WO2004079346A1 - Method and device for the analysis of products in the form of a capsule and of empty capsules by means of nir reflection spectroscopy - Google Patents

Method and device for the analysis of products in the form of a capsule and of empty capsules by means of nir reflection spectroscopy Download PDF

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Publication number
WO2004079346A1
WO2004079346A1 PCT/IB2004/000552 IB2004000552W WO2004079346A1 WO 2004079346 A1 WO2004079346 A1 WO 2004079346A1 IB 2004000552 W IB2004000552 W IB 2004000552W WO 2004079346 A1 WO2004079346 A1 WO 2004079346A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
mounting
nir
analysis
jaws
Prior art date
Application number
PCT/IB2004/000552
Other languages
French (fr)
Inventor
Holger Gerhard HAUG
Alexander Pysik
Original Assignee
Warner-Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03006924A external-priority patent/EP1462792A1/en
Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc
Publication of WO2004079346A1 publication Critical patent/WO2004079346A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
    • G01N21/9508—Capsules; Tablets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0339—Holders for solids, powders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A method and a device for the analysis of products in the form of a capsule and of empty capsules by means of NIR reflection spectroscopy are proposed in which the capsule is rotated around at least one axis during the recording of the reflection spectrum. A rotary drive (2) is provided on the capsule mounting (1) to this end.

Description

Method and device for the analysis of products in the form of a capsule and of empty capsules bv means of NIR reflection spectroscopy
Description
The invention derives from a method and a device for the analysis of products in the form of a capsule and of empty capsules by means of NIR reflection spectroscopy.
NIR reflection spectroscopy is employed in pharmacy amongst others to analyse capsules and the content of capsules. It enables both the physical and chemical properties of the capsules to be determined. These include in particular the particle size, water content, identity or content of actives. Compared with chemical processes such as chromatography, NIR spectroscopy has the advantage that the sample in most cases does not have to be destroyed for the analysis and the gain of time because no or only minimal sample preparation is necessary.
The state of the art recognises methods and devices for NIR reflection spectroscopy on capsules in which the capsules are arranged at a fixed location. However, only a small part of the capsule case and contents can be measured when the capsules are in fixed positions. The distribution of the capsule contents in the capsule and the spread is not known in advance and is neither taken into consideration nor determined in the measurement. It may therefore be the case that, if the capsule is not completely full, the capsule contents are located only at one end of the capsule. If measurement is restricted to the middle of the capsule, the capsule contents are not captured in the measurement. In contrast, the method according to the invention and the device according to the invention have the advantage that the rotation of the capsule during the measuring process ensures that several readings are obtained which yield a mean value in respect of the spread and density of the capsule contents. Should the capsule contents be only at one end of the capsule at the start of measurement, they are distributed over the entire capsule through the rotation. Non-reproducible conditions of the capsule contents in respect of the distribution within the capsule are thus balanced out. Furthermore, a large part of the capsule case can be captured with one measurement.
According to an advantageous configuration of the version, the capsule is arranged horizontally and rotated around its longitudinal axis. To this end the device has two jaws between which the capsule is fixed. At least one of the two jaws is brought into rotation by means of a rotary drive. This rotating movement is transmitted to the capsule and the second jaw. The rotation around the longitudinal axis of the horizontally arranged capsule has the advantage that the capsule contents are distributed over the entire capsule and do not slide from one end of the capsule to the other. The fixed location of the spectrometer also ensures that a large part of the capsule case is captured.
There is the further possibility that the capsule is arranged vertically or at any desired angle and that it is then rotated around axes perpendicular to the longitudinal axis.
In place of the reflection, the transmission of the NIR can also be determined and evaluated with the method according to the invention and the device according to the invention. The capsule mounting does not completely enclose the capsule, thereby allowing transmission of the NIR.
Further advantages and advantageous configurations of the invention can be obtained from the following description, the drawing and the claims. Drawings
The drawings show a model embodiment of a device according to the invention which is described in more detail below.
Figure 1 Capsule mounting with rotary drive, perspectiv-partial cross-section view
Figure 2 Pin mounting, front view
Description of the embodiment of the invention
Figure 1 shows a capsule mounting 1 with rotary drive 2 in perspectiv-partial cross-section view. The capsule mounting essentially consists of two jaws 3 and 4 which have a hollow receptacle 5 and 6 for a capsule 19 schematically illustrated in the drawing. Each of the two jaws 3, 4 is secured to a pin 7, 8. The pin 7 is movably located in a pin mounting 9. The pin mounting 9 is shown in Figure 2 and consists of a tubular section 10 and a plate-shaped section 11. The tubular section 10 of the pin mounting 9 has recesses 12 and 13 adapted to the pins 7, 8 for the purpose of guiding the two cylindrical pins 7, 8. Around pin 7 is stretched a helical spring 14 which is fixed between the jaw 3 and the pin mounting 9. The helical spring 14 is pressed together by the clamping of a capsule 19 between the two jaws 3 and 4. The resulting spring force of the helical spring 14 ensures that the capsule 19 is clamped between the two jaws 3, 4. The pin 8 has a gear wheel 15 at the end projecting out of the pin mounting 9. The gear wheel 15 is connected to the rotary drive 2 by means of two further gear wheels 16 and 17. The gearing consisting of the gear wheels 15, 16 and 17 transmits the rotation of the rotary drive 2 to the pin 8 and thus to the capsule 19. The pin 7 is pivoted in the pin mounting 9 and is moved by the rotation of the capsule 19. A suitable rotary drive 2 would be an electric motor with gear box 20, for instance. However, there is also the possibility of initiating the rotation manually by means of a handle or a crank not shown in the drawing. The capsule mounting is placed with its front side 18 on an NIR spectrometer for the purpose of conducting the measurements. The beam axis A of the NIR runs perpendicular to the longitudinal axis B of the capsule 19. Since the two jaws 3 and 4 cover only a small part of the capsule, almost the entire capsule is captured by the NIR. Becausie of the rotation of the capsule 19 around its longitudinal axis B, almost the entire surface of the capsule and the entire capsule contents can be analysed.
All features of the invention can be material to the invention both individually and in any combination.
Reference numbers
1 Capsule mounting
2 Rotary drive
3 Jaw
4 Jaw
5 Receptacle for the capsule
6 Receptacle for the capsule
7 Pin
8 Pin
9 Pin mounting
10 Tubular section of the pin mounting
11 Plate-shaped section of the pin mounting
12 Recess for pin
13 Recess for pin
14 Helical spring
15 Gear wheel
16 Gear wheel
17 Gear wheel
18 Front side 19 Capsule
20 Gear box
A Beam axis of NIR
B Longitudinal axis of capsule 19 and capsule mounting 1

