WO2004096194A3 - PREVENCIÓN DE UNA INFECCIÓN POR HIV-1 MEDIANTE LA INHIBICIÓN DE LA REORGANIZACIÓN Y/O LA ALTERACIÓN DE LOS CONTENIDOS DE LOS DOMINIOS CON BALSAS DE LA MEMBRANA CELULAR, MEDIADAS POR Rho - Google Patents

PREVENCIÓN DE UNA INFECCIÓN POR HIV-1 MEDIANTE LA INHIBICIÓN DE LA REORGANIZACIÓN Y/O LA ALTERACIÓN DE LOS CONTENIDOS DE LOS DOMINIOS CON BALSAS DE LA MEMBRANA CELULAR, MEDIADAS POR Rho Download PDF

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Publication number
WO2004096194A3
WO2004096194A3 PCT/ES2004/000188 ES2004000188W WO2004096194A3 WO 2004096194 A3 WO2004096194 A3 WO 2004096194A3 ES 2004000188 W ES2004000188 W ES 2004000188W WO 2004096194 A3 WO2004096194 A3 WO 2004096194A3
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WO
WIPO (PCT)
Prior art keywords
infection
hiv
rho
prevention
inhibition
Prior art date
Application number
PCT/ES2004/000188
Other languages
English (en)
French (fr)
Other versions
WO2004096194A2 (es
WO2004096194A9 (es
Inventor
Mario Mellado
Frade Jose Miguel Rodriguez
Alonso Carlos Martinez
Santos Manes
Real Gustavo Del
Original Assignee
Consejo Superior Investigacion
Pharmacia Spain S A
Mario Mellado
Frade Jose Miguel Rodriguez
Alonso Carlos Martinez
Santos Manes
Real Gustavo Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Pharmacia Spain S A, Mario Mellado, Frade Jose Miguel Rodriguez, Alonso Carlos Martinez, Santos Manes, Real Gustavo Del filed Critical Consejo Superior Investigacion
Priority to US10/581,903 priority Critical patent/US20070082942A1/en
Priority to CA002522089A priority patent/CA2522089A1/en
Priority to BRPI0409822-6A priority patent/BRPI0409822A/pt
Priority to MXPA05011714A priority patent/MXPA05011714A/es
Priority to EP04730557A priority patent/EP1618874A2/en
Publication of WO2004096194A2 publication Critical patent/WO2004096194A2/es
Publication of WO2004096194A9 publication Critical patent/WO2004096194A9/es
Publication of WO2004096194A3 publication Critical patent/WO2004096194A3/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El presente invento se refiere en general a la prevención o retraso de una infección retroviral mediante el uso de agentes que previenen la agregación de receptores retrovirales asociados con los dominios con balsas de las membranas celulares. El presente invento se refiere más concretamente a la prevención o tratamiento de una infección por HIV-1 mediante el uso de agentes que inhiben la activación de Rho-A, actuando sobre la actividad de GTPasa o sobre la isoprenilación de proteínas. El presente invento se refiere también a la prevención o retraso de una infección por HIV-1 mediante el desplazamiento de los receptores para citoquinas de los dominios con balsas de las membranas celulares.
PCT/ES2004/000188 2003-04-30 2004-04-30 PREVENCIÓN DE UNA INFECCIÓN POR HIV-1 MEDIANTE LA INHIBICIÓN DE LA REORGANIZACIÓN Y/O LA ALTERACIÓN DE LOS CONTENIDOS DE LOS DOMINIOS CON BALSAS DE LA MEMBRANA CELULAR, MEDIADAS POR Rho WO2004096194A2 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/581,903 US20070082942A1 (en) 2003-04-30 2004-04-30 Prevention of hiv-1 infection by inhibition of rho-mediated reorganization and/or content alteration of cell membrane raft
CA002522089A CA2522089A1 (en) 2003-04-30 2004-04-30 Prevention of hiv-1 infection by inhibition of rho-mediated reorganization and/or content alteration of cell membrane raft domains
BRPI0409822-6A BRPI0409822A (pt) 2003-04-30 2004-04-30 inibidor de isoprenilação de proteìna ou sal farmaceuticamente aceitável, solvato ou derivado do mesmo, respectivo uso e métodos de tratamento de mamìfero
MXPA05011714A MXPA05011714A (es) 2003-04-30 2004-04-30 Prevencion de una infeccion por hiv-1 mediante la inhibicion de la reorganizacion y/o la alteracion del contenido de los dominios con balsas de la membrana celular, mediadas por rho.
EP04730557A EP1618874A2 (en) 2003-04-30 2004-04-30 Prevention of hiv-1 infection by inhibition of rho-mediated reorganisation and/or content alteration of cell membrane raft domains

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46642903P 2003-04-30 2003-04-30
US60/466,429 2003-04-30

Publications (3)

Publication Number Publication Date
WO2004096194A2 WO2004096194A2 (es) 2004-11-11
WO2004096194A9 WO2004096194A9 (es) 2005-01-20
WO2004096194A3 true WO2004096194A3 (es) 2005-05-06

