WO2005000291A8 - Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives - Google Patents

Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives

Info

Publication number
WO2005000291A8
WO2005000291A8 PCT/US2004/020347 US2004020347W WO2005000291A8 WO 2005000291 A8 WO2005000291 A8 WO 2005000291A8 US 2004020347 W US2004020347 W US 2004020347W WO 2005000291 A8 WO2005000291 A8 WO 2005000291A8
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
pulmonary fibrosis
idiopathic pulmonary
triptolide derivatives
triptolide
Prior art date
Application number
PCT/US2004/020347
Other languages
French (fr)
Other versions
WO2005000291A1 (en
Inventor
John M Fidler
John H Musser
Original Assignee
Pharmagenesis Inc
John M Fidler
John H Musser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagenesis Inc, John M Fidler, John H Musser filed Critical Pharmagenesis Inc
Publication of WO2005000291A1 publication Critical patent/WO2005000291A1/en
Publication of WO2005000291A8 publication Critical patent/WO2005000291A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The use of immunosuppressive triptolide derivatives for the treatment of idiopathic pulmonary fibrosis (IPF) is described.
PCT/US2004/020347 2003-06-27 2004-06-25 Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives WO2005000291A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48333503P 2003-06-27 2003-06-27
US60/483,335 2003-06-27

Publications (2)

Publication Number Publication Date
WO2005000291A1 WO2005000291A1 (en) 2005-01-06
WO2005000291A8 true WO2005000291A8 (en) 2006-01-19

Family

ID=33552053

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/020447 WO2005020887A2 (en) 2003-06-27 2004-06-25 Method for treatment of severe acute respiratory syndrome
PCT/US2004/020347 WO2005000291A1 (en) 2003-06-27 2004-06-25 Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020447 WO2005020887A2 (en) 2003-06-27 2004-06-25 Method for treatment of severe acute respiratory syndrome

Country Status (1)

Country Link
WO (2) WO2005020887A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4680589B2 (en) 2002-05-31 2011-05-11 ファーマジェネシス， インコーポレイテッド Triptolide derivatives for the regulation of apoptosis and immunosuppression
US6943259B2 (en) 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
WO2005077008A2 (en) 2004-02-09 2005-08-25 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from tripterygium wilfordii
ATE554758T1 (en) 2004-03-02 2012-05-15 Pharmagenesis Inc TRIPTOLIDE-LACTONE RING DERIVATIVES AS IMMUNE MODULATORS AND ANTI-CANCER AGENT
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP2393818A4 (en) 2009-02-05 2013-09-04 Pharmagenesis Inc Triptolide c-ring derivatives as anticancer agents and immune modulators
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
WO2010129918A1 (en) 2009-05-07 2010-11-11 Regents Of The University Of Minnesota Triptolide prodrugs
CN107663225A (en) * 2016-07-29 2018-02-06 欣凯医药化工中间体（上海）有限公司 A kind of fluoro triptolide lactone ring derivatives
WO2018222351A1 (en) * 2017-05-27 2018-12-06 Pharmagenesis, Inc. Triptolide lactone derivatives as immunomodulators and anticancer agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150539A (en) * 1998-09-02 2000-11-21 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility

Also Published As

Publication number Publication date
WO2005000291A1 (en) 2005-01-06
WO2005020887A3 (en) 2005-04-28
WO2005020887A2 (en) 2005-03-10

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Free format text: IN PCT GAZETTE 01/2005 UNDER (22) REPLACE "28 JUNE 2004 (28.06.2004)" BY "25 JUNE 2004 (25.06.2004)"

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