WO2004085642A1 - 関節炎関連遺伝子及びこれの関節炎検査等への利用 - Google Patents

関節炎関連遺伝子及びこれの関節炎検査等への利用 Download PDF

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Publication number
WO2004085642A1
WO2004085642A1 PCT/JP2004/004352 JP2004004352W WO2004085642A1 WO 2004085642 A1 WO2004085642 A1 WO 2004085642A1 JP 2004004352 W JP2004004352 W JP 2004004352W WO 2004085642 A1 WO2004085642 A1 WO 2004085642A1
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WIPO (PCT)
Prior art keywords
arthritis
midkine
remedy
onset
examining
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PCT/JP2004/004352
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English (en)
French (fr)
Inventor
Takashi Muramatsu
Kiyoko Maruyama
Hisako Muramatsu
Naoki Ishiguro
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Takashi Muramatsu
Kiyoko Maruyama
Hisako Muramatsu
Naoki Ishiguro
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Application filed by Takashi Muramatsu, Kiyoko Maruyama, Hisako Muramatsu, Naoki Ishiguro filed Critical Takashi Muramatsu
Priority to JP2005504126A priority Critical patent/JP4646070B2/ja
Publication of WO2004085642A1 publication Critical patent/WO2004085642A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

本発明は、関節炎、特にリウマチ性関節炎の発症に関与する因子の解明を第一の目的とし、さらに、見出した因子をターゲットとした関節炎治療薬のスクリーニング方法、関節炎治療薬ならびに検査薬を提供することを課題とする。　ミッドカイン遺伝子ノックアウトマウスでは関節炎の発症が野性型マウスに比較して有意に少なかった。また、関節リウマチ患者のほとんどの例では血清中および滑膜液中のミッドカインレベルが高値であった。このことからミッドカイン発現と関節リウマチとの間に強い相関があることが示された。ミッドカイン遺伝子欠損マウスへのミッドカインの投与により、抗体誘導性関節炎の頻度が高まった。
PCT/JP2004/004352 2003-03-27 2004-03-26 関節炎関連遺伝子及びこれの関節炎検査等への利用 WO2004085642A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005504126A JP4646070B2 (ja) 2003-03-27 2004-03-26 関節炎関連遺伝子及びこれの関節炎検査等への利用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-127573 2003-03-27
JP2003127573 2003-03-27

Publications (1)

Publication Number Publication Date
WO2004085642A1 true WO2004085642A1 (ja) 2004-10-07