Family

ID=33418378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2004/000188 WO2004096194A2 (es) 2003-04-30 2004-04-30 PREVENCIÓN DE UNA INFECCIÓN POR HIV-1 MEDIANTE LA INHIBICIÓN DE LA REORGANIZACIÓN Y/O LA ALTERACIÓN DE LOS CONTENIDOS DE LOS DOMINIOS CON BALSAS DE LA MEMBRANA CELULAR, MEDIADAS POR Rho

Country Status (6)

Country Link
US (1) US20070082942A1 (es)
EP (1) EP1618874A2 (es)
BR (1) BRPI0409822A (es)
CA (1) CA2522089A1 (es)
MX (1) MXPA05011714A (es)
WO (1) WO2004096194A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5804545B2 (ja) * 2009-11-25 2015-11-04 学校法人 創価大学 胚様体分化制御剤
US10369166B2 (en) * 2014-09-30 2019-08-06 Susan Eve VECHT-LIFSHITZ Pharmaceutical compositions for treating ebola virus disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024660A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Method for inhibition of viral morphogenesis
WO2000002558A1 (fr) * 1998-07-08 2000-01-20 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
WO2000047196A2 (en) * 1999-02-11 2000-08-17 Hollis-Eden Pharmaceuticals, Inc. Use of statins for treating viral infections
US20020142940A1 (en) * 2000-10-17 2002-10-03 Graham Barney Scott Method of inhibiting viral infection using HMG-COA reductase inhibitors and isoprenylation inhibitors
WO2003039477A2 (en) * 2001-11-07 2003-05-15 U.S. Army Medical Research Institute Of Infections Diseases Department Of The Army Generation of virus-like particles and demonstration of lipid rafts as sites of filovirus entry and budding

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024660A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Method for inhibition of viral morphogenesis
WO2000002558A1 (fr) * 1998-07-08 2000-01-20 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
WO2000047196A2 (en) * 1999-02-11 2000-08-17 Hollis-Eden Pharmaceuticals, Inc. Use of statins for treating viral infections
US20020142940A1 (en) * 2000-10-17 2002-10-03 Graham Barney Scott Method of inhibiting viral infection using HMG-COA reductase inhibitors and isoprenylation inhibitors
WO2003039477A2 (en) * 2001-11-07 2003-05-15 U.S. Army Medical Research Institute Of Infections Diseases Department Of The Army Generation of virus-like particles and demonstration of lipid rafts as sites of filovirus entry and budding

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ARGYRIS E G ET AL: "Human Immunodeficiency Virus Type 1 Enters Primary Human Brain Microvascular Endothelial Cells by a Mechanism Involving Cell Surface Proteoglycans Independent of Lipid Rafts", JOURNAL OF VIROLOGY 2003 UNITED STATES, vol. 77, no. 22, 2003, pages 12140 - 12151, XP008036228, ISSN: 0022-538X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; December 2002 (2002-12-01), NALBONE GILLES ET AL: "[Pleiotropic effects of statins: Implications in the treatment of cardiovascular diseases.]", XP002298999, Database accession no. PREV200300146776 *
DEL REAL G ET AL: "Statins inhibit HIV-1 infection by down-regulating Rho activity", JOURNAL OF EXPERIMENTAL MEDICINE 16 AUG 2004 UNITED STATES, vol. 200, no. 4, 16 August 2004 (2004-08-16), pages 541 - 547, XP008036231, ISSN: 0022-1007 *
GOWER T L ET AL: "Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (APR 2001) VOL. 45, NO. 4, PP. 1231-1237. PUBLISHER: AMER SOC MICROBIOLOGY, 1752 N ST NW, WASHINGTON, DC 20036-2904 USA. ISSN: 0066-4804., April 2001 (2001-04-01), XP008036221 *
MANES SANTOS ET AL: "Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection", EMBO REPORTS, vol. 1, no. 2, August 2000 (2000-08-01), pages 190 - 196, XP008036256, ISSN: 1469-221X *
MAZIERE J C ET AL: "LOVASTATIN INHIBITS HIV-1 EXPRESSION IN H9 HUMAN T LYMPHOCYTES CULTURED IN CHOLESTEROL-POOR MEDIUM", BIOMEDICINE AND PHARMACOTHERAPY, ELSEVIER, PARIS, FR, vol. 48, no. 2, 1994, pages 63 - 67, XP000965739, ISSN: 0753-3322 *
M-S (MEDECINE SCIENCES), vol. 18, no. 12, December 2002 (2002-12-01), pages 1257 - 1265, ISSN: 0767-0974 *

Also Published As

Publication number Publication date
WO2004096194A2 (es) 2004-11-11
BRPI0409822A (pt) 2006-05-09
EP1618874A2 (en) 2006-01-25
US20070082942A1 (en) 2007-04-12
CA2522089A1 (en) 2004-11-11
MXPA05011714A (es) 2006-04-27
WO2004096194A9 (es) 2005-01-20

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