-01 | 2004-07-27 | Procede de preparation de l-threonine |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1649032A1 (fr) |
WO (1) | WO2005014841A1 (fr) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
EP1975241A1 (fr) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2036979A1 (fr) | 2007-09-15 | 2009-03-18 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2055785A1 (fr) | 2007-11-02 | 2009-05-06 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2060636A1 (fr) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Procédé de fabrication d'acides aminés L en utilisant des souches de la famille des Enterobacteriaceae améliorées |
EP2098597A1 (fr) | 2008-03-04 | 2009-09-09 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
DE102008002309A1 (de) | 2008-06-09 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
US7638313B2 (en) * | 2003-01-30 | 2009-12-29 | Degussa Ag | Processes for the fermentative preparation of L-threonine using strains of Escherichia in which the yjgF gene is inactivated |
DE102008040352A1 (de) | 2008-07-11 | 2010-01-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102008044768A1 (de) | 2008-08-28 | 2010-03-04 | Evonik Degussa Gmbh | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
WO2010084995A2 (fr) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | Procédé de production d'un acide l-aminé |
EP3385275A1 (fr) | 2017-04-07 | 2018-10-10 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides l aromatiques à l'aide de troncs améliorés de la famille des enterobacteriaceae |
CN109136299A (zh) * | 2017-06-19 | 2019-01-04 | 卢松 | 一种制备、提取以及纯化苏氨酸的方法 |
EP3608409A1 (fr) | 2018-08-09 | 2020-02-12 | Evonik Operations GmbH | Procédé de préparation d'acides aminés l au moyen de souches améliorées de la famille des enterobacteriaceae |
EP3677594A1 (fr) | 2019-01-07 | 2020-07-08 | Evonik Operations GmbH | Procédé de production de l-tryptophane utilisant des souches améliorées de la famille des entérobactéries |
US11053526B2 (en) | 2018-08-09 | 2021-07-06 | Evonik Operations Gmbh | Process for preparing L amino acids using improved strains of the enterobacteriaceae family |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0139592A2 (fr) * | 1983-10-27 | 1985-05-02 | Les Produits Organiques Du Santerre Orsan | Procédé et installation de production d'amino-acides par fermentation |
US5260216A (en) * | 1990-09-21 | 1993-11-09 | Ajinomoto Co., Inc. | Apparatus for amino acid fermentation |
US6025169A (en) * | 1990-11-30 | 2000-02-15 | Ajinomoto Co., Inc. | Process for production of lysine by fermentation |
-
2004
- 2004-07-27 WO PCT/EP2004/008389 patent/WO2005014841A1/fr not_active Application Discontinuation
- 2004-07-27 EP EP04763524A patent/EP1649032A1/fr not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0139592A2 (fr) * | 1983-10-27 | 1985-05-02 | Les Produits Organiques Du Santerre Orsan | Procédé et installation de production d'amino-acides par fermentation |
US5260216A (en) * | 1990-09-21 | 1993-11-09 | Ajinomoto Co., Inc. | Apparatus for amino acid fermentation |
US6025169A (en) * | 1990-11-30 | 2000-02-15 | Ajinomoto Co., Inc. | Process for production of lysine by fermentation |
Non-Patent Citations (17)
Title |
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ALVAREZ-VASQUEZ F ET AL: "Modeling, optimization and experimental assessment of continuous L-(-)-carnitine production by Escherichia coli cultures.", BIOTECHNOLOGY AND BIOENGINEERING. 30 DEC 2002, vol. 80, no. 7, 30 December 2002 (2002-12-30), pages 794 - 805, XP002305528, ISSN: 0006-3592 * |
BRYERS J D: "Effects of cell recycle on microbial cell viability and metabolism", JOURNAL OF PARENTERAL SCIENCE AND TECHNOLOGY, vol. 42, no. 2, 1988, pages 40 - 46, XP008038268, ISSN: 0279-7976 * |
BULL D N ET AL: "Enhanced product formation in continuous fermentations with microbial cell recycle", BIOTECHNOLOGY AND BIOENGINEERING, vol. 23, no. 2, 1981, pages 373 - 389, XP002305532, ISSN: 0006-3592 * |
CANOVAS M ET AL: "Modeling of the biotransformation of crotonobetaine into L-(-)-carnitine by Escherichia coli strains", BIOTECHNOLOGY AND BIOENGINEERING, vol. 77, no. 7, 30 March 2002 (2002-03-30), pages 764 - 775, XP002305527, ISSN: 0006-3592 * |
DEBABOV V G: "The threonine story", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 79, 2003, pages 113 - 136, XP008014933, ISSN: 0724-6145 * |
DEBABOV V: "Construction of strains producing L-threonine", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON THE GENETICS OF INDUSTRIAL MICROORGANISMS, TOKYO, JAPAN, 1982, pages 254 - 258, XP008031179 * |
HENRY K L ET AL: "Continuous recombinant bacterial fermentations utilizing selective flocculation and recycle.", BIOTECHNOLOGY PROGRESS. 1990 JAN-FEB, vol. 6, no. 1, January 1990 (1990-01-01), pages 7 - 12, XP002305530, ISSN: 8756-7938 * |
OBON J M ET AL: "High-density Escherichia coli cultures for continuous L(-)-carnitine production", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 51, no. 6, June 1999 (1999-06-01), pages 760 - 764, XP002305526, ISSN: 0175-7598 * |
