WO2004108665A3 - A process for preparation of clopidogrel - Google Patents

A process for preparation of clopidogrel Download PDF

Info

Publication number
WO2004108665A3
WO2004108665A3 PCT/IN2004/000106 IN2004000106W WO2004108665A3 WO 2004108665 A3 WO2004108665 A3 WO 2004108665A3 IN 2004000106 W IN2004000106 W IN 2004000106W WO 2004108665 A3 WO2004108665 A3 WO 2004108665A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
isomer
salt
compound
chlorophenyl
Prior art date
Application number
PCT/IN2004/000106
Other languages
French (fr)
Other versions
WO2004108665A2 (en
Inventor
Mukesh Nathalal Vaghela
Rajeev Budhdev Rehani
Rajamannar Thennati
Original Assignee
Sun Pharmaceutical Ind Ltd
Mukesh Nathalal Vaghela
Rajeev Budhdev Rehani
Rajamannar Thennati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Ind Ltd, Mukesh Nathalal Vaghela, Rajeev Budhdev Rehani, Rajamannar Thennati filed Critical Sun Pharmaceutical Ind Ltd
Publication of WO2004108665A2 publication Critical patent/WO2004108665A2/en
Publication of WO2004108665A3 publication Critical patent/WO2004108665A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention provides a process for the preparation of S-isomer of methyl α-(4,5,6,7-tetrahydro-5-thieno[3,2-c]pyridyl)(2-chlorophenyl)acetate, a compound of formula (4), or a salt thereof comprising, (a) resolving racemic α-[(2-thien-2-yl)ethylamino]-a-(2-chlorophenyl)methylacetate, a compound of formula 1 or a salt thereof to obtain S-isomer of a compound of formula (1) or a salt thereof and R-isomer of formula (1) or a salt thereof, (b) racemizing the R-isomer of formula 1 or a salt thereof to obtain a racemic compound of formula (1) and optionally converting it into a salt thereof, (c) optionally repeating steps 'a' and 'b', (d) converting the S-isomer of compound of formula (1) obtained in step 'a' to S-isomer of methyl α-(4,5,6,7-tetrahydro-5-thieno[3,2-c]pyridyl)(2-chlorophenyl) acetate.
PCT/IN2004/000106 2003-04-24 2004-04-19 A process for preparation of clopidogrel WO2004108665A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN407/MUM/2003 2003-04-24
IN407MU2003 2003-04-24

Publications (2)

Publication Number Publication Date
WO2004108665A2 WO2004108665A2 (en) 2004-12-16
WO2004108665A3 true WO2004108665A3 (en) 2005-03-24

Family

ID=33495856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000106 WO2004108665A2 (en) 2003-04-24 2004-04-19 A process for preparation of clopidogrel

Country Status (1)

Country Link
WO (1) WO2004108665A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1851231A2 (en) * 2005-02-24 2007-11-07 Teva Pharmaceutical Industries Ltd Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
WO2007032023A2 (en) 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
US20070191609A1 (en) * 2006-02-13 2007-08-16 Lee Pharma Limited Process for preparation of clopidogrel bisulphate form-1
SI22383A (en) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure of synthesis of klopidogrel and new form of its pharmaceutically acceptable salts
US20120232274A1 (en) * 2009-11-09 2012-09-13 Pharmazell Gmbh Process for preparation of clopiodogrel bisulfate form-1
CN102558138A (en) * 2010-12-08 2012-07-11 湖北成田制药股份有限公司 Preparation method for 2-halogenated phenyl-2-(2-thiophene diethylamino) acetic ester and salt thereof
CN103483356B (en) * 2013-09-30 2016-01-13 浙江美诺华药物化学有限公司 A kind of vitriol of (S)-clopidogrel or the preparation method of hydrochloride
CN103509037B (en) * 2013-10-21 2016-08-31 山东鲁药制药有限公司 A kind of clopidogrel and the preparation method of intermediate thereof
CN114689737B (en) * 2021-12-31 2023-12-08 浙江车头制药股份有限公司 Analysis method of S-o-chlorophenylglycine methyl tartrate related substances

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204469A (en) * 1990-07-10 1993-04-20 Sanofi Process for the preparation of an n-phenylacetic derivative of tetrahydrothieno(3,2-c)pyridine and its chemical intermediate
WO1998051681A1 (en) * 1997-05-13 1998-11-19 Sanofi-Synthelabo New intermediates and process for the preparation thereof
WO2000027840A1 (en) * 1998-11-09 2000-05-18 Sanofi-Synthelabo Process for racemization
US6495691B1 (en) * 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204469A (en) * 1990-07-10 1993-04-20 Sanofi Process for the preparation of an n-phenylacetic derivative of tetrahydrothieno(3,2-c)pyridine and its chemical intermediate
WO1998051681A1 (en) * 1997-05-13 1998-11-19 Sanofi-Synthelabo New intermediates and process for the preparation thereof
WO2000027840A1 (en) * 1998-11-09 2000-05-18 Sanofi-Synthelabo Process for racemization
US6495691B1 (en) * 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives

Also Published As

Publication number Publication date
WO2004108665A2 (en) 2004-12-16

Similar Documents

Publication Publication Date Title
FR2841264B1 (en) PROCESS FOR THE PREPARATION OF A HIGH RESISTANCE AI-Zn-Mg-Cu ALLOY
AT503771A5 (en) METAL ALLOY, FROM THIS SHAPED CAVITY INSERT AND METHOD FOR THE PRODUCTION THEREOF
WO2004108665A3 (en) A process for preparation of clopidogrel
EP1695142A4 (en) Antireflective coatings for via fill and photolithography applications and methods of preparation thereof
SG135020A1 (en) A method to delay locking of server files on edit
ZA200604641B (en) Method of reconstructing a bituminous-surfaced pavement
IL180581A (en) Method of determining the sequence of a nucleic acid polymer
DE60309363D1 (en) A method of manufacturing a body-worn electronic device adapted to the shape of a body part of an individual
IS8366A (en) Pharmaceutical preparation comprising pyrimidine-A-derivative-coated with acid polymer
TWI339656B (en) Method of manufacturing acetic acid
DE60236171D1 (en) PROCESS FOR FOR THE PREPARATION OF A 14-HYDROXYNORMORPHINONE DERIVATIVE
DE602004002651D1 (en) Process for the preparation of a vinyl compound.
IL174070A0 (en) Method for the manufacture of thip
EP1635970A4 (en) Method of fabricating a clipless bicycle pedal
EP1632290A4 (en) Solid acid catalyst containing tin and method for preparation thereof
IL172663A0 (en) A process for the preparation of ??-(phenoxy)phenylacetic acid derivatives
FI20020593A (en) Process for the preparation of conjugated linoleic acid
DK1216226T3 (en) Process for the preparation of phenylacetic acid derivatives
HK1090655A1 (en) Method for the preparation of 1,3-propane disulfonic acid compounds 13-
AU2003276703A1 (en) Method for the preparation of a silicon-containing polysulfide-type polymer
GB0313619D0 (en) A method of automatically analysing the structure of a software system
GB2414946B (en) Method of manufacturing split nut
ATE314100T1 (en) METHOD FOR PRODUCING A JELLY ELEMENT
DK1165483T3 (en) Process for the preparation of carbonyl fluoride
AU2003236955A1 (en) Techniques to characterize iso-dense effects for microdevice manufacture

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase