WO2004087907A3 - Crystal structure of streptococcus undecaprenyl pyrophosphate synthase and uses thereof - Google Patents

Crystal structure of streptococcus undecaprenyl pyrophosphate synthase and uses thereof Download PDF

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Publication number
WO2004087907A3
WO2004087907A3 PCT/IB2004/000903 IB2004000903W WO2004087907A3 WO 2004087907 A3 WO2004087907 A3 WO 2004087907A3 IB 2004000903 W IB2004000903 W IB 2004000903W WO 2004087907 A3 WO2004087907 A3 WO 2004087907A3
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WO
WIPO (PCT)
Prior art keywords
pyrophosphate synthase
undecaprenyl pyrophosphate
crystal structure
streptococcus
undecaprenyl
Prior art date
Application number
PCT/IB2004/000903
Other languages
French (fr)
Other versions
WO2004087907A2 (en
Inventor
Kimberly Furlong Fennell
Mahmoud Naim Mansour
Xiayang Qiu
Original Assignee
Pfizer Prod Inc
Kimberly Furlong Fennell
Mahmoud Naim Mansour
Xiayang Qiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Kimberly Furlong Fennell, Mahmoud Naim Mansour, Xiayang Qiu filed Critical Pfizer Prod Inc
Priority to JP2006506388A priority Critical patent/JP2006524048A/en
Priority to EP04721605A priority patent/EP1611234A2/en
Publication of WO2004087907A2 publication Critical patent/WO2004087907A2/en
Publication of WO2004087907A3 publication Critical patent/WO2004087907A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention is directed generally to the structure of prenyltransferases, particularly undecaprenyl pyrophosphate synthase, an enzyme important in bacterial cell wall synthesis. The invention relates to the crystal structure of undecaprenyl pyrophosphate synthase from Streptococcus pneumoniae and its interaction with cofactors and ligands. The invention also relates to the structure of ligand and cofactor binding sites of undecaprenyl pyrophosphate synthase.
PCT/IB2004/000903 2003-03-31 2004-03-18 Crystal structure of streptococcus undecaprenyl pyrophosphate synthase and uses thereof WO2004087907A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006506388A JP2006524048A (en) 2003-03-31 2004-03-18 Crystal structure of Streptococcus undecaprenyl pyrophosphate synthase and uses thereof
EP04721605A EP1611234A2 (en) 2003-03-31 2004-03-18 Crystal structure of streptococcus undecaprenyl pyrophosphate synthase and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45905303P 2003-03-31 2003-03-31
US60/459,053 2003-03-31

Publications (2)

Publication Number Publication Date
WO2004087907A2 WO2004087907A2 (en) 2004-10-14
WO2004087907A3 true WO2004087907A3 (en) 2004-12-02

Family

ID=33131859

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000903 WO2004087907A2 (en) 2003-03-31 2004-03-18 Crystal structure of streptococcus undecaprenyl pyrophosphate synthase and uses thereof

Country Status (4)

Country Link
US (1) US20040191271A1 (en)
EP (1) EP1611234A2 (en)
JP (1) JP2006524048A (en)
WO (1) WO2004087907A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009114939A1 (en) 2008-03-17 2009-09-24 National Research Council Of Canada Aromatic prenyltransferase from hop
JP6531304B2 (en) * 2014-05-28 2019-06-19 住友ゴム工業株式会社 Isoprene oligomer, polyisoprene, method for producing the same, rubber composition, and pneumatic tire

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537774B1 (en) * 1998-10-14 2003-03-25 Smithkline Beecham Corporation UPS (undecaprenyl diphosphate synthase
WO2003048733A2 (en) * 2001-12-05 2003-06-12 Smithkline Beecham Corporation Undecaprenyl pyrophosphate synthase (upps) enzyme and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537774B1 (en) * 1998-10-14 2003-03-25 Smithkline Beecham Corporation UPS (undecaprenyl diphosphate synthase
WO2003048733A2 (en) * 2001-12-05 2003-06-12 Smithkline Beecham Corporation Undecaprenyl pyrophosphate synthase (upps) enzyme and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FUJIHASHI MASAHIRO ET AL: "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 8, 10 April 2001 (2001-04-10), pages 4337 - 4342, XP002269811, ISSN: 0027-8424 *
KO TZU-PING ET AL: "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 50, 14 December 2001 (2001-12-14), pages 47474 - 47482, XP002285389, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
US20040191271A1 (en) 2004-09-30
JP2006524048A (en) 2006-10-26
WO2004087907A2 (en) 2004-10-14
EP1611234A2 (en) 2006-01-04

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