WO2005014578A1 - Composes de phenylsulfonyle en tant qu'agents antipsychotiques - Google Patents

Composes de phenylsulfonyle en tant qu'agents antipsychotiques Download PDF

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Publication number
WO2005014578A1
WO2005014578A1 PCT/EP2004/008965 EP2004008965W WO2005014578A1 WO 2005014578 A1 WO2005014578 A1 WO 2005014578A1 EP 2004008965 W EP2004008965 W EP 2004008965W WO 2005014578 A1 WO2005014578 A1 WO 2005014578A1
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WIPO (PCT)
Prior art keywords
methyl
disorders
methoxy
benzazepine
tetrahydro
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PCT/EP2004/008965
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English (en)
Inventor
David Gwyn Cooper
Ian Thomson Forbes
Vincenzo Garzya
Andrew Derrick Gribble
Andrew P Lightfoot
Andrew H Payne
Graham Walker
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Glaxo Group Limited
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Publication date
Priority claimed from GB0318707A external-priority patent/GB0318707D0/en
Priority claimed from GB0318715A external-priority patent/GB0318715D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of WO2005014578A1 publication Critical patent/WO2005014578A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Definitions

  • This invention relates to novel compounds, pharmaceutical compositions containing them and their use in therapy, in particular as antipsychotic agents.
  • a and B represent the groups -(CH 2 ) m - and -(CH 2 ) n - respectively;
  • R 1 represents hydrogen or C h alky!
  • R 2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC ⁇ alkyl, trifluoromethyl, trifluoromethoxy, C 1 . 6 alkyl, C ⁇ profession 6 a
  • R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring
  • R 4 represents hydrogen, hydroxy, d-ealkyl, C ⁇ - 6 alkoxy, trifluoromethyl, trifluoromethoxy, halogen, -OS0 2 CF 3 , -(CH 2 ) P C 3 . 6 cycloalkyl, -(CH 2 ) q OC ⁇ - 6 alkyl or -(CH 2 ) p OC 3 . 6 cycloalkyl;
  • X represents -CH- or N
  • R 5 and R 6 each independently represent hydrogen, C ⁇ . 6 alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring;
  • alkyl refers to straight or branched hydrocarbon chains containing the specified number of carbon atoms.
  • C ⁇ alkyl means a straight or branched alkyl containing at least 1 , and at most 6, carbon atoms.
  • alkyl as used herein include, but are not limited to, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, isobutyl, isopropyl, t-butyl and 1 ,1-dimethylpropyl.
  • alkoxy refers to a straight or branched alkoxy group containing the specified number of carbon atoms.
  • C ⁇ . 6 alkoxy means a straight or branched alkoxy group containing at least 1 , and at most 6, carbon atoms.
  • alkoxy as used herein include, but are not limited to, methoxy, ethoxy, propoxy, prop-2-oxy, butoxy, but-2-oxy, 2-methylprop-1-oxy, 2-methylprop-2-oxy, pentoxy or hexyloxy.
  • fluoroalkoxy refers to a straight or branched alkoxy group containing the specified number of carbon atoms wherein any of the carbon atoms may be substituted with one or more fluorine atoms.
  • fluoroalkoxy examples include, but are not limited to, 2-fluoroethoxy.
  • cycloalkyl refers to a non-aromatic hydrocarbon ring containing the specified number of carbon atoms.
  • C 3 . 7 cycloalkyl means a non-aromatic ring containing at least three, and at most seven, ring carbon atoms.
  • Examples of "cycloalkyl” as used herein include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.
  • a C 6 . 7 cycloalkyl group is preferred.
  • halogen refers to the elements fluorine, chlorine, bromine and iodine. Preferred halogens are fluorine, chlorine and bromine.
  • aryl refers to a phenyl or a naphthyl ring.
  • heteroaryl refers to a 5- or 6-membered heterocyclic aromatic ring or a fused bicyclic heteroaromatic ring system.
  • heterocyclyl refers to a 3- to 7-membered monocyclic saturated ring containing at least one heteroatom independently selected from oxygen, nitrogen and sulfur.
  • suitable heterocyclic rings include, but are not limited to, piperidine and morpholine.
  • heterocyclic aromatic ring refers to a monocyclic unsaturated ring containing at least one heteroatom independently selected from oxygen, nitrogen and sulfur.
  • suitable 5- and 6-membered heterocyclic aromatic rings include, but are not limited to, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, triazolyl, triazinyl, pyridazinyl, pyrazinyl, pyrimidinyl, pyrazolyl, isothiazolyl and isoxazolyl.
  • fused bicyclic heteroaromatic ring system refers to a ring system comprising one six-membered unsaturated ring and one 5- or 6-membered unsaturated or saturated ring fused together, the ring system containing at least one heteroatom independently selected from oxygen, nitrogen and sulfur.
  • suitable fused bicyclic heteroaromatic ring systems include, but are not limited to, indolyl, benzofuranyl, quinolyl and benzothienyl.
  • Further examples include but are not limited to, isoquinolyl, quinolizinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, cinnolinyl, isoindolyl, indolizinyl, indazolyl, pyrrolopyridinyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzoxadiazolyl, benzothiadiazolyl, dihydrobenzothienyl, dihydrobenzofuranyl, benzodioxolanyl, methylenedioxyphenyl, dihydrobenzodioxinyl and the like.
  • azacycloalkyl ring refers to a 4- to 7-membered monocyclic saturated ring containing one nitrogen atom.
  • suitable azacycloalkyl rings are azetidine, pyrrolidine, piperidine and azepine.
  • oxo-substituted azacycloalkyl ring refers to an azacycloalkyl ring as defined above substituted by one oxo group.
  • suitable oxo-substituted azacycloalkyl rings include, but are not limited to, azetidinone, pyrrolidinone, piperidinone and azepinone.
  • substituted refers to substitution with the named substituent or substituents, multiple degrees of substitution being allowed unless otherwise stated.
  • solvate refers to a complex of variable stoichiometry formed by a solute (in this invention, a compound of formula (I) or a salt thereof) and a solvent.
  • solvents for the purpose of the invention may not interfere with the biological activity of the solute.
  • suitable solvents include water, methanol, ethanol and acetic acid. Most preferably the solvent used is water and the solvate may also be referred to as a hydrate.
  • the salts of formula (I) should be physiologically (i.e. pharmaceutically) acceptable.
  • suitable physiologically acceptable salts will be apparent to those skilled in the art and include for example acid addition salts formed with inorganic acids e.g. hydrochloric, hydrobromic, sulfuric, nitric or phosphoric acid; and organic acids e.g. succinic, maleic, malic, mandelic, acetic, fumaric, glutamic, lactic, citric, tartaric, benzoic, benzenesulfonic, p-toluenesulfonic, methanesulfonic or naphthalenesulfonic acid.
  • Other non- physiologically acceptable salts e.g. oxalates, may be used, for example in the isolation of compounds of formula (I) and are included within the scope of this invention.
  • Certain of the compounds of formula (I) may form acid addition salts with one or more equivalents of the acid.
  • the present invention includes within its scope all possible stoichiometric and non-stoichiometric forms thereof.
  • Certain compounds of formula (I) may exist in stereoisomeric forms (e.g. they may contain one or more asymmetric carbon atoms).
  • the individual stereoisomers (enantiomers and diastereomers) and mixtures of these are included within the scope of the present invention.
  • the present invention also covers the individual isomers of the compounds represented by formula (I) as mixtures with isomers thereof in which one or more chiral centres are inverted.
  • compounds of formula (I) may exist in tautomeric forms other than that shown in the formula and these are also included within the scope of the present invention.
  • the groups R 2 and R 4 may be located on any position on their respective phenyl rings.
  • R 2 represents optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring
  • the optional substituents may be independently selected from C ⁇ - 6 alkyl, d ⁇ alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-d- 6 alkyl, -CONR 5 R 6 and -NR 5 COR 6 , wherein R 5 and R 6 have any of the meanings given hereinbefore.