Claims

Claims
1. Method for the analysis of products in the form of a capsule and of empty capsules by means of NIR reflection spectroscopy, characterised in that the capsule is rotated around at least one axis during the recording of the reflection spectrum.
2. Method according to claim 1 , characterised in that the capsule is arranged horizontally and rotated around its longitudinal axis.
3. Device for the analysis of products in the form of a capsule and of empty capsules by means of NIR reflection spectroscopy, in particular for the performance of the method according to claim 1 and 2, with an NIR spectrometer and with a capsule mounting for the capsule, characterised in that the capsule mounting is pivoted and a rotary drive is provided for the rotation of the capsule mounting around at least one axis.
4. Device according to claim 3, characterised in that two jaws are provided as a capsule mounting with in each case a cavity facing the capsule in the mounted state for the accommodation of one end of the capsule.
5. Device according to claim 4, characterised in that a spring is provided which presses the two jaws together.
Device according to claim 4 or 5, characterised in that each of the two jaws is arranged on a pin.
7. Device according to claim 6, characterised in that a pin mounting is provided in which one of the two pins is axially movably mounted and that a helical spring fixed between one of the two jaws and the mounting is provided as the spring.
8. Device according to claim 7, characterised in that the rotary drive is connected with at least one of the two pins.
9. Device according to claim 8, characterised in that the rotary drive is connected with at least one of the two pins by means of a toothed gearing.
PCT/IB2004/000552 2003-03-07 2004-02-20 Method and device for the analysis of products in the form of a capsule and of empty capsules by means of nir reflection spectroscopy WO2004079346A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45282403P 2003-03-07 2003-03-07
US60/452,824 2003-03-07
EP03006924A EP1462792A1 (en) 2003-03-26 2003-03-26 Method and device for the analysis of products in the form of a capsule and of empty capsules by means of NIR reflection spectroscopy
EP03006924.9 2003-03-26

Publications (1)

