WO2004084964A1 - Porous calcium phosphate high molecular weight hydrogel composite having through hole, method for preparing the same, artificial bone or sustained release material for drug using the same - Google Patents

Porous calcium phosphate high molecular weight hydrogel composite having through hole, method for preparing the same, artificial bone or sustained release material for drug using the same Download PDF

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Publication number
WO2004084964A1
WO2004084964A1 PCT/JP2004/002599 JP2004002599W WO2004084964A1 WO 2004084964 A1 WO2004084964 A1 WO 2004084964A1 JP 2004002599 W JP2004002599 W JP 2004002599W WO 2004084964 A1 WO2004084964 A1 WO 2004084964A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
drug
molecular weight
high molecular
calcium phosphate
Prior art date
Application number
PCT/JP2004/002599
Other languages
French (fr)
Japanese (ja)
Inventor
Atsuo Ito
Noriko Asaka
Tokoha Sakurai
Masaki Uchida
Yu Sogo
Tetsuya Tateishi
Original Assignee
National Institute Of Advanced Industrial Science And Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Advanced Industrial Science And Technology filed Critical National Institute Of Advanced Industrial Science And Technology
Publication of WO2004084964A1 publication Critical patent/WO2004084964A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A porous calcium phosphate high molecular weight hydrogel composite having through holes which has artificial three-dimensional through holes having a diameter of 70 μm to 4 mm, has a porosity of 20 to 80 %, and contains calcium phosphate having a Ca/P mole ratio of 0.75 to 2.1 as a primary component, wherein the through hole is packed with the high molecular weight hydrogel; a method for preparing the composite; and an artificial bone or a sustained release material for a drug using the composite. The above composite can carry an effective ingredient such as a drug only by the immersion thereof in a solution containing the ingredient.
PCT/JP2004/002599 2003-03-03 2004-03-03 Porous calcium phosphate high molecular weight hydrogel composite having through hole, method for preparing the same, artificial bone or sustained release material for drug using the same WO2004084964A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-056095 2003-03-03
JP2003056095A JP4228070B2 (en) 2003-03-03 2003-03-03 Porous calcium phosphate polymer hydrogel composite having penetration, method for producing the same, and artificial bone or drug sustained-release body using the same

Publications (1)

Publication Number Publication Date
WO2004084964A1 true WO2004084964A1 (en) 2004-10-07

Family

ID=33094799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/002599 WO2004084964A1 (en) 2003-03-03 2004-03-03 Porous calcium phosphate high molecular weight hydrogel composite having through hole, method for preparing the same, artificial bone or sustained release material for drug using the same

Country Status (2)