  • R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring
  • the optional substituents may be independently selected from dialkyl, C ⁇ . 6 alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-d. 6 alkyl, di(C 1 . 6 alkyl)amino, d. 6 alkanoyl and d- alkoxyC ⁇ . 4 alkyl.
  • the optional substituents are selected from C 1 . 4 alkyl, d ⁇ alkoxy, halogen, trifluoromethyl and cyano.
  • R 1 represents hydrogen or dialkyl. More preferably, R 1 represents hydrogen or methyl. Even more preferably, R 1 represents methyl.
  • R 2 represents hydrogen, halogen, d-ealkyl, d. 6 alkoxy, C ⁇ . 6 alkylthio or did. 6 alkylamino. More preferably, R 2 represents hydrogen, d ⁇ alkoxy or diC ⁇ . 4 alkylamino. Even more preferably, R 2 represents hydrogen, methoxy, ethoxy, isopropoxy or dimethylamino.
  • R 2 represents an optionally substituted aryl ring, an optionally substituted heteroaryl ring, or an optionally substituted heterocyclyl ring
  • the optional substituents are independently selected from chloro, fluoro, bromo, methyl, ethyl, t-butyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano, -S-methyl, -CONH 2 and -NHCOMe.
  • R 3 represents phenyl, pyridyl (e.g. 2-pyridyl), benzoxazolyl (e.g. 2-benzoxazolyl), benzothiazolyl (e.g. 2-benzothiazolyl), indolyl (e.g. 2- or 3-indolyl), benzotriazolyl (e.g. 1- benzotriazolyl), isoxazolyl, thienyl, furyl, thiazolyl, benzofuranyl, benzothienyl or naphthyl, all of which may be optionally substituted. More preferably, R 3 represents phenyl, optionally substituted phenyl or pyridyl (e.g. 2-pyridyl).
  • R 3 represents optionally substituted phenyl
  • the optional substituents are independently selected from halogen, trifluoromethyl, C ⁇ _ 4 alkyl, C ⁇ alkoxy, acetyl and cyano. More preferably, when R 3 represents optionally substituted phenyl, the optional substituents are independently selected from chloro (e.g. 2-, 3- and 4-chloro or 2,3- and 3,4-dichloro), fluoro (e.g. 2- or 4-fluoro), methyl (e.g. 2- or 4-methyl), methoxy (e.g. 2-methoxy) and trifluoromethyl (e.g. 3- or 4-trifluoromethyl).
  • chloro e.g. 2-, 3- and 4-chloro or 2,3- and 3,4-dichloro
  • fluoro e.g. 2- or 4-fluoro
  • methyl e.g. 2- or 4-methyl
  • methoxy e.g. 2-methoxy
  • trifluoromethyl e.g.
  • R 3 represents optionally substituted benzothiazolyl or benzotriazolyl
  • the optional substituents are selected from halogen. More preferably, the optional substituents are selected from fluoro (e.g. 5-fluoro).
  • R 2 represents pyridyl
  • the optional substituent is methyl (e.g. 3-methyl).
  • R 4 represents hydrogen, dialkyl or d_ 4 alkoxy. More preferably, R 4 represents hydrogen.
  • R 5 and R 6 independently represent hydrogen or dialkyl. More preferably, R 5 and R 6 independently represent hydrogen or methyl.
  • p 0.
  • R 7 and R 8 represent hydrogen or together represent -(CH 2 ) S -.
  • s represents 2.
  • X represents -CH-
  • Z represents a bond.
  • the R 2 group is located at the para-position relative to the group B i.e. a compound of formula (IA)
  • R 2 is located in the para-position i.e. compounds of formula (IA), R 2 is preferably hydrogen, methoxy, ethoxy, isopropoxy or dimethylamino.
  • n 1 and the invention is a compound of formula (IB):
  • n 2 and n is 1 and the invention is a compound of formula (IC):
  • m is 2 and n is 2 and the invention is a compound of formula (IE):
  • m is 2 and n is 2 and the R 2 group is located at the para-position relative to the group B and the invention is a compound of formula (IF):
  • R 7 and R 8 together represent -(CH 2 ) S - wherein s is as hereinbefore described and the invention is a compound of formula (IG):
  • R 7 and R 8 together represent -(CH 2 ) S - wherein s is 2 and the invention is a compound of formula (IH):
  • X is -CH- and there is provided a compound of formula (IJ):
  • a and B represent the groups -(CH 2 ) m - and -(CH 2 ) n - respectively;
  • R 1 represents hydrogen or d. 6 alkyl
  • R 2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyd. 6 alkyl, trifluoromethyl, trifluoromethoxy, d. 6 alkyl, d. 6 alkoxy, d_ 6 fluoroalkoxy, -(CH 2 ) p C 3 . 6 cycloalkyl, -(CH 2 ) p OC 3 . ecycloalkyl, -COd_ 6 alkyl, -S0 2 Ci. 6 alkyl, -SOd. 6 alkyl, -S-d. 6 alkyl, -C0 2 Ci. 6 alkyl, -C0 2 NR 5 R 6 ,
  • R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring
  • R 4 represents hydrogen, hydroxy, C ⁇ - 6 alkyl, d. 6 alkoxy, trifluoromethyl, trifluoromethoxy, halogen, -OS0 2 CF 3 , -(CH 2 )pC M cycloalkyl, -(CH 2 ) q OC ⁇ . 6 alkyl or -(CH 2 ) p OC 3 . 6 cycloalkyl
  • R 5 and R 6 each independently represent hydrogen, d_ 6 alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring;
  • R 7 and R 8 represent hydrogen ord_ 6 alkyl, or R 7 and R 8 together represent -(CH 2 ) S -; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1 , 2 and 3; q represents an integer selected from 1 , 2 and 3; r represents an integer selected from 1, 2 and 3; s represents an integer selected from 2, 3 and 4; or a pharmaceutically acceptable salt or solvate thereof.
  • the groups R 2 and R 4 may be located on any position on their respective phenyl rings.
  • R 2 represents optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring
  • the optional substituents may be independently selected from C ⁇ . 6 alkyl, d. 6 alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-d. 6 alkyl, -CONR 5 R 6 and -NR 5 COR 6 , wherein R 5 and R 6 have any of the meanings given hereinbefore.
  • R 3 when R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring, the optional substituents may be independently selected from d_ 6 alkyl, d ⁇ alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-d_ 6 alkyl, d C ⁇ alkyOamino, d. 6 alkanoyl and d ⁇ alkoxyd ⁇ alkyl.
  • the optional substituents are selected from d. 4 alkyl, d_ 4 alkoxy, halogen trifluoromethyl and cyano.
  • R 1 represents hydrogen or dialkyl. More preferably, R 1 represents hydrogen or methyl. Even more preferably, R 1 represents methyl.
  • R 2 represents hydrogen, dialkyl, d. 6 alkoxy or did- 6 alkylamino. More preferably, R 2 represents hydrogen, C ⁇ . 4 alkoxy or diC ⁇ . alkylamino. Even more preferably, R 2 represents hydrogen, methoxy, ethoxy or dimethylamino.
  • R 2 represents an optionally substituted aryl ring, an optionally substituted heteroaryl ring, or an optionally substituted heterocyclyl ring
  • the optional substituents are independently selected from chloro, fluoro, bromo, methyl, ethyl, t- butyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano, -S-methyl, -CONH 2 and -NHCOMe.
  • R 3 represents phenyl, pyridyl (e.g. 2-pyridyl), benzoxazolyl (e.g. 2-benzoxazolyl), benzothiazolyl (e.g.
  • R 3 represents phenyl, optionally substituted phenyl or pyridyl (e.g. 2-pyridyl).
  • R 3 when R 3 represents optionally substituted phenyl, the optional substituents are independently selected from halogen, trifluoromethyl, dialkyl, C ⁇ alkoxy and cyano. More preferably, when R 3 represents optionally substituted phenyl, the optional substituents are independently selected from chloro (e.g. 2-, 3- and 4-chloro or 3,4-dichloro), fluoro (e.g. 2- or 4-fluoro), methyl (e.g. 2- or 4-methyl), methoxy (e.g. 2-methoxy) and trifluoromethyl (e.g. 3- or 4-trifluoromethyl).