Publication Number Publication Date
WO2004079346A1 true WO2004079346A1 (en) 2004-09-16

Family

ID=32963786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000552 WO2004079346A1 (en) 2003-03-07 2004-02-20 Method and device for the analysis of products in the form of a capsule and of empty capsules by means of nir reflection spectroscopy

Country Status (1)

Country Link
WO (1) WO2004079346A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005114143A1 (en) * 2004-05-12 2005-12-01 Pioneer Hi-Bred International, Inc. Non-destructive single seed or several seeds nir analyzer and method
US7274456B2 (en) 2004-05-12 2007-09-25 Pioneer Hi-Bred International, Inc. Non-destructive single seed or several seeds NIR analyzer and method
US7274457B2 (en) 2004-05-12 2007-09-25 Pioneer Hi-Bred International, Inc. Non-destructive derivation of weight of single seed or several seeds
CN104634790A (en) * 2015-02-09 2015-05-20 杭州乔戈里科技有限公司 Capsule detection method and high-speed fully-automatic detection device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59163545A (en) * 1983-03-09 1984-09-14 Fuji Electric Co Ltd Inspecting device for external appearance of capsule
US4734584A (en) * 1986-09-16 1988-03-29 Trebor Industries, Inc. Quantitative near-infrared measurement instrument for multiple measurements in both reflectance and transmission modes
US4882493A (en) * 1988-03-09 1989-11-21 Indiana University Foundation Sample holders or reflectors for intact capsules and tablets and for liquid microcells for use in near-infrared reflectance spectrophotometers
FR2638834A1 (en) * 1988-11-10 1990-05-11 Charbonnages De France Sample holder for Fourier-transform spectrophotometer, and spectrophotometer comprising same
EP0896215A1 (en) * 1997-08-08 1999-02-10 Pfizer Limited Spectrophotometric analysis
US5999253A (en) * 1995-12-20 1999-12-07 Astra Aktiebolag Apparatus and method for spectrometry
US20020011567A1 (en) * 2000-03-13 2002-01-31 Ozanich Richard M. Apparatus and method and techniques for measuring and correlating characteristics of fruit with visible/near infra-red spectrum

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59163545A (en) * 1983-03-09 1984-09-14 Fuji Electric Co Ltd Inspecting device for external appearance of capsule
US4734584A (en) * 1986-09-16 1988-03-29 Trebor Industries, Inc. Quantitative near-infrared measurement instrument for multiple measurements in both reflectance and transmission modes
US4882493A (en) * 1988-03-09 1989-11-21 Indiana University Foundation Sample holders or reflectors for intact capsules and tablets and for liquid microcells for use in near-infrared reflectance spectrophotometers
FR2638834A1 (en) * 1988-11-10 1990-05-11 Charbonnages De France Sample holder for Fourier-transform spectrophotometer, and spectrophotometer comprising same
US5999253A (en) * 1995-12-20 1999-12-07 Astra Aktiebolag Apparatus and method for spectrometry
EP0896215A1 (en) * 1997-08-08 1999-02-10 Pfizer Limited Spectrophotometric analysis
US20020011567A1 (en) * 2000-03-13 2002-01-31 Ozanich Richard M. Apparatus and method and techniques for measuring and correlating characteristics of fruit with visible/near infra-red spectrum

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 009, no. 016 (P - 329) 23 January 1985 (1985-01-23) *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005114143A1 (en) * 2004-05-12 2005-12-01 Pioneer Hi-Bred International, Inc. Non-destructive single seed or several seeds nir analyzer and method
US7274456B2 (en) 2004-05-12 2007-09-25 Pioneer Hi-Bred International, Inc. Non-destructive single seed or several seeds NIR analyzer and method
US7274457B2 (en) 2004-05-12 2007-09-25 Pioneer Hi-Bred International, Inc. Non-destructive derivation of weight of single seed or several seeds
US7483137B2 (en) 2004-05-12 2009-01-27 Pioneer Hi-Bred International, Inc. Non-destructive derivation of weight of single seed or several seeds
US7508517B2 (en) 2004-05-12 2009-03-24 Pioneer Hi-Bred International, Inc. Non-destructive single seed or several seeds NIR analyzer and method
CN104634790A (en) * 2015-02-09 2015-05-20 杭州乔戈里科技有限公司 Capsule detection method and high-speed fully-automatic detection device

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