WO2004067560A3 - Nouveaux polypeptides liant la proteine vp16 herpes simplex - Google Patents

Nouveaux polypeptides liant la proteine vp16 herpes simplex Download PDF

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Publication number
WO2004067560A3
WO2004067560A3 PCT/EP2004/000681 EP2004000681W WO2004067560A3 WO 2004067560 A3 WO2004067560 A3 WO 2004067560A3 EP 2004000681 W EP2004000681 W EP 2004000681W WO 2004067560 A3 WO2004067560 A3 WO 2004067560A3
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WO
WIPO (PCT)
Prior art keywords
herpes simplex
polypeptides
protein binding
binding polypeptides
infections
Prior art date
Application number
PCT/EP2004/000681
Other languages
English (en)
Other versions
WO2004067560A2 (fr
Inventor
Michael Meisterernst
Gerhard Mittler
Ulf Schaberg
Thomas Stuehler
Original Assignee
Gsf Forschungszentrum Umwelt
Michael Meisterernst
Gerhard Mittler
Ulf Schaberg
Thomas Stuehler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt, Michael Meisterernst, Gerhard Mittler, Ulf Schaberg, Thomas Stuehler filed Critical Gsf Forschungszentrum Umwelt
Publication of WO2004067560A2 publication Critical patent/WO2004067560A2/fr
Publication of WO2004067560A3 publication Critical patent/WO2004067560A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
    • G01N2333/035—Herpes simplex virus I or II
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne de nouveaux polypeptides capable de lier le domaine H1 d'une protéine VP16 Herpes simplex, et des polynucléotides isolés codant ces polypeptides. La présente invention porte également sur des vecteurs, des cellules hôtes, des anticorps, et sur des procédés de recombinaison pour obtenir ces polypeptides. Cette invention concerne aussi des méthodes de diagnostic et des thérapies utiles pour traiter des infections dues au virus Herpes simplex, EBV ou Karposi Sarcoma ainsi que des troubles associés à ces infections.
PCT/EP2004/000681 2003-01-27 2004-01-27 Nouveaux polypeptides liant la proteine vp16 herpes simplex WO2004067560A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44251703P 2003-01-27 2003-01-27
US60/442,517 2003-01-27

Publications (2)

Publication Number Publication Date
WO2004067560A2 WO2004067560A2 (fr) 2004-08-12
WO2004067560A3 true WO2004067560A3 (fr) 2005-05-12

Family

ID=32825232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/000681 WO2004067560A2 (fr) 2003-01-27 2004-01-27 Nouveaux polypeptides liant la proteine vp16 herpes simplex

Country Status (1)

Country Link
WO (1) WO2004067560A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072633A1 (fr) * 2001-03-14 2002-09-19 Consejo Superior De Investigaciones Científicas Nouvelle proteine surexprimee dans le cancer de la prostate
WO2002103028A2 (fr) * 2001-05-30 2002-12-27 Biomedical Center Criblage in silico de sequences exprimees associees a un phenotype

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072633A1 (fr) * 2001-03-14 2002-09-19 Consejo Superior De Investigaciones Científicas Nouvelle proteine surexprimee dans le cancer de la prostate
WO2002103028A2 (fr) * 2001-05-30 2002-12-27 Biomedical Center Criblage in silico de sequences exprimees associees a un phenotype

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 1 May 2000 (2000-05-01), ADAMS, D. ET AL.: "CG12254-PA (LD07688p)", XP002294846, Database accession no. Q9VDR1 *
DATABASE EMBL 11 January 2001 (2001-01-11), NCI-CGAP: "nae02a10.x1 NCI_CGAP_Ov18 Homo sapiens cDNA clone IMAGE: 3434011 3' similar to TR: Q9VDR1 Q9VDR1 CG12254 PROTEIN, mRNA sequence", XP002312321, Database accession no. BF732211 *
DATABASE EMBL 14 October 2000 (2000-10-14), MARRA, M. ET AL.: "uy57f10.y1 McCarrey Eddy round spermatid Mus musculus cDNA clone IMAGE: 3663691 5' similar to TR: Q9VDR1 Q9VDR1 CG12254 PROTEIN, mRNA sequence", XP002294845, Database accession no. BF021756 *
DATABASE EMBL 15 July 1998 (1998-07-15), ECKNER, R. ET AL.: "E1A-associated protein p300", XP002312014, Database accession no. Q09472 *
DATABASE EMBL 23 October 2001 (2001-10-23), MELTON, D. ET AL.: "id21g12.x1 Melton Normalized Mixed Mouse Pancreas 1 N1-MMS1 Mus musculus cDNA clone IMAGE: 5663831 3' similar to TR: Q9UGR7 Q9UGR7 DJ85F18.1, mRNA sequence", XP002312013, Database accession no. BI901314 *
DATABASE EMBL 30 November 2002 (2002-11-30), MELTON, D. ET AL.: "io43d02.x1 Human insulinoma Homo sapiens cDNA clone IMAGE: 6129074 3' similar to TR: Q9VDR1 Q9VDR1 CG12254 PROTEIN, mRNA sequence", XP002312320, Database accession no. BU789592 *
DATABASE EMBL 4 February 2001 (2001-02-04), NCI-CGAP: "mab90c03.y1 NCI_CGAP_SP2 Mus musculus cDNA clone IMAGE: 3977476 5' similar to TR: Q9VDR1 Q9VDR1 CG12254 PROTEIN, mRNA sequence", XP002294844, Database accession no. BG146318 *
IKEDA, K. ET AL.: "The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms", GENES TO CELLS, vol. 7, no. 1, January 2002 (2002-01-01), pages 49 - 58, XP002294841 *
MEISTERERNST, M.: "Transcription Regulation in Eukaryotes: Structure and function of proteins that modulate RNA polymerase II transcription", 1999, HUMAN FRONTIER SCIENCE PROGRAM, XP008034481 *
MITTLER, G. ET AL.: "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells", EMBO JOURNAL, vol. 22, no. 24, 15 December 2003 (2003-12-15), pages 6494 - 6504, XP002294843 *
NÄÄR, A.M. ET AL.: "Composite co-activator ARC mediates chromatin-directed transcriptional activation", NATURE, vol. 398, no. 6730, 29 April 1999 (1999-04-29), pages 828 - 832, XP002294840 *
WANG, C. ET AL.: "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 296, no. 2, 16 August 2002 (2002-08-16), pages 281 - 287, XP002294842 *

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Publication number Publication date
WO2004067560A2 (fr) 2004-08-12

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