  • chloro e.g. 2-, 3- and 4-chloro or 3,4-dichloro
  • fluoro e.g. 2- or 4-fluoro
  • methyl e.g. 2- or 4-methyl
  • methoxy e.g. 2-methoxy
  • trifluoromethyl e.g. 3- or 4-trifluoromethyl
  • R 3 represents optionally substituted benzothiazolyl or benzotriazolyl
  • the optional substituents are selected from halogen. More preferably, the optional substituents are selected from fluoro (e.g. 5-fluoro).
  • R 4 represents hydrogen, dialkyl or d_ 4 alkoxy. More preferably, R 4 represents hydrogen.
  • R 5 and R 6 independently represent hydrogen or dialkyl. More preferably, R 5 and R 6 independently represent hydrogen or methyl.
  • R 7 and R 8 represent hydrogen or together represent -(CH 2 ) S -.
  • X is N and there is provided a compound of formula (IK):
  • a and B represent the groups -(CH 2 ) m - and -(CH 2 ) n - respectively;
  • R 1 represents hydrogen or d. 6 alkyl;
  • R 2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyd. 6 alkyl, trifluoromethyl, trifluoromethoxy, Ci-ealkyl, d. 6 alkoxy, d-efluoroalkoxy, -(CH 2 ) p C 3 . 6 cycloalkyl, -(CH 2 ) p OC 3 . ecycloalkyl, -COd-ealkyl, -S0 2 C ⁇ . 6 alkyl, -SOd.
  • R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring
  • R 5 and R 6 each independently represent hydrogen, d_ 6 alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1 , 2 and 3; q represents an integer selected from 1 , 2 and 3; or a pharmaceutically acceptable salt or solvate thereof.
  • the groups R 2 and R 4 may be located on any position on their respective phenyl rings.
  • R 2 represents optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring
  • the optional substituents may be independently selected from d-ealkyl, d_ 6 alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-d. 6 alkyl, -CONR 5 R 6 and -NR 5 COR 6 , wherein R 5 and R 6 have any of the meanings given hereinbefore.
  • R 3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring
  • the optional substituents may be independently selected from d-ealkyl, d. 6 alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, -S-C ⁇ _ 6 alkyl, di(d. 6 alkyl)amino, d. 6 alkanoyl and C ⁇ _ alkoxyC 1 - alkyl.
  • R 1 represents hydrogen or dialkyl. More preferably, R 1 represents hydrogen or methyl. Even more preferably, R 1 represents methyl.
  • R 2 represents hydrogen, halogen, Ci-ealkyl, d. 6 alkoxy, d. 6 alkylthio or did. 6 alkylamino. More preferably, R 2 represents hydrogen, d ⁇ alkoxy or did- 6 alkylamino. Even more preferably, R 2 represents hydrogen, methoxy, ethoxy, isopropoxy or dimethylamino.
  • R 2 represents an optionally substituted aryl ring, an optionally substituted heteroaryl ring, or an optionally substituted heterocyclyl ring
  • the optional substituents are independently selected from chloro, fluoro, bromo, methyl, ethyl, t- butyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano, -S-methyl, -CONH 2 and -NHCOMe.
  • R 3 represents phenyl, pyridyl (e.g. 2-pyridyl), isoxazolyl, thienyl, furyl, thiazolyl, benzofuranyl, benzothienyl or naphthyl, all of which may be optionally substituted. More preferably, R 3 represents phenyl, optionally substituted phenyl or pyridyl (e.g. 2-pyridyl).
  • R 3 represents optionally substituted phenyl
  • the optional substituents are independently selected from halogen, trifluoromethyl, dialkyl, d_
  • R 3 represents optionally substituted phenyl
  • the optional substituents are independently selected from chloro (e.g. 2-, 3- and 4- chloro, 2,3-dichloro and 3,4-dichloro), fluoro (e.g. 2- or 4-fluoro), methyl, methoxy and trifluoromethyl.
  • R 3 represents optionally substituted pyridyl
  • the optional substituent is methyl (e.g. 3-methyl).
  • R 4 represents hydrogen, d- alkyl or C ⁇ _ 4 alkoxy. More preferably, R 4 represents hydrogen.
  • R 5 and R 6 independently represent hydrogen or dialkyl. More preferably, R 5 and R 6 independently represent hydrogen or methyl.
  • Z represents a bond.
  • the compounds of the present invention may be in the form of their free base or physiologically acceptable salts thereof, particularly the monohydrochloride or monomesylate salts or pharmaceutically acceptable derivatives thereof.
  • the present invention also provides a general process (A) for preparing compounds of formula (I) which process comprises:
  • W is a leaving group, such as fluoro, chloro, bromo or iodo and R 1' to R 4' , R 7' and R 8' represent R 1 to R 4 , R 7 or R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 , R 7 and R 8 , and X, Z, A and B are as hereinbefore defined.
  • This general method (A) can be conveniently performed by heating the two reactants in an inert solvent e.g. dimethylformamide or dimethylsulfoxide, under basic conditions e.g. potassium carbonate or sodium hydride, or in the presence of caesium fluoride, at elevated temperature e.g. 120°C.
  • an inert solvent e.g. dimethylformamide or dimethylsulfoxide
  • basic conditions e.g. potassium carbonate or sodium hydride
  • caesium fluoride e.g. 120°C.
  • general method (A) can be conveniently carried out in an inert solvent using palladium catalysed conditions as published by Buchwald (J. Org. Chem. 1997, 1264).
  • the present invention also provides a general process (B) for preparing compounds of formula (I), which process comprises:
  • L is a leaving group, such as halogen or C _ 4 alkoxy
  • M is a metal, such as lithium or magnesium
  • A, B, X, Z and R 1' to R 4' , R 7' and R 8' represent R 1 to R 4 and R 7 and R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 or R 7 and R 8 .
  • This general method (B) can be conveniently performed by mixing the two components at preferably -70°C to room temperature in a suitable solvent such as tetrahydrofuran or ether for 10 minutes to 18 hours. Removal of certain R 1' protecting groups e.g. trifluoroacetyl, can also take place simultaneously during this process.
  • the present invention also provides a general process (C) for preparing compounds of formula (I), which process comprises:
  • L is a leaving group, such as halogen or C ⁇ alkoxy
  • M is a metal, such as lithium or magnesium, or M is hydrogen
  • A, B, X and Z are as hereinbefore defined and R 1' to R 4' , R 7' and R 8' represent R 1 to R 4 , R 7 and R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 , R 7 and R 8 .
  • This general method (C) can be conveniently performed by mixing the two components at preferably -70°C to room temperature in a suitable solvent such as tetrahydrofuran or ether for 10 minutes to 18 hours. Removal of certain R 1' protecting groups e.g. trifluoroacetyl, can also take place simultaneously during this process.
  • M is hydrogen
  • this general method can be conveniently performed by treating (VI) and (VII) with a Lewis acid under Friedel-Crafts conditions at elevated temperature in a suitable solvent.
  • W is a leaving group, such as fluoro, chloro, bromo or iodo and R 1' toR 4' , R 7' and R 8' represent R 1 to R 4 , R 7 or R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 , R 7 and R 8 , and X, Z, A and B are as hereinbefore defined, in a suitable solvent under basic conditions at elevated temperature; or
  • L is a leaving group, such as halogen or C ⁇ . 4 alkoxy
  • M is a metal, such as lithium or magnesium
  • A, B, X, Z and R 1' to R 4' , R 7' and R 8' represent R 1 to R 4 and R 7 and R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 or R 7 and R 8 in a suitable solvent; or
  • L is a leaving group
  • M is a metal and A, B, X and Z are as hereinbefore defined and R 1' to R 4 , R 7' and R 8' represent R 1 to R 4 , R 7 and R 8 as hereinbefore defined or are groups that may be readily convertible to R 1 to R 4 , R 7 and R 8 in a suitable solvent or when M is hydrogen, treating (VI) and (VII) with a Lewis acid under Friedel-Crafts conditions at elevated temperature in a suitable solvent; and thereafter optionally for process (a), process (b) or process (c):
  • Interconversion of one of the R 1' to R 4' , R 7' and R 8' and Z groups to the corresponding R to R 4 , R 7 and R 8 and Z groups typically arises when one compound of formula (I) is used as the immediate precursor of another compound of formula (I), or when it is easier to introduce a more complex or reactive substituent at the end of a synthetic sequence.
