WO2004111011A3 - Synthese d'amides d'acide 2-aryl pyrimidine 4-carboxylique - Google Patents

Synthese d'amides d'acide 2-aryl pyrimidine 4-carboxylique Download PDF

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Publication number
WO2004111011A3
WO2004111011A3 PCT/US2004/016859 US2004016859W WO2004111011A3 WO 2004111011 A3 WO2004111011 A3 WO 2004111011A3 US 2004016859 W US2004016859 W US 2004016859W WO 2004111011 A3 WO2004111011 A3 WO 2004111011A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid amides
aryl
synthesis
aryl pyrimidine
Prior art date
Application number
PCT/US2004/016859
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English (en)
Other versions
WO2004111011A2 (fr
Inventor
Jeffrey M Marra
R Richard Goehring
Julio Perez
Linas R Stasaitis
Yanbing Liu
Original Assignee
Euro Celtique Sa
Jeffrey M Marra
R Richard Goehring
Julio Perez
Linas R Stasaitis
Yanbing Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa, Jeffrey M Marra, R Richard Goehring, Julio Perez, Linas R Stasaitis, Yanbing Liu filed Critical Euro Celtique Sa
Publication of WO2004111011A2 publication Critical patent/WO2004111011A2/fr
Publication of WO2004111011A3 publication Critical patent/WO2004111011A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé pour préparer des amides d'acide 2-aryl pyrimidine 4-carboxylique comprenant la mise en réaction de l'aryle carboxamidine avec un amide 2-oxo-3-butényle substitué en position 4. L'invention concerne également un procédé pour préparer des amides d'acide 2-aryle pyrimidine 4-carboxylique comprenant la mise en réaction de l'aryle carboxamidine avec un ester de 2-oxo-3-butényle substitué en position 4 et la conversion de l'ester ainsi obtenu en un amide. L'invention concerne, de plus, un procédé pour préparer des esters 2 oxo-3 buténoïques substitués en position 4.
PCT/US2004/016859 2003-05-30 2004-05-28 Synthese d'amides d'acide 2-aryl pyrimidine 4-carboxylique WO2004111011A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47422103P 2003-05-30 2003-05-30
US60/474,221 2003-05-30

Publications (2)

Publication Number Publication Date
WO2004111011A2 WO2004111011A2 (fr) 2004-12-23
WO2004111011A3 true WO2004111011A3 (fr) 2005-03-24

Family

ID=33551484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/016859 WO2004111011A2 (fr) 2003-05-30 2004-05-28 Synthese d'amides d'acide 2-aryl pyrimidine 4-carboxylique

Country Status (1)

Country Link
WO (1) WO2004111011A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675215A (zh) * 2012-05-17 2012-09-19 盛世泰科生物医药技术(苏州)有限公司 一种2-甲基嘧啶-4-羧酸乙酯的合成方法
EP2968307A4 (fr) 2013-03-15 2017-01-04 Purdue Pharma LP Dérivés de carboxamide et leur utilisation
US9884865B2 (en) 2013-08-26 2018-02-06 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
CN110615751B (zh) * 2018-06-19 2021-08-17 上海医药工业研究院 一种2-氧代硫代丙酰胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764598A (en) * 1969-09-24 1973-10-09 Takeda Chemical Industries Ltd Pyrimidopyridazine derivatives
WO2001068612A2 (fr) * 2000-03-10 2001-09-20 Euro-Celtique S.A. Pyridines, pyrimidines, pyrazines et triazines substituees par aryle et leur utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764598A (en) * 1969-09-24 1973-10-09 Takeda Chemical Industries Ltd Pyrimidopyridazine derivatives
WO2001068612A2 (fr) * 2000-03-10 2001-09-20 Euro-Celtique S.A. Pyridines, pyrimidines, pyrazines et triazines substituees par aryle et leur utilisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002304000 *
F.KUNCKELL UND .ZUMBUSCH: "Über die Einwirkung von Mucobrom- und Mucochlor-Saüre auf Benzamidin", CHEM.BER., vol. 35, 1902, pages 3164 - 3168, XP008038054 *
T.A.RILEY, W.J.HENNEN, N.K:DALLEY AND B.E.WILSON: "Synthesis of 2-(beta-ribofuranosyl)pyrimidines, a new class of C-nucleosides", J. HETEROCYCLIC CHEM., vol. 24, 1987, pages 955 - 964, XP002303985 *
TIETZE, LUTZ-F.; MEIER, HEINRICH; VOSS, EDGAR, SYNTHESIS, vol. 4, 1988, pages 274 - 277 *

Also Published As

Publication number Publication date
WO2004111011A2 (fr) 2004-12-23

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