WO2004090510A1 - Aiguille a fibre optique destinee a l'analyse spectroscopique de liquides - Google Patents

Aiguille a fibre optique destinee a l'analyse spectroscopique de liquides Download PDF

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Publication number
WO2004090510A1
WO2004090510A1 PCT/DK2004/000267 DK2004000267W WO2004090510A1 WO 2004090510 A1 WO2004090510 A1 WO 2004090510A1 DK 2004000267 W DK2004000267 W DK 2004000267W WO 2004090510 A1 WO2004090510 A1 WO 2004090510A1
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WO
WIPO (PCT)
Prior art keywords
optical fibre
fibre
liquid
holes
optical
Prior art date
Application number
PCT/DK2004/000267
Other languages
English (en)
Inventor
John Erland ØSTERGAARD
Original Assignee
Alight Technologies A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alight Technologies A/S filed Critical Alight Technologies A/S
Publication of WO2004090510A1 publication Critical patent/WO2004090510A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • G02B6/02385—Comprising liquid, e.g. fluid filled holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150847—Communication to or from blood sampling device
    • A61B5/150862—Communication to or from blood sampling device intermediate range, e.g. within room or building
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • G02B6/02342—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes characterised by cladding features, i.e. light confining region
    • G02B6/02347—Longitudinal structures arranged to form a regular periodic lattice, e.g. triangular, square, honeycomb unit cell repeated throughout cladding
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • G02B6/02342—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes characterised by cladding features, i.e. light confining region
    • G02B6/02376—Longitudinal variation along fibre axis direction, e.g. tapered holes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne une aiguille à fibre optique destinée à manipuler des petits échantillons de liquide en vue d'une spectroscopie. L'aiguille est formée par une fibre optique et comporte un ou plusieurs trous traversant, de préférence une fibre cristalline ou une fibre à largeur de bande interdite photonique. L'aiguille peut collecter le liquide par prélèvement du liquide dans ces trous traversant par action capillaire. Lorsque contenu dans les trous traversants, le liquide est aisément éclairé par une lumière guide dans l'aiguille à fibre optique, et la lumière émise ou diffusée à partir du liquide est aisément collectée et guidée vers un photodétecteur tel qu'un spectromètre. La fibre optique peut être utilisée en tant qu'aiguille hypodermique pour collecter des échantillons de sang ou en tant que pipette de collecte d'échantillons à partir d'une plaque de microtitration dans le criblage de compositions chimiques destinées à des médicaments.
PCT/DK2004/000267 2003-04-14 2004-04-14 Aiguille a fibre optique destinee a l'analyse spectroscopique de liquides WO2004090510A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46229903P 2003-04-14 2003-04-14
US60/462,299 2003-04-14

Publications (1)

Publication Number Publication Date
WO2004090510A1 true WO2004090510A1 (fr) 2004-10-21

Family

ID=33159848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000267 WO2004090510A1 (fr) 2003-04-14 2004-04-14 Aiguille a fibre optique destinee a l'analyse spectroscopique de liquides

Country Status (1)

Country Link
WO (1) WO2004090510A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138340A3 (fr) * 2005-06-14 2007-05-03 Dominion Assets Llc Procede et appareil permettant de detecter le glucose de maniere non invasive chez un sujet humain
WO2008050291A3 (fr) * 2006-10-24 2008-06-26 Koninkl Philips Electronics Nv Quantification de l'hémoglobine glyquée
US8140139B2 (en) 2005-06-14 2012-03-20 Dominion Assets, Llc Method and apparatus for the non-invasive sensing of glucose in a human subject
US8311373B1 (en) 2009-07-22 2012-11-13 The United States Of America As Represented By The Secretary Of The Navy Capillary electrophoresis chemical sensor
CN110602983A (zh) * 2017-05-17 2019-12-20 雷迪奥米特医学公司 用于检测流体中分析物的多孔光纤
EP2735860B1 (fr) * 2012-11-21 2020-09-30 RISE Research Institutes of Sweden AB Dispositif optofluidique
CN114858781A (zh) * 2022-07-04 2022-08-05 华北电力大学 一种基于拉曼增强光谱的变压器油中溶解气体检测系统
US20220301806A1 (en) * 2020-03-24 2022-09-22 Mohammed Nasser System and Method for Injecting a Medication

