WO2004108749A3 - Binding peptides: methods for their generation and use - Google Patents

Binding peptides: methods for their generation and use Download PDF

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Publication number
WO2004108749A3
WO2004108749A3 PCT/NL2004/000407 NL2004000407W WO2004108749A3 WO 2004108749 A3 WO2004108749 A3 WO 2004108749A3 NL 2004000407 W NL2004000407 W NL 2004000407W WO 2004108749 A3 WO2004108749 A3 WO 2004108749A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
binding molecules
generation
binding peptides
designed
Prior art date
Application number
PCT/NL2004/000407
Other languages
French (fr)
Other versions
WO2004108749A2 (en
Inventor
Erwin Houtzager
Wietse Willebrands
Roo Guy De
Keesjan Francoijs
Irma Maria Caecilia Vijn
Original Assignee
Catchmabs B V
Erwin Houtzager
Wietse Willebrands
Roo Guy De
Keesjan Francoijs
Irma Maria Caecilia Vijn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catchmabs B V, Erwin Houtzager, Wietse Willebrands, Roo Guy De, Keesjan Francoijs, Irma Maria Caecilia Vijn filed Critical Catchmabs B V
Priority to CA002529001A priority Critical patent/CA2529001A1/en
Priority to AU2004245429A priority patent/AU2004245429A1/en
Priority to EP04748639A priority patent/EP1634076A2/en
Publication of WO2004108749A2 publication Critical patent/WO2004108749A2/en
Publication of WO2004108749A3 publication Critical patent/WO2004108749A3/en
Priority to US11/299,288 priority patent/US20060177437A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided are means, methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
PCT/NL2004/000407 2003-06-10 2004-06-09 Binding peptides: methods for their generation and use WO2004108749A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002529001A CA2529001A1 (en) 2003-06-10 2004-06-09 Binding peptides: methods for their generation and use
AU2004245429A AU2004245429A1 (en) 2003-06-10 2004-06-09 Binding peptides: methods for their generation and use
EP04748639A EP1634076A2 (en) 2003-06-10 2004-06-09 Binding peptides: methods for their generation and use
US11/299,288 US20060177437A1 (en) 2003-06-10 2005-12-09 Binding peptides: methods for their generation and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03076792 2003-06-10
EP03076792.5 2003-06-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/299,288 Continuation US20060177437A1 (en) 2003-06-10 2005-12-09 Binding peptides: methods for their generation and use

Publications (2)

Publication Number Publication Date
WO2004108749A2 WO2004108749A2 (en) 2004-12-16
WO2004108749A3 true WO2004108749A3 (en) 2005-02-24

Family

ID=33495614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2004/000407 WO2004108749A2 (en) 2003-06-10 2004-06-09 Binding peptides: methods for their generation and use

Country Status (5)

Country Link
US (1) US20060177437A1 (en)
EP (1) EP1634076A2 (en)
AU (1) AU2004245429A1 (en)
CA (1) CA2529001A1 (en)
WO (1) WO2004108749A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037427A1 (en) * 2001-12-10 2005-02-17 Erwin Houtzager Structure for presenting desired peptide sequences
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
DK2314629T4 (en) 2002-07-18 2023-02-06 Merus Nv RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
ES2408582T3 (en) 2003-05-30 2013-06-21 Merus B.V. Fab library for the preparation of a mixture of antibodies
EP1746103A1 (en) 2005-07-20 2007-01-24 Applied NanoSystems B.V. Bifunctional protein anchors
JP2010533004A (en) 2007-07-13 2010-10-21 バク アイピー ベスローテン フェンノートシャップ Single domain antigen binding protein that binds to mammalian IgG
CN103459427B (en) 2011-02-01 2018-03-30 Bac Ip私人有限公司 For the antigen-binding proteins of epitope in the CH1 domains of human IgG antibody
JOP20200312A1 (en) 2015-06-26 2017-06-16 Novartis Ag Factor xi antibodies and methods of use
TW201802121A (en) 2016-05-25 2018-01-16 諾華公司 Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof
US11168147B2 (en) 2016-12-23 2021-11-09 Novartis Ag Factor XI antibodies and methods of use
EP3765495A1 (en) 2018-03-13 2021-01-20 Smivet B.V. Single domain antibodies binding to tetanus neurotoxin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998222A (en) * 1993-11-29 1999-12-07 Utah State University Reconditioning antibiotic-adulterated milk products
WO2000023580A1 (en) * 1998-10-21 2000-04-27 Affibody Technology Sweden Ab A method of affinity separation and ligands for use therein
US6194552B1 (en) * 1990-11-16 2001-02-27 Center For Innovative Technology Immunosorbents with developed binding efficiency and method of manufacture
EP1318195A1 (en) * 2001-12-10 2003-06-11 CatchMabs B.V. A structure for presenting desired peptide sequences

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194552B1 (en) * 1990-11-16 2001-02-27 Center For Innovative Technology Immunosorbents with developed binding efficiency and method of manufacture
US5998222A (en) * 1993-11-29 1999-12-07 Utah State University Reconditioning antibiotic-adulterated milk products
WO2000023580A1 (en) * 1998-10-21 2000-04-27 Affibody Technology Sweden Ab A method of affinity separation and ligands for use therein
EP1318195A1 (en) * 2001-12-10 2003-06-11 CatchMabs B.V. A structure for presenting desired peptide sequences

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOMEN P L ET AL: "Site Directed Immobilization of Proteins", 1990, JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, PAGE(S) 293-302, ISSN: 0021-9673, XP002956086 *
NYGREN PER-AKE ET AL: "Scaffolds for engineering novel binding sites in proteins", CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD., LONDON, GB, vol. 7, no. 4, 1997, pages 463 - 469, XP002196760, ISSN: 0959-440X *

Also Published As

Publication number Publication date
EP1634076A2 (en) 2006-03-15
WO2004108749A2 (en) 2004-12-16
CA2529001A1 (en) 2004-12-16
AU2004245429A1 (en) 2004-12-16
US20060177437A1 (en) 2006-08-10

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