OKAMOTO K ET AL: "Development of an industrially stable process for L-threonine fermentation by an L-methionine-auxotrophic mutant of Escherichia coli", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 89, no. 1, 6 January 2000 (2000-01-06), pages 87 - 89, XP002305525, ISSN: 1389-1723 * |
OKAMOTO K ET AL: "Hyperproduction of L-threonine by an Escherichia coli mutant with impaired L-threonine uptake", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, vol. 61, no. 11, November 1997 (1997-11-01), pages 1877 - 1882, XP001018682, ISSN: 0916-8451 * |
SCHUGERL K: "Integrated processing of biotechnology products", BIOTECHNOLOGY ADVANCES, ELSEVIER PUBLISHING, BARKING, GB, vol. 18, no. 7, 1 November 2000 (2000-11-01), pages 581 - 599, XP004317587, ISSN: 0734-9750 * |
SHIU-LAN L ET AL: "Study on the microfiltration of Escherichia coli-containing fermentation broth by a ceramic membrane filter", JOURNAL OF MEMBRANE SCIENCE, vol. 110, no. 2, 21 February 1996 (1996-02-21), pages 203 - 210, XP004041728, ISSN: 0376-7388 * |
TODA KIYOSHI: "Theoretical and methodological studies of continuous microbial bioreactors.", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, vol. 49, no. 4, August 2003 (2003-08-01), pages 219 - 233, XP008038115, ISSN: 0022-1260 * |
VAN DER WIELEN L A M ET AL: "Integrated product formation and recovery in fermentation", CURRENT OPINION IN BIOTECHNOLOGY, vol. 3, no. 2, 1992, pages 130 - 138, XP002304966, ISSN: 0958-1669 * |
YU PENG ET AL: "Continuous production of cell-free recombinant proteins using Escherichia coli", BIOTECHNOLOGY PROGRESS, vol. 9, no. 6, 1993, pages 587 - 593, XP002305529, ISSN: 8756-7938 * |
ZENG A-P ET AL: "Production of 2,3-butanediol in a membrane bioreactor with cell recycle", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 34, no. 4, 1991, pages 463 - 468, XP008038261, ISSN: 0175-7598 * |
ZENG A-P: "Continuous culture", 1999, IN: "MANUAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY" (ED. DEMAIN A L ET AL), 2ND ED., ASM PRESS, WASHINGTON, ISBN: 1-55581-128-0, XP002305534 * |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7638313B2 (en) * | 2003-01-30 | 2009-12-29 | Degussa Ag | Processes for the fermentative preparation of L-threonine using strains of Escherichia in which the yjgF gene is inactivated |
DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
EP1975241A1 (fr) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2036979A1 (fr) | 2007-09-15 | 2009-03-18 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
DE102007044134A1 (de) | 2007-09-15 | 2009-03-19 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102007052270A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2055785A1 (fr) | 2007-11-02 | 2009-05-06 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2465869A1 (fr) | 2007-11-02 | 2012-06-20 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
EP2060636A1 (fr) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Procédé de fabrication d'acides aminés L en utilisant des souches de la famille des Enterobacteriaceae améliorées |
EP2098597A1 (fr) | 2008-03-04 | 2009-09-09 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
DE102008002309A1 (de) | 2008-06-09 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2133420A1 (fr) | 2008-06-09 | 2009-12-16 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides L en utilisant des troncs améliorés de la famille des enterobacteriaceae |
DE102008040352A1 (de) | 2008-07-11 | 2010-01-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2147972A1 (fr) | 2008-07-11 | 2010-01-27 | Evonik Degussa GmbH | Procédé de fabrication de tryptophan L en utilisant des souches améliorées de la famille des enterobacteriaceae |
EP2163613A2 (fr) | 2008-08-28 | 2010-03-17 | Evonik Degussa GmbH | Procédé de fabrication de liaisons organo-chimiques en utilisant des troncs améliorés de la famille des enterobacteriaceae |
DE102008044768A1 (de) | 2008-08-28 | 2010-03-04 | Evonik Degussa Gmbh | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
WO2010084995A2 (fr) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | Procédé de production d'un acide l-aminé |
EP3385275A1 (fr) | 2017-04-07 | 2018-10-10 | Evonik Degussa GmbH | Procédé de fabrication d'aminoacides l aromatiques à l'aide de troncs améliorés de la famille des enterobacteriaceae |
CN109136299A (zh) * | 2017-06-19 | 2019-01-04 | 卢松 | 一种制备、提取以及纯化苏氨酸的方法 |
EP3608409A1 (fr) | 2018-08-09 | 2020-02-12 | Evonik Operations GmbH | Procédé de préparation d'acides aminés l au moyen de souches améliorées de la famille des enterobacteriaceae |
US11053526B2 (en) | 2018-08-09 | 2021-07-06 | Evonik Operations Gmbh | Process for preparing L amino acids using improved strains of the enterobacteriaceae family |
EP3677594A1 (fr) | 2019-01-07 | 2020-07-08 | Evonik Operations GmbH | Procédé de production de l-tryptophane utilisant des souches améliorées de la famille des entérobactéries |
Also Published As
Publication number | Publication date |
---|---|
EP1649032A1 (fr) | 2006-04-26 |
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