  • conversion of R 1' from a t-butoxycarbonyl (BOC) group to hydrogen is conducted by the treatment of the N-BOC protected compound with hydrogen chloride in ethanol or dioxan at room temperature.
  • Conversion of R 1' from hydrogen to an alkyl group is conducted by the treatment of the NH compound with the appropriate aldehyde in dichloroethane in the presence of a reducing agent, such as sodium triacetoxyborohydride, or by the treatment of the NH compound with the appropriate alkyl halide, such as iodomethane, under standard alkylation conditions (potassium carbonate in DMF at 60°C).
  • Compounds of formula (II) may be prepared using a similar process to general process B, using a suitably functionalised phenyl Grignard or organolithium reagent, where necessary utilising protection or interconversion of the functional group W.
  • Compounds of formula (VI) where M is a metal can be prepared by halogenation (e.g. iodination or bromination) of compounds of formula (VI) where M is hydrogen, followed by formation of the lithium or Grignard reagent.
  • halogenation e.g. iodination or bromination
  • Compounds of formula (I) have antagonist affinity for the serotonin 5-HT2C.
  • 5- HT2A and 5-HTg receptors These properties may give rise to anti-psychotic activity (e.g. improved effects on cognitive dysfunction) activity with reduced extra pyramid a I side effects (eps), and/or anxiolytic/antidepressant activity.
  • anti-psychotic activity e.g. improved effects on cognitive dysfunction
  • eps extra pyramid a I side effects
  • anxiolytic/antidepressant activity could include, but are not limited to, attenuation of cognitive symptoms via 5-HT 6 receptor blockade (see Reavill, C. and Rogers, D.C., 2001 , Investigational Drugs 2, 104-109), and reduced anxiety (see for example Kennett et al., Neuropharmacology 1997 Apr- May; 36 (4-5): 609-20), protection against EPS (Reavill et al., Brit. J. Pharmacol., 1999; 126: 572-574) and antidepress
  • Certain compounds of formula (I) have also been found to exhibit affinity for dopamine receptors, in particular the D3 and D2 receptors, and are useful in the treatment of disease states which require modulation of such receptors, such as psychotic conditions. Many of the compounds of formula (I) have also been found to have greater affinity for dopamine D3 than for D2 receptors.
  • antipsychotics antipsychotics
  • the therapeutic effect of currently available antipsychotic agents is generally believed to be exerted via blockade of D2 receptors; however this mechanism is also thought to be responsible for undesirable eps associated with many antipsychotic agents.
  • blockade of the dopamine D3 receptor may give rise to beneficial antipsychotic activity without significant eps (see for example Sokoloff et al, Nature, 1990; 347: 146-151 ; and Schwartz et al, Clinical Neuropharmacology, Vol 16, No. 4, 295-314, 1993).
  • Compounds of formula (I) may also exhibit affinity for other receptors not mentioned above, resulting in beneficial antipsychotic activity.
  • DSM-IV Diagnostic and Statistical Manual of Mental Disorders
  • ICD-10 International Classification of Diseases
  • the compounds of formula (I) are of use as antipsychotic agents for example in the treatment of schizophrenia, schizo-affective disorders, schizophreniform disorders, psychotic depression, mania, acute mania, paranoid and delusional disorders.
  • the compounds of formula (I) are of use in the treatment of schizophrenia including the subtypes Paranoid Type (295.30), Disorganised Type (295.10), Catatonic Type (295.20), Undifferentiated Type (295.90) and Residual Type (295.60); Schizophreniform Disorder (295.40); Schizoaffective Disorder (295.70) including the subtypes Bipolar Type and Depressive Type; Delusional Disorder (297.1 ) including the subtypes Erotomanic Type, Grandiose Type, Jealous Type, Persecutory Type, Somatic Type, Mixed Type and Unspecified Type; Brief Psychotic Disorder (298.8); Shared Psychotic Disorder (297.3); Psychotic Disorder Due to a General Medical Condition including the subtypes With Delusions and With Hallucinations; Substance-Induced Psychotic Disorder including the subtypes With Delusions (293.81) and With Hallucinations (293.82); and Psychotic Disorder Not Otherwise Specified (298.9).
  • the compounds of formula (I) are also of use in the treatment of depression and mood disorders including Major Depressive Episode, Manic Episode, Mixed Episode and Hypomanic Episode; Depressive Disorders including Major Depressive Disorder, Dysthymic Disorder (300.4), Depressive Disorder Not Otherwise Specified (311 ); Bipolar Disorders including Bipolar I Disorder, Bipolar II Disorder (Recurrent Major Depressive Episodes with Hypomanic Episodes) (296.89), Cyclothymic Disorder (301.13) and Bipolar Disorder Not Otherwise Specified (296.80); Other Mood Disorders including Mood Disorder Due to a General Medical Condition (293.83) which includes the subtypes With Depressive Features, With Major Depressive-like Episode, With Manic Features and With Mixed Features), Substance-Induced Mood Disorder (including the subtypes With Depressive Features, With Manic Features and With Mixed Features) and Mood Disorder Not Otherwise Specified (296.90).
  • the compounds of formula (I) are also of use in the treatment of anxiety disorders including Social Anxiety Disorder, Panic Attack, Agoraphobia, Panic Disorder, Agoraphobia Without History of Panic Disorder (300.22), Specific Phobia (300.29) including the subtypes Animal Type, Natural Environment Type, Blood-lnjection-lnjury Type, Situational Type and Other Type), Social Phobia (300.23), Obsessive-Compulsive Disorder (300.3), Posttraumatic Stress Disorder (309.81), Acute Stress Disorder (308.3), Generalized Anxiety Disorder (300.02), Anxiety Disorder Due to a General Medical Condition (293.84), Substance-Induced Anxiety Disorder and Anxiety Disorder Not Otherwise Specified (300.00).
  • the compounds of formula (I) are also of use in the treatment of substance-related disorders including Substance Use Disorders such as Substance Dependence, Substance Craving and Substance Abuse; Substance-Induced Disorders such as Substance Intoxication, Substance Withdrawal, Substance-Induced Delirium, Substance-Induced Persisting Dementia, Substance-Induced Persisting Amnestic Disorder, Substance-Induced Psychotic Disorder, Substance-Induced Mood Disorder, Substance-Induced Anxiety Disorder, Substance- Induced sexual Dysfunction, Substance-Induced Sleep Disorder and Hallucinogen Persisting Perception Disorder (Flashbacks); Alcohol-Related Disorders such as Alcohol Dependence (303.90), Alcohol Abuse (305.00), Alcohol Intoxication (303.00), Alcohol Withdrawal (291.81), Alcohol Intoxication Delirium, Alcohol Withdrawal Delirium, Alcohol-Induced Persisting Dementia, Alcohol-Induced Persisting Am
  • the compounds of formula (I) are also of use in the treatment of sleep disorders including primary sleep disorders such as Dyssomnias such as Primary Insomnia (307.42), Primary Hypersomnia (307.44), Narcolepsy (347), Breathing-Related Sleep Disorders (780.59), Circadian Rhythm Sleep Disorder (307.45) and Dyssomnia Not Otherwise Specified (307.47); primary sleep disorders such as Parasomnias such as Nightmare Disorder (307.47), Sleep Terror Disorder (307.46), Sleepwalking Disorder (307.46) and Parasomnia Not Otherwise Specified (307.47); Sleep Disorders Related to Another Mental Disorder such as Insomnia Related to Another Mental Disorder (307.42) and Hypersomnia Related to Another Mental Disorder (307.44); Sleep Disorder Due to a General Medical Condition; and Substance-Induced Sleep Disorder including the subtypes Insomnia Type, Hypersomnia Type, Parasomnia Type and Mixed Type.
