WO2004082575A3 - Diagnostics and therapeutics for diseases associated with phosphodiesterase 6b (pde6b) - Google Patents

Diagnostics and therapeutics for diseases associated with phosphodiesterase 6b (pde6b) Download PDF

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Publication number
WO2004082575A3
WO2004082575A3 PCT/EP2004/002397 EP2004002397W WO2004082575A3 WO 2004082575 A3 WO2004082575 A3 WO 2004082575A3 EP 2004002397 W EP2004002397 W EP 2004002397W WO 2004082575 A3 WO2004082575 A3 WO 2004082575A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
pde6b
diseases
phosphodiesterase
therapeutics
Prior art date
Application number
PCT/EP2004/002397
Other languages
French (fr)
Other versions
WO2004082575A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2004082575A2 publication Critical patent/WO2004082575A2/en
Publication of WO2004082575A3 publication Critical patent/WO2004082575A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a human PDE6B which is associated with the cardiovascular disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE6B as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/002397 2003-03-18 2004-03-09 Diagnostics and therapeutics for diseases associated with phosphodiesterase 6b (pde6b) WO2004082575A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03006102.2 2003-03-18
EP03006102 2003-03-18

Publications (2)

Publication Number Publication Date
WO2004082575A2 WO2004082575A2 (en) 2004-09-30
WO2004082575A3 true WO2004082575A3 (en) 2005-01-27

Family

ID=33016832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002397 WO2004082575A2 (en) 2003-03-18 2004-03-09 Diagnostics and therapeutics for diseases associated with phosphodiesterase 6b (pde6b)

Country Status (1)

Country Link
WO (1) WO2004082575A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103963A2 (en) * 1982-08-24 1984-03-28 Northern Telecom Limited Apparatus for stranding at least two wires together
US5498521A (en) * 1990-01-24 1996-03-12 President And Fellows Of Harvard College Diagnosis of hereditary retinal degenerative diseases
WO2003007979A1 (en) * 2001-07-18 2003-01-30 Board Of Regents, The University Of Texas System An anti-angiogenic state in mice and humans with retinal photorecptor cell degeneration
WO2004033495A2 (en) * 2002-10-11 2004-04-22 Bayer Healthcare Ag Regulation of human pde6b

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103963A2 (en) * 1982-08-24 1984-03-28 Northern Telecom Limited Apparatus for stranding at least two wires together
US5498521A (en) * 1990-01-24 1996-03-12 President And Fellows Of Harvard College Diagnosis of hereditary retinal degenerative diseases
WO2003007979A1 (en) * 2001-07-18 2003-01-30 Board Of Regents, The University Of Texas System An anti-angiogenic state in mice and humans with retinal photorecptor cell degeneration
WO2004033495A2 (en) * 2002-10-11 2004-04-22 Bayer Healthcare Ag Regulation of human pde6b

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COLLINS ET AL: "The human Beta-Subunit of Rod Photoreceptor cGMP Phosphodiesterase: Complete Retinal cDNA Sequence and Evidence for Expression in Brain", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 13, no. 3, July 1992 (1992-07-01), pages 698 - 704, XP002144170, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
WO2004082575A2 (en) 2004-09-30

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