WO2004089408A3 - Preparations de vaccins - Google Patents

Preparations de vaccins Download PDF

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Publication number
WO2004089408A3
WO2004089408A3 PCT/GB2004/001504 GB2004001504W WO2004089408A3 WO 2004089408 A3 WO2004089408 A3 WO 2004089408A3 GB 2004001504 W GB2004001504 W GB 2004001504W WO 2004089408 A3 WO2004089408 A3 WO 2004089408A3
Authority
WO
WIPO (PCT)
Prior art keywords
mutation
live
attenuated mutant
neisseria bacteria
vaccine preparations
Prior art date
Application number
PCT/GB2004/001504
Other languages
English (en)
Other versions
WO2004089408A2 (fr
Inventor
Cornelia Suzanna Mcclean
Simon William Keen
Gillian May Martin
Original Assignee
Xenova Res Ltd
Cornelia Suzanna Mcclean
Simon William Keen
Gillian May Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Res Ltd, Cornelia Suzanna Mcclean, Simon William Keen, Gillian May Martin filed Critical Xenova Res Ltd
Publication of WO2004089408A2 publication Critical patent/WO2004089408A2/fr
Publication of WO2004089408A3 publication Critical patent/WO2004089408A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des préparations vivantes ou mortes à partir de bactéries Neisseria mutantes atténuées, par exemple, N. meningitidis, présentant les mutations suivantes: a) mutation d'atténuation auxotrophique, par exemple, mutation de AroA ou de AroB, b) mutation de capsule, par exemple, mutation de synX ou galE et également c) mutation réduisant une recombinaison bactérienne ou un captage d'ADN exogène, telle que les mutations de RecA et/ou de comA. Les mutants et leurs préparations peuvent être utilisés dans des compositions de vaccin.
PCT/GB2004/001504 2003-04-07 2004-04-07 Preparations de vaccins WO2004089408A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308691A GB0308691D0 (en) 2003-04-07 2003-04-07 Vaccine preparations
GB0308691.5 2003-04-07

Publications (2)

Publication Number Publication Date
WO2004089408A2 WO2004089408A2 (fr) 2004-10-21
WO2004089408A3 true WO2004089408A3 (fr) 2004-12-02

Family

ID=9956824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/001504 WO2004089408A2 (fr) 2003-04-07 2004-04-07 Preparations de vaccins

Country Status (2)

Country Link
GB (1) GB0308691D0 (fr)
WO (1) WO2004089408A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2556813C2 (ru) * 2009-02-20 2015-07-20 Острэйлиан Паултри Срс Пти Лимитед Живые аттенуированные вакцины
WO2014037445A1 (fr) * 2012-09-05 2014-03-13 Lohmann Animal Health Gmbh Préparation de vaccins vivants
JP6336461B2 (ja) * 2012-12-07 2018-06-06 ローマン・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＬｏｈｍａｎｎ Ａｎｉｍａｌ Ｈｅａｌｔｈ ＧｍｂＨ 生ワクチンの調製
WO2020168146A1 (fr) * 2019-02-14 2020-08-20 University Of Florida Research Foundation, Inc. Vaccin à base de snodgrassella alvi commensale d'abeilles contre neisseriaceae pathogènes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056901A2 (fr) * 1997-06-09 1998-12-17 Medical Research Council Vaccin vivant attenue
WO2001009350A2 (fr) * 1999-08-03 2001-02-08 Smithkline Beecham Biologicals S.A. Composition de vaccin
WO2001087939A2 (fr) * 2000-05-18 2001-11-22 Microscience Limited Genes de virulence, proteines, et leur utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056901A2 (fr) * 1997-06-09 1998-12-17 Medical Research Council Vaccin vivant attenue
WO2001009350A2 (fr) * 1999-08-03 2001-02-08 Smithkline Beecham Biologicals S.A. Composition de vaccin
WO2001087939A2 (fr) * 2000-05-18 2001-11-22 Microscience Limited Genes de virulence, proteines, et leur utilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOLMES L ET AL: "IN VIVO EVALUATIONS OF LIVE ATTENUATED NEISSERIA MENINGITIDIS SEROGROUP B CONSTRUCTS", IMMUNOLOGY, OXFORD, GB, vol. 101, no. SUPPL 1, December 2000 (2000-12-01), pages 34, XP001013651, ISSN: 0019-2805 *
SWARTLEY JOHN S ET AL: "Identification of a genetic locus involved in the biosynthesis of N-acetyl-D-mannosamine, a precursor of the (alpha-2 fwdarw 8)-linked polysialic acid capsule of serogroup B Neisseria meningitidis", JOURNAL OF BACTERIOLOGY, vol. 176, no. 5, 1994, pages 1530 - 1534, XP002293244, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
GB0308691D0 (en) 2003-05-21
WO2004089408A2 (fr) 2004-10-21

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