  • D3 receptors may have utility as adjunct therapy in Parkinson's Disease, particularly with compounds such as L-DOPA and possibly dopaminergic agonists, to reduce the side effects experienced with these treatments on long term use (e.g. see Schwartz et al., Brain Res. Reviews, 1998, 26, 236-242).
  • the compounds could also have utility for the treatment of substance abuse where it has been suggested that D3 receptors are involved (e.g. see Levant, 1997, Pharmacol. Rev., 49, 231-252). Examples of such substance abuse include alcohol, cocaine, heroin and nicotine abuse.
  • disorders such as Parkinson's disease, neuroleptic-induced parkinsonism and tardive dyskinesias; depression; anxiety; agitation; tension; social or emotional withdrawal in psychotic patients; cognitive impairment including memory disorders such as Alzheimer's disease; psychotic states associated with neurodegenerative disorders, e.g. Alzheimer's disease; eating disorders; obesity; sexual dysfunction; sleep disorders; emesis; movement disorders; obsessive-compulsive disorders; amnesia; aggression; autism; vertigo; dementia; circadian rhythm disorders; convulsions; epilepsy; and gastric motility disorders e.g. IBS.
  • IBS gastric motility disorders
  • the compounds of formula (I) are also of use in the treatment of eating disorders such as Anorexia Nervosa (307.1) including the subtypes Restricting Type and Binge-Eating/Purging Type; Bulimia Nervosa (307.51) including the subtypes Purging Type and Nonpurging Type; Obesity; Compulsive Eating Disorder; and Eating Disorder Not Otherwise Specified (307.50).
  • eating disorders such as Anorexia Nervosa (307.1) including the subtypes Restricting Type and Binge-Eating/Purging Type; Bulimia Nervosa (307.51) including the subtypes Purging Type and Nonpurging Type; Obesity; Compulsive Eating Disorder; and Eating Disorder Not Otherwise Specified (307.50).
  • the compounds of formula (I) are also of use in the treatment of Autistic Disorder (299.00); Attention-Deficit /Hyperactivity Disorder including the subtypes Attention-Deficit /Hyperactivity Disorder Combined Type (314.01), Attention-Deficit /Hyperactivity Disorder Predominantly Inattentive Type (314.00), Attention-Deficit /Hyperactivity Disorder Hyperactive-Impulse Type (314.01) and Attention-Deficit /Hyperactivity Disorder Not Otherwise Specified (314.9); Hyperkinetic Disorder; Disruptive Behaviour Disorders such as Conduct Disorder including the subtypes childhood-onset type (321.81), Adolescent-Onset Type (312.82) and Unspecified Onset (312.89), Oppositional Defiant Disorder (313.81) and Disruptive Behaviour Disorder Not Otherwise Specified; and Tic Disorders such as Tourette's Disorder (307.23).
  • Attention-Deficit /Hyperactivity Disorder including the subtypes Attention-Deficit
  • the compounds of formula (I) are also of use in the treatment of Personality Disorders including the subtypes Paranoid Personality Disorder (301.0), Schizoid Personality Disorder (301.20), Schizotypal Personality Disorder (301 ,22), Antisocial Personality Disorder (301 J), Borderline Personality Disorder (301 ,83), Histrionic Personality Disorder (301.50), Narcissistic Personality Disorder (301 ,81), Avoidant Personality Disorder (301.82), Dependent Personality Disorder (301.6), Obsessive-Compulsive Personality Disorder (301.4) and Personality Disorder Not Otherwise Specified (301.9).
  • Paranoid Personality Disorder (301.0
  • Schizoid Personality Disorder 301.20
  • Schizotypal Personality Disorder 301 ,22
  • Antisocial Personality Disorder 301 J
  • Borderline Personality Disorder 301 ,83
  • Histrionic Personality Disorder 301.50
  • Narcissistic Personality Disorder 301 ,81
  • Avoidant Personality Disorder (301.82)
  • Dependent Personality Disorder (301.6
  • the compounds of formula (I) are also of use for enhancement of cognition or for the treatment of cognition impairment, including the treatment of cognition impairment in other diseases such as schizophrenia, bipolar disorder, depression and other psychiatric disorders.
  • the compounds of formula (I) are also of use in the treatment of sexual dysfunctions including Sexual Desire Disorders such as Hypoactive Sexual Desire Disorder (302.71), and Sexual Aversion Disorder (302.79); sexual arousal disorders such as Female sexual Arousal Disorder (302.72) and Male Erectile Disorder (302.72); orgasmic disorders such as Female Orgasmic Disorder (302.73), Male Orgasmic Disorder (302.74) and Premature Ejaculation (302.75); sexual pain disorder such as Dyspareunia (302.76) and Vaginismus (306.51); sexual Dysfunction Not Otherwise Specified (302.70); paraphilias such as Exhibitionism (302.4), Fetishism (302.81), Frotteurism (302.89), Pedophilia (302.2), sexual Masochism (302.83), Sexual Sadism (302.84), Transvestic Fetishism (302.3), Voyeurism (302.82) and Paraphilia Not Otherwise Specified (302.9); gender identity disorders such as Gender Identity Disorder in Children (302.6) and Gender Identity Disorder in Ad
  • the invention provides a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof for use in therapy.
  • the invention also provides a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof for use in the treatment of a condition which requires modulation of a dopamine receptor.
  • the invention also provides a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof for use in the treatment of schizophrenia, mood disorders, anxiety disorders, substance-related disorders, sleep disorders, eating disorders, autistic disorder, attention-deficit/hyperactivity disorder, disruptive behaviour disorder, tic disorders, personality disorders, cognition impairment in other diseases, sexual dysfunction, Parkinson's disease, dyskinetic disorders, depression, bipolar disorder, cognitive impairment, obesity, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, vertigo, dementia and circadian rhythm disorders.
  • the invention also provides a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof for use in the treatment of psychotic disorders, schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety, cognitive impairment, eating disorders, obesity, sexual dysfunction, sleep disorders, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, autism, vertigo, dementia, circadian rhythm disorders and gastric motility disorders.
  • psychotic disorders schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety, cognitive impairment, eating disorders, obesity, sexual dysfunction, sleep disorders, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, autism, vertigo, dementia, circadian rhythm disorders and gastric motility disorders.
  • the invention also provides the use of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for the treatment of a condition which requires modulation of a dopamine receptor.
  • the invention also provides the use of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for the treatment of schizophrenia, mood disorders, anxiety disorders, substance-related disorders, sleep disorders, eating disorders, autistic disorder, attention-deficit/hyperactivity disorder, disruptive behaviour disorder, tic disorders, personality disorders, cognition impairment in other diseases, sexual dysfunction, Parkinson's disease, dyskinetic disorders, depression, bipolar disorder, cognitive impairment, obesity, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, vertigo, dementia and circadian rhythm disorders.
  • the invention also provides the use of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for the treatment of psychotic disorders, schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety, cognitive impairment, eating disorders, obesity, sexual dysfunction, sleep disorders, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, autism, vertigo, dementia, circadian rhythm disorders and gastric motility disorders.
  • psychotic disorders schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety, cognitive impairment, eating disorders, obesity, sexual dysfunction, sleep disorders, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, autism, vertigo, dementia, circadian rhythm disorders and gastric motility disorders.
  • the invention also provides a method of treating a condition which requires modulation of a dopamine receptor, which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof.
  • the invention also provides a method of treating schizophrenia, mood disorders, anxiety disorders, substance-related disorders, sleep disorders, eating disorders, autistic disorder, attention-deficit/hyperactivity disorder, disruptive behaviour disorder, tic disorders, personality disorders, cognition impairment in other diseases, sexual dysfunction, Parkinson's disease, dyskinetic disorders, depression, bipolar disorder, cognitive impairment, obesity, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, vertigo, dementia and circadian rhythm disorders which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof.
