EP1648429A4 - Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides - Google Patents

Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides

Info

Publication number
EP1648429A4
EP1648429A4 EP04786044A EP04786044A EP1648429A4 EP 1648429 A4 EP1648429 A4 EP 1648429A4 EP 04786044 A EP04786044 A EP 04786044A EP 04786044 A EP04786044 A EP 04786044A EP 1648429 A4 EP1648429 A4 EP 1648429A4
Authority
EP
European Patent Office
Prior art keywords
hexameric
herbicides
antibiotics
development
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP04786044A
Other languages
German (de)
French (fr)
Other versions
EP1648429A2 (en
Inventor
Eileen K Jaffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fox Chase Cancer Center filed Critical Fox Chase Cancer Center
Publication of EP1648429A2 publication Critical patent/EP1648429A2/en
Publication of EP1648429A4 publication Critical patent/EP1648429A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP04786044A 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides Ceased EP1648429A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48525303P 2003-07-07 2003-07-07
US57731204P 2004-06-04 2004-06-04
PCT/US2004/021722 WO2005007817A2 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides

Publications (2)

Publication Number Publication Date
EP1648429A2 EP1648429A2 (en) 2006-04-26
EP1648429A4 true EP1648429A4 (en) 2009-09-02

Family

ID=34083333

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04786044A Ceased EP1648429A4 (en) 2003-07-07 2004-07-07 Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides

Country Status (6)

Country Link
EP (1) EP1648429A4 (en)
JP (1) JP2007529995A (en)
AU (1) AU2004257208B2 (en)
CA (1) CA2531692A1 (en)
IL (1) IL173016A (en)
WO (1) WO2005007817A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153410B2 (en) 2003-07-07 2012-04-10 Fox Chase Cancer Center Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
US20060162014A1 (en) 2003-07-07 2006-07-20 Jaffe Eileen K Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059606A1 (en) * 1998-05-16 1999-11-25 Mogam Biotechnology Research Institute Use of rosmarinic acid and derivatives thereof as an immunosuppressant or an inhibitor of sh2-mediated process
JP4112730B2 (en) * 1999-02-22 2008-07-02 オリザ油化株式会社 Antibacterial agent for oral cavity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JAFFE EILEEN K ET AL: "Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 22, 31 May 2002 (2002-05-31), pages 19792 - 19799, XP002536531, ISSN: 0021-9258 *
JAFFE EILEEN K: "Investigations on the metal switch region of human porphobilinogen synthase.", JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY : JBIC : A PUBLICATION OF THE SOCIETY OF BIOLOGICAL INORGANIC CHEMISTRY JAN 2003, vol. 8, no. 1-2, January 2003 (2003-01-01), pages 176 - 184, XP002536529, ISSN: 0949-8257 *
KASHLAN OSSAMA B ET AL: "Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: Refinements and consequences.", BIOCHEMISTRY, vol. 42, no. 6, 18 February 2003 (2003-02-18), pages 1696 - 1706, XP002536530, ISSN: 0006-2960 *
KUNDRAT LENKA ET AL: "A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 33, 6 June 2003 (2003-06-06), pages 31325 - 31330, XP002536528, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1648429A2 (en) 2006-04-26
AU2004257208A1 (en) 2005-01-27
JP2007529995A (en) 2007-11-01
CA2531692A1 (en) 2005-01-27
IL173016A (en) 2012-03-29
IL173016A0 (en) 2006-06-11
WO2005007817A3 (en) 2005-11-03
WO2005007817A2 (en) 2005-01-27
AU2004257208B2 (en) 2010-02-25

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