WO2004064728A3 - Composes de tetracycline possedant des activites therapeutiques ciblees - Google Patents

Composes de tetracycline possedant des activites therapeutiques ciblees Download PDF

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Publication number
WO2004064728A3
WO2004064728A3 PCT/US2004/001036 US2004001036W WO2004064728A3 WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3 US 2004001036 W US2004001036 W US 2004001036W WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
tetracycline compounds
specific tetracycline
specific
compounds
Prior art date
Application number
PCT/US2004/001036
Other languages
English (en)
Other versions
WO2004064728A2 (fr
Inventor
Stuart B Levy
Michael Draper
Mark L Nelson
Graham Jones
Original Assignee
Paratek Pharm Innc
Stuart B Levy
Michael Draper
Mark L Nelson
Graham Jones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc, Stuart B Levy, Michael Draper, Mark L Nelson, Graham Jones filed Critical Paratek Pharm Innc
Publication of WO2004064728A2 publication Critical patent/WO2004064728A2/fr
Publication of WO2004064728A3 publication Critical patent/WO2004064728A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des méthodes et des composés de traitement de maladies avec des composés de tétracycline possédant une activité thérapeutique ciblée.
PCT/US2004/001036 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees WO2004064728A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44114103P 2003-01-16 2003-01-16
US60/441,141 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004064728A2 WO2004064728A2 (fr) 2004-08-05
WO2004064728A3 true WO2004064728A3 (fr) 2004-12-16

Family

ID=32771908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001036 WO2004064728A2 (fr) 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees

Country Status (1)

Country Link
WO (1) WO2004064728A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072506A2 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
KR101148415B1 (ko) * 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
CA2553510C (fr) * 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Derives a cycle aromatique a provenant de composes de tetracycline
US7807842B2 (en) * 2004-05-21 2010-10-05 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
WO2006020573A2 (fr) * 2004-08-11 2006-02-23 Barbeau Donald L Composes pharmaceutiques non cardiotoxiques
EP2284156A3 (fr) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
CA2585418A1 (fr) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines et procedes d'utilisation
BRPI0607353A2 (pt) * 2005-02-15 2009-09-01 Wyeth Corp composto de fórmula (i); composição farmacêutica; uso do composto para o tratamento ou controle de infecções bacterianas em animais de sangue quente; processo para a preparação de tetraciclinas 9-(n-substituìdas-n-substituìdas-glicil) de fórmulas 5; 7; 10; e tetraciclina 9-(n-substituìda-n-substituìda glicil) de fómulas 5; 7; 10
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
US8486921B2 (en) 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2479169B1 (fr) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthèse d'un intermédiaire de l'énone
WO2008045507A2 (fr) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis
ES2701725T3 (es) * 2006-12-21 2019-02-25 Paratek Pharm Innc Compuestos de tetraciclina sustituida para el tratamiento de trastornos inflamatorios de la piel
CA2925939C (fr) * 2006-12-21 2019-10-01 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
EP2307027A4 (fr) * 2008-07-11 2012-08-15 Neumedics Dérivés de tétracycline présentant une activité antibiotique réduite et des bénéfices neuroprotecteurs
CA2737470A1 (fr) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Composes de tetracycline utilises dans le traitement de la polyarthrite rhumatoide et methodes therapeutiques associees
EP2424834B1 (fr) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
JP2013521314A (ja) * 2010-03-10 2013-06-10 ユニバーシティー ヘルス ネットワーク 癌の処置のためのチゲサイクリンの使用
CN102204921B (zh) * 2011-04-14 2012-12-26 苏州大学 一种四环素类衍生物在制备放疗增敏药物中的应用
NO2738156T3 (fr) * 2011-07-26 2018-06-02
JP5887423B2 (ja) 2012-11-21 2016-03-16 日本曹達株式会社 非フェノール系化合物を用いた記録材料
CN103142624A (zh) * 2013-03-01 2013-06-12 西南大学 抗生素替加环素在制备抗癌药物中的应用
US10610588B2 (en) 2015-02-09 2020-04-07 Yeda Research And Development Co. Ltd. Methods of preventing secondary infections
RU2764723C2 (ru) * 2016-06-22 2022-01-19 Кбп Байосайенсиз Ко., Лтд. Кристаллические формы 9-аминометил-замещенного соединения тетрациклина и способ их получения
US20210403416A1 (en) * 2018-06-13 2021-12-30 Texas Tech University System Novel Modified Tetracyclines for Treatment of Alcohol Use Disorder, Pain and Other Disorders Involving Potential Inflammatory Processes
US20230390309A1 (en) 2020-10-14 2023-12-07 Institut Du Cerveau Et De La Moelle Epiniere Tetracycline derivatives for treating neurodegenerative or neuroinflammatory diseases
WO2022167954A1 (fr) * 2021-02-03 2022-08-11 Skybio Llc Transporteur chimiquement couplé pour médicaments bioactifs à faible hydrophobicité dans le système nerveux central
WO2024008951A1 (fr) 2022-07-08 2024-01-11 Icm (Institut Du Cerveau Et De La Moelle Épinière) Dérivés de tétracycline

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Also Published As

Publication number Publication date
WO2004064728A2 (fr) 2004-08-05

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