WO2005007817A3 - Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides - Google Patents

Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides Download PDF

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Publication number
WO2005007817A3
WO2005007817A3 PCT/US2004/021722 US2004021722W WO2005007817A3 WO 2005007817 A3 WO2005007817 A3 WO 2005007817A3 US 2004021722 W US2004021722 W US 2004021722W WO 2005007817 A3 WO2005007817 A3 WO 2005007817A3
Authority
WO
WIPO (PCT)
Prior art keywords
hexameric
herbicides
antibiotics
development
target
Prior art date
Application number
PCT/US2004/021722
Other languages
French (fr)
Other versions
WO2005007817A9 (en
WO2005007817A2 (en
Inventor
Eileen K Jaffe
Original Assignee
Fox Chase Cancer Ct
Eileen K Jaffe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2006518868A priority Critical patent/JP2007529995A/en
Priority to EP04786044A priority patent/EP1648429A4/en
Priority to AU2004257208A priority patent/AU2004257208B2/en
Priority to CA002531692A priority patent/CA2531692A1/en
Application filed by Fox Chase Cancer Ct, Eileen K Jaffe filed Critical Fox Chase Cancer Ct
Publication of WO2005007817A2 publication Critical patent/WO2005007817A2/en
Publication of WO2005007817A3 publication Critical patent/WO2005007817A3/en
Priority to US11/327,762 priority patent/US20060162014A1/en
Priority to IL173016A priority patent/IL173016A/en
Publication of WO2005007817A9 publication Critical patent/WO2005007817A9/en
Priority to US12/106,498 priority patent/US7863029B2/en
Priority to US12/142,435 priority patent/US8153410B2/en
Priority to US12/942,320 priority patent/US20110207816A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Compositions for inhibiting multimeric proteins porphobilinogen synthase and Class Ia ribonucleotide reductase, herbicide resistant plants adapted to be transgenic for multimeric porphobilinogen synthase and methods of use.
PCT/US2004/021722 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides WO2005007817A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2006518868A JP2007529995A (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for developing antibiotics and herbicides
EP04786044A EP1648429A4 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides
AU2004257208A AU2004257208B2 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides
CA002531692A CA2531692A1 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides
US11/327,762 US20060162014A1 (en) 2003-07-07 2006-01-06 Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
IL173016A IL173016A (en) 2003-07-07 2006-01-08 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides
US12/106,498 US7863029B2 (en) 2004-06-04 2008-04-21 Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
US12/142,435 US8153410B2 (en) 2003-07-07 2008-06-19 Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
US12/942,320 US20110207816A1 (en) 2003-07-07 2010-11-09 Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48525303P 2003-07-07 2003-07-07
US60/485,253 2003-07-07
US57731204P 2004-06-04 2004-06-04
US60/577,312 2004-06-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/327,762 Continuation-In-Part US20060162014A1 (en) 2003-07-07 2006-01-06 Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules

Publications (3)

Publication Number Publication Date
WO2005007817A2 WO2005007817A2 (en) 2005-01-27
WO2005007817A3 true WO2005007817A3 (en) 2005-11-03
WO2005007817A9 WO2005007817A9 (en) 2006-04-06

Family

ID=34083333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/021722 WO2005007817A2 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides

Country Status (6)

Country Link
EP (1) EP1648429A4 (en)
JP (1) JP2007529995A (en)
AU (1) AU2004257208B2 (en)
CA (1) CA2531692A1 (en)
IL (1) IL173016A (en)
WO (1) WO2005007817A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060162014A1 (en) * 2003-07-07 2006-07-20 Jaffe Eileen K Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
US8153410B2 (en) 2003-07-07 2012-04-10 Fox Chase Cancer Center Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140363A (en) * 1998-05-16 2000-10-31 Mogam Biotechnology Research Institute Use of rosmarinic acid and derivatives thereof as an immunosuppressant or an inhibitor of SH2-mediated processes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4112730B2 (en) * 1999-02-22 2008-07-02 オリザ油化株式会社 Antibacterial agent for oral cavity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140363A (en) * 1998-05-16 2000-10-31 Mogam Biotechnology Research Institute Use of rosmarinic acid and derivatives thereof as an immunosuppressant or an inhibitor of SH2-mediated processes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BREINIG S. ET AL.: "Control of tetrapyrrole biosynthesis by alternate quaternary forms of prophobilinogen synthase.", NATURE STRUCTURAL BIOLOGY., vol. 10, no. 9, September 2003 (2003-09-01), pages 757 - 763, XP002991515 *
ERSKINE P. ET AL.: "The X-ray Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with Substrate and Three Inhibitors.", JOURNAL OF MOLECULAR BIOLOGY., vol. 312, no. 1, 7 September 2001 (2001-09-07), pages 133 - 141, XP004466124 *
JAFFE E. ET AL.: "The porphobilnogen synthase family of metalloenzymes.", ACTA CRYSTALLOGRAPHICA, vol. 56, no. 2, February 2000 (2000-02-01), pages 115 - 128, XP002991516 *
KERVINEN J. ET AL.: "Mechanistic Basis for Suicide Inactivation of Porphobilinogen Synthase by 4,7-Dioxosebacic Acid, an Inhibitor That Shows Dramatic Species Selectivity.", BIOCHEMISTRY, vol. 40, no. 28, 2001, pages 8227 - 8236, XP002991518 *
KERVINEN J. ET AL.: "Prophobilniogen Synthase from Pea: Expression from an Artificial Gene Kinetic Characterzation and Novel Implications for Subtunit Interactions.", BIOCHEMISTRY, vol. 39, no. 30, 2000, pages 9018 - 1029, XP002991517 *
WANG Z. ET AL.: "Kinetic study on the dimer-tetramer interconversion of glycogen phosphorylase a.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 259, no. 3, 31 October 2000 (2000-10-31), pages 609 - 617, XP002991514 *

Also Published As

Publication number Publication date
AU2004257208A1 (en) 2005-01-27
IL173016A (en) 2012-03-29
CA2531692A1 (en) 2005-01-27
JP2007529995A (en) 2007-11-01
WO2005007817A2 (en) 2005-01-27
AU2004257208B2 (en) 2010-02-25
EP1648429A2 (en) 2006-04-26
EP1648429A4 (en) 2009-09-02
IL173016A0 (en) 2006-06-11

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