WO2004070009A3 - Macromolecules multivalentes ciblees - Google Patents

Macromolecules multivalentes ciblees Download PDF

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Publication number
WO2004070009A3
WO2004070009A3 PCT/US2004/002816 US2004002816W WO2004070009A3 WO 2004070009 A3 WO2004070009 A3 WO 2004070009A3 US 2004002816 W US2004002816 W US 2004002816W WO 2004070009 A3 WO2004070009 A3 WO 2004070009A3
Authority
WO
WIPO (PCT)
Prior art keywords
targeted
macromolecules
multivalent macromolecules
targeted multivalent
dextran
Prior art date
Application number
PCT/US2004/002816
Other languages
English (en)
Other versions
WO2004070009A2 (fr
Inventor
Susan E Alters
Jeffrey Lynn Cleland
Pamela C Garzone
John S Pease
Charles Aaron Wartchow
Original Assignee
Targesome Inc
Susan E Alters
Jeffrey Lynn Cleland
Pamela C Garzone
John S Pease
Charles Aaron Wartchow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targesome Inc, Susan E Alters, Jeffrey Lynn Cleland, Pamela C Garzone, John S Pease, Charles Aaron Wartchow filed Critical Targesome Inc
Publication of WO2004070009A2 publication Critical patent/WO2004070009A2/fr
Publication of WO2004070009A3 publication Critical patent/WO2004070009A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des macromolécules ciblées comprenant un liposome recouvert de dextran et plus d'une entité de ciblage, ainsi qu'un procédé de fabrication et une méthode d'utilisation.
PCT/US2004/002816 2003-01-31 2004-02-02 Macromolecules multivalentes ciblees WO2004070009A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44395403P 2003-01-31 2003-01-31
US60/443,954 2003-01-31
US45870903P 2003-03-28 2003-03-28
US60/458,709 2003-03-28
US46358103P 2003-04-16 2003-04-16
US60/463,581 2003-04-16

Publications (2)

Publication Number Publication Date
WO2004070009A2 WO2004070009A2 (fr) 2004-08-19
WO2004070009A3 true WO2004070009A3 (fr) 2005-04-07

Family

ID=32854296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002816 WO2004070009A2 (fr) 2003-01-31 2004-02-02 Macromolecules multivalentes ciblees

Country Status (1)

Country Link
WO (1) WO2004070009A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1745788A1 (fr) * 2005-07-22 2007-01-24 KTB Tumorforschungsgesellschaft mbH Acylglycerophospholipides pour le traitement du cancer et de la cachexie
FR2895262B1 (fr) * 2005-12-22 2009-07-17 Lab Francais Du Fractionnement Inhibition de la reponse immunitaire anti-fviii
CN100491406C (zh) * 2006-11-24 2009-05-27 暨南大学 一种磷酸胆碱壳聚糖衍生物的合成方法
CN101554366B (zh) * 2009-05-19 2011-10-19 武汉理工大学 适用于胃肠道定位给药的羧甲基甲壳糖凝胶的制备方法
JP2014533702A (ja) * 2011-11-23 2014-12-15 オージースター セラピューティクス プロプライアタリ リミテッド 改良された相乗作用抗糖尿病組成物
CN104814928B (zh) * 2015-04-29 2017-06-13 江西省科学院应用化学研究所 一种载二氢杨梅素三元复合脂质体的制备方法
WO2017155948A1 (fr) * 2016-03-07 2017-09-14 Memorial Sloan Kettering Cancer Center Liposomes radiomarqués ciblant la moelle osseuse, le système réticulo-endothélial et/ou les nœuds lymphoïdes et méthodes de diagnostic et usage thérapeutique associés
CN113425860B (zh) * 2021-07-07 2022-08-02 湖南中医药高等专科学校 砷荧光量子点及其制备方法与应用
CN113603806B (zh) * 2021-07-16 2022-09-02 武汉纳乐吉生命科技有限公司 一种基于右旋糖酐修饰的胱氨酰胺衍生物、其制备及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US6224903B1 (en) * 1996-10-11 2001-05-01 Sequus Pharmaceuticals, Inc. Polymer-lipid conjugate for fusion of target membranes
US6316024B1 (en) * 1996-10-11 2001-11-13 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
WO2002097116A2 (fr) * 2001-05-30 2002-12-05 The Scripps Research Institute Systeme de delivrance d'acides nucleiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US6224903B1 (en) * 1996-10-11 2001-05-01 Sequus Pharmaceuticals, Inc. Polymer-lipid conjugate for fusion of target membranes
US6316024B1 (en) * 1996-10-11 2001-11-13 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
WO2002097116A2 (fr) * 2001-05-30 2002-12-05 The Scripps Research Institute Systeme de delivrance d'acides nucleiques

Also Published As

Publication number Publication date
WO2004070009A2 (fr) 2004-08-19

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