WO2004076678A3 - Dispositif de dosage de matrice solide translucide destine a une analyse microreseau - Google Patents

Dispositif de dosage de matrice solide translucide destine a une analyse microreseau Download PDF

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Publication number
WO2004076678A3
WO2004076678A3 PCT/US2004/004675 US2004004675W WO2004076678A3 WO 2004076678 A3 WO2004076678 A3 WO 2004076678A3 US 2004004675 W US2004004675 W US 2004004675W WO 2004076678 A3 WO2004076678 A3 WO 2004076678A3
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WO
WIPO (PCT)
Prior art keywords
arrays
translucent
assay device
reconfigurable
certain embodiments
Prior art date
Application number
PCT/US2004/004675
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English (en)
Other versions
WO2004076678A2 (fr
Inventor
Lawrence R Green
Original Assignee
Pritest Inc
Lawrence R Green
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Priority claimed from US10/373,408 external-priority patent/US7268925B1/en
Priority claimed from US10/373,546 external-priority patent/US6861251B2/en
Application filed by Pritest Inc, Lawrence R Green filed Critical Pritest Inc
Priority to US10/550,629 priority Critical patent/US20060211044A1/en
Priority to CA2519903A priority patent/CA2519903C/fr
Priority to EP04711880A priority patent/EP1599597B1/fr
Priority to DE602004028445T priority patent/DE602004028445D1/de
Priority to AT04711880T priority patent/ATE476494T1/de
Publication of WO2004076678A2 publication Critical patent/WO2004076678A2/fr
Publication of WO2004076678A3 publication Critical patent/WO2004076678A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne des procédés et des compositions concernant des réseaux de matrice translucide. Dans certains modes de réalisation, les réseaux sont reconfigurables. Les réseaux reconfigurales peuvent être produits à l'aide de petites molécules de liaison, telles que des aptamères ou des afficorps qui se lient, de préférence, à la partie spécifique IgG des anticorps. De tels réseaux peuvent être utilisés pour détecter toute cible qui se lie sélectivement ou spécifiquement à un IgG. Les réseaux de matrice translucide peuvent utiliser de la cellophane, de la rayonne ou une forme colloïdale translucide de nitrocellulose pour enrober le substrat. D'autres modes de réalisation concernent des procédés d'analyse de données et des appareils de détection d'analytes. Certains modes de réalisation concernent un dispositif de dosage total optique (TOADTM) qui peut être utilisé avec des tranches GRABBERTM et/ou des dispositifs de dosage de cupules microdosées FOOTPADTM.
PCT/US2004/004675 2003-02-24 2004-02-17 Dispositif de dosage de matrice solide translucide destine a une analyse microreseau WO2004076678A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/550,629 US20060211044A1 (en) 2003-02-24 2004-02-17 Translucent solid matrix assay device dor microarray analysis
CA2519903A CA2519903C (fr) 2003-02-24 2004-02-17 Dispositif de dosage de matrice solide translucide destine a une analyse microreseau
EP04711880A EP1599597B1 (fr) 2003-02-24 2004-02-17 Dispositif de dosage avec matrice solide translucide destine a une analyse microreseau
DE602004028445T DE602004028445D1 (de) 2003-02-24 2004-02-17 Lichtdurchlässige festmatrix-prüfvorrichtung zur mikroarray-analyse
AT04711880T ATE476494T1 (de) 2003-02-24 2004-02-17 Lichtdurchlässige festmatrix-prüfvorrichtung zur mikroarray-analyse

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/373,408 US7268925B1 (en) 2003-02-24 2003-02-24 Image sensor optimization
US10/373,546 US6861251B2 (en) 2003-02-24 2003-02-24 Translucent solid matrix assay device for microarray analysis
US10/373,546 2003-02-24
US10/373,408 2003-02-24
US54072004P 2004-01-29 2004-01-29
US60/540,720 2004-01-29

Publications (2)

Publication Number Publication Date
WO2004076678A2 WO2004076678A2 (fr) 2004-09-10
WO2004076678A3 true WO2004076678A3 (fr) 2006-03-02

Family

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PCT/US2004/004675 WO2004076678A2 (fr) 2003-02-24 2004-02-17 Dispositif de dosage de matrice solide translucide destine a une analyse microreseau

Country Status (6)

