WO2004082568A3 - Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar) - Google Patents

Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar) Download PDF

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Publication number
WO2004082568A3
WO2004082568A3 PCT/EP2004/002175 EP2004002175W WO2004082568A3 WO 2004082568 A3 WO2004082568 A3 WO 2004082568A3 EP 2004002175 W EP2004002175 W EP 2004002175W WO 2004082568 A3 WO2004082568 A3 WO 2004082568A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
c5ar
diseases
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2004/002175
Other languages
French (fr)
Other versions
WO2004082568A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer filed Critical Bayer Healthcare Ag
Priority to US10/548,962 priority Critical patent/US20060240436A1/en
Priority to EP04717062A priority patent/EP1606621B1/en
Priority to DE602004017439T priority patent/DE602004017439D1/en
Publication of WO2004082568A2 publication Critical patent/WO2004082568A2/en
Publication of WO2004082568A3 publication Critical patent/WO2004082568A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a human C5AR which is associated with the cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of C5AR as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/002175 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar) WO2004082568A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/548,962 US20060240436A1 (en) 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar)
EP04717062A EP1606621B1 (en) 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar)
DE602004017439T DE602004017439D1 (en) 2003-03-17 2004-03-04 DIAGNOSTIC AND THERAPY PROCEDURES OF C5A RECEPTOR-ASSOCIATED DISEASES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03005467 2003-03-17
EP03005467.0 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004082568A2 WO2004082568A2 (en) 2004-09-30
WO2004082568A3 true WO2004082568A3 (en) 2005-01-13

Family

ID=33016821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002175 WO2004082568A2 (en) 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar)

Country Status (6)

Country Link
US (1) US20060240436A1 (en)
EP (1) EP1606621B1 (en)
AT (1) ATE412903T1 (en)
DE (1) DE602004017439D1 (en)
ES (1) ES2314383T3 (en)
WO (1) WO2004082568A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005015206A2 (en) * 2003-08-08 2005-02-17 Genova Ltd. Secreted polypeptide species associated with cardiovascular disorders
ES2587344T3 (en) * 2003-12-24 2016-10-24 Novo Nordisk A/S Transgenic mouse comprising a polynucleotide encoding human or humanized C5aR
EP3798230B1 (en) 2011-06-06 2022-08-03 Novo Nordisk A/S Therapeutic antibodies
EP3349773A4 (en) * 2015-09-14 2019-05-01 Cincinnati Children's Hospital Medical Center Methods and compositions for treatment of gaucher disease via modulation of c5a receptor
TW202140553A (en) 2020-01-13 2021-11-01 美商威特拉公司 Antibody molecules to c5ar1 and uses thereof
TW202246331A (en) 2021-01-13 2022-12-01 美商威特拉公司 Humanized complement 5a receptor 1 antibodies and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614370A (en) * 1994-03-18 1997-03-25 Merck & Co., Inc. Assay to identify human C5a antagonists and agonists
US5861272A (en) * 1995-06-02 1999-01-19 Human Genome Sciences, Inc. C5A receptor
WO2002022556A1 (en) * 2000-09-14 2002-03-21 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof ugs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614370A (en) * 1994-03-18 1997-03-25 Merck & Co., Inc. Assay to identify human C5a antagonists and agonists
US5861272A (en) * 1995-06-02 1999-01-19 Human Genome Sciences, Inc. C5A receptor
WO2002022556A1 (en) * 2000-09-14 2002-03-21 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof ugs
EP1318140A1 (en) * 2000-09-14 2003-06-11 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof ugs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABE KATSUSHIGE ET AL: "Enhanced expression of complement C5a receptor mRNA in human diseased kidney assessed by in situ hybridization", KIDNEY INTERNATIONAL, vol. 60, no. 1, July 2001 (2001-07-01), pages 137 - 146, XP002284411, ISSN: 0085-2538 *
DRAPEAU G ET AL: "SYNTHETIC C5A RECEPTOR AGONISTS PHARMACOLOGY, METABOLISM AND IN VIVO CARDIOVASCULAR AND HEMATOLOGIC EFFECTS", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 45, no. 6, 24 March 1993 (1993-03-24), pages 1289 - 1299, XP001098793, ISSN: 0006-2952 *
PETITCLERC ERIC ET AL: "Pathologic leukocyte infiltration of the rabbit aorta confers a vasomotor effect to chemotactic peptides through cyclooxygenase-derived metabolites", JOURNAL OF IMMUNOLOGY, vol. 156, no. 9, 1996, pages 3426 - 3434, XP002284412, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
EP1606621A2 (en) 2005-12-21
DE602004017439D1 (en) 2008-12-11
EP1606621B1 (en) 2008-10-29
ES2314383T3 (en) 2009-03-16
WO2004082568A2 (en) 2004-09-30
US20060240436A1 (en) 2006-10-26
ATE412903T1 (en) 2008-11-15

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