  • the invention also provides a method of treating psychotic disorders, schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety, cognitive impairment, eating disorders, obesity, sexual dysfunction, sleep disorders, emesis, movement disorders, obsessive-compulsive disorders, amnesia, aggression, autism, vertigo, dementia, circadian rhythm disorders and gastric motility disorders which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) as hereinbefore described or a pharmaceutically acceptable salt or solvate thereof.
  • a preferred use for dopamine antagonists according to the present invention is in the treatment of psychotic disorders, schizophrenia, Parkinson's disease, substance abuse, dyskinetic disorders, depression, bipolar disorder, anxiety and cognitive impairment.
  • Treatment includes prophylaxis, where this is appropriate for the relevant condition(s).
  • the compounds according to the invention may advantageously be used in conjunction with one or more other therapeutic agents, for instance 5HT 3 antagonists, serotonin agonists, NK-1 antagonists, selective serotonin reuptake inhibitors (SSRI), noradrenaline re-uptake inhibitors (SNRI), non-selective reuptake inhibitors of one or more of serotonin, noradrenaline and norepinephrine, CRF-1 antagonists, tricyclic antidepressants, dopaminergic antidepressants, H 3 antagonists, 5HT 1A antagonists, 5HTI B antagonists, 5HT 1D antagonists, 5HT 4 partial agonists, D-i agonists, M agonists and/or anticonvulsant agents.
  • the compounds according to the invention may also advantageously be used in conjunction with cyclooxygenase-2 (COX-2) inhibitors.
  • the compounds of the combination or composition may be administered simultaneously (either in the same or different pharmaceutical formulations), separately or sequentially.
  • Suitable 5HT 3 antagonists which may be used in combination of the compounds of the inventions include for example ondansetron, granisetron and metoclopramide.
  • Suitable serotonin agonists which may be used in combination with the compounds of the invention include sumatriptan, rauwolscine, yohimbine and metoclopramide.
  • Suitable SSRIs which may be used in combination with the compounds of the invention include fluoxetine, citalopram, femoxetine, fluvoxamine, paroxetine, indalpine, sertraline and zimeldine.
  • Suitable SNRIs which may be used in combination with the compounds of the invention include venlafaxine and reboxetine.
  • Suitable tricyclic antidepressants which may be used in combination with a compound of the invention include imipramine, amitriptiline, chlomipramine and nortriptiline.
  • Suitable dopaminergic antidepressants which may be used in combination with a compound of the invention include bupropion and amineptine.
  • Suitable anticonvulsant agents which may be used in combination of the compounds of the inventions include for example divalproex, carbamazepine and diazepam.
  • Suitable COX-2 inhibitors include rofecoxib (available under the tradename VIOXX®, from Merck, US patent number 5,474,995); celecoxib (available under the tradename CELEBREX®, from Pfizer, US patent number 5,466,823); valdecoxib (available under the tradename BEXTRA®, from Pfizer, US patent number 6,633,272); etoricoxib (available under the tradename ARCOXIA®, from Merck, US patent number 5,861 ,419); lumiracoxib (available under the tradename PREXIGE®, from Novartis); paracoxib (US patent number 5,932,598); COX-189 from Novartis; BMS347070 from Bristol Myers Squibb; tiracoxib (JTE522) from Japan Tobacco; ABT963 from Abbott; CS502 from Sankyo; 2-(4- ethoxyphenyl)-3-(3-methanesulfonylphenyl
  • the compounds of formula (I) and their pharmaceutically acceptable salts and solvates thereof are also suitable for combination with other typical and atypical antipsychotics to provide improved treatment of psychotic disorders.
  • Particular advantages associated with the combinations, uses and methods of treatment of compounds of formula (I) and their pharmaceutically acceptable salts and solvates thereof include equivalent or improved efficacy at doses of administration which are lower than those commonly used for the individual components. Improved treatments of positive symptoms and/or negative symptoms and/or cognitive symptoms of the psychotic disorder may also be observed.
  • the combinations, uses and methods of treatment of the invention may also provide advantages in treatment of patients who fail to respond adequately or who are resistant to treatment with certain antipsychotic agents (also known as neuroleptic agents).
  • adjunctive administration is meant the coterminous or overlapping administration of each of the components in the form of separate pharmaceutical compositions or devices.
  • This regime of therapeutic administration of two or more therapeutic agents is referred to generally by those skilled in the art and herein as adjunctive therapeutic administration; it is also known as add-on therapeutic administration.
  • Any and all treatment regimes in which a patient receives separate but coterminous or overlapping therapeutic administration of the compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one antipsychotic agent are within the scope of the current invention.
  • a patient is typically stabilised on a therapeutic administration of one or more of the components for a period of time and then receives administration of another component.
  • the compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof may be administered as adjunctive therapeutic treatment to patients who are receiving administration of at least one antipsychotic agent, but the scope of the invention also includes the adjunctive therapeutic administration of at least one antipsychotic agent to patients who are receiving administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof.
  • the combination therapies of the invention may also be administered simultaneously.
  • simultaneous administration is meant a treatment regime wherein the individual components are administered together, either in the form of a single pharmaceutical composition or device comprising or containing both components, or as separate compositions or devices, each comprising one of the components, administered simultaneously.
  • Such combinations of the separate individual components for simultaneous combination may be provided in the form of a kit-of-parts.
  • the invention provides a method of treatment of a psychotic disorder by adjunctive therapeutic administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof to a patient receiving therapeutic administration of at least one antipsychotic agent.
  • the invention provides the use of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of at least one antipsychotic agent.
  • the invention further provides compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof for use for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of at least one antipsychotic agent.
  • the invention provides a method of treatment of a psychotic disorder by adjunctive therapeutic administration of at least one antipsychotic agent to a patient receiving therapeutic administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof.
  • the invention provides the use of at least one antipsychotic agent in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof.
  • the invention further provides at least one antipsychotic agent for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof.
  • the invention provides a method of treatment of a psychotic disorder by simultaneous therapeutic administration of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof in combination with at least one antipsychotic agent.
  • the invention further provides the use of a combination of compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one antipsychotic agent in the manufacture of a medicament for simultaneous therapeutic administration in the treatment of a psychotic disorder.
  • the invention further provides the use of compounds of formula (I) or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for simultaneous therapeutic administration with at least one antipsychotic agent in the treatment of a psychotic disorder.
  • the invention further provides compounds of formula (I) or a pharmaceutically acceptable salt thereof for use for simultaneous therapeutic administration with at least one antipsychotic agent in the treatment of a psychotic disorder.
  • the invention further provides the use of at least one antipsychotic agent in the manufacture of a medicament for simultaneous therapeutic administration with compounds of formula (I) or a pharmaceutically acceptable salt thereof in the treatment of a psychotic disorder.
  • the invention provides a method of treatment of a psychotic disorder by simultaneous therapeutic administration of a pharmaceutical composition comprising compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one mood stabilising or antimanic agent, a pharmaceutical composition comprising compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one mood stabilising or antimanic agent, the use of a pharmaceutical composition comprising compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one mood stabilising or antimanic agent in the manufacture of a medicament for the treatment of a psychotic disorder, and a pharmaceutical composition comprising compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and at least one mood stabilising or antimanic agent for use in the treatment of a psychotic disorder.
  • the invention provides a kit-of-parts for use in the treatment of a psychotic disorder comprising a first dosage form comprising compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof and one or more further dosage forms each comprising a antipsychotic agent for simultaneous therapeutic administration.
  • psychotic disorder includes those disorders mentioned above, such as schizophrenia, mood disorders, anxiety disorders, substance-related disorders, sleep disorders, eating disorders, autistic disorder, attention- deficit/hyperactivity disorder, disruptive behaviour disorder, tic disorders, personality disorders, cognition impairment in other diseases, sexual dysfunction, dyskinetic disorders, depression, bipolar disorder, cognitive impairment and obsessive-compulsive disorders and all the various forms of the disorders as mentioned herein, which are contemplated as part of the present invention.
