WO2003028698A3 - Method and device for producing granulates that comprise at least one pharmaceutical active substance - Google Patents

Method and device for producing granulates that comprise at least one pharmaceutical active substance Download PDF

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Publication number
WO2003028698A3
WO2003028698A3 PCT/EP2002/010743 EP0210743W WO03028698A3 WO 2003028698 A3 WO2003028698 A3 WO 2003028698A3 EP 0210743 W EP0210743 W EP 0210743W WO 03028698 A3 WO03028698 A3 WO 03028698A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substance
pharmaceutical active
producing granulates
granulated material
granulates
Prior art date
Application number
PCT/EP2002/010743
Other languages
German (de)
French (fr)
Other versions
WO2003028698A2 (en
Inventor
Klaus-Juergen Steffens
Rudolf Schroeder
Original Assignee
Klaus-Juergen Steffens
Rudolf Schroeder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klaus-Juergen Steffens, Rudolf Schroeder filed Critical Klaus-Juergen Steffens
Priority to AU2002342755A priority Critical patent/AU2002342755A1/en
Priority to EP02779415A priority patent/EP1429735A2/en
Publication of WO2003028698A2 publication Critical patent/WO2003028698A2/en
Publication of WO2003028698A3 publication Critical patent/WO2003028698A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

The invention relates to a method for producing granulates that comprise at least one pharmaceutical active substance according to which the powder to be granulated is introduced into an extruder. A granulated material is formed by adding granulating liquid and is compacted by transverse forces. A gas or a gas mixture can be optionally introduced into the compacted granulated material in order to render the granulated material porous.
PCT/EP2002/010743 2001-09-26 2002-09-25 Method and device for producing granulates that comprise at least one pharmaceutical active substance WO2003028698A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002342755A AU2002342755A1 (en) 2001-09-26 2002-09-25 Method and device for producing granulates that comprise at least one pharmaceutical active substance
EP02779415A EP1429735A2 (en) 2001-09-26 2002-09-25 Method and device for producing granulates that comprise at least one pharmaceutical active substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10147414.8 2001-09-26
DE10147414 2001-09-26

Publications (2)

Publication Number Publication Date
WO2003028698A2 WO2003028698A2 (en) 2003-04-10
WO2003028698A3 true WO2003028698A3 (en) 2003-10-23

Family

ID=7700318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010743 WO2003028698A2 (en) 2001-09-26 2002-09-25 Method and device for producing granulates that comprise at least one pharmaceutical active substance

Country Status (3)

Country Link
EP (1) EP1429735A2 (en)
AU (1) AU2002342755A1 (en)
WO (1) WO2003028698A2 (en)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
US8834925B2 (en) 2006-08-25 2014-09-16 Purdue Pharma L.P. Tamper resistant dosage forms
US9161917B2 (en) 2008-05-09 2015-10-20 Grünenthal GmbH Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US9913814B2 (en) 2014-05-12 2018-03-13 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
US11844865B2 (en) 2004-07-01 2023-12-19 Grünenthal GmbH Abuse-proofed oral dosage form