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JP (1) JP4646070B2 (ja)
WO (1) WO2004085642A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007055378A1 (ja) * 2005-11-14 2007-05-18 Cell Signals Inc. 調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法
WO2008059616A1 (fr) 2006-11-14 2008-05-22 Medical Therapies Limited Anticorps reconnaissant le domaine c de la midkine
WO2008059877A1 (fr) 2006-11-14 2008-05-22 Ribomic Inc. Aptamère contre la midkine et son utilisation
WO2014021339A1 (ja) 2012-07-30 2014-02-06 国立大学法人名古屋大学 ヒトミッドカインに対するモノクローナル抗体
WO2020022499A1 (ja) * 2018-07-27 2020-01-30 国立大学法人大阪大学 老化の抑制、加齢性の疾患もしくは症状の予防、改善、もしくは治療、または寿命の延長のための組成物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0591880A (ja) * 1991-02-28 1993-04-16 Nippon Koutai Kenkyusho:Kk ヒトｍｋ遺伝子
EP0569703A2 (en) * 1992-04-24 1993-11-18 American Cyanamid Company Method of treating and preventing viral infections using HBNF and MK protein
WO1994013800A2 (en) * 1992-12-11 1994-06-23 Cancer Research Campaign Technology Limited Mk protein preparation and use in cell culture
WO1999003493A1 (fr) * 1997-07-14 1999-01-28 Meiji Milk Products Co., Ltd. Medicaments contenant midkine en tant principe actif ou inhibiteurs desdits medicaments
WO1999038971A1 (fr) * 1998-02-02 1999-08-05 Meiji Milk Products Co., Ltd. Proteine se liant a la midkine
JP2000072799A (ja) * 1998-08-24 2000-03-07 Meiji Milk Prod Co Ltd チロシンに富むレセプター様タンパク質
JP2004012447A (ja) * 2002-06-05 2004-01-15 Takashi Muramatsu リウマチの診断法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0591880A (ja) * 1991-02-28 1993-04-16 Nippon Koutai Kenkyusho:Kk ヒトｍｋ遺伝子
EP0569703A2 (en) * 1992-04-24 1993-11-18 American Cyanamid Company Method of treating and preventing viral infections using HBNF and MK protein
WO1994013800A2 (en) * 1992-12-11 1994-06-23 Cancer Research Campaign Technology Limited Mk protein preparation and use in cell culture
WO1999003493A1 (fr) * 1997-07-14 1999-01-28 Meiji Milk Products Co., Ltd. Medicaments contenant midkine en tant principe actif ou inhibiteurs desdits medicaments
WO1999038971A1 (fr) * 1998-02-02 1999-08-05 Meiji Milk Products Co., Ltd. Proteine se liant a la midkine
JP2000072799A (ja) * 1998-08-24 2000-03-07 Meiji Milk Prod Co Ltd チロシンに富むレセプター様タンパク質
JP2004012447A (ja) * 2002-06-05 2004-01-15 Takashi Muramatsu リウマチの診断法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MURAMATSU T.: "MIDKINE AND PLEIOTROPHIN: TWO RELATED PROTEINS INVOLVED IN DEVELOPMENT, SURVIVAL, INFLAMMATION AND TUMORIGENESIS", JOURNAL OF BIOCHEMISTRY, vol. 132, no. 3, September 2002 (2002-09-01), pages 359 - 371, XP009009323 *
TAKADA T. ET AL: "MIDKINE A RETINOIC ACID-INDUCIBLE HEPARIN-BINDING CYTOKINE IN INFLAMMATORY RESPONSES: CHEMOTACTIC ACTIVITY TO NEUTROPHILS AND ASSOCIATION WITH INFLAMMATORY SYNOVITIS", JOURNAL OF BIOCHEMISTRY, vol. 122, no. 2, August 1997 (1997-08-01), pages 453 - 458, XP002911186 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007055378A1 (ja) * 2005-11-14 2007-05-18 Cell Signals Inc. 調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法
US8128934B2 (en) 2005-11-14 2012-03-06 Ribomic, Inc. Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
JP5398987B2 (ja) * 2005-11-14 2014-01-29 セルミド リミテッド 調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法
US8716230B2 (en) 2005-11-14 2014-05-06 Ribomic Inc. Methods for treatment or prevention of diseases associated with functional disorder of regulatory T cells
WO2008059616A1 (fr) 2006-11-14 2008-05-22 Medical Therapies Limited Anticorps reconnaissant le domaine c de la midkine
WO2008059877A1 (fr) 2006-11-14 2008-05-22 Ribomic Inc. Aptamère contre la midkine et son utilisation
US8080649B2 (en) 2006-11-14 2011-12-20 Ribomic Inc. Aptamer against midkine and use thereof
JP5190573B2 (ja) * 2006-11-14 2013-04-24 株式会社リボミック ミッドカインに対するアプタマー及びその使用
EP2803674A2 (en) 2006-11-14 2014-11-19 Medical Therapies Limited Antibody recognizing C-domain of midkine
WO2014021339A1 (ja) 2012-07-30 2014-02-06 国立大学法人名古屋大学 ヒトミッドカインに対するモノクローナル抗体
US9840552B2 (en) 2012-07-30 2017-12-12 National University Corporation Nagoya University Monoclonal antibody against human midkine
WO2020022499A1 (ja) * 2018-07-27 2020-01-30 国立大学法人大阪大学 老化の抑制、加齢性の疾患もしくは症状の予防、改善、もしくは治療、または寿命の延長のための組成物

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JP4646070B2 (ja) 2011-03-09

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WO2004085642A1 (ja) 関節炎関連遺伝子及びこれの関節炎検査等への利用

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