WO2004108884A3 - Composite materials and particles - Google Patents

Composite materials and particles Download PDF

Info

Publication number
WO2004108884A3
WO2004108884A3 PCT/SE2004/000917 SE2004000917W WO2004108884A3 WO 2004108884 A3 WO2004108884 A3 WO 2004108884A3 SE 2004000917 W SE2004000917 W SE 2004000917W WO 2004108884 A3 WO2004108884 A3 WO 2004108884A3
Authority
WO
WIPO (PCT)
Prior art keywords
mixture
solvent
amphifilic
composite material
polymer
Prior art date
Application number
PCT/SE2004/000917
Other languages
French (fr)
Other versions
WO2004108884A2 (en
Inventor
Anna Imberg
Original Assignee
Anna Imberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anna Imberg filed Critical Anna Imberg
Publication of WO2004108884A2 publication Critical patent/WO2004108884A2/en
Publication of WO2004108884A3 publication Critical patent/WO2004108884A3/en
Priority to US11/336,819 priority Critical patent/US20060188573A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention is a method of making a composite material (from a route given by the phase behavior of a suitable chemical system that is described in a phase diagram), which comprises at least one amphifilic component and at least one polymer component. It comprises providing a mixture of at least one polymer and at least one amphifilic compound in a volatile solvent or solvent mixture as well as providing a phase diagram of the chemical system that describes how the components of the chemical system interact in thermodynamic stable phases as a function temperature, concentration and pressure. The polymer should be a homopolymer, a random block copolymer or a mixture thereof, preferably biodegradable. The amphifilic compound has the ability to form a bilayer-containing phase. The solvent is removed from the mixture by a process selected from the phase diagram in dependence of the final composite material to be achieved, whereby a material is formed, such as liquid extraction against a second solvent, or by spraying. It also relates to the composite material, in particular particles, solid implants, semi-solid, gel-like matrices, useful for applications such as encapsulation of therapeutically active components or surface coating.
PCT/SE2004/000917 2003-06-10 2004-06-10 Composite materials and particles WO2004108884A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/336,819 US20060188573A1 (en) 2003-06-10 2006-01-23 Composite materials and particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0301722-5 2003-06-10
SE0301722A SE527505C2 (en) 2003-06-10 2003-06-10 Composite materials and particles

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10560165 A-371-Of-International 2004-06-10
US11/336,819 Continuation-In-Part US20060188573A1 (en) 2003-06-10 2006-01-23 Composite materials and particles

Publications (2)

Publication Number Publication Date
WO2004108884A2 WO2004108884A2 (en) 2004-12-16
WO2004108884A3 true WO2004108884A3 (en) 2005-02-17

Family

ID=29212456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2004/000917 WO2004108884A2 (en) 2003-06-10 2004-06-10 Composite materials and particles

Country Status (2)

Country Link
SE (1) SE527505C2 (en)
WO (1) WO2004108884A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9724304B2 (en) * 2012-06-14 2017-08-08 Temple University—Of the Commonwealth System of Higher Education Nanospheres for therapeutic agent delivery

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006921A1 (en) * 1991-10-04 1993-04-15 Gs Biochem Ab Particles, method of preparing said particles and uses thereof
WO2000056282A1 (en) * 1999-03-24 2000-09-28 The Secretary Of State For Defence Particle based vaccine composition
US6153217A (en) * 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6277413B1 (en) * 1998-07-17 2001-08-21 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
JP3231087B2 (en) * 1992-07-09 2001-11-19 大日本印刷株式会社 Manufacturing method of liquid crystal optical element, microencapsulated liquid crystal and manufacturing method thereof
WO2002002716A2 (en) * 2000-06-29 2002-01-10 The Procter & Gamble Company Cubic liquid crystalline compositions and methods for their preparation
WO2002003961A1 (en) * 2000-07-07 2002-01-17 Corixa Corporation Microspheres and adjuvants for dna vaccine delivery
US20020158226A1 (en) * 2001-02-21 2002-10-31 Lynch Matthew Lawrence Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
WO2002098951A2 (en) * 2001-06-01 2002-12-12 Yamanouchi Europe B.V. Lipid-polymer-conjugates
WO2003043605A1 (en) * 2001-11-21 2003-05-30 Institut National De La Sante Et De La Recherche Medicale Method for preparing microparticles free of toxic solvent, resulting microparticles and pharmaceutical compositions

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006921A1 (en) * 1991-10-04 1993-04-15 Gs Biochem Ab Particles, method of preparing said particles and uses thereof
JP3231087B2 (en) * 1992-07-09 2001-11-19 大日本印刷株式会社 Manufacturing method of liquid crystal optical element, microencapsulated liquid crystal and manufacturing method thereof
US6277413B1 (en) * 1998-07-17 2001-08-21 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US6153217A (en) * 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
WO2000056282A1 (en) * 1999-03-24 2000-09-28 The Secretary Of State For Defence Particle based vaccine composition
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
WO2002002716A2 (en) * 2000-06-29 2002-01-10 The Procter & Gamble Company Cubic liquid crystalline compositions and methods for their preparation
WO2002003961A1 (en) * 2000-07-07 2002-01-17 Corixa Corporation Microspheres and adjuvants for dna vaccine delivery
US20020158226A1 (en) * 2001-02-21 2002-10-31 Lynch Matthew Lawrence Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
WO2002098951A2 (en) * 2001-06-01 2002-12-12 Yamanouchi Europe B.V. Lipid-polymer-conjugates
WO2003043605A1 (en) * 2001-11-21 2003-05-30 Institut National De La Sante Et De La Recherche Medicale Method for preparing microparticles free of toxic solvent, resulting microparticles and pharmaceutical compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARTUCCI R. ET AL.: "Electron paramagnetic resonance investigation of biological systems", RECENT RES. DEVEL. BIOPHYS. CHEM., vol. 2, 2001, pages 85 - 101, XP002981486 *
DATABASE WPI Week 200176, Derwent World Patents Index; Class A85, AN 1994-153896, XP002981482 *
JOHANSSON A.K. ET AL.: "Phase behavior of the quaternary poly(DL-lactide-co-glycolide)/monoolein/1-methyl-2-pyrrolidinone/water system: An experimental and theoretical study", J. PHYS. CHEM. B., vol. 105, 2001, pages 12157 - 12164, XP002981484 *
SIEKMANN B. ET AL.: "Preparation and structural investigations of colloidal dispersions prepared from cubic monoglyceride-water phases", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 244, 2002, pages 33 - 43, XP002981485 *
SPICER P.T. ET AL.: "Novel process for producing cubic liquid crystalline nanoparticles (cubosomes)", LANGMUIR, vol. 17, 2001, pages 5748 - 5756, XP002981483 *

Also Published As

Publication number Publication date
SE0301722D0 (en) 2003-06-10
SE0301722L (en) 2005-02-11
SE527505C2 (en) 2006-03-28
WO2004108884A2 (en) 2004-12-16

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