Country Link
JP (1) JP4228070B2 (en)
WO (1) WO2004084964A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090777A1 (en) * 2005-02-23 2006-08-31 Hi-Lex Corporation Medical material, artificial tooth root and method of producing material for clinical use
CN101066469B (en) * 2007-05-09 2010-05-19 上海理工大学 Preparation process of porous collagen sponge
CN102580167A (en) * 2012-03-31 2012-07-18 上海理工大学 Preparation method of three-dimensional chitosan porous support
JP5166864B2 (en) * 2005-02-23 2013-03-21 株式会社ハイレックスコーポレーション Artificial tooth root
CN113398333A (en) * 2021-06-01 2021-09-17 南京方拓新材料科技有限责任公司 Hydrogel-based calcium magnesium phosphate material and application thereof as bone repair material
CN114569223A (en) * 2022-01-25 2022-06-03 苏州卓恰医疗科技有限公司 Body implant with filler and method for the production thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007222611A (en) * 2006-01-26 2007-09-06 National Institute Of Advanced Industrial & Technology Artificial bone with sustained-release property of chemical and manufacturing method thereof
WO2008041704A1 (en) * 2006-10-02 2008-04-10 National Institute For Materials Science Controlled release preparation
WO2008041774A1 (en) * 2006-10-02 2008-04-10 National Institute For Materials Science Sustained-release preparation having bone conduction ability
JP5008135B2 (en) * 2007-05-31 2012-08-22 Ｈｏｙａ株式会社 Porous body comprising apatite / collagen composite and method for producing the same
JP4934773B2 (en) * 2007-05-31 2012-05-16 Ｈｏｙａ株式会社 Porous body comprising apatite / collagen composite and method for producing the same
JP5232484B2 (en) * 2008-01-31 2013-07-10 日本特殊陶業株式会社 Biological implant
CA2732907A1 (en) * 2008-07-02 2010-01-07 Next21 K.K. Artificial bone material having controlled calcium ion elution
WO2010146574A1 (en) * 2009-06-15 2010-12-23 Cartiheal (2009) Ltd. Solid forms for tissue repair
EP3417889A1 (en) * 2009-12-13 2018-12-26 Amit Prakash Govil Bioactive grafts and composites
JP5741988B2 (en) * 2010-05-10 2015-07-01 国立研究開発法人理化学研究所 Hydrogel, dried product thereof, and method for producing hydrogel
JP6961504B2 (en) * 2018-01-26 2021-11-05 国立大学法人 岡山大学 Sustained release device
CN110982125B (en) * 2019-12-19 2022-01-21 武汉纺织大学 Shape self-recovery porous composite gel and preparation method and application thereof
CN118056500A (en) * 2022-11-18 2024-05-21 思摩尔国际控股有限公司 Porous ordered matrix material and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5858041A (en) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 Bone defficient part and void part filling material
JPS62295666A (en) * 1986-06-16 1987-12-23 呉羽化学工業株式会社 Continuous two-dimensional porous implant material and its production
JPH078547A (en) * 1993-06-29 1995-01-13 Asahi Optical Co Ltd Sintered type bone filler containing living body absorbable high polymer
JP2001198208A (en) * 2000-01-19 2001-07-24 Natl Inst For Res In Inorg Mater Calcium phosphate type biocompatible ceramic sintered body and method of manufacturing the same
WO2003035576A1 (en) * 2001-10-21 2003-05-01 National Institute Of Advanced Industrial Science And Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5858041A (en) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 Bone defficient part and void part filling material
JPS62295666A (en) * 1986-06-16 1987-12-23 呉羽化学工業株式会社 Continuous two-dimensional porous implant material and its production
JPH078547A (en) * 1993-06-29 1995-01-13 Asahi Optical Co Ltd Sintered type bone filler containing living body absorbable high polymer
JP2001198208A (en) * 2000-01-19 2001-07-24 Natl Inst For Res In Inorg Mater Calcium phosphate type biocompatible ceramic sintered body and method of manufacturing the same
WO2003035576A1 (en) * 2001-10-21 2003-05-01 National Institute Of Advanced Industrial Science And Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090777A1 (en) * 2005-02-23 2006-08-31 Hi-Lex Corporation Medical material, artificial tooth root and method of producing material for clinical use
JP5166864B2 (en) * 2005-02-23 2013-03-21 株式会社ハイレックスコーポレーション Artificial tooth root
CN101066469B (en) * 2007-05-09 2010-05-19 上海理工大学 Preparation process of porous collagen sponge
CN102580167A (en) * 2012-03-31 2012-07-18 上海理工大学 Preparation method of three-dimensional chitosan porous support
CN113398333A (en) * 2021-06-01 2021-09-17 南京方拓新材料科技有限责任公司 Hydrogel-based calcium magnesium phosphate material and application thereof as bone repair material
CN113398333B (en) * 2021-06-01 2022-10-11 东南大学苏州医疗器械研究院 Hydrogel-based calcium magnesium phosphate material and application thereof as bone repair material
CN114569223A (en) * 2022-01-25 2022-06-03 苏州卓恰医疗科技有限公司 Body implant with filler and method for the production thereof
CN114569223B (en) * 2022-01-25 2023-12-08 苏州卓恰医疗科技有限公司 Body implant with filler and method for producing the same

Also Published As

Publication number Publication date
JP2004261456A (en) 2004-09-24
JP4228070B2 (en) 2009-02-25

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