WO2004087050A3 - Inhibiteurs des kinesines mitotiques - Google Patents

Inhibiteurs des kinesines mitotiques Download PDF

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Publication number
WO2004087050A3
WO2004087050A3 PCT/US2004/009027 US2004009027W WO2004087050A3 WO 2004087050 A3 WO2004087050 A3 WO 2004087050A3 US 2004009027 W US2004009027 W US 2004009027W WO 2004087050 A3 WO2004087050 A3 WO 2004087050A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitotic kinesin
kinesin inhibitors
compounds
ksp kinesin
treating
Prior art date
Application number
PCT/US2004/009027
Other languages
English (en)
Other versions
WO2004087050A2 (fr
Inventor
Donald E Slaughter
Raju Subramanian
Mark E Fraley
Thomayant Prueksaritanont
Hong Shu
Original Assignee
Merck & Co Inc
Donald E Slaughter
Raju Subramanian
Mark E Fraley
Thomayant Prueksaritanont
Hong Shu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Donald E Slaughter, Raju Subramanian, Mark E Fraley, Thomayant Prueksaritanont, Hong Shu filed Critical Merck & Co Inc
Publication of WO2004087050A2 publication Critical patent/WO2004087050A2/fr
Publication of WO2004087050A3 publication Critical patent/WO2004087050A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur des composés dihydropyrrole qui sont utiles dans le traitement des maladies à prolifération cellulaire, dans le traitement des troubles associés à l'activité de la kinésine KSP et dans l'inhibition de la kinésine KSP. L'invention porte également sur des compositions comprenant ces composés et sur leurs méthodes d'utilisation dans le traitement du cancer chez des mammifères.
PCT/US2004/009027 2003-03-28 2004-03-24 Inhibiteurs des kinesines mitotiques WO2004087050A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45849403P 2003-03-28 2003-03-28
US60/458,494 2003-03-28

Publications (2)

Publication Number Publication Date
WO2004087050A2 WO2004087050A2 (fr) 2004-10-14
WO2004087050A3 true WO2004087050A3 (fr) 2005-03-24

Family

ID=33131804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009027 WO2004087050A2 (fr) 2003-03-28 2004-03-24 Inhibiteurs des kinesines mitotiques

Country Status (1)

Country Link
WO (1) WO2004087050A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2599390A1 (fr) * 2005-03-16 2006-09-28 Merck & Co., Inc. Inhibiteurs mitotiques de la kinesine
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
KR101591656B1 (ko) 2007-01-10 2016-02-19 엠에스디 이탈리아 에스.알.엘. 폴리(ａｄｐ-리보오스) 폴리머라아제(ｐａｒｐ) 억제제로서의 아미드 치환된 인다졸
WO2009052288A1 (fr) 2007-10-19 2009-04-23 Schering Corporation Dérivés de 1,3,4-thiadiazole spiro-condensés pour inhiber l'activité de la kinésine ksp

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUJARD ET AL.: "Ring closing metathesis of phenyl-substituted dienes", TETRAHEDRON LETTERS, vol. 40, no. 1999, 1999, pages 8785 - 8788, XP004184063 *

Also Published As

Publication number Publication date
WO2004087050A2 (fr) 2004-10-14

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