  • antipsychotic drugs examples include, but are not limited to: butyrophenones, such as haloperidol, pimozide, and droperidol; phenothiazines, such as chlorpromazine, thioridazine, mesoridazine, trifluoperazine, perphenazine, fluphenazine, thiflupromazine, prochlorperazine, and acetophenazine; thioxanthenes, such as thiothixene and chlorprothixene; thienobenzodiazepines; dibenzodiazepines; benzisoxazoles; dibenzothiazepines; imidazolidinones ; benzisothiazolyl-piperazines; triazine such as lamotrigine; dibenzoxazepines, such as loxapine; dihydroindolones, such as molindone; aripiprazole;
  • tradenames and suppliers of selected antipsychotic drugs that are suitable for use in the present invention are as follows : clozapine (available under the tradename CLOZARIL®, from Mylan, Zenith Goldline, UDL, Novartis); olanzapine (available under the tradename ZYPREXA®, from Lilly ; ziprasidone (available under the tradename GEODON®, from Pfizer); risperidone (available under the tradename RISPERDAL®, from Janssen); quetiapine fumarate (available under the tradename SEROQUEL®, from AstraZeneca); sertindole (available under the tradename SERLECT®); amisulpride (available under the tradename SOLION®, from Sanofi-Synthelabo); haloperidol (available under the tradename HALDOL®, from Ortho-McNeil); haloperidol decanoate (available under the tradename HALDOL decanoate®
  • antipsychotic drugs include promazine (available under the tradename SPARINE®), triflurpromazine (available under the tradename VESPRIN®), chlorprothixene (available under the tradename TARACTAN®), droperidol (available under the tradename INAPSINE®), acetophenazine (available under the tradename TINDAL®;), prochlorperazine (available under the tradename COMPAZINE®), methotrimeprazine (available under the tradename NOZINAN®), pipotiazine (available under the tradename PIPOTRIL®), iloperidone, pimozide and flupenthixol.
  • promazine available under the tradename SPARINE®
  • triflurpromazine available under the tradename VESPRIN®
  • chlorprothixene available under the tradename TARACTAN®
  • droperidol available under the tradename INAPSINE®
  • acetophenazine available under the tradename TINDAL®
  • suitable antipsychotic agents include olanzapine, risperidone, quetiapine, aripiprazole, haloperidol, clozapine, ziprasidone and osanetant.
  • the compounds of the present invention are usually administered as a standard pharmaceutical composition.
  • the present invention therefore provides in a further aspect a pharmaceutical composition comprising a compound of formula (I) as hereinbefore described or a pharmaceutically (i.e. physiologically) acceptable salt thereof and a pharmaceutically (i.e. physiologically) acceptable carrier.
  • the pharmaceutical composition can be for use in the treatment of any of the conditions described herein.
  • the compounds of formula (I) may be administered by any convenient method, for example by oral, parenteral (e.g. intravenous), buccal, sublingual, nasal, rectal or transdermal administration and the pharmaceutical compositions adapted accordingly.
  • the compounds of formula (I) as hereinbefore described and their pharmaceutically acceptable salts which are active when given orally can be formulated as liquids or solids, for example syrups, suspensions or emulsions, tablets, capsules and lozenges.
  • a liquid formulation will generally consist of a suspension or solution of the compound or pharmaceutically acceptable salt in a suitable liquid carrier(s) for example an aqueous solvent such as water, ethanol or glycerine, or a non-aqueous solvent, such as polyethylene glycol or an oil.
  • a suitable liquid carrier(s) for example an aqueous solvent such as water, ethanol or glycerine, or a non-aqueous solvent, such as polyethylene glycol or an oil.
  • the formulation may also contain a suspending agent, preservative, flavouring or colouring agent.
  • a composition in the form of a tablet can be prepared using any suitable pharmaceutical carrier(s) routinely used for preparing solid formulations.
  • suitable pharmaceutical carrier(s) include magnesium stearate, starch, lactose, sucrose and cellulose.
  • a composition in the form of a capsule can be prepared using routine encapsulation procedures.
  • pellets containing the active ingredient can be prepared using standard carriers and then filled into a hard gelatin capsule; alternatively, a dispersion or suspension can be prepared using any suitable pharmaceutical carrier(s), for example aqueous gums, celluloses, silicates or oils and the dispersion or suspension then filled into a soft gelatin capsule.
  • suitable pharmaceutical carrier(s) for example aqueous gums, celluloses, silicates or oils
  • Typical parenteral compositions consist of a solution or suspension of the compound or pharmaceutically acceptable salt in a sterile aqueous carrier or parenterally acceptable oil, for example polyethylene glycol, polyvinyl pyrrolidone, lecithin, arachis oil or sesame oil.
  • the solution can be lyophilised and then reconstituted with a suitable solvent just prior to administration.
  • compositions for nasal administration may conveniently be formulated as aerosols, drops, gels and powders.
  • Aerosol formulations typically comprise a solution or fine suspension of the active substance in a pharmaceutically acceptable aqueous or non-aqueous solvent and are usually presented in single or multidose quantities in sterile form in a sealed container, which can take the form of a cartridge or refill for use with an atomising device.
  • the sealed container may be a unitary dispensing device such as a single dose nasal inhaler or an aerosol dispenser fitted with a metering valve which is intended for disposal once the contents of the container have been exhausted.
  • the dosage form comprises an aerosol dispenser
  • a propellant which can be a compressed gas such as compressed air or an organic propellant such as a fluorochlorohydrocarbon.
  • the aerosol dosage forms can also take the form of a pump-atomiser.
  • compositions suitable for buccal or sublingual administration include tablets, lozenges and pastilles, wherein the active ingredient is formulated with a carrier such as sugar and acacia, tragacanth, or gelatin and glycerin.
  • a carrier such as sugar and acacia, tragacanth, or gelatin and glycerin.
  • compositions for rectal administration are conveniently in the form of suppositories containing a conventional suppository base such as cocoa butter.
  • compositions suitable for transdermal administration include ointments, gels and patches.
  • the composition is in unit dose form such as a tablet, capsule or ampoule.
  • Each dosage unit for oral administration contains preferably from 1 to 250 mg (and for parenteral administration contains preferably from 0.1 to 25 mg) of a compound of the formula (I) or a pharmaceutically acceptable salt thereof calculated as the free base.
  • the pharmaceutically acceptable compounds of the invention will normally be administered in a daily dosage regimen (for an adult patient) of, for example, an oral dose of between 1 mg and 500 mg, preferably between 10 mg and 400 mg, e.g. between 10 and 250 mg or an intravenous, subcutaneous, or intramuscular dose of between 0.1 mg and 100 mg, preferably between 0.1 mg and 50 mg, e.g. between 1 and 25 mg of the compound of the formula (I) or a pharmaceutically acceptable salt thereof calculated as the free base, the compound being administered 1 to 4 times per day.
  • the compounds will be administered for a period of continuous therapy, for example for a week or more. No toxicological effects are indicated or expected when a compound of the invention is administered in the above mentioned dosage range.
  • the ability of the compounds to bind selectively to human D2/D3 dopamine receptors can be demonstrated by measuring their binding to cloned receptors.
  • the inhibition constants (K j ) of test compounds for displacement of [ 125 l]-lodosulpride binding to human D2/D3 receptors expressed in CHO cells were determined as follows. The cell lines were shown to be free from bacterial, fungal and mycoplasmal contaminants, and stocks of each were stored frozen in liquid nitrogen. Cultures were grown as monolayers or in suspension in standard cell culture media. Cells were recovered by scraping (from monolayers) or by centrifugation (from suspension cultures), and were washed two or three times by suspension in phosphate buffered saline followed by collection by centrifugation. Cell pellets were stored frozen at - 80°C. Crude cell membranes were prepared by homogenisation followed by high-speed centrifugation, and characterisation of cloned receptors achieved by radioligand binding.
  • CHO cell membranes Preparation of CHO cell membranes: Cell pellets were gently thawed at room temperature, and resuspended in about 20 volumes of ice-cold Extraction buffer; 5mM EDTA, 50mM Trizma pre-set crystals (pH7.4@37°C), 1 mM MgCl2, 5mM KCI and 120mM NaCl. The suspension was homogenised using an Ultra-Turrax at full speed for 15 seconds. The homogenate was centrifuged at 18,000 r.p.m for 15 min at 4°C in a Sorvall RC5C centrifuge. Supernatant was discarded, and homogenate re-suspended in extraction buffer then centrifugation was repeated.
