WO2004061112A3 - Method of identifying organisms having a mutated signal transduction pathway - Google Patents

Method of identifying organisms having a mutated signal transduction pathway Download PDF

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Publication number
WO2004061112A3
WO2004061112A3 PCT/IL2003/001119 IL0301119W WO2004061112A3 WO 2004061112 A3 WO2004061112 A3 WO 2004061112A3 IL 0301119 W IL0301119 W IL 0301119W WO 2004061112 A3 WO2004061112 A3 WO 2004061112A3
Authority
WO
WIPO (PCT)
Prior art keywords
signal transduction
transduction pathway
organism
identifying
mutated signal
Prior art date
Application number
PCT/IL2003/001119
Other languages
French (fr)
Other versions
WO2004061112A2 (en
Inventor
Hanan Stein
Aviah Zilberstein
Gadi Miller
Original Assignee
Univ Ramot
Hanan Stein
Aviah Zilberstein
Gadi Miller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot, Hanan Stein, Aviah Zilberstein, Gadi Miller filed Critical Univ Ramot
Priority to AU2003288697A priority Critical patent/AU2003288697A1/en
Publication of WO2004061112A2 publication Critical patent/WO2004061112A2/en
Publication of WO2004061112A3 publication Critical patent/WO2004061112A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method of identifying an organism having a mutated signal transduction pathway which comprises: (i) exposing a plurality of organisms to a compound capable of negatively affecting physiology and/or morphology of an organism having a normal signal transduction pathway; while at the same time not substantially affecting the physiology and/or morphology of the organism having the mutated signal transduction pathway; and (ii) identifying an organism of the plurality of organisms not substantially effected by the compound, thereby identifying the organism having the mutated signal transduction pathway.
PCT/IL2003/001119 2003-01-06 2003-12-31 Method of identifying organisms having a mutated signal transduction pathway WO2004061112A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003288697A AU2003288697A1 (en) 2003-01-06 2003-12-31 Method of identifying organisms having a mutated signal transduction pathway

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43798503P 2003-01-06 2003-01-06
US60/437,985 2003-01-06

Publications (2)

Publication Number Publication Date
WO2004061112A2 WO2004061112A2 (en) 2004-07-22
WO2004061112A3 true WO2004061112A3 (en) 2004-08-26

Family

ID=32713261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/001119 WO2004061112A2 (en) 2003-01-06 2003-12-31 Method of identifying organisms having a mutated signal transduction pathway

Country Status (2)

Country Link
AU (1) AU2003288697A1 (en)
WO (1) WO2004061112A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057490A (en) * 1993-01-08 2000-05-02 Novartis Finance Corporation Method for selecting disease resistant mutant plants
WO2001053323A2 (en) * 2000-01-24 2001-07-26 Ramot University Authority For Applied Research & Industrial Development Ltd. Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
US6495737B1 (en) * 1996-08-12 2002-12-17 Rutgers, The State University Of New Jersey Methods and compositions for improving salicylic acid-independent systemic acquired disease resistance in plants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057490A (en) * 1993-01-08 2000-05-02 Novartis Finance Corporation Method for selecting disease resistant mutant plants
US6495737B1 (en) * 1996-08-12 2002-12-17 Rutgers, The State University Of New Jersey Methods and compositions for improving salicylic acid-independent systemic acquired disease resistance in plants
WO2001053323A2 (en) * 2000-01-24 2001-07-26 Ramot University Authority For Applied Research & Industrial Development Ltd. Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DEANE C R ET AL: "Selection of hydroxyproline-resistant proline-accumulating mutants of cauliflower (Brassica oleracea var. botrytis)", EUPHYTICA, vol. 85, no. 1-3, 1995, pages 329 - 334, XP008031278, ISSN: 0014-2336 *
FINKELSTEIN RUTH R: "Mutations at two new Arabidopsis ABA response loci are similar to the abi3 mutations", PLANT JOURNAL, vol. 5, no. 6, 1994, pages 765 - 771, XP002284188, ISSN: 0960-7412 *
GULATI ANJU ET AL: "In vitro selection and characterization of trans-4-hydroxy-L-proline resistant callus lines of Vigna radiata: Tolerance to NaCl", PLANT PHYSIOLOGY AND BIOCHEMISTRY (PARIS), vol. 31, no. 5, 1993, pages 699 - 705, XP008031580, ISSN: 0981-9428 *
HILPERT BERNADETTE ET AL: "Isolation and characterization of signal transduction mutants of Arabidopsis thaliana that constitutively activate the octadecanoid pathway and form necrotic microlesions", PLANT JOURNAL, vol. 26, no. 4, May 2001 (2001-05-01), pages 435 - 446, XP002284038, ISSN: 0960-7412 *
MANI SRIKRISHNAN ET AL: "Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis", PLANT PHYSIOLOGY (ROCKVILLE), vol. 128, no. 1, January 2002 (2002-01-01), pages 73 - 83, XP002284200, ISSN: 0032-0889 *
NAMBARA EIJI ET AL: "A screen for genes that function in abscisic acid signaling in Arabidopsis thaliana", GENETICS, vol. 161, no. 3, July 2002 (2002-07-01), pages 1247 - 1255, XP002283966, ISSN: 0016-6731 *
NANJO T ET AL: "Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 461, no. 3, 19 November 1999 (1999-11-19), pages 205 - 210, XP004260550, ISSN: 0014-5793 *
PEGO JONATAS V ET AL: "Photosynthesis, sugars and the regulation of gene expression", JOURNAL OF EXPERIMENTAL BOTANY, vol. 51, no. Spec. Issue, February 2000 (2000-02-01), pages 407 - 416, XP002284036, ISSN: 0022-0957 *
SHAH J ET AL: "CHARACTERIZATION OF A SALICYLIC ACID-INSENSITIVE MUTANT (SAI1) OF ARABIDOPSIS THALIANA, IDENTIFIED IN A SELECTIVE SCREEN UTILIZING THE SA-INDUCIBLE EXPRESSION OF THE TMS2 GENE", MOLECULAR PLANT-MICROBE INTERACTIONS, APS PRESS, ST. PAUL, MN, US, vol. 10, no. 1, 1997, pages 69 - 78, XP000916767, ISSN: 0894-0282 *
TIRYAKI ISKENDER ET AL: "An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1", PLANT PHYSIOLOGY (ROCKVILLE), vol. 130, no. 2, October 2002 (2002-10-01), pages 887 - 894, XP002283967, ISSN: 0032-0889 *
ZHOU LI ET AL: "Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, no. 17, 18 August 1998 (1998-08-18), pages 10294 - 10299, XP002284189, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2003288697A8 (en) 2004-07-29
AU2003288697A1 (en) 2004-07-29
WO2004061112A2 (en) 2004-07-22

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