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032051A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Process for the preparation of a secured against misuse, solid dosage form
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
EP1663163A2 (en) * 2003-09-10 2006-06-07 Janssen Pharmaceutica N.V. Particles shaped as platelets
DE102005005449A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
KR101616246B1 (en) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 Pharmaceutical dosage form
MX2012000317A (en) 2009-07-22 2012-02-08 Gruenenthal Gmbh Hot-melt extruded controlled release dosage form.
RU2015138422A (en) 2009-07-22 2018-12-25 Грюненталь Гмбх STABLE DURING OXIDATION, STRONG-BREAKED DOSAGE FORM
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
ES2487244T3 (en) 2010-09-02 2014-08-20 Grünenthal GmbH Handling resistant dosage form comprising an anionic polymer
AU2012292418B2 (en) 2011-07-29 2017-02-16 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
MX356421B (en) 2012-02-28 2018-05-29 Gruenenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer.
CN104394851B (en) 2012-04-18 2017-12-01 格吕伦塔尔有限公司 Anti-distort and anti-agent amount are come down in torrents pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096438A1 (en) 2013-05-29 2015-12-30 Gruenenthal Gmbh DOSAGE FORM RESISTANT TO INDEBITED USE WITH BIMODAL RELEASE PROFILE, PROCESS
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
BR112016000194A8 (en) 2013-07-12 2019-12-31 Gruenenthal Gmbh tamper-resistant dosage form containing ethylene vinyl acetate polymer
CN105934241B (en) 2013-11-26 2020-06-05 格吕伦塔尔有限公司 Preparation of powdered pharmaceutical composition by cryogenic grinding
JP2017516789A (en) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Multiparticulates protected against ethanol overdose
EP3285745A1 (en) 2015-04-24 2018-02-28 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
EP3445337B1 (en) * 2016-04-22 2021-03-24 University Of Mississippi Twin-screw dry granulation for producing solid formulations
DE102016218135A1 (en) * 2016-09-21 2018-03-22 Robert Bosch Gmbh Production module for the production of solid dosage forms

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1629423A1 (en) * 1966-04-02 1971-01-14 Gruenzweig & Hartmann Process for the production of synthetic resin foams and use of a pipe produced by this process
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
JPH07184550A (en) * 1993-12-24 1995-07-25 Lotte Co Ltd Production of chewing gum having reduced specific gravity
US5496865A (en) * 1993-12-08 1996-03-05 Brugg Kabel Ag Additive-charged porous carrier material

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19918325A1 (en) * 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1629423A1 (en) * 1966-04-02 1971-01-14 Gruenzweig & Hartmann Process for the production of synthetic resin foams and use of a pipe produced by this process
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
US5496865A (en) * 1993-12-08 1996-03-05 Brugg Kabel Ag Additive-charged porous carrier material
JPH07184550A (en) * 1993-12-24 1995-07-25 Lotte Co Ltd Production of chewing gum having reduced specific gravity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 10 30 November 1995 (1995-11-30) *
SCHROEDER R ET AL: "A new system for continuous wet granulation", PHARMAZEUTISCHE INDUSTRIE 2002 GERMANY, vol. 64, no. 3, 2002, pages 283 - 288, XP009012069, ISSN: 0031-711X *
See also references of EP1429735A2 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844865B2 (en) 2004-07-01 2023-12-19 Grünenthal GmbH Abuse-proofed oral dosage form
US8834925B2 (en) 2006-08-25 2014-09-16 Purdue Pharma L.P. Tamper resistant dosage forms
US8846086B2 (en) 2006-08-25 2014-09-30 Purdue Pharma L.P. Tamper resistant dosage forms
US8894987B2 (en) 2006-08-25 2014-11-25 William H. McKenna Tamper resistant dosage forms
US8894988B2 (en) 2006-08-25 2014-11-25 Purdue Pharma L.P. Tamper resistant dosage forms
US8911719B2 (en) 2006-08-25 2014-12-16 Purdue Pharma Lp Tamper resistant dosage forms
US9084816B2 (en) 2006-08-25 2015-07-21 Purdue Pharma L.P. Tamper resistant dosage forms
US9095614B2 (en) 2006-08-25 2015-08-04 Purdue Pharma L.P. Tamper resistant dosage forms
US9095615B2 (en) 2006-08-25 2015-08-04 Purdue Pharma L.P. Tamper resistant dosage forms
US9101661B2 (en) 2006-08-25 2015-08-11 Purdue Pharma L.P. Tamper resistant dosage forms
US9161917B2 (en) 2008-05-09 2015-10-20 Grünenthal GmbH Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US9913814B2 (en) 2014-05-12 2018-03-13 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol

Also Published As

Publication number Publication date
WO2003028698A2 (en) 2003-04-10
AU2002342755A1 (en) 2003-04-14
EP1429735A2 (en) 2004-06-23

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