  • the protein content was determined using a BCA protocol and bovine serum albumin as a standard (Smith, P. K., et al., Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85 (1985)).
  • Binding experiments Crude D2/D3 cell membranes were incubated with 0.03nM [ 125 l]- lodosulpride (-2000 Ci/mmol; Amersham, U. K., and the test compound in a buffer containing 50mM Trizma pre-set crystals (pH 7.4 @ 37°C), 120mM NaCl, 5mM KCI, 2mM CaCl2, 1 mM MgCl2, 0.3% (w/v) bovine serum albumin. The total volume is 0.2ml and incubated in a water bath at 37°C for 40 minutes.
  • the exemplified compounds have pKj values within the range of 6.6 - 8.5 at the dopamine D 2 receptor (for example between 6.6 - 8.2 or between 6.8 - 8.5).
  • the exemplified compounds have pKj values within the range of 7.2 - 8.5 at the serotonin 5- HT 6 receptor (for example between 7.2 - 8.5 or between 7.2 - 8.1 ).
  • Binding experiments on cloned 5-HT?A and 5-HT? ⁇ receptors Compounds can be tested following the procedures outlined in WO 94/04533.
  • the exemplified compounds have pKj values within the range of 6.6 - 8.2 at the serotonin 5- HT 2C receptor, (for example between 6.6 - 8.0 or between 7.0 - 8.2) and 7.3 - 9.2 at the serotonin 5-HT 2A receptor (for example between 7.3 - 9.2 or between 7.5 - 9.1 ).
  • the sulfonyl chloride D1 c was dissolved in acetonitrile (500 mL) and potassium fluoride (37 g, 625 mmol) and 18-crown-6 (1 crystal) added. The mixture was stirred for 18 hours, then quenched with cold aqueous sodium bicarbonate solution until the pH equalled 8. The mixture was extracted twice with ethyl acetate, washed with bicarbonate solution then brine, dried and evaporated to afford the sulfonyl fluoride D1 (25 g).
  • the sulfonyl fluoride D1 (25 g) was dissolved in dry tetrahydrofuran (250 mL) and 4- fluorophenylmagnesium bromide in tetrahydrofuran (2.5 equivalents) was added over 15 minutes with ice bath cooling, an exotherm only apparent during the first part of the addition.
  • the resulting solution was stirred overnight without cooling, then added over a 10 minute period to a solution of sodium potassium tartrate tetrahydrate (250 g) in water (450 mL) with stirring.
  • Diethyl ether was added (400 mL) and the organic layer separated, dried, evaporated, and crystallised from diethyl ether to give crystalline fluorophenyl sulfone D2 17 g (51%).
  • Examples 2-29 were prepared from the 4-fluorophenyl sulfone D2 and the appropriate amine using a procedure similar to Examples 1 and 30.
  • Example 30 Example 30.
  • Examples 31-35 were prepared from the 4-fluorophenyl sulfone D2 and the appropriate amine using a procedure similar to Example 30.

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Abstract

L'invention concerne des composés de formule (I), dans laquelle A et B représentent respectivement les groupes -(CH2)m- et -(CH2)n-, R1 représente l'hydrogène ou C1-6alkyle, R2 représente l'hydrogène, halogène, hydroxy, cyano, nitro, hydroxy, C1-6 alkyle, trifluorométhyle, trifluorométhoxy, C1-6alkyle, C1-6alkoxy, C1-6fluoroalkoxy, -(CH 2)pC3-6cycloalkyle, -(CH2)pOC3-6cycloalkyle, -COC1-6alkyle, -SO2C1-6alkyle, -SOC1-6alkyle, -S-C1-6alkyle, -CO2C1-6alkyle, -CO2NR5R6, -SO2NR5R6, -(CH2)pNR5R6, -(CH2)pNR5COR6, un anneau d'aryle facultativement substitué, un anneau d'hétéroaryle facultativement substitué ou un anneau d'hétérocyclyle facultativement substitué, R3 représente un anneau d'aryle facultativement substitué ou un anneau d'hétéroaryle facultativement substitué, R4 représente l'hydrogène, hydroxy, C1-6alkyle, C1-6alkoxy, trifluorométhyle, trifluoroméethoxy, halogène, -OSO2CF3, -(CH2)pC3-6cycloalkyle, -(CH2)qOC1-6alkyle ou -(CH2)pOC3-6cycloalkyle, X représente -CH- ou N, Z représente une liaison, -O-, -(CH2)r-, -CH2O-, -OCH2- ou C=O, R5 et R6 représentent respectivement et indépendamment l'hydrogène, C1-6alkyle ou, avec l'azote ou d'autres atomes auxquels ils sont attachés, ils forment un anneau d'azacycloalkyle ou un anneau d'azacycloalkyle substitué par oxo, R7 et R8 représentent l'hydrogène ou C1-6alkyle, ou R7 et R8 représentent ensemble -(CH2)s-, m et n représentent indépendamment un nombre entier sélectionné parmi 1 et 2, p représente indépendamment un nombre entier sélectionné parmi 0, 1, 2 et 3, q représente un nombre entier sélectionné parmi 1, 2 et 3, r représente un nombre entier sélectionné parmi 1, 2 et 3, s représente un nombre entier sélectionné parmi 2, 3 et 4 ou un sel acceptable pharmaceutiquement ou un solvate correspondant, à condition que lorsque X représente N, Z constitue une liaison -(CH2)r- ou C=O. Les composés de la formule (I) sont utilisés en thérapie, notamment, en tant qu'agents antipsychotiques.
PCT/EP2004/008965 2003-08-08 2004-08-05 Composes de phenylsulfonyle en tant qu'agents antipsychotiques WO2005014578A1 (fr)

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GB0318707A GB0318707D0 (en) 2003-08-08 2003-08-08 Novel compounds
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GB0318715A GB0318715D0 (en) 2003-08-08 2003-08-08 Novel compounds

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007040282A1 (fr) * 2005-10-06 2007-04-12 Nippon Soda Co., Ltd. Compose d'amine cyclique et agent pesticide
WO2008055847A1 (fr) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Arylsulfonyl pyrrolidines en tant qu'inhibiteurs de 5-ht6
USRE45364E1 (en) 2004-03-31 2015-02-03 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062205A1 (fr) * 2001-12-21 2003-07-31 Smithkline Beecham P.L.C. Derives de 7-sulfonyl-3-benzazepine utilises comme modulateurs du recepteur a la dopamine et utilisation de ces derniers dans le traitement des troubles du systeme nerveux central

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062205A1 (fr) * 2001-12-21 2003-07-31 Smithkline Beecham P.L.C. Derives de 7-sulfonyl-3-benzazepine utilises comme modulateurs du recepteur a la dopamine et utilisation de ces derniers dans le traitement des troubles du systeme nerveux central

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE45364E1 (en) 2004-03-31 2015-02-03 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
WO2007040282A1 (fr) * 2005-10-06 2007-04-12 Nippon Soda Co., Ltd. Compose d'amine cyclique et agent pesticide
EA014057B1 (ru) * 2005-10-06 2010-08-30 Ниппон Сода Ко., Лтд. Поперечно связанные соединения циклических аминов и средства для борьбы с вредителями
US7999102B2 (en) 2005-10-06 2011-08-16 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
US8338607B2 (en) 2005-10-06 2012-12-25 Nippon Soda Co., Ltd. Cyclic amine compounds and agents for pest control
US8536340B2 (en) 2005-10-06 2013-09-17 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
US8697867B2 (en) 2005-10-06 2014-04-15 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
WO2008055847A1 (fr) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Arylsulfonyl pyrrolidines en tant qu'inhibiteurs de 5-ht6
JP2010509266A (ja) * 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ６阻害剤としてのアリールスルホニルピロリジン

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