WO2004069857A3 - “peptides, compositions and uses thereof” - Google Patents

“peptides, compositions and uses thereof” Download PDF

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Publication number
WO2004069857A3
WO2004069857A3 PCT/GB2004/000470 GB2004000470W WO2004069857A3 WO 2004069857 A3 WO2004069857 A3 WO 2004069857A3 GB 2004000470 W GB2004000470 W GB 2004000470W WO 2004069857 A3 WO2004069857 A3 WO 2004069857A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
maximakinin
analogs
fusion
multimeric
Prior art date
Application number
PCT/GB2004/000470
Other languages
French (fr)
Other versions
WO2004069857A2 (en
Inventor
Chris Shaw
David Hirst
Tianbao Chen
Martin O'rourke
Pingfan Rao
Original Assignee
Uutech Ltd
Chris Shaw
David Hirst
Tianbao Chen
Martin O'rourke
Pingfan Rao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0302623A external-priority patent/GB0302623D0/en
Priority claimed from GB0312992A external-priority patent/GB0312992D0/en
Application filed by Uutech Ltd, Chris Shaw, David Hirst, Tianbao Chen, Martin O'rourke, Pingfan Rao filed Critical Uutech Ltd
Publication of WO2004069857A2 publication Critical patent/WO2004069857A2/en
Publication of WO2004069857A3 publication Critical patent/WO2004069857A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A bradykinin agonist peptide, maximakinin, isolated from toad (Bombina maxima) defensive skin secretion, fragments and analogs thereof, are disclosed. The structure of maximakinin is DLPKINRKGPRPPGFSPFR. Also disclosed are maximakinin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including maximakinin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding maximakinin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides.
PCT/GB2004/000470 2003-02-06 2004-02-06 “peptides, compositions and uses thereof” WO2004069857A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0302623.4 2003-02-06
GB0302623A GB0302623D0 (en) 2003-02-06 2003-02-06 Maximakinin
GB0312992.1 2003-06-06
GB0312992A GB0312992D0 (en) 2003-06-06 2003-06-06 Peptides,compositions and uses thereof

Publications (2)

Publication Number Publication Date
WO2004069857A2 WO2004069857A2 (en) 2004-08-19
WO2004069857A3 true WO2004069857A3 (en) 2004-11-18

Family

ID=32852406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000470 WO2004069857A2 (en) 2003-02-06 2004-02-06 “peptides, compositions and uses thereof”

Country Status (1)

Country Link
WO (1) WO2004069857A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0704352D0 (en) * 2007-03-07 2007-04-11 Univ Belfast "Peptide, compositions and uses thereof"
EP2568995B1 (en) 2010-05-14 2016-07-20 Max-Delbrück-Centrum für Molekulare Medizin Therapeutic use of agonists of bradykinin receptor 1 or 2, for modulation collateral blood vessel growth
EP2420245A1 (en) * 2010-08-18 2012-02-22 Max-Delbrück-Centrum Für Molekulare Medizin Therapeutic use of agonists or antagonists of bradykinin receptor 1 or 2, for modulation collateral blood vessel growth
EP2830643A1 (en) * 2012-03-26 2015-02-04 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for prevention or treatment of ischemia related organ damage

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112596A (en) * 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
WO2003028666A2 (en) * 2001-10-04 2003-04-10 The Regents Of The University Of California Isolated polypeptides and compositions from the venom of p. transvaalicus and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112596A (en) * 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
WO2003028666A2 (en) * 2001-10-04 2003-04-10 The Regents Of The University Of California Isolated polypeptides and compositions from the venom of p. transvaalicus and methods of use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEN TIANBAO ET AL: "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom.", PEPTIDES (NEW YORK), vol. 24, no. 6, June 2003 (2003-06-01), pages 853 - 861, XP002291362, ISSN: 0196-9781 *
FUJITA HIROYUKI ET AL: "Isolation and characterization of ovokinin, a bradykinin B-1 agonist peptide derived from ovalbumin", PEPTIDES (TARRYTOWN), vol. 16, no. 5, 1995, pages 785 - 790, XP002291360, ISSN: 0196-9781 *
LAI REN ET AL: "A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 286, no. 2, 17 August 2001 (2001-08-17), pages 259 - 263, XP002291358, ISSN: 0006-291X *
LAI REN ET AL: "Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima.", PEPTIDES (NEW YORK), vol. 24, no. 2, February 2003 (2003-02-01), pages 199 - 204, XP002291361, ISSN: 0196-9781 *
O'ROURKE MARTIN ET AL: "The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima.", REGULATORY PEPTIDES. 15 SEP 2004, vol. 121, no. 1-3, 15 September 2004 (2004-09-15), pages 65 - 72, XP002291363, ISSN: 0167-0115 *
PANG L ET AL: "Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 SEP 1998, vol. 161, no. 5, 1 September 1998 (1998-09-01), pages 2509 - 2515, XP002291359, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2004069857A2 (en) 2004-08-19

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