Country Link
US (1) US20060211044A1 (fr)
EP (1) EP1599597B1 (fr)
AT (1) ATE476494T1 (fr)
CA (1) CA2519903C (fr)
DE (1) DE602004028445D1 (fr)
WO (1) WO2004076678A2 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292647A1 (en) * 2004-12-03 2006-12-28 Green Lawrence R Reflex supplemental testing - A rapid, efficient and highly accurate method to identify subjects with an infection, disease or other condition
US20080124738A1 (en) * 2005-03-01 2008-05-29 Pritest, Inc Compositions and methods of testing for tuberculosis and mycobacterium infection
JP2009505106A (ja) 2005-08-19 2009-02-05 ナノスフェアー インコーポレイテッド Ｄｎａ及び抗体を含むハイブリッド基板を調製するための方法及びその使用
WO2007095634A2 (fr) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. detection d'une proteine prion
KR100819234B1 (ko) * 2006-05-25 2008-04-02 삼성전자주식회사 네비게이션 단말의 목적지 설정 방법 및 장치
US8610690B2 (en) * 2007-07-27 2013-12-17 Tpk Touch Solutions Inc. Capacitive sensor and method for manufacturing same
US20090075837A1 (en) * 2007-09-18 2009-03-19 Primorigen Biosciences, Llc Frameless multiplexed microarrays
CN101896605A (zh) 2007-10-12 2010-11-24 普罗诺塔股份有限公司 适体在蛋白质组学中的用途
US8928602B1 (en) 2009-03-03 2015-01-06 MCube Inc. Methods and apparatus for object tracking on a hand-held device
US8797279B2 (en) 2010-05-25 2014-08-05 MCube Inc. Analog touchscreen methods and apparatus
US8421082B1 (en) 2010-01-19 2013-04-16 Mcube, Inc. Integrated CMOS and MEMS with air dielectric method and system
US8476129B1 (en) 2010-05-24 2013-07-02 MCube Inc. Method and structure of sensors and MEMS devices using vertical mounting with interconnections
US8823007B2 (en) 2009-10-28 2014-09-02 MCube Inc. Integrated system on chip using multiple MEMS and CMOS devices
US8710597B1 (en) 2010-04-21 2014-04-29 MCube Inc. Method and structure for adding mass with stress isolation to MEMS structures
US8477473B1 (en) 2010-08-19 2013-07-02 MCube Inc. Transducer structure and method for MEMS devices
US8553389B1 (en) 2010-08-19 2013-10-08 MCube Inc. Anchor design and method for MEMS transducer apparatuses
US20110110589A1 (en) * 2009-11-06 2011-05-12 Kabushiki Kaisha Toshiba Image Contrast Enhancement
US9709509B1 (en) * 2009-11-13 2017-07-18 MCube Inc. System configured for integrated communication, MEMS, Processor, and applications using a foundry compatible semiconductor process
US8637943B1 (en) 2010-01-04 2014-01-28 MCube Inc. Multi-axis integrated MEMS devices with CMOS circuits and method therefor
US8794065B1 (en) 2010-02-27 2014-08-05 MCube Inc. Integrated inertial sensing apparatus using MEMS and quartz configured on crystallographic planes
US8936959B1 (en) 2010-02-27 2015-01-20 MCube Inc. Integrated rf MEMS, control systems and methods
US8367522B1 (en) 2010-04-08 2013-02-05 MCube Inc. Method and structure of integrated micro electro-mechanical systems and electronic devices using edge bond pads
US8928696B1 (en) 2010-05-25 2015-01-06 MCube Inc. Methods and apparatus for operating hysteresis on a hand held device
US8869616B1 (en) 2010-06-18 2014-10-28 MCube Inc. Method and structure of an inertial sensor using tilt conversion
US8652961B1 (en) 2010-06-18 2014-02-18 MCube Inc. Methods and structure for adapting MEMS structures to form electrical interconnections for integrated circuits
US8993362B1 (en) 2010-07-23 2015-03-31 MCube Inc. Oxide retainer method for MEMS devices
US8723986B1 (en) 2010-11-04 2014-05-13 MCube Inc. Methods and apparatus for initiating image capture on a hand-held device
WO2012107497A1 (fr) * 2011-02-08 2012-08-16 Quentiq AG Système, procédé et appareil pour l'analyse distante de micromatrices de composants chimiques
US8969101B1 (en) 2011-08-17 2015-03-03 MCube Inc. Three axis magnetic sensor device and method using flex cables
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US20150124072A1 (en) * 2013-11-01 2015-05-07 Datacolor, Inc. System and method for color correction of a microscope image
WO2017035343A1 (fr) * 2015-08-26 2017-03-02 Access Medical Systems, Ltd. Dosage immunologique à sensibilité améliorée
