WO2005012227A3 - Procede de preparation de 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, un metabolite de la tolterodine - Google Patents

Procede de preparation de 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, un metabolite de la tolterodine Download PDF

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Publication number
WO2005012227A3
WO2005012227A3 PCT/IB2004/002511 IB2004002511W WO2005012227A3 WO 2005012227 A3 WO2005012227 A3 WO 2005012227A3 IB 2004002511 W IB2004002511 W IB 2004002511W WO 2005012227 A3 WO2005012227 A3 WO 2005012227A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolterodine
diisopropylamino
phenylpropyl
metabolite
hydroxymethyl
Prior art date
Application number
PCT/IB2004/002511
Other languages
English (en)
Other versions
WO2005012227A2 (fr
Inventor
Yatendra Kumar
Mohan Prasad
Kaushal Nayyar
Namita Sharma
Original Assignee
Ranbaxy Lab Ltd
Yatendra Kumar
Mohan Prasad
Kaushal Nayyar
Namita Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Yatendra Kumar, Mohan Prasad, Kaushal Nayyar, Namita Sharma filed Critical Ranbaxy Lab Ltd
Publication of WO2005012227A2 publication Critical patent/WO2005012227A2/fr
Publication of WO2005012227A3 publication Critical patent/WO2005012227A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention se rapporte à des procédés de préparation de 2-(3-diisopropylamino-1-phénylpropyl)-4-hydroxyméthyl-phénol répondant à la formule (I) et étant un métabolite de la toltérodine.
PCT/IB2004/002511 2003-08-05 2004-08-04 Procede de preparation de 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, un metabolite de la tolterodine WO2005012227A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN969DE2003 2003-08-05
IN969/DEL/2003 2003-08-05

Publications (2)

Publication Number Publication Date
WO2005012227A2 WO2005012227A2 (fr) 2005-02-10
WO2005012227A3 true WO2005012227A3 (fr) 2005-04-28

Family

ID=34113379

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002511 WO2005012227A2 (fr) 2003-08-05 2004-08-04 Procede de preparation de 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, un metabolite de la tolterodine

Country Status (1)

Country Link
WO (1) WO2005012227A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1999107A2 (fr) 2006-03-20 2008-12-10 Pfizer Limited Dérivés amine
BRPI0713314A2 (pt) * 2006-06-20 2012-03-06 Lek Pharmaceuticals D.D. Processo para a preparação de 3-(2-hidróxi-5-fenil substituído)-n-alquil-3-fenilpropilaminas
MX2011011937A (es) 2009-05-11 2012-01-27 Ratiopharm Gmbh Desfesoterodina en la forma de una sal del acido tartarico.
EP2364966A1 (fr) 2010-03-09 2011-09-14 LEK Pharmaceuticals d.d. Procédé pour la préparation de 3-(2-hydroxy-5-substitue phényl)-3-phénylpropylamines, intermédiaires pour la préparation de tolterodine
CN102329244A (zh) * 2010-07-13 2012-01-25 凯瑞斯德生化(苏州)有限公司 一种rs-托特罗定的制备方法及中间体化合物
WO2012025941A2 (fr) * 2010-08-25 2012-03-01 Cadila Healthcare Limited Procédés permettant la préparation de fésotérodine
EP2686288B1 (fr) 2011-04-07 2015-03-25 Alembic Pharmaceuticals Limited Procédé de préparation de fésotérodine
EP2800735B1 (fr) * 2012-01-07 2016-03-30 Alembic Pharmaceuticals Limited Procédé de préparation de fésotérodine
ITMI20121232A1 (it) 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
CN103044273B (zh) * 2012-11-29 2014-12-24 珠海保税区丽珠合成制药有限公司 一种酒石酸托特罗定的合成方法
WO2017137955A1 (fr) 2016-02-14 2017-08-17 Celestis Pharmaceuticals Pvt. Ltd. Nouveau (r) et 3-(2-(allyloxy)-5-méthylphényl)-n,n-diisopropyl-3- phénylpropan-1-amine racémique et son utilisation pour la synthèse de (r) et de 2-(3- (diisopropylamino)-1-phénylpropyl)-4-(hydroxyméthyl)phénol racémique
CN114213265A (zh) * 2021-12-22 2022-03-22 南京美瑞制药有限公司 一种制备托特罗定氧化杂质的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011337A1 (fr) * 1992-11-06 1994-05-26 Pharmacia Ab Nouvelles 3,3-diphenylpropylamines, leur utilisation et leur preparation
WO1998043942A1 (fr) * 1997-03-27 1998-10-08 Pharmacia & Upjohn Ab Nouveaux composes, leur utilisation et leur preparation
EP0957073A1 (fr) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Dérivés de 3,3-diphénylpropylamines
WO2001035957A1 (fr) * 1999-11-16 2001-05-25 Sanol Arznei Schwarz Gmbh Sels stables de nouveaux derives de 3,3-diphenylpropylamines
WO2001096279A1 (fr) * 2000-06-14 2001-12-20 Schwarz Pharma Ag Synthese raccourcie de derives de 3,3-diarylpropylamines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011337A1 (fr) * 1992-11-06 1994-05-26 Pharmacia Ab Nouvelles 3,3-diphenylpropylamines, leur utilisation et leur preparation
WO1998043942A1 (fr) * 1997-03-27 1998-10-08 Pharmacia & Upjohn Ab Nouveaux composes, leur utilisation et leur preparation
EP0957073A1 (fr) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Dérivés de 3,3-diphénylpropylamines
WO2001035957A1 (fr) * 1999-11-16 2001-05-25 Sanol Arznei Schwarz Gmbh Sels stables de nouveaux derives de 3,3-diphenylpropylamines
WO2001096279A1 (fr) * 2000-06-14 2001-12-20 Schwarz Pharma Ag Synthese raccourcie de derives de 3,3-diarylpropylamines

Also Published As

Publication number Publication date
WO2005012227A2 (fr) 2005-02-10

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