WO2004111240A3 - Sequence for the bacillomycin d synthesis in bacillus amyloliquefaciens fzb42 - Google Patents

Sequence for the bacillomycin d synthesis in bacillus amyloliquefaciens fzb42 Download PDF

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Publication number
WO2004111240A3
WO2004111240A3 PCT/DE2004/001249 DE2004001249W WO2004111240A3 WO 2004111240 A3 WO2004111240 A3 WO 2004111240A3 DE 2004001249 W DE2004001249 W DE 2004001249W WO 2004111240 A3 WO2004111240 A3 WO 2004111240A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacillomycin
synthesis
sequence
bacillus amyloliquefaciens
amyloliquefaciens fzb42
Prior art date
Application number
PCT/DE2004/001249
Other languages
German (de)
French (fr)
Other versions
WO2004111240A2 (en
Inventor
Rainer Borriss
Alexandra Koumoutsi
Joachim Vater
Helmut Junge
Birgit Krebs
Original Assignee
Rainer Borriss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rainer Borriss filed Critical Rainer Borriss
Priority to DE112004001054.3T priority Critical patent/DE112004001054B4/en
Publication of WO2004111240A2 publication Critical patent/WO2004111240A2/en
Publication of WO2004111240A3 publication Critical patent/WO2004111240A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Dentistry (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the DNA and amino acid sequences for the Bacillomycin D-Operons and the use of the sequences for the biosynthesis of antibiotically effective lipopeptides and methods for the production thereof. The above is of application in medicine, biotechnology, agriculture and the pharmaceutical industry.
PCT/DE2004/001249 2003-06-12 2004-06-14 Sequence for the bacillomycin d synthesis in bacillus amyloliquefaciens fzb42 WO2004111240A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112004001054.3T DE112004001054B4 (en) 2003-06-12 2004-06-14 Sequence for BacillomycinD synthesis in Bacillus amyloliquefaciens FZB42

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10326394.2 2003-06-12
DE10326394 2003-06-12

Publications (2)

Publication Number Publication Date
WO2004111240A2 WO2004111240A2 (en) 2004-12-23
WO2004111240A3 true WO2004111240A3 (en) 2005-05-12

Family

ID=33546544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001249 WO2004111240A2 (en) 2003-06-12 2004-06-14 Sequence for the bacillomycin d synthesis in bacillus amyloliquefaciens fzb42

Country Status (2)

Country Link
DE (1) DE112004001054B4 (en)
WO (1) WO2004111240A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011015803A1 (en) 2011-04-01 2012-10-04 Abitep Gmbh Agent for the treatment of microbial diseases in crop plants
KR101291915B1 (en) 2011-07-06 2013-08-07 고려대학교 산학협력단 Bacillus amyloliquefaciens GYL4 effective against plant pathogenic fungi and method for preparing antibiotics using the same
CN104023533B (en) 2011-12-22 2016-06-15 Sds生物技术株式会社 Plant disease controlling agent
CN110452863B (en) * 2019-07-27 2021-08-27 湖北大学 Application of ornithine cyclohexane enzyme in improving yield of iturin A produced by bacillus amyloliquefaciens
GB201911925D0 (en) * 2019-08-20 2019-10-02 Sporegen Ltd Formulations for prevention or reduction of c. difficile infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19641213B4 (en) * 1996-09-26 2006-02-16 Peter Dr. Bendzko Cyclic peptides, process for their preparation and their use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOUMOUTSI ALEXANDRA ET AL: "Structural and functional characterization of gene clusters directing nonribosomal synthesis of bioactive cyclic lipopeptides in Bacillus amyloliquefaciens strain FZB42.", JOURNAL OF BACTERIOLOGY, vol. 186, no. 4, February 2004 (2004-02-01), pages 1084 - 1096, XP002301555, ISSN: 0021-9193 *
MOYNE ANNE-LAURE ET AL: "Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D", FEMS MICROBIOLOGY LETTERS, vol. 234, no. 1, 1 May 2004 (2004-05-01), pages 43 - 49, XP002301557, ISSN: 0378-1097 *
STELLER S ET AL: "Purification of the fengycin synthetase multienzyme system from Bacillus subtilis b213", JOURNAL OF CHROMATOGRAPHY. BIOMEDICAL APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 737, no. 1-2, January 2000 (2000-01-01), pages 267 - 275, XP004184276, ISSN: 0378-4347 *
TSUGE KENJI ET AL: "Cloning, sequencing, and characterization of the iturin A operon", JOURNAL OF BACTERIOLOGY, vol. 183, no. 21, November 2001 (2001-11-01), pages 6265 - 6273, XP002301556, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
DE112004001054D2 (en) 2006-03-02
WO2004111240A2 (en) 2004-12-23
DE112004001054B4 (en) 2018-06-14

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