WO2003033658A3 - Neutrokine-alpha et variant d'epissage de neutrokine-alpha - Google Patents

Neutrokine-alpha et variant d'epissage de neutrokine-alpha Download PDF

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Publication number
WO2003033658A3
WO2003033658A3 PCT/US2002/032910 US0232910W WO03033658A3 WO 2003033658 A3 WO2003033658 A3 WO 2003033658A3 US 0232910 W US0232910 W US 0232910W WO 03033658 A3 WO03033658 A3 WO 03033658A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutrokine
alpha
methods
alphasv
antibodies
Prior art date
Application number
PCT/US2002/032910
Other languages
English (en)
Other versions
WO2003033658A2 (fr
Inventor
Guo-Liang Yu
Reinhard Ebner
Jian Ni
Craig A Rosen
Michael W Laird
Stephen Ullrich
Original Assignee
Human Genome Sciences Inc
Guo-Liang Yu
Reinhard Ebner
Jian Ni
Craig A Rosen
Michael W Laird
Stephen Ullrich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Guo-Liang Yu, Reinhard Ebner, Jian Ni, Craig A Rosen, Michael W Laird, Stephen Ullrich filed Critical Human Genome Sciences Inc
Priority to CA002476675A priority Critical patent/CA2476675A1/fr
Priority to EP02786413A priority patent/EP1507793A4/fr
Priority to AU2002351495A priority patent/AU2002351495A1/en
Publication of WO2003033658A2 publication Critical patent/WO2003033658A2/fr
Publication of WO2003033658A3 publication Critical patent/WO2003033658A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention se rapporte à des molécules d'acide nucléique codant Neutrokine-alpha et/ou des polypeptides de Neutrokine-alphaSV, et contenant des formes solubles du domaine extracellulaire. L'invention concerne aussi Neutrokine-alpha et/ou des polypeptides de Neutrokine-alphaSV, ainsi que vecteurs, des cellules hôtes et des procédés recombinants de fabrication correspondants. Cette invention a également trait à des anticorps ou à des portions d'anticorps qui se lient de manière spécifique à Neutrokine-alpha et/ou à Neutrokine-alphaSV, ainsi qu'à des procédés diagnostiques et thérapeutiques utilisant ces anticorps. L'invention se rapporte aussi à des procédés diagnostiques de détection de troubles liés au système immunitaire et à des procédés thérapeutiques de traitement de troubles liés au système immunitaire au moyen des compositions selon l'invention.
PCT/US2002/032910 2001-10-17 2002-10-16 Neutrokine-alpha et variant d'epissage de neutrokine-alpha WO2003033658A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002476675A CA2476675A1 (fr) 2001-10-17 2002-10-16 Neutrokine-alpha et variant d'epissage de neutrokine-alpha
EP02786413A EP1507793A4 (fr) 2001-10-17 2002-10-16 Neutrokine-alpha et variant d'epissage de neutrokine-alpha
AU2002351495A AU2002351495A1 (en) 2001-10-17 2002-10-16 Neutrokine-alpha and neutrokine-alpha splice variant

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US32950801P 2001-10-17 2001-10-17
US60/329,508 2001-10-17
US32974701P 2001-10-18 2001-10-18
US60/329,747 2001-10-18
US33083501P 2001-10-31 2001-10-31
US60/330,835 2001-10-31
US33147801P 2001-11-16 2001-11-16
US60/331,478 2001-11-16
US33672601P 2001-12-07 2001-12-07
US60/336,726 2001-12-07
US36854802P 2002-04-01 2002-04-01
US60/368,548 2002-04-01

Publications (2)

Publication Number Publication Date
WO2003033658A2 WO2003033658A2 (fr) 2003-04-24
WO2003033658A3 true WO2003033658A3 (fr) 2004-05-27

Family

ID=27559746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032910 WO2003033658A2 (fr) 2001-10-17 2002-10-16 Neutrokine-alpha et variant d'epissage de neutrokine-alpha

Country Status (4)