US10825123B2 (en) * 2015-11-30 2020-11-03 Ncr Corporation Watermarked enabled scanning
US10430955B2 (en) * 2016-08-31 2019-10-01 The Regents Of The University Of California High content screening workflows for microscope imaging
DE102018114092B4 (de) 2018-06-13 2021-04-29 Infineon Technologies Ag Verfahren, Vorrichtungen und Systeme zur Überwachung von Datenwandlern welche einen Kalibrierungsdatensatz aufweisen
DE102018114091B4 (de) * 2018-06-13 2021-04-29 Infineon Technologies Ag Verfahren zur Datenwandlung, bei denen ein Zustand basierend auf zeitpunktzugehörigen Linearitätsparametern bestimmt wird, sowie Vorrichtungen und Systeme zur Datenwandlung, eingerichtet, einen Zustand basierend auf zeitpunktzugehörigen Linearitätsparametern zu bestimmen
TWI767434B (zh) * 2020-12-01 2022-06-11 國立成功大學 蛋白質微陣列、其檢測方法、其用途及含有該蛋白質微陣列之試劑盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831012A (en) * 1994-01-14 1998-11-03 Pharmacia & Upjohn Aktiebolag Bacterial receptor structures
US20030228637A1 (en) * 2001-04-10 2003-12-11 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501495A (en) * 1981-06-17 1985-02-26 Smithkline Beckman Corporation Slide carrier
EP0366241A3 (fr) * 1988-10-04 1990-05-23 Fisher Scientific Company Dispositif avec surface adsorbante et méthode de fabrication
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
JP2763958B2 (ja) * 1990-06-11 1998-06-11 ネクスター ファーマスーティカルズ，インコーポレイテッド 核酸リガンド
US5886353A (en) * 1995-04-21 1999-03-23 Thermotrex Corporation Imaging device
GB2303511A (en) * 1995-07-19 1997-02-19 Univ Manchester Compensating for backscattered light
JP2002516045A (ja) * 1996-11-08 2002-05-28 ナショナル・コンピューター・システムズ・インコーポレーテッド 較正画素出力を伴う光走査
US20020050518A1 (en) * 1997-12-08 2002-05-02 Roustaei Alexander R. Sensor array
US6069973A (en) * 1998-06-30 2000-05-30 Xerox Corporation Method and apparatus for color correction in a multi-chip imaging array
US6542249B1 (en) * 1999-07-20 2003-04-01 The University Of Western Ontario Three-dimensional measurement method and apparatus
US6399295B1 (en) * 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
WO2001057501A1 (fr) * 2000-02-03 2001-08-09 Alpha Innotech Corporation Lecteur de jeux ordonnes de microechantillons ameliore
US6556932B1 (en) * 2000-05-01 2003-04-29 Xerox Corporation System and method for reconstruction of spectral curves using measurements from a color sensor and a spectral measurement system model
JP4222756B2 (ja) * 2000-05-04 2009-02-12 センター フォア ブラッド リサーチ インコーポレイテッド 固相生体分子分析調製同定システム用コロイド組成物
US7088388B2 (en) * 2001-02-08 2006-08-08 Eastman Kodak Company Method and apparatus for calibrating a sensor for highlights and for processing highlights
EP1379545A2 (fr) * 2001-04-19 2004-01-14 Gesellschaft für biotechnologische Forschung mbH (GBF) Procede de production de series d'anticorps stables regenerables
WO2002093144A1 (fr) * 2001-05-10 2002-11-21 Regents Of The University Of Minnesota Imagerie d'echantillons biologiques au moyen d'un photodetecteur electronique
DE10126286A1 (de) * 2001-05-30 2002-12-19 Leica Microsystems Verfahren und Vorrichtung zum Punktweisen scannen einer Probe
US6767733B1 (en) * 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US7275807B2 (en) * 2002-11-27 2007-10-02 Edc Biosystems, Inc. Wave guide with isolated coupling interface
US7268925B1 (en) * 2003-02-24 2007-09-11 Pritest, Inc. Image sensor optimization

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831012A (en) * 1994-01-14 1998-11-03 Pharmacia & Upjohn Aktiebolag Bacterial receptor structures
US20030228637A1 (en) * 2001-04-10 2003-12-11 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof

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CA2519903A1 (fr) 2004-09-10
US20060211044A1 (en) 2006-09-21
EP1599597A2 (fr) 2005-11-30
CA2519903C (fr) 2011-11-01
DE602004028445D1 (de) 2010-09-16
EP1599597A4 (fr) 2008-04-16
WO2004076678A2 (fr) 2004-09-10
EP1599597B1 (fr) 2010-08-04

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