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0198135A2 (fr) * 1985-04-17 1986-10-22 Indiana University Foundation Dispositif pour la mesure optique à distance d'une atmosphère et procédé pour la détermination d'une substance étrangère dans un fluide
US4622974A (en) * 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
JPS6279332A (ja) * 1985-10-02 1987-04-11 Sumitomo Electric Ind Ltd 光学センサ
US5615673A (en) 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
WO2002014946A1 (fr) * 2000-08-14 2002-02-21 University Of Southampton Fibres optiques creuses de verre non siliceux
WO2002042814A1 (fr) * 2000-11-21 2002-05-30 The University Of Sydney Terminaison d'une fibre optique polymere
US6535753B1 (en) * 1998-08-20 2003-03-18 Microsense International, Llc Micro-invasive method for painless detection of analytes in extra-cellular space
US6539155B1 (en) * 1998-06-09 2003-03-25 Jes Broeng Microstructured optical fibres

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622974A (en) * 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
EP0198135A2 (fr) * 1985-04-17 1986-10-22 Indiana University Foundation Dispositif pour la mesure optique à distance d'une atmosphère et procédé pour la détermination d'une substance étrangère dans un fluide
JPS6279332A (ja) * 1985-10-02 1987-04-11 Sumitomo Electric Ind Ltd 光学センサ
US5615673A (en) 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
US6539155B1 (en) * 1998-06-09 2003-03-25 Jes Broeng Microstructured optical fibres
US6535753B1 (en) * 1998-08-20 2003-03-18 Microsense International, Llc Micro-invasive method for painless detection of analytes in extra-cellular space
WO2002014946A1 (fr) * 2000-08-14 2002-02-21 University Of Southampton Fibres optiques creuses de verre non siliceux
WO2002042814A1 (fr) * 2000-11-21 2002-05-30 The University Of Sydney Terminaison d'une fibre optique polymere

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 0112, no. 83 (P - 615) 12 September 1987 (1987-09-12) *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138340A3 (fr) * 2005-06-14 2007-05-03 Dominion Assets Llc Procede et appareil permettant de detecter le glucose de maniere non invasive chez un sujet humain
US8140139B2 (en) 2005-06-14 2012-03-20 Dominion Assets, Llc Method and apparatus for the non-invasive sensing of glucose in a human subject
US9037206B2 (en) 2005-06-14 2015-05-19 Dominion Assets, Llc Method and apparatus for the non-invasive sensing of glucose in a human subject
WO2008050291A3 (fr) * 2006-10-24 2008-06-26 Koninkl Philips Electronics Nv Quantification de l'hémoglobine glyquée
US8311373B1 (en) 2009-07-22 2012-11-13 The United States Of America As Represented By The Secretary Of The Navy Capillary electrophoresis chemical sensor
EP2735860B1 (fr) * 2012-11-21 2020-09-30 RISE Research Institutes of Sweden AB Dispositif optofluidique
CN110602983A (zh) * 2017-05-17 2019-12-20 雷迪奥米特医学公司 用于检测流体中分析物的多孔光纤
CN110602983B (zh) * 2017-05-17 2022-07-19 雷迪奥米特医学公司 用于检测流体中分析物的多孔光纤
US11638544B2 (en) 2017-05-17 2023-05-02 Radiometer Medical Aps Porous optical fiber for the detection of an analyte in a fluid
US20220301806A1 (en) * 2020-03-24 2022-09-22 Mohammed Nasser System and Method for Injecting a Medication
CN114858781A (zh) * 2022-07-04 2022-08-05 华北电力大学 一种基于拉曼增强光谱的变压器油中溶解气体检测系统
CN114858781B (zh) * 2022-07-04 2022-10-21 华北电力大学 一种基于拉曼增强光谱的变压器油中溶解气体检测系统

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