Country Link
EP (1) EP1507793A4 (fr)
AU (1) AU2002351495A1 (fr)
CA (1) CA2476675A1 (fr)
WO (1) WO2003033658A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
CA2407910C (fr) 2000-06-16 2013-03-12 Steven M. Ruben Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
CA2583900A1 (fr) 2004-10-13 2006-04-27 The Washington University Utilisation de baff dans le traitement du sepsis
EP3037544A1 (fr) 2005-10-13 2016-06-29 Human Genome Sciences, Inc. Procedes et compositions destinees au traitement de patients atteints de lupus erythematosus systémique positifs pour des auto-anticorps
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
AU2006318539B2 (en) 2005-11-23 2012-09-13 Genentech, Inc. Methods and compositions related to B cell assays
WO2007123765A2 (fr) 2006-03-31 2007-11-01 Human Genome Sciences Inc. NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha
CN103030696B (zh) 2006-05-30 2016-09-28 健泰科生物技术公司 抗体和免疫偶联物及其用途
KR20150008503A (ko) 2007-10-30 2015-01-22 제넨테크, 인크. 양이온 교환 크로마토그래피에 의한 항체 정제
US10927144B2 (en) 2008-08-14 2021-02-23 Genentech, Inc. Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
CA2734275A1 (fr) 2008-09-10 2010-03-18 Genentech, Inc. Compositions et procedes permettant d'eviter la degradation oxydative des proteines
BR112012021873B8 (pt) 2010-03-22 2021-09-14 Genentech Inc composição de matéria, artigo de manufatura, métodos para preparar uma composição, para aumentar a estabilidade de uma proteína em solução aquosa livre de polissorbato e para prevenir ou reduzir a agregação de uma proteína em solução aquosa livre de polissorbato
BR112012027828A2 (pt) 2010-05-03 2016-08-09 Genentech Inc composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína
KR101924653B1 (ko) 2010-06-24 2018-12-03 제넨테크, 인크. 단백질-함유 제제를 안정화시키기 위한 알킬글리코시드 함유 조성물 및 방법
CN104125963B (zh) 2011-12-22 2018-08-17 弗·哈夫曼-拉罗切有限公司 使用离子交换膜层析改进下游蛋白质纯化步骤的方法
MX2021012032A (es) 2019-04-01 2021-11-03 Genentech Inc Composiciones y metodos para estabilizar formulaciones que contienen proteinas.
CN110176272B (zh) * 2019-04-18 2021-05-18 浙江工业大学 一种基于多序列联配信息的蛋白质二硫键预测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9612752A (pt) * 1996-10-25 2000-01-18 Human Genome Sciences Inc Neutrocina
AU2001288260A1 (en) * 2000-08-15 2002-03-13 Human Genome Sciences, Inc. Neutrokine-alpha and neutrokine-alpha splice variant

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
MACKAY ET AL.: "Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations", J. EXP. MED., vol. 190, no. 11, 6 December 1999 (1999-12-06), pages 1697 - 1710, XP000915435 *
MOORE ET AL.: "BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator", SCIENCE, vol. 285, 9 July 1999 (1999-07-09), pages 260 - 263, XP002142252 *
NARDELLI ET AL.: "B lymphocyte stimulator (BLyS): A therapeutic trichotomy for the treatment of B lymphocyte diseases", LEUKEMIA AND LYMPHOMA, vol. 43, no. 7, 2002, pages 1367 - 1373, XP002973536 *
SCHNEIDER ET AL.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth", J. EXP. MED., vol. 189, no. 11, 17 June 1999 (1999-06-17), pages 1747 - 1756, XP000915409 *
See also references of EP1507793A4 *
WARE ET AL.: "APRIL and BAFF connect autoimmunity and cancer", J. EXP. MEDICINE, vol. 192, no. 11, 2000, pages F35 - F37, XP002224635 *

Also Published As

Publication number Publication date
AU2002351495A1 (en) 2003-04-28
WO2003033658A2 (fr) 2003-04-24
EP1507793A4 (fr) 2006-02-01
CA2476675A1 (fr) 2003-04-24
EP1507793A2 (fr) 2005-02-23

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